EKS-CAP-00140

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00140

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/Akt	489.0	3.3E-147	148	404	257

Status

Unreviewed

Ensembl Protein

ENSCPOP00000013982

UniProt Accession

H0VTI4;

Protein Name

Protein Synonyms/Alias

Gene Name

AKT3

Gene Synonyms/Alias

AKT3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000015504	ENSCPOP00000013982	ENSCPOT00000015656

Organism

Cavia porcellus

Functional Description

Protein Length

478

Protein Sequence
(FASTA)

MSDVTIVKEG WVQKRGEYIK NWRPRYFLLK TDGSFIGYKE KPQDVDLPYP LNNFSVAKCQ 60

LMKTERPKPN TFIIRCLQWT TVIERTFHVD TPEEREEWTE AIQAVADRLQ RQEEERMNCS 120

PTSQIDNIGE EEMDASTTHH KRKTMNDFDY LKLLGKGTFG KVILVREKAS GKYYAMKILK 180

KEVIIAKDEV AHTLTESRVL KNTRHPFLTS LKYSFQTKDR LCFVMEYVNG GEAVFHLSRE 240

RVSEDRTRFY GAEIVSALDY LHSGKIVYRD LKLENLMLDK DGHIKITDFG LCKEGITDAA 300

TMKTFCGTPE YLAPEVLEDN DYGRAVDWWG LGVVMYEMMC GRLPFYNQDH EKLFELILME 360

DIKFPRTLSS DAKSLLSGLL IKDPNKRLGG GPDDAKEIMR HSFFSGVNWQ DVYDKKLVPP 420

FKPQVTSETD TRYFDEEFTA QTITITPPEK YDEDGMDCMD NERRPHFPQF SYSASGRE 478

Nucleotide Sequence
(FASTA)

ATGAGCGATG TTACCATTGT GAAAGAAGGC TGGGTTCAGA AGAGGGGAGA GTATATAAAA 60

AACTGGAGGC CAAGATACTT CCTTTTGAAG ACAGATGGCT CATTCATAGG ATACAAAGAG 120

AAACCTCAAG ATGTGGATTT ACCTTATCCC CTCAACAATT TTTCAGTGGC AAAATGCCAG 180

TTAATGAAAA CAGAACGACC AAAGCCAAAC ACATTTATTA TCAGATGTCT CCAGTGGACC 240

ACTGTTATAG AAAGAACATT TCATGTAGAT ACTCCAGAGG AAAGGGAAGA ATGGACAGAA 300

GCTATTCAGG CAGTAGCAGA CAGACTGCAG AGGCAAGAAG AGGAGAGAAT GAATTGCAGT 360

CCAACTTCAC AAATCGATAA CATAGGAGAG GAAGAGATGG ATGCTTCTAC GACCCATCAT 420

AAAAGAAAGA CAATGAATGA TTTTGACTAT TTGAAACTAC TAGGTAAAGG CACTTTTGGG 480

AAAGTCATTT TGGTTCGAGA GAAAGCAAGT GGAAAGTACT ATGCTATGAA GATTCTGAAG 540

AAAGAAGTCA TTATTGCTAA GGATGAAGTG GCACACACTC TAACTGAAAG CAGAGTATTA 600

AAGAACACTA GACATCCGTT TTTAACATCC TTGAAATACT CCTTCCAGAC AAAAGACCGT 660

TTGTGTTTTG TGATGGAATA TGTTAATGGG GGAGAGGCTG TTTTTCATTT GTCGAGAGAG 720

CGGGTGTCTG AGGACCGCAC ACGTTTCTAT GGTGCAGAAA TTGTCTCAGC CTTGGACTAC 780

CTACATTCCG GAAAGATTGT GTACCGTGAT CTCAAGTTGG AGAATTTGAT GCTGGATAAA 840

GATGGCCACA TAAAAATTAC AGATTTTGGA CTTTGCAAAG AAGGGATCAC AGATGCAGCC 900

ACCATGAAGA CATTCTGTGG CACACCAGAA TACCTGGCAC CAGAGGTGTT AGAGGACAAT 960

GACTACGGCC GCGCTGTGGA CTGGTGGGGC CTGGGGGTTG TCATGTATGA GATGATGTGC 1020

GGAAGGTTAC CTTTCTACAA CCAGGACCAT GAGAAACTTT TTGAACTAAT ACTAATGGAA 1080

GACATTAAAT TTCCACGAAC ACTCTCTTCA GATGCAAAAT CGTTGCTTTC AGGGCTCTTG 1140

ATAAAGGATC CAAATAAACG CCTTGGTGGA GGACCAGATG ATGCAAAAGA AATTATGAGA 1200

CACAGTTTTT TCTCTGGAGT AAACTGGCAA GATGTATATG ATAAAAAGCT TGTGCCTCCT 1260

TTTAAGCCTC AGGTAACATC TGAGACAGAC ACCAGATACT TTGATGAAGA ATTCACAGCT 1320

CAGACTATTA CAATAACACC ACCTGAAAAA TACGATGAAG ATGGTATGGA CTGCATGGAC 1380

AACGAGAGGC GGCCACATTT CCCTCAGTTT TCCTATTCTG CGAGTGGACG CGAA 1434

Domain Profile

S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60

         fd+lkllGkGtfGkvilvreka++k+ya+kilkkevi+akdevahtlte+rvlk+t+hpf

Q: 148   FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPF  207

         9***********************************************************

S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120

         l++lkysfqtk++lc+v+eyvnGGe  fhls+erv sedr+rfygaeivsaldylhs ++

Q: 208   LTSLKYSFQTKDRLCFVMEYVNGGEAVFHLSRERV-SEDRTRFYGAEIVSALDYLHSGKI  266

         ********************************986.9***********************

S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180

         vyrdlklenl+ldkdGhikitdfGlcke+i+d++++ktfcGtpeylapevled+dyg+av

Q: 267   VYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAV  326

         ************************************************************

S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240

         dwwglGvv+yem+cGrlpfyn+dheklfelil+e++kfpr+ls++aksllsGll kdp+k

Q: 327   DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNK  386

         ************************************************************

S: 241   rlGggkddakeireheff  258

         rlGgg+ddakei++h+ff

Q: 387   RLGGGPDDAKEIMRHSFF  404

         *****************9

Domain Sequence
(FASTA)

FDYLKLLGKG TFGKVILVRE KASGKYYAMK ILKKEVIIAK DEVAHTLTES RVLKNTRHPF 60

LTSLKYSFQT KDRLCFVMEY VNGGEAVFHL SRERVSEDRT RFYGAEIVSA LDYLHSGKIV 120

YRDLKLENLM LDKDGHIKIT DFGLCKEGIT DAATMKTFCG TPEYLAPEVL EDNDYGRAVD 180

WWGLGVVMYE MMCGRLPFYN QDHEKLFELI LMEDIKFPRT LSSDAKSLLS GLLIKDPNKR 240

LGGGPDDAKE IMRHSFF 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013