EKS-CAP-00150

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00150

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	527.4	5.7E-159	467	743	277

Status

Unreviewed

Ensembl Protein

ENSCPOP00000019914

UniProt Accession

H0WAA3;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR4

Gene Synonyms/Alias

FGFR4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000022113	ENSCPOP00000019914	ENSCPOT00000019966

Organism

Cavia porcellus

Functional Description

Protein Length

801

Protein Sequence
(FASTA)

MRLLLALLGV LLGPHGAPAL SFEASEEMDL EPCLAPSLEQ QEQELTIALG QPVRLCCGLG 60

ERGGHWYKEG SRLAPAGRVR SWRGRLEIAA FLPEDAGHYL CLARSSMIVL HNLTLVADDS 120

LTPSNDDEDP KVNRGSSNGH IYLQQAPYWT HPQRMEKKLH AVPAGNTVKF RCPAAGNPMP 180

TIHWLKDGHA FHGENRIGGI RLRHQHWSLV MESVVPSDRG TYTCLVENPL GSIRYSYLLD 240

VLERSPHRPI LQAGLPANTT AVAGSDVELL CKVYSDAQPH IQWLKHIVIN GSSFGADGFP 300

YVQVLKTADI NSSEVEVLYL RNVSAEDAGE YTCLAGNSIG LSYQSAWLTV LPEEDPTRTA 360

AASEVRYTDI ILYSSGSLAL AVLLLLAGLY RGQALHSQHS RQPATVQKLS RFPLGRQFSL 420

ESGSSGKSSS SLVRGVRLSS SGPPLLAGLV NLDLPLDPLW EFPRDRLVLG KPLGEGCFGQ 480

VVRAEAVGMD PAQPDQTSTV AVKMLKDNAS DKDLADLVSE MEVMKLIGRH KNIINLLGVC 540

TQEGPLYVIV ECAAKGNLRE FLRARRPPGP DLSPDGPRSS EGPLSFPALV SCAYQVARGM 600

QYLESRKCIH RDLAARNVLV TEDNVMKIAD FGLARGVHHI DYYKKTSNGR LPVKWMAPEA 660

LFDRVYTHQS DVWSFGILLW EIFTLGGSPY PGIPVEELFS LLREGHRMDR PPTCPPELYG 720

LMRECWHAAP SQRPTFKQLV EALDKVLLAV SEEYLDLRLT FGPYSPSGGD ASSTCSSSDS 780

VFSHDPLPLG PNPFPFPGVQ T 801

Nucleotide Sequence
(FASTA)

