EKS-CAP-00400

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00400

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	447.4	1.3E-134	275	524	250

Status

Unreviewed

Ensembl Protein

ENSCPOP00000014047

UniProt Accession

H0VTP1;

Protein Name

Protein Synonyms/Alias

Gene Name

YES1

Gene Synonyms/Alias

YES1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000015578	ENSCPOP00000014047	ENSCPOT00000015730

Organism

Cavia porcellus

Functional Description

Protein Length

541

Protein Sequence
(FASTA)

MGCIKSKEDK SPAIKYRTEN TPEPISAGVS QYGAEHPAVT PSSSVKGSSA NFSSLSITPF 60

GGSSGVTPFG GASSSFSVVP SSYPASLTGG VTIFVALYDY EARTTEDLSF KKGERFQIIN 120

NTEGDWWEAR SIATGKNGYI PSNYVAPADS IQAEEWYFGK MGRKDAERLL LNPGNQQGIF 180

LVRESETTKG AYSLSIRDWD EVRGDNVKHY KIRKLDNGGY YITTRAQFDT LQKLVKHYTE 240

HADGLCHKLT TVCPTVKPQT QGLAKDAWEI PRESLRLEVK LGQGCFGEVW MGTWNGTTKV 300

AIKTLKPGTM MPEAFLQEAQ IMKKLRHDKL VPLYAVVSEE PIYIVTEFMS KGSLLDFLKE 360

GDGKYLKLPQ LVDMAAQIAD GMAYIERMNY IHRDLRAANI LVGENLVCKI ADFGLARLIE 420

DNEYTARQGA KFPIKWTAPE AALYGRFTIK SDVWSFGILQ TELVTKGRVP YPGMVNREVL 480

EQVERGYRMP CPQGCPESLH ELMNLCWKKD PDERPTFEYI QSFLEDYFTA TEPQYQPGEN 540

L 541

Nucleotide Sequence
(FASTA)

ATGGGCTGCA TTAAAAGTAA GGAAGACAAA AGTCCAGCCA TTAAATACAG AACTGAGAAC 60

ACCCCAGAAC CGATCAGTGC TGGTGTCAGC CAGTATGGGG CAGAACACCC TGCAGTGACG 120

CCATCGTCTT CAGTGAAGGG CTCCTCTGCG AACTTCAGCA GTCTCTCCAT CACACCCTTC 180

GGGGGATCCT CAGGGGTGAC TCCTTTTGGG GGAGCATCGT CTTCATTCTC AGTGGTGCCA 240

AGTTCATACC CTGCTAGTTT AACAGGTGGT GTTACTATAT TTGTGGCCTT ATATGATTAT 300

GAAGCTAGAA CTACAGAAGA CCTTTCATTT AAGAAGGGCG AGAGATTTCA AATCATTAAC 360

AATACGGAAG GAGACTGGTG GGAAGCGCGG TCGATCGCCA CAGGAAAGAA CGGTTACATC 420

CCCAGCAATT ACGTGGCGCC TGCAGATTCC ATTCAGGCAG AAGAATGGTA TTTTGGCAAA 480

ATGGGGAGAA AAGATGCTGA ACGATTACTT CTGAATCCTG GGAATCAACA AGGCATATTC 540

TTAGTAAGAG AAAGTGAAAC TACTAAAGGT GCTTACTCCC TCTCTATCCG TGATTGGGAT 600

GAAGTAAGGG GCGACAATGT GAAACACTAC AAAATTAGGA AACTTGACAA TGGTGGATAC 660

TACATCACAA CCAGAGCACA ATTCGATACA CTGCAGAAAC TGGTAAAACA CTACACAGAA 720

CATGCTGATG GTTTGTGCCA CAAGTTAACA ACTGTGTGTC CAACTGTGAA ACCCCAGACT 780

CAAGGTCTGG CAAAAGATGC TTGGGAAATC CCTCGGGAAT CTCTGCGACT AGAGGTTAAA 840

TTAGGACAAG GATGCTTCGG TGAAGTATGG ATGGGAACCT GGAATGGAAC CACAAAAGTA 900

GCAATCAAAA CACTAAAGCC AGGGACAATG ATGCCAGAAG CTTTTCTTCA AGAAGCACAG 960

ATAATGAAAA AGCTGAGACA TGATAAACTT GTTCCACTCT ACGCTGTTGT TTCTGAAGAG 1020

CCCATTTACA TCGTCACTGA GTTCATGTCC AAAGGAAGCT TACTAGATTT CCTCAAAGAA 1080

GGAGATGGAA AGTATTTGAA GCTTCCACAG CTGGTCGACA TGGCTGCTCA GATTGCCGAT 1140

GGTATGGCAT ATATTGAAAG AATGAACTAT ATCCACCGAG ATCTTCGGGC TGCTAATATT 1200

CTTGTAGGAG AAAACCTTGT GTGCAAAATA GCAGATTTTG GTTTAGCAAG ATTAATTGAA 1260

GACAATGAAT ACACTGCAAG ACAAGGTGCA AAATTTCCAA TCAAATGGAC AGCTCCTGAG 1320

GCAGCACTTT ATGGTCGATT TACAATAAAG TCTGATGTAT GGTCCTTTGG AATTCTACAG 1380

ACAGAACTTG TAACAAAGGG GAGAGTGCCC TATCCAGGTA TGGTAAACCG CGAGGTGCTG 1440

GAACAGGTGG AGCGGGGATA CAGGATGCCC TGCCCTCAGG GCTGCCCAGA ATCACTCCAT 1500

GAATTGATGA ACCTTTGCTG GAAGAAGGAC CCTGATGAAA GACCAACGTT TGAATATATT 1560

CAGTCCTTCT TGGAAGACTA CTTCACTGCT ACAGAGCCAC AGTACCAGCC AGGAGAAAAC 1620

TTA 1623

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g++kva+ktlk+gt++peafl+eaqi+kklrh+klv ly

Q: 275   LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY  334

         68999*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflke +gk+lklp+lvd+aaq+a+Gmay+e++n+ihr

Q: 335   AVVSE-EPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHR  393

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvge+lv+k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 394   DLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  453

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGil te+vtkG+vPypGm n+evleqvergyr+p+p+ cpe+l+el++ cwkkdp+e

Q: 454   WSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDE  513

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe++q++l

Q: 514   RPTFEYIQSFL  524

         *******9986

Domain Sequence
(FASTA)

LRLEVKLGQG CFGEVWMGTW NGTTKVAIKT LKPGTMMPEA FLQEAQIMKK LRHDKLVPLY 60

AVVSEEPIYI VTEFMSKGSL LDFLKEGDGK YLKLPQLVDM AAQIADGMAY IERMNYIHRD 120

LRAANILVGE NLVCKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILQTELV TKGRVPYPGM VNREVLEQVE RGYRMPCPQG CPESLHELMN LCWKKDPDER 240

PTFEYIQSFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013