EKS-CAP-00423

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00423

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	325.3	3.4E-97	1079	1343	265

Status

Unreviewed

Ensembl Protein

ENSCPOP00000013535

UniProt Accession

H0VSD6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K1

Gene Synonyms/Alias

MAP3K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000015017	ENSCPOP00000013535	ENSCPOT00000015164

Organism

Cavia porcellus

Functional Description

Protein Length

1348

Protein Sequence
(FASTA)

REMESKETLK GLHKMDDRPE ERMIREKLKA TCMPAWKHEW LERRNRRGPV VVKPIPIKGD 60

GPEMSSLATE CQGDSLASTA SAAPKGRRSP SPGNSPSGRT VKSESPGVRR KRVSPVPFQS 120

GRITPPRRAP SPDGFSPYSP EETSRRVNKV MRARLYLLQQ IGPNSFLIGG DSPDNKYRVF 180

IGPQNCSCGR GTFCIHLLFV MLRVFQLEPS DPMLWRKTLK NFEVESLFQK YHSRRSSRIK 240

APSRNTIQKF VSRMSNPHTL SSSSTSTSSS ENSIKDEEEQ MCPICLLGML DEESLTVCED 300

GCRNKLHHHC MSIWAEECRR NREPLICPLC RSKWRSHDFY SHELSSPVDS PSSLRAAQQQ 360

TTQQQPLAGS QRRNQESNFN LTHYGAQQIP PAYKDLAEPW IQVFGMELVG CLFSRNWNVR 420

EMALRRLSHD VSGALLLANG ESTGNSGGSG ASSPSAGATS GSSQTSISGD VVEACCSVLS 480

MVCADPVYKV YVAALKTLRA MLVYTPCHSL AERIKLQRLL RPVVDTILVK CADANSRTSQ 540

LSISTLLELC KGQAGELAVG REILKAVGSI GIGGVDYLNC ILGNNIESNN WQELLGRLCL 600

IDRLLLEFPA EFYPHIISTD VSQAEPVEIR WYKKLLSLLT FALQSIDNSH SMVGKLSRRI 660

YLSSARMVTA VPHVFSKLLE MLSVSSSTHF CRMRRRLMAI ADEVEIAEVI QLGMEDTLDG 720

QQNRFLQEAA HSSYPEATED RSLEQTVHLD KTGKRLCATK MSDSSEDISD RLASISVGLP 780

SSATTEQPKP MVQTKGRPHN QCLNTSVLSH HSQQTFPALS SPSSSAPSVP ADSVTDVSKH 840

RPQGFVPCKI PSASPQTQRK FSLQFQRNCS ENKDSDKLSP IFTQSRPLPS STIHRPKPSR 900

PTPGNTSKQG EASKNSMTLD LNSTSKCDDS FGSSSNSSNA VIPSDETVFT PVEEKCRLDV 960

NTELNSSIED LLEASMPSSD TTVTFKSEVA VLSPEKAEND DTYKDDVNHN QKCKEKMEAE 1020

EEEALAIAMA MSASQDALPI VPQLQVENGE DIIIIQQDTP ETLPGHTKAK QPYREDTEWL 1080

KGQQIGLGAF SSCYQAQDVG TGTLMAVKQV TYVRNTSSEQ EEVVEALREE IRMMSHLNHP 1140

NIIRMLGATC EKSNYNLFIE WMAGGSVAHL LSKYGAFKES VVINYTEQLL RGLSYLHENQ 1200

IIHRDVKGAN LLIDSTGQRL RIADFGAAAR LASKGTGAGE FQGQLLGTIA FMAPEVLRGQ 1260

QYGRSCDVWS VGCAIIEMAC AKPPWNAEKH SNHLALIFKI ASATTAPSIP SHLSPGLRDV 1320

ALRCLELQPQ DRPPSRELLK HPVFRTTW 1348

Nucleotide Sequence
(FASTA)

