EKS-CAP-00169

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00169

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	479.1	3.5E-144	284	542	259

Status

Unreviewed

Ensembl Protein

ENSCPOP00000013427

UniProt Accession

H0VS40;

Protein Name

Protein kinase C

Protein Synonyms/Alias

Gene Name

PRKCA

Gene Synonyms/Alias

PRKCA;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000014901	ENSCPOP00000013427	ENSCPOT00000015046

Organism

Cavia porcellus

Functional Description

Protein Length

617

Protein Sequence
(FASTA)

FFRGFGKQGF QCQVCCFVVH KRCHEFVTFS CPGADKGPDT DDPRSKHKFK IHTYGSPTFC 60

DHCGSLLYGL IHQGMKCDTC DMNVHKQCVI NVPSLCGMDH TEKRGRIYLK AEVTDEKLHV 120

TVRDAKNLIP MDPNGLSDPY VKLKLIPDPK NESKQKTKTI RSTLNPQWNE SFTFKLKPSD 180

KDRRLSVEIW DWDRTTRNDF MGSLSFGVSE LMKMPASGWY KLLNQEEGEY YNVPIPEGDE 240

EGNMELRQKF EKAKLGPAGN KVISPSEDRK QPSNNLDRVK LTDFNFLMVL GKGSFGKVML 300

ADRKGTEELY AIKILKKDVV IQDDDVECTM VEKRVLALLD KPPFLTQLHS CFQTVDRLYF 360

VMEYVNGGDL MYHIQQVGKF KEPQAVFYAA EISIGLFFLH KRGIIYRDLK LDNVMLDSEG 420

HIKIADFGMC KEHMMDGVTT RTFCGTPDYI APEIIAYQPY GKSVDWWAYG VLLYEMLAGQ 480

PPFDGEDEDE LFQSIMEHNV SYPKSLSKEA VSICKGLMTK HPAKRLGCGP EGERDVREHA 540

FFRRIDWEKL ENREIQPPFK PKVCGKGAEN FDKFFTRGQP VLTPPDQLVI ANIDQSDFEG 600

FSYVNPQFVH PILQSAV 617

Nucleotide Sequence
(FASTA)

