EKS-CAP-00162

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00162

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	444.6	1.0E-133	423	683	261

Status

Unreviewed

Ensembl Protein

ENSCPOP00000013579

UniProt Accession

H0VSH3;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA5

Gene Synonyms/Alias

RPS6KA5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000015065	ENSCPOP00000013579	ENSCPOT00000015212

Organism

Cavia porcellus

Functional Description

Protein Length

795

Protein Sequence
(FASTA)

SGSGIGDVGT SGDGGDGGEQ LLTVKHELRT ANLTGHTEKV GIENFELLKV LGTGAYGKVF 60

LVRKISGHDA GKLYAMKVLK KATIVQKAKT TEHTRTERQV LEHIRQSPFL VTLHYAFQTE 120

TKLHLILDYI NGGELFTHLS QRERFTEREV QIYVGEIVLA LEHLHKLGII YRDIKLENIL 180

LDSNGHVVLT DFGLSKEFVA DESERAYSFC GTIEYMAPDI VRGGDSGHDK AVDWWSLGVL 240

MYELLTGASP FTVDGEKNSQ AEISRRILKS EPPYPQEMSA LAKDLIQRLL MKDPKKRLGC 300

GPRDADEIKE HLFFQKINWD DLAAKKVPAP FKPVIRDELD VSNFAEEFTE MDPTYSPAAL 360

PQSSERLFQG YSFVAPSILF KRNAAVIDPL QFHMEVERPG VTNVARSAMM KDSPFYQHYD 420

LDLKDKPLGE GSFSICRKCI HKKSNQAFAV KIISKRMEAN TQKEITALKL CEGHPNIVKL 480

HEIFHDQLHT FLVMELLNGG ELFERIKKKK HFSETEASYI MRKLVSAVSH MHDVGVVHRD 540

LKPENLLFTD ENDNLEIKVI DFGFARLKPP DNQPLKTPCF TLHYAAPELL NHNGYDESCD 600

LWSLGVILYT MLSGQVPFQS HDRSLTCTSA VEIMKKIKKG DFSFEGEAWK NVSQEAKDLI 660

QGLLTVDPNK RLKMSGLRYN EWLQDGSQLS SNPLMTPDIL GSSGAAVHTC VKATFHAFNK 720

YKREGFCLQN VDKAPLAKRR KMKKTSTSTE TRSSSSESSH SSSSHSHGKT TPTKALPPSH 780

AADGAHPETL FQFSD 795

Nucleotide Sequence
(FASTA)