CGTGAGATGG AGAGTAAAGA AACTCTTAAA GGGTTGCACA AGATGGACGA CCGCCCGGAA 60

GAACGAATGA TCAGGGAGAA ACTAAAGGCA ACATGTATGC CAGCTTGGAA GCATGAGTGG 120

TTGGAAAGGC GAAACAGGAG AGGCCCTGTG GTGGTAAAGC CAATCCCTAT CAAAGGAGAT 180

GGACCTGAAA TGAGCAGCTT GGCAACCGAG TGTCAAGGAG ACAGCCTGGC CAGCACTGCT 240

TCTGCAGCCC CCAAAGGCCG GCGGAGCCCA TCTCCTGGGA ACTCCCCGTC AGGTCGCACA 300

GTGAAATCAG AATCTCCAGG AGTAAGGAGA AAGAGAGTTT CCCCAGTACC CTTTCAGAGC 360

GGCAGAATCA CACCACCCCG GAGAGCTCCT TCGCCAGATG GCTTCTCACC GTACAGCCCT 420

GAGGAAACAA GCCGCCGTGT GAACAAAGTG ATGCGGGCGA GACTGTACTT ACTGCAGCAG 480

ATAGGACCCA ACTCCTTCCT GATCGGGGGA GATAGCCCAG ACAATAAGTA CCGGGTGTTT 540

ATTGGGCCAC AGAACTGCAG CTGTGGCCGT GGAACATTTT GTATTCATCT GTTATTTGTT 600

ATGCTCCGGG TGTTTCAGCT AGAACCTTCA GACCCAATGT TGTGGAGAAA GACTTTAAAG 660

AATTTTGAGG TTGAGAGTTT GTTCCAGAAA TACCACAGTA GGCGTAGCTC GAGAATCAAA 720

GCTCCATCTC GTAACACCAT CCAGAAGTTT GTTTCACGCA TGTCAAATCC TCATACATTG 780

TCATCATCTA GTACTTCTAC ATCTAGTTCA GAAAACAGCA TAAAAGATGA AGAGGAACAG 840

ATGTGTCCTA TATGCTTACT GGGTATGCTT GATGAAGAAA GTCTTACAGT GTGTGAAGAT 900

GGCTGCAGGA ACAAGCTGCA CCACCACTGC ATGTCCATCT GGGCAGAAGA ATGTAGAAGA 960

AACAGAGAAC CTTTAATATG TCCTCTTTGT AGGTCTAAGT GGAGATCCCA TGATTTCTAC 1020

AGTCACGAGT TGTCAAGCCC TGTAGATTCC CCATCTTCCC TGAGAGCTGC ACAGCAGCAA 1080

ACCACACAGC AGCAGCCTCT AGCTGGATCA CAGAGAAGAA ATCAAGAAAG CAACTTTAAT 1140

CTTACTCATT ATGGAGCTCA GCAGATCCCT CCTGCATATA AAGATTTAGC TGAGCCATGG 1200

ATTCAGGTGT TTGGAATGGA ACTCGTTGGC TGCTTATTTT CTAGAAACTG GAATGTAAGA 1260

GAGATGGCTC TCAGGCGTCT TTCCCACGAT GTTAGTGGGG CCTTGCTGTT GGCAAATGGG 1320

GAGAGCACTG GAAACTCTGG GGGCAGTGGT GCAAGCAGCC CAAGTGCTGG AGCCACCAGT 1380

GGGTCCTCCC AGACCAGCAT CTCAGGAGAC GTGGTGGAGG CATGCTGCAG TGTCTTATCA 1440

ATGGTCTGTG CTGACCCTGT CTACAAAGTA TACGTTGCTG CTTTAAAAAC ATTGAGAGCC 1500

ATGCTGGTAT ATACTCCTTG CCACAGTTTA GCAGAAAGAA TCAAACTTCA GAGACTTCTC 1560

CGGCCAGTTG TAGATACCAT CCTAGTTAAA TGTGCAGATG CCAATAGCCG TACCAGTCAG 1620

CTGTCCATAT CAACACTGTT GGAATTATGC AAAGGCCAAG CAGGAGAGTT GGCAGTTGGT 1680

AGAGAAATAC TTAAAGCTGT AGGATCCATT GGTATTGGAG GTGTGGATTA TCTTAATTGT 1740

ATTCTTGGAA ATAATATTGA GTCAAACAAC TGGCAAGAAC TCCTAGGTCG CCTTTGTCTT 1800

ATAGACAGAC TATTGTTGGA ATTTCCTGCT GAATTTTATC CTCATATCAT CAGTACTGAT 1860

GTTTCACAAG CTGAGCCTGT TGAAATCAGG TGGTATAAAA AGCTGCTGTC CCTCTTAACC 1920

TTTGCTTTAC AGTCCATTGA TAATTCCCAT TCAATGGTTG GTAAACTCTC TCGAAGAATA 1980

TATTTGAGTT CGGCAAGAAT GGTGACTGCA GTACCCCATG TGTTTTCAAA ACTGCTAGAA 2040

ATGCTGAGTG TTTCGAGTTC TACTCACTTC TGCAGGATGC GTCGTCGTTT GATGGCTATT 2100

GCAGATGAAG TGGAAATCGC TGAGGTGATC CAGCTGGGCA TGGAAGACAC TTTGGATGGC 2160

CAACAAAACA GGTTTTTACA GGAAGCTGCC CATTCTAGCT ATCCAGAAGC CACAGAGGAC 2220

AGGTCCCTGG AGCAAACAGT TCATTTAGAC AAAACTGGAA AAAGATTATG TGCTACAAAA 2280

ATGAGTGACA GCTCAGAGGA CATTTCCGAT AGACTGGCCA GCATTTCTGT AGGACTTCCT 2340

