EKS-CAP-00497

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00497

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	413.9	2.9E-124	26	321	296

Status

Unreviewed

Ensembl Protein

ENSCPOP00000014040

UniProt Accession

H0VTN4;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK8

Gene Synonyms/Alias

MAPK8;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000015571	ENSCPOP00000014040	ENSCPOT00000015723

Organism

Cavia porcellus

Functional Description

Protein Length

427

Protein Sequence
(FASTA)

MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP 60

FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ 120

MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180

MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGEMIK GGVLFPGTDH IDQWNKVIEQ 240

LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 300

MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV 360

MDLEERTKNG VIRGQPSPLG AAVTSGSQHP SSSSSVNDVS SMSTDPTLAS DTDSSLEASA 420

GPLGCCR 427

Nucleotide Sequence
(FASTA)

ATGAGCAGAA GCAAGCGTGA CAACAATTTT TATAGTGTAG AAATTGGAGA TTCTACGTTC 60

ACAGTCCTGA AACGATACCA GAATTTAAAA CCTATAGGCT CAGGAGCTCA AGGCATAGTA 120

TGTGCAGCTT ATGATGCCAT TCTGGAAAGA AATGTTGCAA TCAAGAAGCT AAGCCGGCCT 180

TTTCAGAATC AGACTCATGC CAAGCGGGCC TATCGAGAGC TGGTTCTTAT GAAATGTGTT 240

AATCACAAAA ATATAATTGG CCTTTTGAAT GTTTTCACAC CACAGAAATC CCTTGAAGAA 300

TTTCAAGATG TTTACATAGT CATGGAGCTC ATGGATGCCA ACCTCTGCCA AGTGATTCAG 360

ATGGAACTAG ACCACGAAAG AATGTCCTAC CTTCTCTACC AGATGCTGTG TGGGATCAAG 420

CACCTTCACT CTGCCGGGAT TATTCACCGG GACTTAAAGC CCAGTAATAT AGTGGTAAAA 480

TCGGACTGCA CTTTGAAGAT CCTCGACTTC GGGCTGGCTC GGACTGCAGG CACGAGCTTC 540

ATGATGACGC CCTACGTAGT GACGCGCTAC TACCGAGCGC CCGAGGTCAT CCTGGGCATG 600

GGCTACAAGG AGAACGTTGA CATTTGGTCA GTTGGGTGCA TCATGGGAGA AATGATCAAA 660

GGTGGTGTTT TGTTCCCAGG TACAGATCAT ATTGACCAGT GGAATAAAGT CATCGAACAG 720

CTTGGAACAC CGTGTCCTGA GTTCATGAAG AAACTACAGC CAACAGTAAG GACTTACGTG 780

GAAAACAGGC CTAAATATGC TGGCTACAGC TTTGAGAAGC TTTTCCCCGA TGTGCTTTTC 840

CCGGCTGACT CAGAGCACAA CAAACTGAAA GCCAGTCAGG CAAGGGATTT GTTGTCCAAG 900

ATGCTGGTGA TCGATGCGTC TAAAAGGATC TCCGTGGATG AGGCCCTCCA GCACCCCTAC 960

ATCAACGTGT GGTACGACCC CTCCGAGGCG GAAGCCCCAC CACCAAAGAT CCCTGACAAG 1020

CAGCTAGATG AAAGGGAACA CACGATAGAA GAGTGGAAAG AGTTGATATA CAAGGAAGTG 1080

ATGGACTTGG AGGAGAGAAC CAAGAACGGA GTTATCCGGG GGCAGCCCTC TCCTCTAGGT 1140

GCAGCAGTGA CCAGTGGCTC TCAGCATCCA TCGTCATCGT CGTCTGTCAA TGATGTGTCT 1200

TCGATGTCCA CAGATCCGAC TTTGGCCTCG GACACCGACA GCAGTCTCGA GGCGTCGGCC 1260

GGCCCTCTGG GCTGCTGCAG ATGA 1284

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  e++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 26    YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  85

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i ll+vftp+++lee++dvY+v+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 86    IGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  144

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  201

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E+++g +lfpg+d+idq++k++e+lgtp  ef+kk++  ++r+y+

Q: 202   YKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQP-TVRTYV  260

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +fe+lfp+            + ++a+dLl+k+Lv+d++kRisv+eaL+hpY

Q: 261   ENRPKYAGYSFEKLFPDvlfpadsehnklKASQARDLLSKMLVIDASKRISVDEALQHPY  320

         *****************************99*****************************

S: 289   l  289

Q: 321   I  321

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AILERNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

IGLLNVFTPQ KSLEEFQDVY IVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMIKGGVLF PGTDHIDQWN KVIEQLGTPC PEFMKKLQPT VRTYVENRPK 240

YAGYSFEKLF PDVLFPADSE HNKLKASQAR DLLSKMLVID ASKRISVDEA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013