EKS-CAP-00165

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00165

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	495.3	3.2E-149	449	707	259

Status

Unreviewed

Ensembl Protein

ENSCPOP00000013459

UniProt Accession

H0VS67;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

PRKG2

Gene Synonyms/Alias

PRKG2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000014935	ENSCPOP00000013459	ENSCPOT00000015081

Organism

Cavia porcellus

Functional Description

Protein Length

758

Protein Sequence
(FASTA)

MGNGSVKPKH SKHPDGHIGN LSADALRNRV TELERELRRK DAEIQEREYH LKELREQLSK 60

QTVAIAELTE ELQSKCIQLN KLQDVVHMQG ESSLQLSPEK VPRKTSGLVP LHNRRGAKAG 120

VSAEPTTRTY DLNKPPEFSF EKARVRKDSS EKKLITDALN RNQFLKRLDP QQIKDMVECM 180

YGRSYQQGSY IIKQGEPGNH IFVLAEGQLE VSQGEKLLSS IPMWTTFGEL AILYNCTRTA 240

SVKAVTNVKT WALDREVFQN IMRRTAQARD QQYRNFLRSV SLLKNLPEDK LTKIIDCLEV 300

EYYDKGDYII REGEEGSTFF ILAKGKVKVT QSTEGHDQPQ LIKTLQTGEY FGEKALISDD 360

VRSANIIAEE NDVACLVIDR ETFNQTVGTF EELQKYLEGY VANLTRDDEK RHAKRSMSNW 420

KLSKALSLEM IQLKEKVARF SSSSPFQNLE IIATLGVGGF GRVELVKVKN ENVAFAMKCV 480

RKKHIVDTKQ QEHIYSEKRI LEELCSPFIV KLYRTFKDNK YVYMLLEACL GGELWSIMRD 540

RGSFDEPTSK FCVACVTEAF DYLHRLGIIY RDLKPENLIL DAEGYLKLVD FGFAKKIGSG 600

QKTWTFCGTP EYVAPEVILN KGHDFSVDFW SLGILVYELL TGNPPFSGID QMMTYNLILK 660

GIEKMDFPRK ITRRPEDLIR RLCRQNPTER LGNLKNGIND IKKHRWLNGF NWEGLKARNL 720

PSPLRRELSG PIDHSYFDKY PPEKGVPPDE LSGWDKDF 758

Nucleotide Sequence
(FASTA)

