EKS-CAP-00295

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00295

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	428.2	1.1E-128	79	331	253

Status

Unreviewed

Ensembl Protein

ENSCPOP00000015535

UniProt Accession

H0VXV4;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK2

Gene Synonyms/Alias

PLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000021250	ENSCPOP00000015535	ENSCPOT00000021364

Organism

Cavia porcellus

Functional Description

Protein Length

682

Protein Sequence
(FASTA)

MELLRTITYQ PAGGTKMCEQ ALGKGCGGDS KKKRPQQPPE EPQPQAQVPP AAPHHHHHHS 60

HSGPEISRII VDPTTGKRYC RGKVLGKGGF AKCYEMTDLT NNKVYAAKII PHSRVAKPHQ 120

REKIDKEIEL HRILHHKHVV QFYHYFEDKE NIYILLEYCS RRSMAHILKA RKVLTEPEVR 180

YYLRQIVSGL KYLHEQEILH RDLKLGNFFI NEAMELKVGD FGLAARLEPL EHRRRTICGT 240

PNYLSPEVLN KQGHGCESDI WALGCVMYTM LLGRPPFETT NLKETYRCIR EARYTMPSSL 300

LAPAKHLIAS MLSKNPEDRP SLDDIIRHDF FLQGFTPDRL SSSCCHTVPD FHLSSPAKNF 360

FKKAAAALFG GKKDKARYID THNRVSKEDE EIYKLRHDLK KTSITQQPSK HRTDEELQPP 420

PTTVARSGTP AVENKQQIGD AIRMIVRGTL GSCSSSSECL EDSTMGSVAD TVARVLRGCL 480

ENMPEADSIP KEQLSTSFQW VTKWVDYSNK YGFGYQLSDH TVGVLFNNGA HMSLLPDKKT 540

VHYYAELGQC SVFPATDAPE QFISQVTVLK YFSHYMEENL MDGGDLPSVT DIRRPRLYLL 600

QWLKSDKALM MLFNDGTFQV NFYHDHTKII ICSQNEEYLL TYINEDRIST TLRLTTLLMS 660

GCSSELKNRM EYALNMLLQR CN 682

Nucleotide Sequence
(FASTA)

