EKS-CAP-00066

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00066

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	353.9	5.7E-106	12	294	283

Status

Unreviewed

Ensembl Protein

ENSCPOP00000013220

UniProt Accession

H0VRK4;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK7

Gene Synonyms/Alias

CDK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000014671	ENSCPOP00000013220	ENSCPOT00000014816

Organism

Cavia porcellus

Functional Description

Protein Length

345

Protein Sequence
(FASTA)

MAADVKSRAK RYEKLDFLGE GQFATVYKAR DKNTNQIVAI KKIKLGHRSE AKDGINRTAL 60

REIKLLQELS HPNIIGLLDA FGHKSNISLV FDFMETDLEV IIKDNSLVLT PSHIKAYMLM 120

TLQGLYLHQH WILHRDLKPN NLLLDENGVL KLADFGLAKS FGSPNRAYTH QVVTRWYRAP 180

ELLFGARMYG VGVDMWAVGC ILAELLLRVP FLPGDSDLDQ LTRIFETLGT PTEEQWPDMC 240

SLPDYVTFKS FPGIPLQHIF SAAGDDLLDL IQGLFLFNPC TRITATQALK TPYFSNRPGP 300

APGCQLPRPN CPAEALKEQS NPAMVTKRKR TEALEQGGLP KKLVF 345

Nucleotide Sequence
(FASTA)

ATGGCTGCGG ATGTGAAGTC TCGAGCAAAG CGCTATGAGA AGCTGGATTT CCTCGGAGAG 60

GGACAGTTTG CTACGGTTTA CAAGGCCAGA GACAAGAACA CCAACCAGAT CGTCGCCATT 120

AAGAAAATCA AACTTGGACA TAGGTCAGAA GCCAAAGATG GTATAAATAG AACAGCCTTA 180

AGAGAGATAA AATTATTACA AGAGCTAAGT CATCCAAATA TAATTGGTCT CCTTGATGCT 240

TTTGGACATA AATCTAATAT TAGTCTTGTC TTTGATTTCA TGGAAACTGA TTTAGAGGTT 300

ATAATAAAGG ATAATAGTCT TGTGCTGACA CCATCGCACA TTAAAGCTTA CATGTTGATG 360

ACTCTTCAAG GACTGTATTT ACATCAACAT TGGATTCTAC ATAGAGATCT GAAACCAAAC 420

AATTTGCTGT TGGATGAAAA TGGAGTTCTA AAATTGGCAG ATTTTGGCCT GGCCAAATCA 480

TTTGGGAGCC CCAACAGAGC TTATACACAC CAGGTTGTAA CTAGATGGTA TCGGGCACCA 540

GAGTTACTGT TTGGAGCAAG GATGTATGGT GTGGGTGTGG ACATGTGGGC TGTTGGCTGT 600

ATATTAGCAG AGCTGCTTTT AAGGGTTCCT TTTTTGCCAG GAGACTCAGA TCTCGATCAG 660

CTTACAAGAA TATTTGAAAC TTTGGGCACA CCAACTGAGG AGCAGTGGCC TGACATGTGC 720

AGTCTACCAG ATTACGTGAC ATTCAAGAGT TTCCCTGGAA TCCCATTGCA GCACATCTTC 780

AGTGCAGCAG GAGATGACTT GCTCGATCTC ATACAAGGCT TATTCTTATT TAATCCATGT 840

ACTCGGATTA CAGCCACACA GGCATTAAAA ACTCCATACT TCAGTAATCG GCCAGGGCCA 900

GCACCTGGGT GTCAGCTGCC CAGACCGAAC TGTCCAGCGG AAGCCCTGAA GGAGCAGTCA 960

AACCCAGCCA TGGTGACAAA GCGAAAAAGA ACAGAGGCCT TGGAACAAGG AGGATTGCCC 1020

AAGAAGCTCG TTTTTTAG 1038

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkelkh  57

         yekl+ +geG++++vyka+dk+t+++vA+Kki+l +++e   g++ talrEi+ll+el+h

Q: 12    YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEakdGINRTALREIKLLQELSH  71

         99********************************88764444******************

S: 58    knivkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylH  117

         +ni+ Ll+ +  +k+++ Lvf+f+e+dL+ ++k+++   l+++++k ++l+ l+gl ylH

Q: 72    PNIIGLLDAFG-HKSNISLVFDFMETDLEVIIKDNSL-VLTPSHIKAYMLMTLQGL-YLH  128

         ***********.99**********************9.*****************9.9**

S: 118   snkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgake  177

         +++ilHRDlKp+NlL++++g+lklaDfGla++f+sp+++yt++vvT+wYraPelL+ga+

Q: 129   QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM  188

         ************************************************************

S: 178   YstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykks  237

         Y+  vD+W+vgcilaell r p+++g+s+ dql+rif++lgtp+e++wp++ +lp+y  +

Q: 189   YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV-T  247

         *********************************************************8.9

S: 238   fpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         f++ +   l++ ++++ ++ ldl++ l+ ++p +Ri+a++al+++yf

Q: 248   FKSFPGIPLQHIFSAAGDDLLDLIQGLFLFNPCTRITATQALKTPYF  294

         9999999******9999*****************************9

Domain Sequence
(FASTA)

YEKLDFLGEG QFATVYKARD KNTNQIVAIK KIKLGHRSEA KDGINRTALR EIKLLQELSH 60

PNIIGLLDAF GHKSNISLVF DFMETDLEVI IKDNSLVLTP SHIKAYMLMT LQGLYLHQHW 120

ILHRDLKPNN LLLDENGVLK LADFGLAKSF GSPNRAYTHQ VVTRWYRAPE LLFGARMYGV 180

GVDMWAVGCI LAELLLRVPF LPGDSDLDQL TRIFETLGTP TEEQWPDMCS LPDYVTFKSF 240

PGIPLQHIFS AAGDDLLDLI QGLFLFNPCT RITATQALKT PYF 283

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013