EKS-CAP-00374

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00374

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	359.0	1.8E-107	166	576	411

Status

Unreviewed

Ensembl Protein

ENSCPOP00000013389

UniProt Accession

H0VS07;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK1

Gene Synonyms/Alias

EIF2AK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000014860	ENSCPOP00000013389	ENSCPOT00000015005

Organism

Cavia porcellus

Functional Description

Protein Length

623

Protein Sequence
(FASTA)

MLGGGSGAWD QETEGDGEGS LAEPPAIDFP AEGAEPKYDE SDVPAELQVL KEPLQQPSFP 60

AVANQLLLVS LLEHLSHVHE TNPVRSKQVF KLLCQTFIKM GLLSSFTCSD EFSSLRLHHN 120

RAITHLMRSA KERVRQGSYE DNSYVPKIRS REIAFEAQTS RYLNEFEELA ILGKGGYGRV 180

YKVRNKLDGQ HYAIKKILIK GATKTDCMKV LREVKVLAGL QHPNIVGYHT AWIEHVHVVQ 240

PQADRVPIEL PSLEVLSDQE EDRDKHVIND ESSSSSIIFA EFTSEKEKHV GESDVENQNN 300

KLVNYTTNLV IRNNSEFESS VGLVDSSAGS VVKHQPLLRH NSDLEGNFTS TEESSGENLN 360

SFGQTEVPYH LMLHIQMQLC ELSLWDWITE RNQRAQDSVD EAACPYVIAS AATKIFQELV 420

EGVFYIHNMG IVHRDLKPRN IFLHGPDQQV KIGDFGLACT DIIQKNMSWT SRSGKGISTH 480

TSKVGTCLYA SPEQLEGSEY DAKSDMYSLG VILLELFQPF GTEMERAAVL TGVRTGRIPE 540

SLSKRSPVQA KYIQHLTSRN AAQRPSAHQL LQSELFQTPG NANLTLQMKI IEQEKEIEAL 600

KKQLSLLSQD KGVKSTGIPH GVG 623

Nucleotide Sequence
(FASTA)

