EKS-CAP-00494

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00494

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	426.5	4.2E-128	25	307	283

Status

Unreviewed

Ensembl Protein

ENSCPOP00000013179

UniProt Accession

H0VRG6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK13

Gene Synonyms/Alias

MAPK13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000014626	ENSCPOP00000013179	ENSCPOT00000014771

Organism

Cavia porcellus

Functional Description

Protein Length

365

Protein Sequence
(FASTA)

ASSGKKGFYK QDVNKTAWEL PKTYASPTHI GSGAYGAVCS AIDKRSGEKV AIKKLSRPFQ 60

SEIFAKRAYR ELRLLKHMQH ENVIGLLDVF TSASSPRNFQ DFYLVMPFMQ TDLQKIMGME 120

FSEDKIQYLV YQMLKGLKYI HSAGIVHRDL KPGNLAVNED CELKILDFGL ARHADPEMTG 180

YVVTRWYRAP EVILNWMHYN QTVDIWSVGC IMAEMLTGKT LFKGKDYLDQ LTQIFKVTGV 240

PGADFVQKLK DKSAKSYIQS LPQTPKKDFT QLFPHASPQA TDLLEKILEL DVDKRLTAAQ 300

ALAHPFFEPF RDPEEETEAS QPFDDSLEHK KLTVDEWKQH IYKEIMNFSP IARKDSRRQS 360

SMKLQ 365

Nucleotide Sequence
(FASTA)

GCTTCATCCG GAAAAAAGGG CTTCTACAAG CAGGATGTCA ACAAGACGGC CTGGGAGCTG 60

CCCAAGACCT ACGCGTCCCC GACGCACATC GGCAGTGGAG CCTACGGCGC CGTGTGCTCC 120

GCCATCGACA AGCGGTCAGG GGAGAAGGTG GCCATCAAGA AGCTGAGCCG GCCCTTCCAG 180

TCTGAGATCT TCGCCAAGCG GGCCTACCGC GAGCTCAGGT TGCTGAAGCA CATGCAGCAT 240

GAGAACGTCA TCGGGCTCCT GGACGTCTTC ACCTCAGCCT CCTCCCCACG CAACTTCCAG 300

GACTTCTACC TGGTGATGCC CTTCATGCAG ACGGACCTGC AGAAGATCAT GGGCATGGAG 360

TTCAGTGAGG ACAAGATCCA GTACTTGGTG TACCAGATGC TCAAGGGTCT CAAGTACATC 420

CACTCTGCCG GCATCGTCCA CAGGGACCTG AAGCCCGGGA ACCTGGCCGT GAATGAGGAC 480

TGTGAGCTGA AGATCCTGGA TTTTGGGCTG GCCCGGCATG CGGACCCTGA GATGACTGGC 540

TACGTGGTGA CGCGCTGGTA CCGGGCCCCT GAGGTCATCC TCAATTGGAT GCACTACAAC 600

CAGACAGTGG ACATCTGGTC TGTGGGCTGC ATCATGGCGG AGATGCTGAC GGGGAAAACC 660

CTGTTCAAGG GAAAAGATTA CCTGGACCAG CTGACCCAGA TCTTCAAAGT GACCGGAGTC 720

CCGGGGGCTG ACTTTGTGCA GAAGCTGAAG GACAAATCGG CCAAATCCTA CATCCAGTCC 780

TTGCCCCAGA CTCCCAAGAA GGACTTCACT CAGCTCTTCC CACATGCCAG CCCCCAGGCC 840

ACTGACCTGC TGGAGAAGAT CCTGGAGCTG GATGTGGACA AGCGCCTGAC GGCTGCGCAG 900

GCCCTGGCCC ACCCCTTCTT TGAGCCCTTC CGGGACCCTG AGGAGGAGAC AGAGGCCTCG 960

CAACCCTTCG ATGACTCCCT GGAGCACAAG AAGCTCACGG TGGACGAGTG GAAGCAGCAC 1020

ATCTACAAGG AGATCATGAA CTTCAGCCCC ATCGCCCGCA AGGACTCTCG GCGCCAGAGC 1080

AGCATGAAGC TGCAGTGA 1098

Domain Profile

S: 2     eslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNii  61

          s +++g+Gayg v+sa+dkr++e+vaikklsrpfq+e+ akr++REl+llk+++heN+i

Q: 25    ASPTHIGSGAYGAVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELRLLKHMQHENVI  84

         66789*******************************************************

S: 62    klldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHsa  121

          lldvft++++ ++++d+Ylv+ +m+tdL+k++ ++ +s+++i++l+yq+l+glky+Hsa

Q: 85    GLLDVFTSASSPRNFQDFYLVMPFMQTDLQKIMGME-FSEDKIQYLVYQMLKGLKYIHSA  143

         **********************************99.9**********************

S: 122   nviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslkey  181

         +++HrDlKP+Nl+vnedcelkildFGlar+ad+e    +t+yv+trwYraPe++l++++y

Q: 144   GIVHRDLKPGNLAVNEDCELKILDFGLARHADPE----MTGYVVTRWYRAPEVILNWMHY  199

         **********************************....**********************

S: 182   tkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyik  241

         +++vDiWsvGCI+aE+ltgk+lf+gkd++dql++i++v+g p ++f++k+++++a++yi+

Q: 200   NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQIFKVTGVPGADFVQKLKDKSAKSYIQ  259

         ************************************************************

S: 242   slpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         slp+++kkdf++lfp+as++a dLlek+L+ld dkR+++++aL+hp++

Q: 260   SLPQTPKKDFTQLFPHASPQATDLLEKILELDVDKRLTAAQALAHPFF  307

         **********************************************95

Domain Sequence
(FASTA)

ASPTHIGSGA YGAVCSAIDK RSGEKVAIKK LSRPFQSEIF AKRAYRELRL LKHMQHENVI 60

GLLDVFTSAS SPRNFQDFYL VMPFMQTDLQ KIMGMEFSED KIQYLVYQML KGLKYIHSAG 120

IVHRDLKPGN LAVNEDCELK ILDFGLARHA DPEMTGYVVT RWYRAPEVIL NWMHYNQTVD 180

IWSVGCIMAE MLTGKTLFKG KDYLDQLTQI FKVTGVPGAD FVQKLKDKSA KSYIQSLPQT 240

PKKDFTQLFP HASPQATDLL EKILELDVDK RLTAAQALAH PFF 283

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013