EKS-CAP-00174

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00174

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	438.6	8.3E-132	379	633	255

Status

Unreviewed

Ensembl Protein

ENSCPOP00000013395

UniProt Accession

H0VS11;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCQ

Gene Synonyms/Alias

PRKCQ;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000014866	ENSCPOP00000013395	ENSCPOT00000015011

Organism

Cavia porcellus

Functional Description

Protein Length

705

Protein Sequence
(FASTA)

MSPFLRIGLS NFDCGSCQSC QGEAVNPYCA VLVKEYVESE NGQMYIQKKP TMYPPWDSTF 60

DAHINKGRVM QIIVKGKNVD LISETTVELY SLAERCRKNN GRTEIWLELK PQGRMLMNAR 120

YFLEMSDTKD MSELETEGFF ALHHRRGAIK QAKVHHVKCH EFTATFFPQP TFCSVCHEFV 180

WGLNKQGYQC RQCNAAIHKK CIDKVIAKCT GSAINSRETM FHKERFKIDM PHRFKVYNYK 240

SPTFCEHCGT LLWGLARQGL KCDACGMNVH HRCQTKVANL CGINQKLMAE ALAMIESTQQ 300

ARSLRDSEHI FREGPVEIGL PCSVKNEARL PYLPTGKKEP QGISWDSPLD GMDKVCHRPE 360

PEPNIEKPTL HLKLKIDDFI LHKMLGKGSF GKVFLAEFKK TNQFFAIKAL KKDVVLMDDD 420

VECTMVEKRV LSLAWEHPFL THMFCTFQTK ENLFFVMEYL NGGDLMYHIQ SCHKFDLPRA 480

TFYAAEIILG LQFLHSKGIV YRDLKLDNIL LDKDGHIKIA DFGMCKENMV GDARTNTFCG 540

TPDYIAPEIL LGQKYNHSVD WWSFGVLLYE MLIGQSPFHG QDEEELFHSI RMDNPFYPRW 600

LEKEAKDLLV KLFVREPEKR LGVRGDIRQH PLFQEINWDE LERKEIDPPF KPKVKSPYDC 660

SNFDKEFLNE KPRLSFADGA LINSMDQNMF RNFSFVNPGM EGLIS 705

Nucleotide Sequence
(FASTA)

