EKS-CAP-00310

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00310

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	467.2	1.8E-140	202	489	288

Status

Unreviewed

Ensembl Protein

ENSCPOP00000013417

UniProt Accession

H0VS30;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1

Gene Synonyms/Alias

TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000014890	ENSCPOP00000013417	ENSCPOT00000015035

Organism

Cavia porcellus

Functional Description

Protein Length

500

Protein Sequence
(FASTA)

MEAAAAAPRH QLLLLMLVAA AATLLPGAKA LQCFCQLCAK DNYTCVTDGL CFVSITETTD 60

RIIHNTMCIA EIDLIPRDRP FVCAPSSKTG AVTTTHCCNQ DHCNKIELPT TEKQSSGLGP 120

VELAAVIAGP VCFVCISLML MVYICHNRTV IHHRVPNEED PSLDRPFISE GTTLKDLIYD 180

MTTSGSGSGL PLLVQRTIAR TIVLQESIGK GRFGEVWRGK WRGEEVAVKI FSSREERSWF 240

REAEIYQTVM LRHENILGFI AADNKDNGTW TQLWLVSDYH EHGSLFDYLN RYTVTVEGMI 300

KLALSTASGL AHLHMEIVGT QGKPAIAHRD LKSKNILVKK NGTCCIADLG LAVRHDSATD 360

TIDIAPNHRV GTKRYMAPEV LDDSINMKHF ESFKRADIYA MGLVFWEIAR RCSIGGIHED 420

YQLPYYDLVP SDPSVEEMRK VVCEQKLRPN IPNRWQSCEA LRVMAKIMRE CWYANGAARL 480

TALRIKKTLS QLSQQEGIKM 500

Nucleotide Sequence
(FASTA)

ATGGAGGCGG CGGCCGCTGC TCCGCGTCAC CAGCTGCTTC TCCTCATGCT GGTGGCAGCG 60

GCGGCGACGC TGCTGCCGGG GGCGAAGGCA TTACAGTGTT TCTGCCAGCT CTGTGCAAAA 120

GACAATTATA CCTGCGTGAC AGATGGCCTC TGCTTTGTCT CTATCACAGA GACTACAGAC 180

AGAATTATAC ACAACACCAT GTGTATAGCT GAAATCGATC TAATTCCTCG AGATAGACCA 240

TTTGTATGTG CACCCTCTTC AAAAACTGGG GCTGTTACCA CAACACATTG CTGCAATCAG 300

GACCATTGCA ATAAAATAGA ACTCCCAACT ACCGAGAAGC AGTCATCTGG CCTTGGTCCT 360

GTGGAGCTGG CAGCTGTCAT TGCGGGGCCG GTCTGCTTCG TGTGCATCTC CCTTATGTTG 420

ATGGTCTATA TCTGCCACAA CCGAACTGTC ATTCATCACC GTGTGCCAAA TGAGGAGGAC 480

CCGTCCCTGG ACCGCCCTTT TATTTCAGAG GGCACCACAT TGAAAGATCT GATTTATGAC 540

ATGACGACGT CGGGGTCTGG GTCAGGTTTG CCATTGCTTG TTCAGAGGAC AATTGCAAGA 600

ACAATTGTGT TACAAGAAAG CATTGGCAAA GGGCGATTCG GAGAAGTCTG GCGAGGAAAA 660

TGGCGGGGAG AAGAAGTTGC TGTGAAGATA TTCTCCTCTA GGGAAGAACG TTCGTGGTTT 720

CGCGAGGCAG AGATTTACCA GACTGTGATG TTACGCCACG AAAACATCCT GGGATTTATA 780

GCAGCAGACA ATAAAGACAA TGGTACATGG ACACAACTCT GGTTGGTGTC GGATTATCAT 840

GAGCACGGAT CCCTTTTTGA TTACTTGAAT AGATACACAG TTACTGTGGA AGGAATGATT 900

AAGCTTGCTC TGTCCACCGC GAGTGGTCTT GCCCATCTTC ATATGGAGAT AGTTGGTACC 960

CAAGGAAAGC CAGCCATTGC ACATAGAGAT TTGAAATCAA AGAACATCTT GGTGAAGAAG 1020

AATGGGACCT GCTGTATTGC AGACTTAGGG CTGGCAGTAA GACATGATTC AGCCACAGAC 1080

ACAATCGACA TTGCTCCAAA CCACCGAGTG GGGACGAAAA GGTACATGGC CCCTGAAGTC 1140

CTAGATGATT CCATAAATAT GAAACATTTT GAATCCTTTA AACGTGCTGA CATCTATGCA 1200

ATGGGCTTAG TATTCTGGGA AATAGCTCGT CGATGCTCCA TTGGTGGAAT TCATGAAGAT 1260

TACCAGCTGC CTTACTATGA TCTTGTACCT TCTGATCCAT CAGTTGAAGA AATGAGAAAA 1320

GTGGTTTGTG AACAGAAGTT GAGGCCAAAT ATTCCAAACA GATGGCAGAG CTGTGAAGCT 1380

CTGAGAGTGA TGGCTAAAAT CATGAGAGAA TGTTGGTATG CTAATGGAGC GGCCAGGCTG 1440

ACGGCTTTGC GGATTAAGAA AACATTGTCA CAGCTCAGTC AACAGGAAGG CATCAAAATG 1500

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 202   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  261

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 262   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  321

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 322   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  379

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem

Q: 380   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  438

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 439   RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  489

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV 240

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013