ATGCTAGGGG GCGGCTCTGG AGCCTGGGAC CAAGAAACAG AGGGCGACGG GGAGGGGTCT 60

CTGGCTGAGC CGCCCGCCAT CGACTTCCCC GCTGAGGGAG CGGAGCCCAA GTATGATGAG 120

TCTGATGTTC CAGCAGAACT TCAGGTATTA AAAGAACCTC TACAACAGCC AAGTTTTCCT 180

GCAGTTGCAA ACCAACTTTT GCTTGTCTCT TTGCTAGAAC ACTTGAGCCA TGTGCATGAA 240

ACAAATCCTG TTCGTTCAAA ACAGGTGTTT AAATTACTTT GTCAGACCTT TATAAAAATG 300

GGGCTGCTGT CTTCTTTCAC CTGCAGTGAT GAGTTTAGCT CATTAAGACT GCATCACAAC 360

AGAGCTATTA CGCATTTAAT GAGGTCTGCG AAAGAGAGAG TTCGGCAGGG TTCTTATGAA 420

GATAATTCTT ATGTGCCGAA AATCAGATCC AGGGAAATAG CCTTTGAAGC ACAAACTTCA 480

CGTTACTTAA ATGAATTTGA AGAACTTGCC ATCTTAGGAA AAGGTGGATA TGGAAGAGTA 540

TATAAGGTCA GGAATAAATT AGATGGTCAG CATTATGCAA TTAAGAAAAT CCTGATTAAG 600

GGTGCAACTA AAACAGATTG CATGAAGGTG TTACGGGAAG TAAAAGTGTT GGCAGGTCTT 660

CAGCACCCCA ACATTGTAGG TTATCACACT GCATGGATAG AGCATGTTCA TGTGGTTCAA 720

CCCCAAGCAG ACAGAGTTCC TATTGAGTTG CCCTCTCTCG AAGTGCTTTC TGACCAGGAA 780

GAGGACAGAG ATAAACATGT TATAAATGAT GAAAGTAGCA GTTCATCCAT TATCTTTGCT 840

GAGTTTACTT CAGAAAAAGA AAAACACGTT GGTGAATCTG ATGTTGAAAA CCAGAATAAC 900

AAATTGGTGA ACTATACTAC CAATTTAGTC ATAAGGAACA ACAGTGAATT TGAGTCATCC 960

GTTGGCTTGG TTGATTCGTC TGCTGGATCA GTCGTTAAGC ATCAACCCCT ACTCAGGCAT 1020

AACTCAGACC TAGAGGGAAA CTTCACATCT ACTGAGGAGT CTTCTGGAGA AAACTTAAAC 1080

TCATTTGGGC AGACAGAGGT GCCGTATCAT CTGATGCTGC ACATCCAGAT GCAGCTGTGC 1140

GAGCTTTCCC TGTGGGACTG GATCACTGAG AGGAACCAGC GGGCCCAAGA CAGTGTGGAT 1200

GAAGCTGCCT GTCCTTATGT TATAGCCAGT GCTGCAACAA AAATTTTTCA AGAATTGGTG 1260

GAAGGTGTTT TTTACATACA TAACATGGGG ATTGTACACA GAGATCTGAA GCCTAGAAAT 1320

ATTTTCCTTC ATGGCCCTGA TCAGCAAGTA AAAATAGGAG ACTTTGGCCT GGCCTGCACA 1380

GACATCATAC AGAAGAACAT GTCCTGGACC AGCAGAAGTG GGAAGGGAAT ATCCACACAC 1440

ACTTCCAAAG TGGGAACCTG TCTGTATGCT TCACCGGAGC AGTTGGAAGG ATCTGAGTAT 1500

GATGCCAAGT CAGACATGTA CAGCTTGGGT GTGATCCTGC TCGAGCTCTT TCAGCCGTTC 1560

GGGACAGAGA TGGAGCGAGC AGCAGTTCTC ACGGGTGTAA GAACTGGTCG GATTCCTGAG 1620

TCGCTCAGTA AAAGGTCCCC AGTGCAGGCC AAATACATCC AGCACCTTAC CAGCAGGAAT 1680

GCAGCCCAGA GACCATCTGC TCATCAGCTG CTGCAGAGTG AACTTTTCCA AACTCCTGGA 1740

AATGCTAATC TCACCCTACA GATGAAAATA ATAGAGCAAG AAAAAGAAAT TGAAGCACTA 1800

AAGAAGCAGC TAAGTCTCCT TTCTCAGGAT AAAGGGGTAA AATCAACTGG AATTCCTCAT 1860

GGTGTTGGA 1869

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakke.lekverevkaLaklehpni  59

         fee+++lGkGg+g+V+k++nkld+++yaik+i ++ a+k+ ++kv+revk+La l+hpni

Q: 166   FEELAILGKGGYGRVYKVRNKLDGQHYAIKKILIKGATKTdCMKVLREVKVLAGLQHPNI  225

         899*********************************************************

S: 60    vrYfaawleekeesl................................tdsseveaeaele  87

         v Y++aw+e+ +  +                                ++ss ++ae+++e

Q: 226   VGYHTAWIEHVHVVQpqadrvpielpslevlsdqeedrdkhvindesSSSSIIFAEFTSE  285

         ************9999*****************************9544999********

S: 88    esesseesdtk.................................................  98

         ++++  esd++

Q: 286   KEKHVGESDVEnqnnklvnyttnlvirnnsefessvglvdssagsvvkhqpllrhnsdle  345

         ********999*************************************************

S: 99    ..........................llyiqmelceketLkdwiderk......llesrs  126

                                   +l+iqm+lce  +L+dwi+er+      ++e+++

Q: 346   gnftsteessgenlnsfgqtevpyhlMLHIQMQLCE-LSLWDWITERNqraqdsVDEAAC  404

         ************************************.*********99887777777777

S: 127   elvm.....rlfkqllegleylHskgliHrdLkpsniFld.sddqvKigDFgLatalaea  180

          +v+     ++f++l+eg+ y+H++g++HrdLkp+niFl+  d+qvKigDFgLa++++ +

Q: 405   PYVIasaatKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHgPDQQVKIGDFGLACTDIIQ  464

         77779***********************************99******************

S: 181   lkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGlilfeLlypfstem  240

         ++ ++++++ ++ ++ht++vgt+ly+sPeqle+s+Y++k+D++sLG+il+eL++pf tem

Q: 465   KNMSWTSRSGKGISTHTSKVGTCLYASPEQLEGSEYDAKSDMYSLGVILLELFQPFGTEM  524

         ************************************************************

S: 241   ervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasellksell  292

         er+ +lt +r+g+ipe+++++ p+++k++q+l+sr++++Rpsa++ll+sel+

Q: 525   ERAAVLTGVRTGRIPESLSKRSPVQAKYIQHLTSRNAAQRPSAHQLLQSELF  576

         *************************************************986

Domain Sequence
(FASTA)

FEELAILGKG GYGRVYKVRN KLDGQHYAIK KILIKGATKT DCMKVLREVK VLAGLQHPNI 60

VGYHTAWIEH VHVVQPQADR VPIELPSLEV LSDQEEDRDK HVINDESSSS SIIFAEFTSE 120

KEKHVGESDV ENQNNKLVNY TTNLVIRNNS EFESSVGLVD SSAGSVVKHQ PLLRHNSDLE 180

GNFTSTEESS GENLNSFGQT EVPYHLMLHI QMQLCELSLW DWITERNQRA QDSVDEAACP 240

YVIASAATKI FQELVEGVFY IHNMGIVHRD LKPRNIFLHG PDQQVKIGDF GLACTDIIQK 300

NMSWTSRSGK GISTHTSKVG TCLYASPEQL EGSEYDAKSD MYSLGVILLE LFQPFGTEME 360

RAAVLTGVRT GRIPESLSKR SPVQAKYIQH LTSRNAAQRP SAHQLLQSEL F 411

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006950	; P:response to stress

KEGG

InterPros

IPR015516	; Haem-reg_EIF2A_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013