EKS-CAP-00335

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00335

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	456.4	2.5E-137	707	963	257

Status

Unreviewed

Ensembl Protein

ENSCPOP00000013382

UniProt Accession

H0VS00;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB3

Gene Synonyms/Alias

ERBB3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000014852	ENSCPOP00000013382	ENSCPOT00000014997

Organism

Cavia porcellus

Functional Description

Protein Length

1328

Protein Sequence
(FASTA)

MRASGALQVL GFLLSLARGS EVGNSQAVCP GTLNGLSVTG DAENQYQTLY KLYERCEVVM 60

GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM 120

LNYNTNSSHA LRQLRFTQLT EILSGGVYIE KNDKLCHMDT IDWRDIVRHP DAEIVVQDNG 180

RSCPPCHEAC KGRCWGPGPE DCQTLTKTIC APQCNGHCFG PDPNQCCHDE CAGGCSGPQD 240

TDCFACRHFN DSGACVPLCP QPLVYNKLTF QLEPNPHTKY QYGGVCVASC PHNFVVDQTS 300

CVRACPPDKM EVNKNGINMC EPCGGLCPKA CEGTGAGSRF QTVDSSNIDG FVNCTKILGN 360

LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ SWPPHMHNFS VFSNLTTIGG 420

RSLYNRGFSL LIMKNLNVTS LGLRSLKEIS AGRIYISANR QLCYHHSLNW TRLLRGPAED 480

RLDIKHNRPR RDCVAEGKVC DPLCSSGGCW GQGPGQCLSC RNYSRGGVCV THCNFLNGEP 540

REFAYEAECF SCHPECQPME GMATCNGSGS DACVQCAHFR DGPHCVSSCP HGVLGAKGPI 600

FKYPDVRNEC RPCHENCTQG CKGPQLQDCL GQPLVLISKT HLALTVTVGL TVILLVLGIT 660

FLYWRGRRIQ NKRAMRRYLE RGESLEPLDP SEKANKVYAR IFKETELRKL KVLGSGVFGT 720

VHKGVWIPEG ESIKIPVCIK VIEDKSGRQS FQAVTDHMLA IGSLDHAHIV RLLGLCPGSS 780

LQLVTQYLPL GSLLDHVRQH RGALGPQLLL NWGVQIAKGM YYLEEHSMVH RNLAARNVLL 840

KSPSQVQVAD FGVADLLPPD DKQLLHSEAK TPIKWMALES IHFGKYTHQS DVWSYGVTVW 900

ELMTFGAEPY AGLRLAEVPD LLEKGERLAQ PQICTIDVYM VMVKCWMIDE NIRPTFKELA 960

NEFTRMARDP PRYLVIRRDS GSGIPPGAEP STLTNKELEE VELEPELDLD SDLEAEEDSL 1020

ATTLGSALSL SAGTLTRPRG SQSLLSPSSG YMPMNQSNLG EAPQESAVCG DSERCPRPVS 1080

LHPVPRARLA SESSEDHVTG CDTELQEKVS MCRSRSRSPR PRGDSAYHSQ RHSLLTPVTP 1140

LSPPGLEEED VNGYVMPDTH LKGTSSSQEG TLSSVGLSSV LGKYEYMNRR RRHSLPRPPR 1200

PGSLEELGYE YMDVGSDLSA SLGSTQSCPL HPVPIIPTAG TTPDEDYEYM NRQRGSGTGG 1260

DYAAMGACPA AEQGYEEMRA FQGPGHNAPH VRYARLKTLR SLEATDSAFD NPDYWHSRLF 1320

PKANAQRT 1328

Nucleotide Sequence
(FASTA)