ATGCGGCTGC TGTTGGCTTT ATTGGGGGTC CTGCTAGGGC CACATGGGGC TCCAGCCTTG 60

TCCTTTGAGG CCTCTGAGGA AATGGACCTG GAGCCCTGCC TGGCCCCCAG CCTAGAGCAA 120

CAAGAGCAGG AGTTGACCAT TGCCCTTGGA CAGCCTGTGC GGCTGTGCTG TGGGCTGGGT 180

GAGCGTGGTG GCCACTGGTA CAAGGAGGGT AGCCGCCTGG CACCTGCTGG CCGGGTACGG 240

AGCTGGAGGG GCCGGCTAGA GATTGCTGCC TTCCTGCCGG AGGATGCTGG CCACTACCTC 300

TGTCTGGCAC GCAGCTCCAT GATTGTCCTA CACAATCTCA CCTTGGTTGC AGATGATTCC 360

TTGACTCCAA GCAATGATGA TGAAGACCCC AAGGTCAACA GAGGCTCCTC AAATGGGCAT 420

ATTTACCTCC AGCAAGCACC TTACTGGACA CATCCCCAGC GTATGGAGAA AAAATTGCAT 480

GCAGTACCTG CTGGGAACAC CGTTAAGTTC CGCTGTCCAG CTGCAGGCAA CCCCATGCCC 540

ACCATCCACT GGCTCAAAGA TGGACACGCT TTCCATGGGG AGAATCGCAT TGGGGGCATT 600

CGACTGCGCC ACCAGCACTG GAGCCTGGTG ATGGAAAGTG TGGTACCCTC GGATCGTGGC 660

ACGTACACCT GCCTTGTGGA GAACCCTTTG GGCAGCATCC GTTACAGCTA TTTACTGGAT 720

GTGCTGGAGC GGTCCCCGCA CCGGCCCATC CTGCAGGCGG GGCTTCCAGC CAACACCACA 780

GCTGTGGCAG GCAGCGATGT GGAGCTACTG TGCAAGGTGT ACAGCGATGC CCAGCCCCAC 840

ATCCAATGGC TGAAGCACAT CGTCATCAAT GGCAGCAGCT TCGGTGCCGA TGGCTTCCCC 900

TACGTCCAGG TCCTAAAGAC AGCAGACATC AATAGCTCCG AGGTGGAAGT CCTGTACCTA 960

CGGAATGTGT CAGCCGAGGA CGCAGGCGAG TACACCTGCC TGGCAGGCAA CTCCATTGGC 1020

CTCTCCTACC AGTCAGCCTG GCTCACGGTG CTGCCAGAGG AAGACCCCAC CAGGACAGCA 1080

GCAGCGTCCG AGGTTAGGTA TACAGACATC ATTCTGTATT CGTCGGGCTC CCTGGCTTTG 1140

GCTGTGCTGC TGCTGCTGGC CGGGCTGTAT CGTGGGCAGG CACTCCACAG CCAGCATTCC 1200

CGCCAGCCCG CCACTGTGCA AAAGTTGTCC CGCTTCCCTT TGGGCCGACA GTTCTCCCTG 1260

GAGTCCGGCT CCTCTGGCAA GTCAAGCTCA TCCCTGGTTC GAGGCGTCCG GCTCTCCTCC 1320

AGTGGCCCCC CCTTGCTTGC TGGTCTCGTG AATCTTGACC TACCTCTGGA CCCACTGTGG 1380

GAGTTCCCCC GGGACAGGCT GGTGCTCGGG AAGCCCCTAG GTGAGGGCTG CTTTGGGCAG 1440

GTGGTGCGGG CAGAGGCTGT CGGCATGGAT CCTGCCCAAC CTGACCAGAC AAGCACCGTG 1500

GCTGTCAAGA TGCTCAAAGA CAATGCCTCT GACAAGGACT TAGCAGACCT GGTCTCTGAG 1560

ATGGAAGTGA TGAAGCTCAT TGGCCGACAC AAGAATATCA TCAACCTGCT GGGTGTCTGC 1620

ACCCAGGAAG GGCCCCTGTA TGTGATCGTG GAGTGTGCTG CCAAGGGCAA CCTGCGGGAG 1680

TTCCTTCGTG CCCGGCGTCC TCCAGGCCCT GACCTCAGCC CTGATGGGCC ACGGAGCAGC 1740

GAGGGGCCCC TGTCCTTCCC CGCTCTGGTC TCCTGTGCCT ACCAGGTGGC CCGAGGCATG 1800

CAGTATCTGG AGTCACGGAA GTGCATCCAC CGGGACCTGG CTGCCCGCAA TGTGCTGGTG 1860

ACTGAGGATA ATGTCATGAA GATTGCTGAC TTCGGGCTGG CCCGTGGTGT CCACCACATT 1920

GATTACTACA AGAAAACCAG CAACGGCCGC CTGCCGGTTA AGTGGATGGC ACCAGAGGCC 1980

TTGTTTGATC GCGTGTACAC ACACCAGAGT GATGTGTGGT CATTTGGGAT CCTGCTCTGG 2040

GAGATCTTCA CACTCGGGGG CTCCCCATAT CCTGGCATCC CTGTGGAAGA GCTGTTCTCA 2100

CTGTTGCGGG AAGGGCATCG GATGGATCGG CCCCCCACCT GCCCCCCGGA ACTGTACGGT 2160

CTGATGCGTG AGTGCTGGCA TGCGGCGCCC TCTCAGAGGC CCACTTTCAA GCAGCTGGTG 2220

GAAGCACTGG ACAAAGTCCT GCTGGCTGTC TCCGAGGAGT ACCTTGACCT CCGCCTGACC 2280

TTTGGACCCT ACTCCCCTTC TGGTGGGGAT GCCAGCAGTA CCTGCTCCTC CAGTGATTCT 2340

GTCTTCAGCC ATGACCCCCT GCCACTGGGA CCAAACCCCT TCCCCTTCCC TGGAGTACAG 2400

ACATGA 2406

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv+aea+g+d  ++++++tvavkmlk++a+dkdladlvsemev+kl

Q: 467   LVLGKPLGEGCFGQVVRAEAVGMDPAQPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKL  526

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iG+hkniinllG+ctqeGplyvive+aakGnlreflrarrp+g + s d +++se  l++

Q: 527   IGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSF  586

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

           lvs+ayqvarGm+yl+s+kcihrdlaarnvlvtednv+kiadfGlar+vh+idyykkt

Q: 587   PALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKT  646

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         +nGrlpvkwmapealfdrvyt+qsdvwsfG+llwei+tlGgspypgi+veelf+ll+eGh

Q: 647   SNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH  706

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm++p +c+ ely lmrecwha++s+rptfkqlve+l

Q: 707   RMDRPPTCPPELYGLMRECWHAAPSQRPTFKQLVEAL  743

         **********************************986

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVRAEA VGMDPAQPDQ TSTVAVKMLK DNASDKDLAD LVSEMEVMKL 60

IGRHKNIINL LGVCTQEGPL YVIVECAAKG NLREFLRARR PPGPDLSPDG PRSSEGPLSF 120

PALVSCAYQV ARGMQYLESR KCIHRDLAAR NVLVTEDNVM KIADFGLARG VHHIDYYKKT 180

SNGRLPVKWM APEALFDRVY THQSDVWSFG ILLWEIFTLG GSPYPGIPVE ELFSLLREGH 240

RMDRPPTCPP ELYGLMRECW HAAPSQRPTF KQLVEAL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Equus caballus"; ?>Felis catus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013