EKS-CAP-00032

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00032

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	340.3	8.6E-102	853	1125	273

Status

Unreviewed

Ensembl Protein

ENSCPOP00000013203

UniProt Accession

H0VRI8;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK2

Gene Synonyms/Alias

JAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000014653	ENSCPOP00000013203	ENSCPOT00000014798

Organism

Cavia porcellus

Functional Description

Protein Length

1138

Protein Sequence
(FASTA)

MEMACLMMTE MEATSTFPVH QNGDIPGNTN SVKQVDPVLQ VYLYHSLGKA EGDYLKFPTG 60

EYVAEEICVA ACKACGITPV YHNMFALMSE TERIWYPPNH VFHIDESSRH NVLYRIRFYF 120

PHWYCSGNNR TYRYGISRGA EAPLLDDFVM SYLFAQQPYL QDSVYGYITL PVDHLDKCHG 180

RAELLEMLRV VRDRKQTQLL MVSEFSFGAF LLKIKNKLLS VEHRICNKQK LHWNELRSNN 240

QFSKKKTTAT NIFCKYLINL ETLQSAFYTE QFEVKEPGRG PSGEEIFATI IITGNGGIQW 300

SRGRHKENET LTEQDLQLYC DFPDIIDVSV KQANQEGSNE SRIVTIHKQD GKNLEIELSS 360

LREALSFVSL IDGYYRLTAD AHHYLCKEVA PPTVLENIQS NCHGPYFSKM DFAISKLKKA 420

GNQTGLYVLR CSPKDFNKYF LTFAVERENV IEYKHCLITK NENREYNLSG TKKNFSNLKD 480

LLNCYQMETV RSDSIIFQFT KCCPPKPKDK SNLLVFRTNG VSDVSTSPTL QRHNNVNQMV 540

FHKIRNEDLI FNESLGQGTF TKIFKGIRRE VGDYGQLHET EVLLKVLDKA HRNYSESFFE 600

AASMMSQLSH KHLVLNYGVC VCGEENILVQ EFVKFGSLDT YLKKNKNSIN ILWKLEVAKQ 660

LAWAMHFLEE KNRIHGNVCA KNILLIREED RKTGNPPFIK LSDPGISITV LPKDILQERI 720

PWVPPECIEN PKNLNLATDK WSFGTTLWEI CSGGDKPLSA LDSQRKLQFY EDRHQLPAPK 780

WTELANLINN CMDYEPDFRP SFRAIIRDLN SLFTPDYELL TENDMLPNTR MTASLSSGAF 840

EDRDPTQFEE RHLKFLQQLG KGNFGSVEMC RYDPLEDNTG EVVAVKKLQH STEEHLRDFE 900

REIEILKSLQ HDNIVKYKGV CYSAVKGRRN LRLIMEYLPY GSLRDYLQKH KERIDHKKLL 960

QYTSQICKGM EYLGTKRYIH RDLATRNILV ENENRVKIGD FGLTKVLPQD KEYYKVKEPG 1020

ESPIFWYAPE SLTESKFSVA SDVWSFGVVL YELFTYIEKS KSPPAEFMRM IGNDKQGQMI 1080

VFHLIELLKN NGRLPRPDGC PDEIYMIMTE CWNNNVNQRP SFKDLSFRVD QIRDNMSG 1138

Nucleotide Sequence
(FASTA)