TTTTTCAGGG GGTTTGGGAA ACAAGGCTTC CAGTGCCAAG TTTGCTGTTT TGTGGTTCAC 60

AAGAGGTGCC ATGAGTTTGT TACTTTTTCT TGTCCGGGTG CAGATAAGGG ACCTGACACT 120

GATGACCCCA GGAGCAAGCA CAAGTTTAAA ATCCACACAT ATGGAAGTCC CACCTTCTGT 180

GATCACTGTG GGTCACTGCT GTACGGACTT ATCCACCAGG GAATGAAATG CGACACCTGC 240

GACATGAATG TTCACAAGCA GTGTGTAATA AATGTCCCCA GCCTCTGTGG AATGGATCAC 300

ACAGAGAAGA GGGGGAGGAT TTACCTGAAG GCTGAGGTCA CTGATGAGAA ACTCCATGTT 360

ACAGTACGAG ATGCAAAAAA TCTAATCCCT ATGGATCCAA ATGGACTTTC AGATCCTTAT 420

GTGAAGCTGA AACTTATTCC TGATCCCAAG AATGAAAGCA AACAGAAAAC CAAAACCATC 480

CGCTCCACAC TGAACCCCCA GTGGAACGAG TCCTTCACAT TCAAATTAAA ACCTTCAGAC 540

AAAGACCGAC GACTGTCTGT AGAGATCTGG GATTGGGATC GAACTACAAG GAACGACTTC 600

ATGGGATCCC TCTCCTTTGG AGTGTCAGAG CTCATGAAGA TGCCAGCCAG TGGATGGTAC 660

AAGTTGCTTA ACCAAGAGGA AGGTGAGTAC TACAACGTGC CCATTCCAGA AGGGGACGAA 720

GAAGGCAACA TGGAGCTCAG GCAGAAATTT GAGAAAGCCA AGCTTGGCCC TGCTGGTAAC 780

AAAGTAATTA GTCCTTCAGA AGACAGAAAA CAGCCCTCCA ATAACCTTGA CAGAGTGAAG 840

CTCACAGACT TCAATTTCCT CATGGTGCTG GGGAAGGGGA GTTTTGGGAA GGTGATGCTG 900

GCCGATAGGA AAGGAACAGA AGAACTGTAC GCAATCAAGA TCCTGAAGAA GGACGTGGTG 960

ATTCAGGATG ATGATGTGGA GTGCACCATG GTGGAAAAGC GGGTCCTGGC CCTGCTCGAT 1020

AAGCCCCCGT TTCTGACACA GCTGCACTCC TGCTTCCAGA CCGTGGATCG GCTTTACTTT 1080

GTCATGGAAT ACGTCAACGG TGGGGACCTC ATGTACCACA TTCAGCAAGT AGGGAAATTT 1140

AAGGAGCCAC AAGCAGTATT CTATGCAGCA GAGATTTCCA TTGGATTGTT CTTTCTTCAT 1200

AAAAGAGGAA TCATCTATAG GGATCTGAAG TTAGATAATG TCATGCTGGA TTCAGAAGGA 1260

CATATCAAAA TTGCTGACTT TGGGATGTGC AAGGAGCACA TGATGGATGG AGTCACGACC 1320

AGGACCTTCT GTGGGACACC AGATTACATC GCCCCAGAGA TAATTGCGTA CCAGCCATAT 1380

GGAAAGTCTG TGGACTGGTG GGCCTATGGC GTCCTGTTGT ATGAAATGCT AGCTGGACAG 1440

CCTCCATTTG ACGGTGAGGA TGAAGATGAA CTGTTTCAGT CTATAATGGA GCACAACGTT 1500

TCCTATCCCA AATCCTTGTC CAAGGAAGCC GTTTCCATCT GCAAAGGACT GATGACCAAA 1560

CACCCAGCCA AGCGGCTGGG CTGTGGGCCT GAAGGGGAGA GAGATGTGAG AGAGCATGCC 1620

TTCTTCCGGA GGATTGACTG GGAGAAGCTG GAGAACAGAG AGATCCAGCC GCCGTTCAAG 1680

CCCAAAGTGT GTGGCAAAGG AGCCGAAAAC TTTGACAAGT TCTTCACACG AGGGCAGCCT 1740

GTCTTAACAC CACCAGATCA GCTGGTCATT GCTAATATAG ACCAGTCTGA TTTTGAAGGG 1800

TTCTCATATG TCAACCCCCA ATTTGTGCAC CCGATCTTGC AGAGTGCAGT A 1851

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f++l+vlGkGsfgkv+la++k+t+elyaik+lkkdvv+qdddve+t+vekrvlal +k+p

Q: 284   FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP  343

         99**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl+ql+scfqt drl+fv+eyvnGGdlm+hiq+++k+ke++a+fyaaei+++l+flh++g

Q: 344   FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRG  403

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnv+ld+eGhik+adfG+cke++++g tt+tfcGtPdyiaPei+++++ygks

Q: 404   IIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKS  463

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdwwa+Gvllyemlagq+Pf+gededelf+si+e++v+yPkslskeav+i+kgl+tk+p+

Q: 464   VDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPA  523

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlG+ +ege+d++ehaff

Q: 524   KRLGCGPEGERDVREHAFF  542

         ******************9

Domain Sequence
(FASTA)

FNFLMVLGKG SFGKVMLADR KGTEELYAIK ILKKDVVIQD DDVECTMVEK RVLALLDKPP 60

FLTQLHSCFQ TVDRLYFVME YVNGGDLMYH IQQVGKFKEP QAVFYAAEIS IGLFFLHKRG 120

IIYRDLKLDN VMLDSEGHIK IADFGMCKEH MMDGVTTRTF CGTPDYIAPE IIAYQPYGKS 180

VDWWAYGVLL YEMLAGQPPF DGEDEDELFQ SIMEHNVSYP KSLSKEAVSI CKGLMTKHPA 240

KRLGCGPEGE RDVREHAFF 259

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004697	; F:protein kinase C activity
GO:0008270	; F:zinc ion binding
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020477	; C2_dom.
IPR018029	; C2_membr_targeting.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014375	; Protein_kinase_C_a/b/g.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00168	; C2; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50004	; C2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00360	; C2DOMAIN.
PR00008	; DAGPEDOMAIN.

Created Date

20-Feb-2013