AGCGGCAGCG GCATCGGCGA CGTGGGGACC AGCGGGGACG GCGGCGACGG CGGCGAGCAG 60

CTCCTTACTG TCAAGCACGA GCTGCGGACT GCTAATTTAA CAGGACATAC AGAGAAAGTG 120

GGGATTGAAA ATTTTGAACT CCTAAAGGTC CTAGGAACTG GAGCTTATGG AAAAGTGTTT 180

CTAGTTCGTA AAATAAGTGG TCATGATGCT GGAAAGTTGT ATGCCATGAA AGTTTTGAAA 240

AAGGCAACAA TTGTTCAAAA GGCCAAAACC ACGGAGCACA CGAGGACAGA GCGACAAGTC 300

CTGGAGCACA TTAGGCAGTC GCCATTTTTG GTGACGTTGC ACTACGCCTT CCAGACAGAA 360

ACTAAACTTC ATCTCATCTT AGATTATATA AATGGTGGAG AACTTTTTAC TCATCTTTCT 420

CAAAGAGAGC GTTTCACAGA GCGCGAGGTG CAGATCTATG TTGGAGAGAT TGTGCTTGCC 480

CTCGAACATC TGCACAAGTT GGGAATTATA TACCGTGACA TTAAGCTTGA GAATATTCTT 540

CTTGATTCTA ACGGCCATGT GGTGCTGACA GATTTTGGTC TGAGTAAGGA GTTTGTGGCT 600

GATGAAAGTG AAAGAGCATA TTCCTTTTGT GGGACTATTG AATACATGGC ACCAGATATC 660

GTCAGAGGGG GAGATTCAGG ACATGACAAG GCAGTTGACT GGTGGAGTTT AGGAGTTCTA 720

ATGTACGAGT TACTAACTGG AGCATCGCCT TTCACTGTTG ATGGAGAAAA AAATTCCCAA 780

GCTGAGATAT CTAGGAGAAT ATTAAAAAGT GAGCCTCCAT ATCCCCAAGA AATGAGTGCA 840

TTAGCTAAAG ACCTGATTCA GCGTCTTCTG ATGAAAGATC CCAAGAAGAG ACTGGGCTGT 900

GGGCCACGGG ATGCAGATGA AATTAAAGAA CATCTCTTCT TCCAGAAAAT AAATTGGGAT 960

GACTTAGCTG CCAAAAAAGT CCCTGCACCA TTTAAGCCAG TCATCCGAGA TGAACTGGAC 1020

GTGAGTAACT TCGCGGAAGA GTTCACGGAG ATGGACCCCA CCTACTCTCC CGCAGCCCTG 1080

CCCCAGAGCT CGGAGAGGCT GTTCCAGGGC TATTCTTTTG TTGCTCCCTC CATCCTATTC 1140

AAGCGTAACG CAGCTGTGAT CGATCCTCTT CAGTTTCACA TGGAAGTTGA ACGTCCCGGA 1200

GTGACAAATG TGGCCAGGAG TGCCATGATG AAGGACTCTC CATTCTATCA ACACTATGAC 1260

CTAGATCTAA AGGACAAACC ACTAGGAGAA GGAAGTTTTT CAATTTGTCG AAAATGTATA 1320

CACAAAAAAA GTAACCAAGC ATTTGCAGTG AAAATAATCA GCAAAAGGAT GGAAGCCAAT 1380

ACTCAGAAAG AAATAACAGC TCTGAAACTC TGTGAAGGAC ACCCCAATAT CGTGAAATTG 1440

CATGAAATTT TCCATGATCA GCTTCATACG TTTCTGGTGA TGGAACTTCT AAATGGGGGA 1500

GAGCTGTTTG AACGCATCAA GAAAAAGAAG CACTTCAGTG AGACAGAAGC CAGCTACATC 1560

ATGCGGAAGC TCGTTTCAGC AGTGAGCCAC ATGCACGATG TCGGGGTAGT GCACAGAGAT 1620

CTCAAACCTG AGAATTTACT GTTCACTGAT GAAAATGATA ACTTGGAAAT TAAAGTAATC 1680

GATTTTGGGT TTGCGCGCCT CAAGCCCCCT GATAATCAGC CTCTGAAGAC GCCATGCTTT 1740

ACCCTTCATT ATGCAGCCCC AGAACTCTTG AATCATAACG GCTACGATGA GTCCTGTGAC 1800

CTGTGGAGCT TGGGTGTCAT CTTGTACACA ATGTTGTCAG GGCAGGTTCC ATTCCAGTCT 1860

CATGACAGAA GCTTGACATG CACTAGTGCG GTGGAAATCA TGAAGAAAAT TAAAAAGGGA 1920

GATTTCTCCT TTGAAGGGGA AGCTTGGAAG AATGTATCTC AAGAGGCTAA AGATCTGATC 1980

CAAGGACTTC TCACAGTTGA TCCAAATAAA AGGCTTAAAA TGTCTGGCTT GAGATACAAT 2040

GAATGGCTTC AAGATGGCAG CCAGCTGTCC TCAAATCCTC TGATGACCCC AGACATTCTG 2100

GGATCCTCGG GAGCTGCTGT GCACACCTGT GTGAAAGCAA CCTTCCATGC CTTTAACAAA 2160

TACAAGAGAG AGGGGTTTTG CCTGCAGAAT GTCGACAAGG CCCCGCTGGC CAAGAGAAGG 2220

AAAATGAAAA AGACCAGCAC GAGCACGGAG ACGCGCAGCA GCTCCAGCGA GAGCTCGCAC 2280

TCGTCCTCCT CGCACTCGCA CGGGAAGACC ACGCCCACCA AGGCGCTGCC CCCCAGCCAC 2340

GCCGCGGACG GCGCCCACCC CGAGACCCTC TTCCAGTTCT CCGAC 2385

Domain Profile

S: 2     evkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkd  60

         +++++lG+Gs+s+c++c+hk++nq+favkii+k+ +++t++ei++l+++e+hpniv+l++

Q: 423   LKDKPLGEGSFSICRKCIHKKSNQAFAVKIISKRmEANTQKEITALKLCEGHPNIVKLHE  482

         5789******************************9*************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         +++d+++++lv+ell+GGel++rikkkk+fse+eas+i+r+lv+av+++h++Gvvhrdlk

Q: 483   IFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK  542

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         pen+l++de+dn+e ik+idfGfa+lk+++n++lktpc+tl+++ape+l+++Gyde+cdl

Q: 543   PENLLFTDENDNLE-IKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNHNGYDESCDL  601

         **************.*********************************************

S: 181   wslGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvs  236

         wslGv+lytml+G+vpf    +++++++a+ei++kik+G+fs++Geaw++vs+eakdl++

Q: 602   WSLGVILYTMLSGQVPFqshdRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQ  661

         *****************9998899************************************

S: 237   klltvdpakrlkleqllkhswl  258

         +lltvdp+krlk+++l++++wl

Q: 662   GLLTVDPNKRLKMSGLRYNEWL  683

         *********************7

Domain Sequence
(FASTA)

LKDKPLGEGS FSICRKCIHK KSNQAFAVKI ISKRMEANTQ KEITALKLCE GHPNIVKLHE 60

IFHDQLHTFL VMELLNGGEL FERIKKKKHF SETEASYIMR KLVSAVSHMH DVGVVHRDLK 120

PENLLFTDEN DNLEIKVIDF GFARLKPPDN QPLKTPCFTL HYAAPELLNH NGYDESCDLW 180

SLGVILYTML SGQVPFQSHD RSLTCTSAVE IMKKIKKGDF SFEGEAWKNV SQEAKDLIQG 240

LLTVDPNKRL KMSGLRYNEW L 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013