ATGTCACCAT TTCTTCGGAT TGGTTTGTCC AACTTTGACT GCGGGTCCTG CCAGTCTTGT 60

CAGGGCGAGG CTGTGAACCC TTACTGCGCT GTGCTTGTCA AAGAGTACGT TGAATCAGAA 120

AATGGGCAGA TGTATATCCA GAAAAAACCA ACCATGTACC CACCCTGGGA CAGCACCTTT 180

GACGCCCACA TCAACAAGGG GAGAGTGATG CAAATCATCG TGAAGGGCAA AAATGTGGAT 240

CTCATCTCTG AAACCACTGT GGAGCTCTAC TCGCTGGCTG AGAGATGCAG AAAGAACAAT 300

GGGAGGACAG AAATATGGTT AGAGCTGAAA CCTCAAGGCC GAATGCTAAT GAATGCAAGA 360

TACTTTCTGG AAATGAGTGA CACAAAAGAC ATGAGTGAAT TGGAGACCGA AGGCTTCTTT 420

GCCCTGCATC ACCGCCGAGG AGCTATCAAA CAGGCCAAAG TCCACCACGT CAAGTGCCAC 480

GAGTTCACCG CCACATTTTT CCCACAACCT ACCTTTTGTT CTGTCTGCCA TGAGTTTGTC 540

TGGGGTCTAA ACAAACAGGG CTACCAGTGT CGACAATGTA ATGCAGCAAT TCACAAGAAG 600

TGTATTGATA AAGTCATAGC TAAGTGCACA GGATCAGCTA TCAATAGCCG AGAAACCATG 660

TTCCACAAGG AGAGATTCAA GATAGACATG CCACACAGAT TCAAAGTCTA CAATTACAAA 720

AGCCCGACCT TCTGTGAGCA CTGTGGGACC CTGCTGTGGG GGCTGGCACG ACAAGGACTC 780

AAGTGTGATG CATGTGGCAT GAACGTCCAC CACCGATGCC AGACAAAAGT TGCCAACCTT 840

TGTGGTATAA ACCAGAAGCT AATGGCTGAA GCACTAGCAA TGATTGAAAG CACCCAGCAG 900

GCTCGCTCCT TAAGAGATTC AGAACACATC TTTCGAGAAG GTCCAGTTGA AATTGGTCTC 960

CCATGTTCAG TCAAAAATGA AGCAAGGCTA CCATACTTAC CAACTGGGAA AAAAGAGCCT 1020

CAAGGAATCT CCTGGGACTC TCCATTGGAT GGGATGGATA AAGTGTGCCA TCGACCAGAA 1080

CCTGAACCAA ACATAGAAAA ACCAACTCTG CACCTGAAGC TAAAAATCGA TGACTTCATT 1140

TTGCATAAAA TGCTGGGGAA GGGAAGTTTT GGCAAGGTCT TCCTTGCAGA ATTCAAGAAA 1200

ACCAATCAGT TTTTTGCAAT AAAAGCTTTA AAGAAAGATG TGGTTTTGAT GGACGACGAT 1260

GTCGAGTGTA CCATGGTAGA GAAGAGAGTC CTCTCCTTGG CCTGGGAGCA CCCATTTCTA 1320

ACACACATGT TCTGTACATT CCAGACCAAG GAAAATCTCT TTTTTGTGAT GGAGTATCTC 1380

AACGGAGGAG ATTTAATGTA CCACATTCAA AGTTGCCACA AGTTTGACCT TCCCAGAGCC 1440

ACATTTTATG CTGCTGAAAT CATCCTTGGT CTGCAGTTCC TTCATTCCAA AGGAATTGTC 1500

TATAGGGACC TGAAACTAGA TAATATCCTG CTAGACAAAG ATGGACACAT CAAAATAGCA 1560

GACTTTGGGA TGTGCAAGGA AAACATGGTA GGAGATGCAA GGACCAACAC TTTCTGCGGG 1620

ACTCCAGACT ACATTGCCCC GGAGATCTTG CTCGGTCAGA AGTATAACCA TTCCGTTGAC 1680

TGGTGGTCCT TTGGTGTTCT CCTCTATGAA ATGTTGATCG GCCAATCACC TTTCCACGGG 1740

CAAGATGAAG AAGAACTTTT CCACTCTATC CGCATGGACA ATCCCTTTTA CCCACGATGG 1800

CTAGAGAAGG AAGCCAAGGA TCTTCTAGTG AAGCTGTTTG TGAGAGAACC TGAAAAGAGG 1860

CTGGGAGTGA GAGGAGACAT CCGCCAACAT CCTTTGTTTC AGGAGATCAA CTGGGATGAA 1920

CTTGAGAGAA AGGAGATTGA CCCACCTTTC AAGCCAAAAG TGAAATCGCC ATACGACTGT 1980

AGCAATTTCG ACAAGGAATT CCTGAATGAG AAACCCCGAC TGTCGTTTGC TGATGGAGCA 2040

CTGATCAACA GCATGGACCA GAACATGTTT AGGAACTTTT CTTTTGTGAA CCCAGGGATG 2100

GAGGGGCTCA TCTCCTGA 2118

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f l+k+lGkGsfgkv+lae kkt++++aik lkkdvvl+dddve+t+vekrvl+la+++p

Q: 379   FILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHP  438

         7899********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl+++f++fqt+++lffv+ey+nGGdlm+hiq+++k++ +ra+fyaaeiil+l+flh+kg

Q: 439   FLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLPRATFYAAEIILGLQFLHSKG  498

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         i+yrdlkldn+lld++Ghik+adfG+cke+++ +++t+tfcGtPdyiaPeil +++y++s

Q: 499   IVYRDLKLDNILLDKDGHIKIADFGMCKENMVGDARTNTFCGTPDYIAPEILLGQKYNHS  558

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdww++Gvllyeml+gqsPf+g+de+elf+si++++++yP++l+kea+++l +l+ ++pe

Q: 559   VDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPE  618

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlGv  +g  di++h++f

Q: 619   KRLGV--RG--DIRQHPLF  633

         *****..55..89999987

Domain Sequence
(FASTA)

FILHKMLGKG SFGKVFLAEF KKTNQFFAIK ALKKDVVLMD DDVECTMVEK RVLSLAWEHP 60

FLTHMFCTFQ TKENLFFVME YLNGGDLMYH IQSCHKFDLP RATFYAAEII LGLQFLHSKG 120

IVYRDLKLDN ILLDKDGHIK IADFGMCKEN MVGDARTNTF CGTPDYIAPE ILLGQKYNHS 180

VDWWSFGVLL YEMLIGQSPF HGQDEEELFH SIRMDNPFYP RWLEKEAKDL LVKLFVREPE 240

KRLGVRGDIR QHPLF 255

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR014376	; Prot_kin_PKC_delta.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013