EKS-CAP-00299

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00299

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	348.3	2.7E-104	12	256	245

Status

Unreviewed

Ensembl Protein

ENSCPOP00000014041

UniProt Accession

H0VTN5;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000015572	ENSCPOP00000014041	ENSCPOT00000015724

Organism

Cavia porcellus

Functional Description

Protein Length

908

Protein Sequence
(FASTA)

MATGIGEKIE DFKVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK AGMVQRVQNE 60

VKIHCQLKHP SILECYNLLL EMCHNGEMNR YLKNRMKPFS EYEARHFMHQ IIKGLLYLHS 120

HGIIHRDLTL SNLLLTRNMN IKIADFGLAT QLQMPHEKHY TLCGTPNYIS PEIATRSAHG 180

LESDIWSLGC MFYTLLIGRP PFDTDTVKNT LNKVVLADYE MPTFLSREAK DLIHQLLRRN 240

PADRLSLSSI LDHPFMFQSA SAKSRDLGTV EDSIDSGHAT ISTEVTTSSS TSMGGSLFDR 300

RRHLIGQPLP NKITIFPKNK NSGDFSSGDG SSFYSQWGNQ EETSNRRGRL IQDAEERPHS 360

RYLRRAHSSD RSSNSNSQSR TKTCTMERCH SAEMLLKSKR SGLDHNQSLS NHLCPGKTPL 420

SDQTPQMEMV QQWFDNLQMN AHVRETTEHN NMNPNNAWAD TRARKGSDVS NNAHFVKQPN 480

AMKYMTGLHG KPEIIQQEPI FGLDPLSEQS KTLGMDSALG HQKHSLRSIT SPLVAHRLKP 540

IRQKTKKAVV SILDSEEVCV ELLKEHTSRE YVKEVLQISS DGNMITVYYP SDGRGFPLTD 600

RPPSPTNNIT RYSFDNLPEK YWKKYQYASR FVQLVRSKSP KITYFTKYAK CILMENSPDA 660

DFEVWFYDGA KIHKTEDFVQ VIEKTGKSYN LKHEHEVNSL QEEIKIYLDH ANEGHRICLT 720

LESIISEEEK KSRSAPFFPI IIGRKPGCTN SPKALSASPV DPNCVMRDGP PLNKLVMSSA 780

ASPAQAPVLN PSAVTPEGLG HPAIASGTGI SSNSPKDCLP KSAQLLKSVF VKNVGWATQL 840

TSGAVWVQFN DGSQLVVQAG VSSISYTSPS GQTTRYGEHD KLPEYIRQKL QCLRSILSMF 900

SNPTPTFL 908

Nucleotide Sequence
(FASTA)