ATGGAGCTCT TGCGGACTAT CACTTACCAA CCGGCCGGAG GCACCAAGAT GTGCGAGCAG 60

GCGCTGGGCA AGGGTTGCGG TGGGGACTCC AAGAAGAAGC GGCCCCAGCA GCCCCCCGAG 120

GAGCCGCAGC CGCAGGCCCA GGTGCCCCCG GCGGCGCCGC ACCACCATCA CCACCACTCG 180

CACTCCGGAC CCGAGATCTC GAGGATTATC GTCGACCCCA CGACGGGGAA ACGCTACTGC 240

CGGGGCAAAG TGCTGGGAAA GGGTGGTTTT GCAAAGTGTT ATGAAATGAC AGATTTGACA 300

AACAACAAAG TCTACGCTGC AAAAATTATT CCTCACAGCA GAGTAGCAAA ACCTCATCAA 360

AGGGAAAAGA TTGACAAAGA AATAGAGCTT CACAGAATTC TTCATCATAA ACACGTAGTG 420

CAGTTTTACC ACTACTTCGA GGACAAAGAA AACATTTACA TTCTCTTGGA ATACTGCAGT 480

AGAAGGTCCA TGGCTCACAT ATTAAAAGCA AGAAAGGTGT TGACAGAGCC AGAAGTCCGA 540

TACTACCTCA GGCAAATTGT GTCTGGACTG AAATACCTTC ATGAACAAGA AATCTTGCAC 600

AGAGATCTCA AATTAGGAAA CTTTTTTATT AATGAAGCCA TGGAACTAAA AGTTGGAGAC 660

TTTGGTTTGG CAGCCAGGCT GGAACCTTTG GAACACAGAA GGAGAACAAT ATGTGGTACC 720

CCAAATTATC TATCTCCTGA AGTCCTCAAC AAACAAGGAC ACGGCTGTGA ATCAGACATT 780

TGGGCCTTAG GCTGTGTAAT GTATACAATG CTGCTAGGAA GACCTCCATT TGAAACTACA 840

AATCTGAAAG AAACTTACAG GTGCATAAGA GAAGCAAGAT ATACAATGCC ATCTTCATTG 900

TTGGCTCCTG CTAAGCATTT AATAGCTAGC ATGTTGTCCA AAAACCCAGA GGATCGGCCC 960

AGTTTGGATG ACATCATTCG ACATGACTTT TTTTTGCAGG GCTTCACTCC AGACAGACTT 1020

TCTTCTAGCT GTTGTCACAC CGTTCCAGAT TTTCATTTAT CAAGCCCAGC TAAGAATTTT 1080

TTTAAGAAAG CTGCTGCTGC TCTTTTTGGT GGCAAGAAAG ACAAAGCAAG ATATATTGAT 1140

ACGCACAACA GAGTATCTAA AGAAGATGAA GAAATTTACA AGCTTAGGCA TGATTTGAAA 1200

AAGACTTCAA TAACTCAGCA ACCAAGCAAA CATAGAACAG ATGAGGAGCT CCAGCCACCA 1260

CCCACTACGG TGGCCAGATC TGGAACGCCT GCAGTAGAAA ACAAGCAGCA GATTGGTGAT 1320

GCTATTCGGA TGATAGTCAG AGGGACACTT GGCAGCTGCA GCAGTAGCAG TGAATGCCTT 1380

GAAGATAGTA CTATGGGAAG TGTTGCAGAC ACAGTGGCAA GAGTCCTTCG AGGATGTCTA 1440

GAAAATATGC CAGAAGCTGA CTCCATTCCC AAAGAGCAAC TGAGCACGTC ATTTCAGTGG 1500

GTCACCAAAT GGGTCGATTA TTCTAACAAA TATGGCTTTG GGTACCAGCT GTCAGACCAC 1560

ACTGTTGGAG TCCTTTTCAA CAATGGTGCA CACATGAGCC TCCTTCCGGA CAAAAAAACA 1620

GTTCACTATT ATGCAGAACT CGGCCAGTGC TCTGTATTTC CAGCAACAGA TGCCCCTGAA 1680

CAATTCATTA GTCAAGTGAC GGTGCTGAAA TACTTTTCCC ACTACATGGA GGAGAACCTC 1740

ATGGATGGTG GTGATCTCCC TAGTGTTACT GATATTCGAA GACCCCGGCT CTACCTCCTC 1800

CAGTGGCTAA AATCTGATAA GGCCTTAATG ATGCTCTTCA ATGATGGCAC CTTCCAGGTG 1860

AATTTCTACC ATGATCATAC AAAAATAATC ATCTGCAGCC AAAATGAAGA ATACCTTCTC 1920

ACTTACATCA ATGAAGATAG GATATCTACA ACTCTTAGAC TGACAACTCT GTTGATGTCT 1980

GGCTGTTCAT CAGAATTAAA AAATCGAATG GAATATGCCC TGAACATGCT TTTACAGAGA 2040

TGTAAC 2046

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y+rgk+lGkGgfakcye++dl++++v+a+k++p+s++ak++qrek++keie+hr l+hk+

Q: 79    YCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKH  138

         99**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v++y++fedken+y++le+csrrs+a++lk+rk+ltepevryylrqivsglkylhe++i

Q: 139   VVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI  198

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+ne++e+k+gdfGla+rle+ e+r++t+cGtPny++Pevl+k+gh++e+

Q: 199   LHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCES  258

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         diW+lGc++yt+l+G+PPfet++lkety++i++a+y++Pssl ++ak+lia++l+k+Pe+

Q: 259   DIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPED  318

         ************************************************************

S: 241   rpsleevlkdefl  253

         rpsl+++++++f+

Q: 319   RPSLDDIIRHDFF  331

         ************8

Domain Sequence
(FASTA)

YCRGKVLGKG GFAKCYEMTD LTNNKVYAAK IIPHSRVAKP HQREKIDKEI ELHRILHHKH 60

VVQFYHYFED KENIYILLEY CSRRSMAHIL KARKVLTEPE VRYYLRQIVS GLKYLHEQEI 120

LHRDLKLGNF FINEAMELKV GDFGLAARLE PLEHRRRTIC GTPNYLSPEV LNKQGHGCES 180

DIWALGCVMY TMLLGRPPFE TTNLKETYRC IREARYTMPS SLLAPAKHLI ASMLSKNPED 240

RPSLDDIIRH DFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013