ATGGGAAATG GTTCAGTGAA ACCTAAACAT TCCAAGCATC CAGATGGCCA CATCGGGAAC 60

CTCAGCGCTG ATGCCCTGCG AAACAGGGTG ACAGAGCTGG AGAGAGAACT GAGGAGGAAG 120

GATGCTGAGA TCCAGGAGCG AGAGTACCAT CTGAAGGAGC TGCGGGAACA GCTATCAAAG 180

CAGACTGTGG CCATTGCTGA GCTCACAGAG GAGCTCCAGA GCAAGTGCAT CCAGCTAAAC 240

AAGCTGCAGG ATGTGGTGCA TATGCAGGGA GAAAGCTCAC TCCAGCTTTC TCCGGAGAAG 300

GTGCCTCGGA AGACTTCAGG ATTGGTCCCT CTCCATAATA GGAGGGGAGC AAAGGCAGGG 360

GTGTCTGCTG AGCCAACAAC CCGAACCTAT GACCTCAACA AGCCCCCTGA GTTTTCTTTT 420

GAGAAAGCCA GAGTCAGAAA GGACTCCAGT GAGAAGAAGC TCATTACTGA TGCCCTTAAC 480

AGAAACCAGT TTCTGAAGAG ACTGGACCCT CAGCAGATCA AAGACATGGT GGAGTGTATG 540

TACGGGAGAA GCTACCAGCA AGGCAGCTAC ATCATTAAGC AAGGAGAGCC TGGAAACCAT 600

ATTTTTGTGC TGGCTGAGGG TCAACTAGAG GTGTCCCAAG GAGAGAAGTT GCTATCATCC 660

ATCCCGATGT GGACCACATT TGGGGAACTA GCCATTTTAT ACAACTGTAC AAGGACAGCA 720

TCTGTGAAAG CTGTTACCAA TGTTAAAACA TGGGCACTAG ATCGAGAAGT TTTCCAGAAC 780

ATTATGAGGA GGACAGCCCA AGCTAGAGAT CAACAATACA GAAACTTCCT CCGAAGTGTG 840

TCCTTACTGA AGAATTTACC TGAAGATAAA CTAACCAAGA TCATTGACTG CTTGGAAGTG 900

GAGTACTATG ACAAAGGAGA TTATATCATT AGAGAGGGTG AGGAAGGAAG TACTTTTTTC 960

ATTTTGGCCA AAGGAAAGGT AAAAGTCACG CAGAGTACTG AGGGTCACGA TCAACCACAG 1020

CTGATAAAAA CACTACAGAC AGGAGAATAC TTTGGAGAAA AAGCTCTCAT CAGTGATGAT 1080

GTGAGATCTG CTAACATTAT TGCTGAAGAA AACGATGTTG CTTGCCTGGT AATTGATCGA 1140

GAAACATTCA ACCAAACTGT CGGGACGTTT GAAGAACTCC AAAAATACCT TGAGGGGTAC 1200

GTGGCGAACC TGACCCGTGA TGATGAAAAA AGACATGCGA AGCGGTCCAT GTCTAACTGG 1260

AAGCTGTCCA AAGCACTCTC TCTGGAGATG ATTCAGCTGA AGGAGAAGGT GGCCAGATTT 1320

TCCTCTTCAT CCCCCTTCCA GAACCTTGAG ATTATCGCAA CACTGGGCGT TGGTGGGTTC 1380

GGAAGAGTTG AGCTTGTTAA GGTAAAAAAT GAGAATGTGG CTTTTGCCAT GAAGTGCGTA 1440

AGGAAGAAGC ACATAGTTGA TACCAAACAG CAAGAGCACA TCTACTCTGA GAAGAGGATC 1500

CTGGAGGAGC TGTGCTCTCC ATTCATTGTG AAATTATATC GTACTTTCAA GGATAATAAG 1560

TATGTATACA TGCTTCTGGA AGCCTGCTTG GGTGGAGAAC TGTGGAGCAT AATGAGGGAC 1620

AGAGGCAGTT TTGATGAACC CACCTCCAAA TTCTGTGTTG CTTGTGTGAC AGAAGCATTT 1680

GATTACCTGC ATCGACTAGG TATTATCTAC AGAGACCTGA AGCCGGAAAA CTTAATTCTA 1740

GATGCTGAGG GTTACCTCAA ATTGGTTGAC TTTGGATTTG CTAAGAAAAT AGGTTCTGGA 1800

CAGAAAACAT GGACGTTTTG TGGGACTCCA GAATATGTAG CTCCTGAGGT CATTCTCAAC 1860

AAAGGACACG ACTTCAGTGT GGATTTTTGG TCCCTGGGAA TTCTAGTATA CGAGCTCCTA 1920

ACCGGCAACC CACCCTTTTC TGGGATTGAC CAAATGATGA CCTACAATTT AATTCTCAAA 1980

GGAATTGAGA AAATGGATTT TCCCAGAAAG ATAACAAGAC GACCTGAGGA TTTGATTCGG 2040

AGGCTTTGCA GGCAAAATCC AACAGAAAGA CTGGGAAATT TGAAGAATGG AATCAATGAC 2100

ATCAAGAAAC ACAGGTGGTT AAATGGTTTC AACTGGGAGG GACTAAAAGC ACGGAATCTT 2160

CCCTCACCTT TACGAAGAGA GCTCAGTGGA CCCATAGATC ACAGCTACTT TGACAAATAT 2220

CCTCCCGAAA AGGGAGTGCC TCCGGACGAG CTGTCAGGCT GGGATAAAGA CTTCTGA 2277

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l++iatlgvggfgrvelvkvk+ e+ afa+k+++kkhivdtkqqeh++sekrilee++s+

Q: 449   LEIIATLGVGGFGRVELVKVKN-ENVAFAMKCVRKKHIVDTKQQEHIYSEKRILEELCSP  507

         689******************9.999**********************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         fivklyrtfkd+kyvy+lleaclggelw+i+rdrgsfd+ t+kf+vacv+ea++ylh+ +

Q: 508   FIVKLYRTFKDNKYVYMLLEACLGGELWSIMRDRGSFDEPTSKFCVACVTEAFDYLHRLG  567

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         iiyrdlkpenl+ld+egylklvdfgfakk++sg+ktwtfcgtpeyvape+ilnkghd+sv

Q: 568   IIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSV  627

         ************************************************************

S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240

         d+w+lgilvyelltg+ppfsg+d+++tynlilkgi+k+++prkit+++edli++lcr+np

Q: 628   DFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNP  687

         ************************************************************

S: 241   aerlgylkggikdikkhkwf  260

         +erlg+lk+gi+dikkh+w+

Q: 688   TERLGNLKNGINDIKKHRWL  707

         *******************7

Domain Sequence
(FASTA)

LEIIATLGVG GFGRVELVKV KNENVAFAMK CVRKKHIVDT KQQEHIYSEK RILEELCSPF 60

IVKLYRTFKD NKYVYMLLEA CLGGELWSIM RDRGSFDEPT SKFCVACVTE AFDYLHRLGI 120

IYRDLKPENL ILDAEGYLKL VDFGFAKKIG SGQKTWTFCG TPEYVAPEVI LNKGHDFSVD 180

FWSLGILVYE LLTGNPPFSG IDQMMTYNLI LKGIEKMDFP RKITRRPEDL IRRLCRQNPT 240

ERLGNLKNGI NDIKKHRWL 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013