ATGGCGACCG GCATCGGGGA GAAGATCGAG GATTTTAAGG TTGGAAACCT CCTCGGTAAA 60

GGATCGTTTG CTGGTGTCTA CAGAGCTGAG TCCATTCACA CTGGTTTGGA AGTTGCAATA 120

AAAATGATAG ATAAAAAAGC CATGTACAAA GCTGGAATGG TGCAGCGTGT CCAAAATGAG 180

GTGAAAATAC ATTGCCAGTT GAAGCATCCA TCTATCTTAG AGTGTTATAA TTTATTATTG 240

GAAATGTGTC ATAATGGAGA AATGAACAGA TATCTAAAGA ATAGAATGAA ACCTTTCTCA 300

GAATATGAAG CTCGACATTT CATGCACCAG ATCATCAAAG GATTACTGTA TCTTCATTCC 360

CATGGTATAA TACACCGGGA CCTCACACTG TCTAATCTGT TACTCACTCG TAATATGAAT 420

ATCAAGATTG CTGATTTTGG TCTAGCAACT CAGTTGCAAA TGCCACATGA AAAGCACTAT 480

ACATTATGTG GAACTCCTAA TTACATTTCA CCAGAAATTG CAACTCGAAG TGCCCATGGA 540

CTTGAATCAG ACATTTGGTC CTTGGGCTGT ATGTTTTACA CGTTACTTAT TGGGAGACCA 600

CCTTTTGACA CTGACACAGT CAAGAACACA TTAAATAAAG TAGTATTGGC AGATTATGAA 660

ATGCCAACTT TTTTGTCAAG AGAGGCCAAG GACCTTATTC ACCAGTTACT TCGTAGAAAT 720

CCAGCAGATC GTTTAAGTCT ATCTTCAATA TTGGACCATC CTTTTATGTT TCAAAGTGCT 780

TCAGCAAAAA GTAGAGATTT GGGGACTGTA GAAGACTCAA TTGATAGTGG ACATGCCACA 840

ATTTCTACTG AAGTTACAAC TTCTTCCAGT ACCAGTATGG GTGGTAGTTT ATTTGACAGA 900

AGAAGACATT TAATTGGTCA ACCACTCCCC AATAAAATTA CTATATTTCC AAAGAATAAA 960

AATTCAGGTG ACTTTTCTTC AGGAGATGGA AGCAGTTTTT ATAGTCAGTG GGGAAATCAA 1020

GAAGAAACTA GTAATAGAAG GGGAAGACTA ATCCAAGATG CAGAAGAAAG GCCACATTCT 1080

CGATACCTAC GTAGAGCTCA TTCCTCTGAT AGATCAAGCA ATTCTAATAG TCAGTCTCGA 1140

ACAAAAACAT GTACGATGGA ACGGTGTCAC TCAGCAGAAA TGCTTTTGAA GTCTAAAAGA 1200

TCAGGACTGG ATCACAATCA ATCACTTTCC AATCATCTCT GTCCAGGAAA AACTCCACTT 1260

TCAGACCAAA CACCTCAGAT GGAAATGGTA CAGCAGTGGT TTGATAATCT GCAAATGAAT 1320

GCTCATGTAA GAGAAACTAC TGAGCACAAC AACATGAACC CAAATAATGC CTGGGCTGAT 1380

ACAAGAGCCA GAAAAGGCTC GGATGTTTCT AACAATGCAC ATTTTGTAAA ACAGCCAAAT 1440

GCTATGAAAT ATATGACTGG ACTTCATGGT AAACCTGAGA TAATTCAACA AGAACCTATT 1500

TTTGGCTTAG ATCCTCTTTC TGAACAAAGC AAAACTCTGG GTATGGACTC AGCGTTGGGT 1560

CATCAGAAAC ATTCGTTACG AAGCATTACA TCTCCTTTGG TTGCTCACAG ATTAAAACCA 1620

ATCAGACAGA AAACCAAAAA GGCTGTGGTG AGCATACTTG ATTCAGAGGA GGTATGTGTG 1680

GAGCTTCTAA AGGAGCATAC GTCTCGGGAA TATGTGAAAG AAGTTCTTCA GATATCTAGT 1740

GATGGCAATA TGATCACTGT TTATTATCCA AGTGATGGAA GAGGCTTTCC TCTCACTGAT 1800

CGACCACCCT CACCTACTAA TAACATCACT AGGTACAGCT TTGACAATTT ACCAGAAAAA 1860

TACTGGAAAA AATACCAATA TGCTTCCAGA TTTGTACAGC TCGTAAGATC TAAATCTCCA 1920

AAAATCACCT ATTTTACAAA GTATGCTAAA TGTATTTTAA TGGAGAATTC TCCTGATGCT 1980

GACTTTGAGG TTTGGTTTTA TGATGGAGCA AAAATACACA AAACAGAAGA TTTTGTTCAA 2040

GTGATTGAAA AGACCGGAAA ATCTTACAAT TTAAAACATG AACATGAAGT TAATAGCCTG 2100

CAAGAGGAAA TAAAAATATA TTTAGACCAT GCTAATGAGG GTCATCGTAT TTGTTTAACA 2160

TTGGAATCTA TAATTTCAGA GGAGGAAAAG AAAAGTAGAA GTGCACCCTT TTTCCCCATA 2220

ATTATAGGAA GAAAACCTGG TTGCACTAAT TCCCCTAAGG CTTTATCAGC TTCTCCTGTG 2280

GATCCAAACT GTGTAATGAG AGATGGACCA CCTTTGAACA AATTGGTCAT GAGTAGTGCT 2340

GCTTCTCCAG CGCAGGCACC AGTACTTAAT CCTTCTGCAG TTACACCTGA AGGACTTGGT 2400

CATCCTGCTA TAGCCTCAGG AACAGGCATC TCCTCTAACA GTCCGAAAGA TTGTCTTCCT 2460

AAATCAGCAC AGCTTTTAAA ATCTGTTTTT GTGAAAAATG TTGGTTGGGC TACCCAGTTA 2520

ACTAGTGGAG CTGTGTGGGT TCAGTTTAAT GATGGGTCAC AGCTGGTGGT CCAGGCAGGC 2580

GTGTCTTCTA TCAGTTACAC CTCACCGAGT GGTCAGACAA CGCGGTATGG AGAACATGAT 2640

AAGTTACCAG AATACATCAG ACAGAAATTA CAGTGTCTTC GTTCTATCCT TTCAATGTTT 2700

TCTAATCCAA CTCCTACTTT TCTTTGA 2727

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         +++g+llGkG+fa +y++++++t+ ++a+k+++k++++k+ + ++v++e++ih++lkh++

Q: 12    FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS  71

         6899********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekr  119

         i++ y+         l+le+c++++++++lk+r k+++e e+r++++qi++gl+ylh++

Q: 72    ILECYN---------LLLEMCHNGEMNRYLKNRmKPFSEYEARHFMHQIIKGLLYLHSHG  122

         **9997.........79***************99**************************

S: 120   ilhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghsle  179

         i+hrdl+l+nl+l++++++ki+dfGlat+l++++e+++tlcGtPnyi+Pe++++++h+le

Q: 123   IIHRDLTLSNLLLTRNMNIKIADFGLATQLQMPHEKHYTLCGTPNYISPEIATRSAHGLE  182

         ************************************************************

S: 180   vdiWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePe  239

         +diWslGc++ytll+G+PPf+t+++k+t++k++ a+y++P+ ls+eak+li++ll+++P+

Q: 183   SDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLSREAKDLIHQLLRRNPA  242

         ************************************************************

S: 240   erpsleevlkdefl  253

         +r+sl+++l+++f+

Q: 243   DRLSLSSILDHPFM  256

         ************98

Domain Sequence
(FASTA)

FKVGNLLGKG SFAGVYRAES IHTGLEVAIK MIDKKAMYKA GMVQRVQNEV KIHCQLKHPS 60

ILECYNLLLE MCHNGEMNRY LKNRMKPFSE YEARHFMHQI IKGLLYLHSH GIIHRDLTLS 120

NLLLTRNMNI KIADFGLATQ LQMPHEKHYT LCGTPNYISP EIATRSAHGL ESDIWSLGCM 180

FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PTFLSREAKD LIHQLLRRNP ADRLSLSSIL 240

DHPFM 245

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013