AGTTCAGCAA CAACAGAGCA ACCAAAGCCA ATGGTTCAAA CAAAAGGTAG ACCCCACAAT 2400

CAGTGTTTGA ACACCTCTGT TTTATCTCAT CATTCCCAAC AAACATTCCC AGCCTTGTCA 2460

TCCCCTTCTT CATCTGCCCC ATCTGTACCA GCTGACTCTG TAACAGATGT CTCCAAGCAT 2520

AGACCTCAGG GATTCGTTCC CTGCAAAATA CCTTCTGCAT CTCCTCAAAC ACAACGCAAG 2580

TTTTCTCTAC AATTCCAGAG AAACTGTTCT GAAAATAAAG ACTCAGACAA ACTTTCCCCT 2640

ATATTCACTC AGTCTAGACC CTTGCCTTCC AGCACCATAC ATAGGCCAAA GCCATCTCGA 2700

CCTACCCCAG GTAATACAAG TAAACAGGGA GAAGCCTCAA AAAATAGCAT GACACTTGAT 2760

TTGAACAGTA CTTCCAAATG TGATGACAGC TTTGGCAGCA GCAGCAACAG CAGTAATGCA 2820

GTTATTCCCA GTGATGAGAC AGTGTTCACG CCAGTAGAGG AAAAATGCAG ATTAGATGTC 2880

AATACAGAGC TCAACTCCAG TATTGAGGAT CTTCTTGAAG CATCTATGCC TTCAAGTGAC 2940

ACAACAGTCA CTTTTAAGTC AGAAGTTGCT GTTCTGTCTC CTGAAAAGGC TGAAAATGAT 3000

GATACCTACA AAGATGATGT GAATCACAAT CAGAAGTGCA AAGAAAAGAT GGAAGCTGAA 3060

GAAGAGGAAG CTTTAGCAAT TGCCATGGCA ATGTCAGCAT CTCAGGATGC TCTTCCCATA 3120

GTTCCTCAAC TACAGGTTGA AAATGGAGAA GATATCATCA TTATTCAACA GGATACACCA 3180

GAGACTCTAC CAGGACATAC CAAAGCAAAA CAGCCTTATA GAGAAGACAC TGAGTGGCTG 3240

AAAGGCCAGC AAATAGGCCT TGGGGCATTT TCTTCTTGTT ACCAAGCACA GGATGTGGGA 3300

ACCGGAACTT TAATGGCTGT CAAACAGGTG ACATACGTCA GAAACACATC TTCTGAGCAA 3360

GAAGAAGTGG TGGAAGCATT AAGAGAAGAA ATAAGAATGA TGAGCCATCT AAATCATCCA 3420

AACATCATTA GGATGTTGGG AGCCACGTGT GAGAAGAGCA ATTACAATCT CTTCATCGAA 3480

TGGATGGCGG GAGGATCTGT GGCCCATCTG CTGAGTAAAT ACGGAGCTTT CAAGGAATCA 3540

GTAGTTATTA ACTATACTGA ACAGTTACTT CGTGGCCTTT CATATCTTCA TGAAAACCAG 3600

ATCATTCATA GAGATGTCAA AGGTGCCAAT TTGCTAATTG ACAGCACAGG TCAGAGACTG 3660

AGAATTGCAG ATTTTGGAGC TGCAGCCAGG TTGGCGTCAA AAGGAACTGG CGCGGGAGAG 3720

TTTCAGGGAC AGTTATTGGG GACAATTGCG TTTATGGCAC CAGAGGTGCT AAGAGGTCAG 3780

CAGTATGGTA GGAGCTGTGA TGTATGGAGT GTGGGCTGTG CTATTATAGA AATGGCTTGT 3840

GCAAAACCAC CTTGGAATGC AGAAAAACAC TCCAACCATC TTGCTTTGAT ATTTAAGATT 3900

GCCAGTGCAA CTACTGCTCC ATCAATCCCT TCACATCTGT CTCCTGGTTT ACGTGATGTG 3960

GCTCTTCGTT GTTTAGAACT TCAACCTCAG GACAGACCTC CATCAAGAGA GCTACTGAAG 4020

CATCCAGTCT TCCGTACAAC GTGGTAG 4047

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1079  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1138

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1139  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1198

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1199  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1258

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1259  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1316

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1317  LRDVALRCLELQPQDRPPSRELLKHPV  1343

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVALRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069	; Pkinase; 1.
PF04434	; SWIM; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013