ATGAGGGCCA GTGGGGCTCT GCAGGTGCTG GGCTTCCTTC TCAGCCTGGC CCGGGGCTCG 60

GAGGTGGGCA ACTCGCAGGC AGTGTGCCCT GGGACTCTGA ACGGACTGAG TGTGACAGGC 120

GATGCTGAGA ATCAATACCA AACACTATAC AAGCTCTATG AAAGGTGTGA GGTGGTGATG 180

GGGAACCTGG AAATTGTTCT CACTGGACAC AATGCGGACC TCTCTTTCTT ACAGTGGATT 240

CGAGAAGTGA CAGGCTATGT CCTCGTGGCC ATGAACGAAT TCTCTACACT CCCCTTGCCT 300

AACCTGCGAG TGGTGCGGGG GACCCAGGTC TACGATGGGA AGTTTGCCAT CTTTGTCATG 360

TTGAACTATA ACACCAACTC CAGCCATGCT CTGCGCCAGC TCCGTTTTAC CCAGCTCACA 420

GAGATCCTGT CAGGGGGTGT TTATATTGAG AAGAATGATA AACTTTGTCA CATGGACACA 480

ATTGACTGGC GGGATATTGT GAGGCACCCA GACGCTGAGA TAGTGGTGCA GGACAATGGC 540

AGAAGCTGTC CCCCATGTCA CGAGGCCTGC AAGGGACGTT GCTGGGGCCC TGGACCAGAG 600

GACTGCCAAA CATTGACAAA GACTATCTGT GCCCCTCAAT GTAACGGTCA CTGCTTTGGG 660

CCGGACCCCA ACCAGTGCTG CCATGATGAG TGTGCAGGCG GTTGCTCTGG CCCTCAGGAC 720

ACCGACTGCT TTGCCTGCCG ACACTTCAAC GACAGCGGAG CCTGTGTGCC CCTGTGCCCA 780

CAGCCTCTTG TGTACAACAA GCTCACTTTC CAGCTCGAAC CCAATCCCCA CACCAAATAC 840

CAGTATGGTG GAGTTTGTGT AGCCAGCTGT CCCCATAACT TCGTGGTGGA TCAGACATCC 900

TGTGTCCGGG CATGTCCTCC TGACAAGATG GAAGTAAATA AAAATGGCAT CAACATGTGT 960

GAACCTTGTG GAGGGTTGTG TCCTAAAGCC TGTGAAGGGA CAGGTGCTGG GAGTCGCTTC 1020

CAGACTGTGG ACTCGAGCAA CATCGATGGG TTTGTGAACT GCACCAAGAT CCTGGGCAAC 1080

CTAGACTTTC TGATCACTGG ACTCAATGGA GACCCTTGGC ACAAGATCCC TGCCTTAGAC 1140

CCTGAGAAGC TCAATGTGTT CCGGACAGTA CGGGAGATCA CAGGTTACTT GAACATCCAG 1200

TCCTGGCCTC CACACATGCA CAACTTCAGT GTTTTTTCCA ATCTGACAAC CATTGGGGGC 1260

AGAAGTCTCT ACAACCGGGG TTTCTCACTA TTGATAATGA AGAATTTGAA TGTTACATCC 1320

CTGGGCCTCC GATCCCTAAA AGAGATAAGC GCTGGTCGTA TCTACATCAG TGCCAATCGG 1380

CAGCTCTGCT ACCATCACTC TCTGAACTGG ACCAGGCTGC TTCGGGGGCC TGCAGAAGAC 1440

AGGCTGGACA TCAAGCATAA TCGGCCCCGC AGGGACTGTG TGGCAGAGGG CAAAGTGTGT 1500

GACCCGCTGT GCTCCTCCGG GGGATGCTGG GGCCAAGGCC CTGGGCAGTG CTTGTCCTGT 1560

CGAAACTACA GCCGAGGGGG TGTCTGTGTG ACCCACTGCA ACTTTCTGAA TGGGGAGCCT 1620

CGTGAGTTTG CCTATGAAGC TGAATGCTTT TCCTGCCACC CAGAATGCCA GCCCATGGAG 1680

GGCATGGCCA CGTGCAATGG CTCGGGCTCT GATGCTTGTG TTCAGTGTGC CCATTTTCGA 1740

GACGGGCCCC ACTGTGTGAG CAGTTGCCCC CATGGAGTCC TAGGTGCCAA AGGTCCTATC 1800

TTCAAGTACC CAGATGTTCG GAATGAATGT CGGCCCTGCC ATGAGAACTG CACCCAGGGG 1860

TGTAAGGGAC CACAGCTACA AGACTGTTTG GGTCAACCAC TGGTACTAAT CAGCAAAACC 1920

CATTTGGCAT TGACTGTGAC AGTTGGATTG ACAGTGATTT TACTGGTCCT GGGCATCACT 1980

TTTCTCTATT GGCGTGGGCG CAGGATTCAG AATAAAAGGG CTATGAGGCG CTACTTGGAA 2040

CGGGGTGAGA GCTTAGAACC TCTGGATCCT AGTGAGAAGG CTAACAAAGT CTATGCCAGA 2100

ATCTTCAAAG AGACAGAACT GAGGAAGCTT AAAGTGCTTG GTTCAGGGGT CTTTGGAACA 2160

GTGCACAAAG GAGTGTGGAT CCCTGAAGGT GAATCCATCA AGATTCCAGT CTGCATTAAA 2220

GTCATTGAGG ACAAGAGTGG ACGGCAGAGT TTTCAAGCTG TGACAGATCA TATGCTCGCC 2280

ATTGGCAGCT TAGACCATGC CCATATTGTA CGGCTGCTAG GACTTTGCCC AGGATCATCT 2340

CTGCAGCTTG TCACTCAATA CTTGCCTCTG GGTTCCCTAT TGGATCATGT GAGACAACAC 2400

CGCGGGGCAC TGGGGCCTCA GCTGCTGCTC AACTGGGGAG TACAAATTGC CAAGGGTATG 2460

TACTACCTAG AGGAGCACAG TATGGTGCAT AGGAATCTGG CTGCCCGAAA TGTGCTGCTT 2520

AAGTCACCCA GTCAGGTTCA AGTCGCAGAT TTTGGTGTGG CTGACCTGCT GCCACCTGAT 2580