ATGGAAATGG CTTGCCTAAT GATGACAGAA ATGGAAGCTA CATCCACATT TCCAGTACAT 60

CAGAATGGTG ATATTCCTGG AAATACTAAT TCTGTGAAGC AAGTCGATCC AGTCCTTCAG 120

GTGTATCTTT ATCATTCCCT TGGGAAAGCT GAGGGAGATT ATCTGAAGTT TCCAACTGGA 180

GAGTATGTTG CAGAAGAAAT TTGTGTTGCT GCTTGTAAAG CCTGTGGCAT CACACCTGTG 240

TATCATAATA TGTTTGCTTT AATGAGTGAA ACAGAAAGGA TCTGGTATCC ACCCAATCAT 300

GTCTTCCATA TAGATGAATC ATCCAGGCAT AATGTACTCT ACAGAATAAG ATTTTACTTT 360

CCTCACTGGT ATTGCAGTGG AAACAACAGA ACCTATCGGT ATGGAATATC TCGAGGTGCT 420

GAAGCTCCTC TTCTTGATGA TTTTGTCATG TCTTACCTTT TTGCTCAGCA ACCATACTTA 480

CAAGATTCAG TCTATGGGTA CATAACACTT CCTGTTGATC ATCTTGACAA ATGTCATGGT 540

AGAGCAGAGT TGTTAGAAAT GTTAAGAGTT GTTAGGGATA GAAAGCAGAC ACAATTACTT 600

ATGGTTTCTG AATTCTCATT TGGTGCTTTT CTCTTAAAAA TAAAAAACAA ACTACTTAGT 660

GTTGAACATA GGATTTGTAA TAAACAGAAG CTACATTGGA ATGAGTTGAG GAGTAACAAC 720

CAATTTTCCA AAAAGAAAAC AACAGCAACA AATATTTTCT GTAAGTATCT TATAAATCTG 780

GAGACTCTTC AGTCTGCCTT CTACACAGAA CAATTTGAAG TAAAAGAACC TGGAAGAGGT 840

CCTTCAGGTG AGGAGATTTT TGCAACCATT ATAATAACTG GAAACGGTGG AATTCAGTGG 900

TCAAGAGGGA GACATAAAGA AAATGAGACA CTGACAGAAC AGGATTTACA GTTGTATTGT 960

GATTTTCCTG ATATTATTGA TGTCAGTGTT AAGCAAGCAA ATCAGGAAGG CTCAAATGAA 1020

AGTAGAATTG TAACTATCCA TAAGCAAGAT GGTAAAAATT TGGAAATTGA ACTGAGTTCA 1080

TTAAGGGAAG CTTTGTCTTT TGTGTCATTG ATTGACGGAT ATTATAGACT GACTGCAGAT 1140

GCTCATCATT ACCTCTGTAA AGAGGTGGCA CCCCCTACAG TGCTTGAGAA CATACAGAGC 1200

AACTGTCATG GGCCCTATTT CAGCAAAATG GATTTTGCCA TCAGTAAATT GAAGAAAGCG 1260

GGTAATCAGA CTGGACTTTA TGTACTTCGG TGCAGCCCTA AGGACTTTAA TAAATATTTT 1320

CTGACTTTTG CTGTTGAGCG AGAAAATGTC ATTGAATATA AACATTGCTT GATTACAAAA 1380

AATGAGAATA GAGAATACAA CCTCAGTGGG ACCAAGAAGA ACTTCAGTAA TCTTAAAGAT 1440

CTTTTGAATT GCTACCAAAT GGAAACTGTT CGCTCAGACA GTATAATTTT CCAGTTTACT 1500

AAATGCTGTC CCCCAAAACC AAAAGATAAA TCAAACCTTC TAGTCTTTAG AACCAATGGT 1560

GTTTCTGATG TATCAACTTC ACCAACATTA CAGAGGCATA ATAATGTGAA CCAAATGGTA 1620

TTTCACAAAA TCAGAAACGA AGATTTGATA TTTAATGAAA GCCTTGGCCA AGGGACTTTC 1680

ACAAAAATTT TTAAAGGAAT AAGGAGAGAA GTAGGAGACT ATGGTCAGCT GCATGAAACA 1740

GAAGTTCTTT TGAAAGTTCT GGATAAAGCA CATAGAAACT ATTCAGAGTC TTTTTTTGAA 1800

GCAGCAAGCA TGATGAGTCA GCTTTCTCAC AAGCATTTGG TTTTAAATTA TGGTGTATGT 1860

GTCTGTGGAG AGGAGAATAT TCTCGTTCAG GAGTTTGTAA AATTTGGATC ATTAGATACA 1920

TACTTGAAAA AGAATAAAAA TTCTATAAAT ATATTGTGGA AACTTGAAGT GGCTAAACAG 1980

TTGGCATGGG CTATGCATTT TCTAGAAGAA AAAAACCGTA TTCATGGGAA TGTATGTGCC 2040

AAAAATATTC TACTTATCAG AGAAGAAGAC AGGAAGACAG GAAATCCTCC TTTCATCAAA 2100

CTTAGTGATC CTGGCATTAG TATTACAGTT TTACCAAAGG ACATTCTTCA GGAGAGAATA 2160

CCATGGGTAC CACCAGAATG CATTGAAAAT CCTAAAAATC TAAATTTGGC AACAGACAAA 2220

TGGAGCTTTG GTACTACTTT GTGGGAAATC TGCAGTGGAG GAGATAAACC TCTGAGTGCT 2280

CTAGATTCTC AAAGAAAATT ACAGTTTTAT GAAGATAGGC ACCAGCTTCC TGCACCAAAA 2340

TGGACAGAAT TAGCAAACCT TATAAATAAT TGTATGGATT ATGAACCAGA TTTTAGGCCT 2400

TCTTTCAGAG CCATCATACG AGATCTTAAC AGTTTATTCA CTCCAGATTA TGAACTGTTA 2460

ACAGAAAATG ACATGTTACC AAACACGAGG ATGACTGCTT CATTGTCTTC TGGTGCTTTT 2520

GAAGATAGAG ACCCTACACA GTTTGAAGAA AGACACTTAA AATTTCTACA GCAACTTGGC 2580

