EKS-CAP-00492

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00492

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	447.2	2.1E-134	24	308	285

Status

Unreviewed

Ensembl Protein

ENSCPOP00000013420

UniProt Accession

H0VS33;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK14

Gene Synonyms/Alias

MAPK14;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000014893	ENSCPOP00000013420	ENSCPOT00000015038

Organism

Cavia porcellus

Functional Description

Protein Length

360

Protein Sequence
(FASTA)

MSQERPKFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGLRV AVKKLSRPFQ 60

SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN DVYLVTHLMG ADLNNIVKCQ 120

KLTDDHVQFL IYQILRGLKY IHSADIIHRD LKPSNLAVNE DCELKILDFG LARHTDDEMT 180

GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLTGR TLFPGTDHIN QLQQIMRLTG 240

TPPAYLINRM PSHEARNYIQ SLTQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA 300

QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVVSFVP PPLDQEEMES 360

Nucleotide Sequence
(FASTA)

ATGTCTCAGG AGAGGCCCAA GTTCTACAGG CAGGAGCTGA ACAAGACGAT CTGGGAGGTG 60

CCGGAACGTT ACCAGAACCT GTCCCCGGTG GGCTCTGGCG CCTATGGCTC CGTGTGTGCT 120

GCTTTTGACA CAAAAACTGG GTTACGTGTG GCCGTGAAGA AACTATCCAG ACCGTTTCAG 180

TCCATCATCC ACGCCAAGAG GACCTACCGA GAGCTTCGGT TACTGAAACA TATGAAACAT 240

GAAAACGTGA TCGGTCTGCT GGACGTCTTT ACCCCTGCAA GGTCTCTGGA GGAATTCAAT 300

GATGTGTACC TGGTGACCCA TCTCATGGGG GCGGATCTGA ACAACATTGT GAAATGCCAG 360

AAGCTCACGG ATGACCACGT CCAGTTCCTT ATCTACCAGA TCCTCCGGGG TCTGAAGTAC 420

ATACATTCAG CCGACATAAT CCACAGGGAC CTCAAACCAA GTAATCTAGC TGTGAATGAA 480

GACTGTGAGC TGAAGATTCT GGATTTCGGA CTGGCTCGAC ATACGGATGA CGAAATGACA 540

GGCTATGTGG CCACCAGGTG GTACAGGGCT CCTGAGATCA TGCTGAATTG GATGCATTAC 600

AACCAGACAG TGGACATCTG GTCGGTGGGC TGCATCATGG CCGAGCTGCT GACTGGAAGA 660

ACGTTGTTTC CTGGTACAGA CCATATTAAC CAGCTTCAGC AGATTATGCG TCTGACGGGG 720

ACGCCCCCCG CTTATCTCAT TAACAGGATG CCAAGCCACG AGGCAAGAAA CTACATCCAG 780

TCGCTGACCC AGATGCCGAA GATGAACTTT GCAAATGTAT TTATTGGTGC CAACCCCTTG 840

GCTGTTGACC TGCTGGAGAA GATGCTTGTA TTGGACTCGG ATAAGAGAAT CACAGCAGCC 900

CAAGCCCTAG CACACGCCTA CTTTGCTCAA TACCACGATC CTGACGATGA ACCAGTGGCT 960

GATCCGTACG ATCAGTCCTT TGAAAGCAGG GACCTCCTCA TAGATGAATG GAAAAGCCTG 1020

ACCTATGACG AAGTCGTCAG CTTTGTGCCA CCCCCCCTTG ACCAAGAAGA GATGGAGTCC 1080

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++l+p+g+Gayg v++a+d++t+ rva+kklsrpfq+ ++akrt+REl+llk++kheN+

Q: 24    YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV  83

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i lldvftp+++lee++dvYlvt+lm++dL++++k qkl+d+h+++l+yqilrglky+Hs

Q: 84    IGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHS  143

         ************************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsNl+vnedcelkildFGlar++d+e    +t+yvatrwYraPei+l++++

Q: 144   ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE----MTGYVATRWYRAPEIMLNWMH  199

         **********************************9....*********************

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI+aElltg++lfpg+d+i+ql++i++++gtp +  ++++ s+earnyi

Q: 200   YNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRMPSHEARNYI  259

         ************************************************************

S: 241   kslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         +sl++++k++f+++f  a++ a+dLlek+Lvld+dkRi++++aL+h Y+

Q: 260   QSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF  308

         ***********************************************96

Domain Sequence
(FASTA)

YQNLSPVGSG AYGSVCAAFD TKTGLRVAVK KLSRPFQSII HAKRTYRELR LLKHMKHENV 60

IGLLDVFTPA RSLEEFNDVY LVTHLMGADL NNIVKCQKLT DDHVQFLIYQ ILRGLKYIHS 120

ADIIHRDLKP SNLAVNEDCE LKILDFGLAR HTDDEMTGYV ATRWYRAPEI MLNWMHYNQT 180

VDIWSVGCIM AELLTGRTLF PGTDHINQLQ QIMRLTGTPP AYLINRMPSH EARNYIQSLT 240

QMPKMNFANV FIGANPLAVD LLEKMLVLDS DKRITAAQAL AHAYF 285

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013