GACAAGCAGC TGCTACACAG TGAGGCCAAG ACTCCAATTA AGTGGATGGC CCTTGAGAGT 2640

ATTCACTTCG GGAAATACAC ACACCAGAGT GACGTCTGGA GCTATGGCGT GACAGTTTGG 2700

GAGCTGATGA CCTTTGGGGC AGAGCCCTAT GCTGGGCTGC GACTGGCTGA AGTACCAGAC 2760

CTGCTGGAGA AGGGGGAGCG GCTGGCACAG CCTCAGATCT GCACCATTGA TGTCTACATG 2820

GTCATGGTCA AGTGTTGGAT GATTGATGAG AATATTCGTC CGACCTTTAA AGAACTAGCC 2880

AATGAGTTCA CCAGGATGGC CCGTGATCCA CCACGGTATC TAGTCATAAG GAGAGACAGT 2940

GGGTCTGGAA TACCTCCTGG GGCAGAGCCC TCTACTCTGA CAAACAAGGA ACTAGAAGAA 3000

GTAGAGCTAG AGCCAGAACT GGACCTTGAC TCAGACTTGG AGGCAGAGGA AGACAGCCTG 3060

GCAACCACGC TAGGTTCTGC CCTCAGCTTA TCAGCTGGAA CACTTACCCG GCCACGAGGG 3120

AGCCAGAGCC TTTTAAGCCC ATCATCTGGA TACATGCCCA TGAACCAAAG TAACCTCGGG 3180

GAAGCCCCCC AGGAGTCTGC AGTTTGTGGG GATAGTGAAC GGTGCCCCCG TCCTGTCTCT 3240

TTACACCCAG TGCCACGGGC ACGCCTGGCA TCAGAATCAT CAGAGGACCA TGTGACAGGC 3300

TGTGACACTG AGCTCCAAGA GAAGGTGTCA ATGTGTAGAA GCCGGAGCCG GAGCCCACGG 3360

CCACGCGGAG ACAGTGCCTA CCATTCCCAG CGCCATAGCC TGCTTACTCC TGTCACCCCA 3420

CTCTCCCCTC CGGGCTTAGA AGAAGAGGAT GTCAACGGTT ATGTCATGCC AGACACACAT 3480

CTTAAAGGCA CTTCTTCCTC CCAGGAAGGT ACCCTTTCTT CAGTGGGTCT CAGTTCTGTC 3540

CTGGGTAAGT ATGAATACAT GAACCGGAGG AGAAGGCATA GTCTACCTCG TCCCCCTAGG 3600

CCTGGTTCCC TCGAGGAGCT GGGTTATGAG TACATGGATG TAGGATCAGA CCTCAGTGCC 3660

TCTCTGGGTA GCACACAGAG TTGCCCACTC CATCCTGTTC CCATCATACC CACTGCTGGC 3720

ACCACTCCTG ATGAGGACTA TGAATATATG AATCGGCAGC GTGGAAGTGG TACAGGGGGG 3780

GATTATGCAG CCATGGGGGC CTGCCCAGCA GCTGAACAAG GCTATGAAGA GATGAGAGCT 3840

TTCCAGGGGC CTGGACACAA TGCCCCCCAT GTTCGCTATG CCCGCCTCAA AACTCTACGA 3900

AGCTTAGAAG CCACTGACTC GGCCTTTGAT AATCCTGACT ACTGGCATAG CAGGCTTTTC 3960

CCTAAGGCTA ATGCCCAGAG AACATAA 3987

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         l+klkvlGsG+fGtv+kG+wipege++kipv+ikv+e+k+g++++++++d++l+++sldh

Q: 707   LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDH  766

         69**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         a++vrllglc  s+lqlvtq+lplG+lld+vr+h+++lG+q llnw+vqiakGm+ylee+

Q: 767   AHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEH  826

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         ++vhr+laarnvl+ksp++v+++dfG+a+ll  d+k+l ++++k+pikw+alesi++ ky

Q: 827   SMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKY  886

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfGa+py+g++++e+pdllekGerlaqp+ictidvymv+vkcw

Q: 887   THQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCW  946

         ************************************************************

S: 241   midaesrpkfkelaeef  257

         mid+++rp+fkela+ef

Q: 947   MIDENIRPTFKELANEF  963

         ****************9

Domain Sequence
(FASTA)

LRKLKVLGSG VFGTVHKGVW IPEGESIKIP VCIKVIEDKS GRQSFQAVTD HMLAIGSLDH 60

AHIVRLLGLC PGSSLQLVTQ YLPLGSLLDH VRQHRGALGP QLLLNWGVQI AKGMYYLEEH 120

SMVHRNLAAR NVLLKSPSQV QVADFGVADL LPPDDKQLLH SEAKTPIKWM ALESIHFGKY 180

THQSDVWSYG VTVWELMTFG AEPYAGLRLA EVPDLLEKGE RLAQPQICTI DVYMVMVKCW 240

MIDENIRPTF KELANEF 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 5.
SM00219	; TyrKc; 1.

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013