AAGGGTAATT TTGGAAGTGT GGAGATGTGC CGGTATGACC CTCTAGAGGA TAATACTGGG 2640

GAGGTGGTAG CTGTAAAAAA GCTCCAGCAC AGTACCGAGG AGCACCTCAG AGATTTTGAA 2700

AGGGAAATTG AAATCTTGAA ATCCCTACAG CATGATAACA TTGTAAAGTA CAAAGGAGTC 2760

TGCTACAGTG CTGTAAAAGG GCGGCGTAAT CTAAGATTAA TTATGGAATA TTTACCATAT 2820

GGGAGTTTAC GAGACTACCT CCAAAAACAC AAAGAACGGA TAGATCACAA AAAACTTCTG 2880

CAATATACAT CTCAGATATG CAAGGGTATG GAGTACCTTG GCACAAAAAG GTATATACAC 2940

AGAGATCTGG CAACAAGAAA TATATTGGTG GAGAATGAGA ACAGAGTTAA AATTGGAGAT 3000

TTTGGATTAA CCAAAGTCTT GCCACAAGAC AAAGAATACT ACAAAGTGAA AGAACCTGGT 3060

GAAAGTCCCA TATTCTGGTA TGCTCCAGAA TCTCTGACAG AGAGCAAGTT TTCTGTGGCC 3120

TCAGATGTTT GGAGTTTTGG AGTAGTTCTT TATGAACTTT TCACATATAT TGAGAAGAGT 3180

AAAAGTCCAC CAGCAGAGTT CATGCGTATG ATTGGCAATG ACAAACAAGG ACAGATGATT 3240

GTGTTCCATT TGATAGAACT CCTAAAGAAT AATGGAAGAT TACCACGACC AGATGGATGC 3300

CCAGATGAGA TTTATATGAT CATGACAGAA TGCTGGAACA ATAACGTAAA CCAGCGCCCC 3360

TCCTTTAAGG ACCTATCATT TCGAGTGGAT CAAATAAGGG ACAACATGAG TGGATGA 3417

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60

         lk++++Lgkg+f++v+++r+d+ +d+t+e va+k L++s+e++ rdf+re+eil++l+h+

Q: 853   LKFLQQLGKGNFGSVEMCRYDPLEDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD  912

         6899********************************************************

S: 61    hivklkgvcvaegen....rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameY  116

         +ivk+kgvc++  +     rl+mey+++GsL++yL+k+ke++++++ll++++q++k+meY

Q: 913   NIVKYKGVCYSAVKGrrnlRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEY  972

         ********8765433334******************************************

S: 117   LedkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripw  175

         L++k+++hrd+a+rn+Lve+e++      vk++d+gl+k+++qd eYy v+e+++s+i+w

Q: 973   LGTKRYIHRDLATRNILVENENR------VKIGDFGLTKVLPQDkEYYKVKEPGESPIFW  1026

         ***********************......*******************************

S: 176   lapeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rkl  222

         +ape+l+e+k +s+asdvWsFgv+lyel+t ++k++sp    +r+++++        +++

Q: 1027  YAPESLTESK-FSVASDVWSFGVVLYELFTyIEKSKSPpaefMRMIGNDkqgqmivfHLI  1085

         **********.*******************************999999999*********

S: 223   elleekerlpkpk.cpaelaelmtnclsyepsqrpsFrai  261

         ell+++ rlp+p+ cp+e++++mt+c++++ +qrpsF+++

Q: 1086  ELLKNNGRLPRPDgCPDEIYMIMTECWNNNVNQRPSFKDL  1125

         *************************************998

Domain Sequence
(FASTA)

LKFLQQLGKG NFGSVEMCRY DPLEDNTGEV VAVKKLQHST EEHLRDFERE IEILKSLQHD 60

NIVKYKGVCY SAVKGRRNLR LIMEYLPYGS LRDYLQKHKE RIDHKKLLQY TSQICKGMEY 120

LGTKRYIHRD LATRNILVEN ENRVKIGDFG LTKVLPQDKE YYKVKEPGES PIFWYAPESL 180

TESKFSVASD VWSFGVVLYE LFTYIEKSKS PPAEFMRMIG NDKQGQMIVF HLIELLKNNG 240

RLPRPDGCPD EIYMIMTECW NNNVNQRPSF KDL 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693	; Tyr_kinase_non-rcpt_Jak2.

Pfam

PF07714	; Pkinase_Tyr; 2.
PF00017	; SH2; 1.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01825	; JANUSKINASE2.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013