EPS-CAP-00119

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CAP-00119

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP5	619.4	9.1E-187	185	496	312

Status

Unreviewed

Ensembl Protein

ENSCPOP00000017179

UniProt Accession

H0W2I6;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP5C

Gene Synonyms/Alias

PPP5C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000023554	ENSCPOP00000017179	ENSCPOT00000024102

Organism

Cavia porcellus

Functional Description

Protein Length

499

Protein Sequence
(FASTA)

MAMAEGERTE CADPPRDEPP ANGALKRAEE LKTQANDYFK AKDYENAIKF YSQAIELNPS 60

NAIYYGNRSL AYLRTECYGY ALADATRAIE IDKKYIKGYY RRAASNMALG KFRAALRDYE 120

TVVKVKPHDK DAKMKYQECN KIVKQKAFER AIAGDEHKRS VVDSLDIESM TIEDEYSGPK 180

LEDGKVTITF MKELMQWYKE QKKLHRKCAY QILVQVKEVL SKLSTLVETT LKETEKITVC 240

GDTHGQFYDL LNIFELNGLP SETNPYIFNG DFVDRGSFSV EVILTLFGFK LLYPDHFHLL 300

RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL AQCINGKVLI MHGGLFSEDG 360

VTLDDIRKIE RNRQPPDSGP MCDLLWSDPQ PQNGRSVSKR GVSCQFGPDI TKAFLEENHL 420

DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN YCDQMGNKAS YIHLRGSDLR PQFHQFTAVP 480

HPNVKPMAYA NTLLQLGMM 499

Nucleotide Sequence
(FASTA)

ATGGCGATGG CGGAGGGCGA GCGGACTGAG TGTGCCGATC CCCCCCGGGA CGAGCCTCCG 60

GCTAATGGCG CTCTGAAACG GGCAGAAGAG CTCAAGACCC AGGCCAACGA CTACTTCAAA 120

GCCAAGGACT ACGAGAACGC CATCAAGTTC TACAGTCAGG CCATTGAGCT GAACCCCAGC 180

AATGCCATCT ACTATGGCAA CCGCAGCCTG GCGTACCTGC GCACTGAGTG CTATGGCTAC 240

GCGTTGGCCG ACGCCACTCG GGCCATCGAG ATCGACAAGA AGTACATCAA AGGTTATTAC 300

CGCCGGGCCG CCAGCAACAT GGCACTGGGC AAGTTCCGGG CCGCCCTCCG TGACTACGAG 360

ACGGTGGTGA AGGTGAAGCC CCATGACAAA GATGCCAAAA TGAAGTATCA GGAGTGCAAC 420

AAGATCGTGA AGCAGAAGGC CTTCGAGCGG GCCATCGCGG GTGACGAGCA CAAGCGCTCC 480

GTCGTGGACT CCCTCGACAT CGAGAGCATG ACCATCGAGG ATGAGTACAG CGGGCCCAAG 540

CTGGAGGACG GCAAAGTGAC AATCACTTTC ATGAAGGAGC TCATGCAGTG GTACAAGGAA 600

CAGAAGAAAT TGCACCGGAA ATGTGCCTAC CAGATCCTGG TGCAGGTCAA AGAGGTCCTG 660

TCCAAGCTGA GCACGCTCGT GGAGACCACG CTCAAAGAGA CAGAGAAGAT TACAGTATGC 720

GGGGACACCC ACGGCCAGTT CTATGACCTC CTCAACATAT TTGAGCTCAA CGGTTTACCG 780

TCGGAAACCA ACCCTTATAT ATTTAATGGT GACTTTGTGG ACCGTGGTTC TTTCTCTGTC 840

GAAGTGATCC TCACCCTTTT CGGATTTAAG CTCCTGTACC CCGATCACTT TCACCTACTT 900

CGAGGCAACC ACGAGACAGA CAACATGAAC CAGATCTACG GCTTCGAGGG CGAGGTGAAG 960

GCCAAGTACA CGGCGCAGAT GTACGAGCTC TTCAGCGAGG TGTTTGAGTG GCTCCCGCTG 1020

GCCCAGTGCA TCAACGGCAA AGTGCTGATC ATGCACGGAG GCCTGTTCAG CGAGGATGGT 1080

GTCACCCTGG ATGACATCCG GAAGATCGAG CGGAATCGGC AGCCCCCGGA CTCAGGCCCC 1140

ATGTGCGACC TGCTGTGGTC AGACCCGCAG CCCCAGAACG GGCGCTCAGT CAGCAAGCGT 1200

GGTGTGAGCT GTCAGTTTGG GCCGGATATC ACCAAGGCCT TCCTGGAGGA GAACCATCTA 1260

GACTACATCA TCCGCAGCCA CGAGGTCAAG GCCGAGGGCT ACGAGGTGGC ACATGGCGGC 1320

CGCTGCGTCA CTGTCTTTTC TGCCCCCAAC TACTGCGACC AGATGGGAAA CAAAGCCTCT 1380

TACATCCACC TCAGGGGCTC CGACCTGCGG CCCCAGTTCC ACCAGTTCAC AGCAGTGCCT 1440

CATCCCAACG TGAAGCCCAT GGCCTATGCC AACACGCTGC TGCAGCTAGG GATGATGTGA 1500

Domain Profile

S: 2     kvsiefikklvndlklkkkllrkkavailvsvadvlfklevelennskedvkitvcGdth  61

         kv+i f+k+l++++k++kkl+rk+a++ilv+v++vl+kl++++e+++ke++kitvcGdth

Q: 185   KVTITFMKELMQWYKEQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTH  244

         799*********************************************************

S: 62    GqfydllnifelnGlpseknpylfnGdfvdrGsfsveviltlfglkllyPdhffllrGnh  121

         GqfydllnifelnGlpse+npy+fnGdfvdrGsfsveviltlfg+kllyPdhf+llrGnh

Q: 245   GQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNH  304

         ************************************************************

S: 122   esdnmnkiyGfegevkakytaklyelfaevfewlPlaqlingkvlvmhGGlfsedgvtld  181

         e+dnmn+iyGfegevkakyta++yelf+evfewlPlaq+ingkvl+mhGGlfsedgvtld

Q: 305   ETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLD  364

         ************************************************************

S: 182   dirkiernaqPPeeGalcellWsdPqeanGrgvskrGvglqfGpdvtkrfleenkldyii  241

         dirkiern+qPP++G++c+llWsdPq++nGr+vskrGv++qfGpd+tk+fleen+ldyii

Q: 365   DIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSVSKRGVSCQFGPDITKAFLEENHLDYII  424

         ************************************************************

S: 242   rshevkaegveveqkgklvtvfsapnycdsqgnlasvihvrnddlrliietfeavehpdv  301

         rshevkaeg+ev+++g++vtvfsapnycd++gn+as+ih+r++dlr+++++f+av+hp+v

Q: 425   RSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLRGSDLRPQFHQFTAVPHPNV  484

         ************************************************************

S: 302   kpmaysngllgl  313

         kpmay+n+ll+l

Q: 485   KPMAYANTLLQL  496

         *********997

Domain Sequence
(FASTA)

KVTITFMKEL MQWYKEQKKL HRKCAYQILV QVKEVLSKLS TLVETTLKET EKITVCGDTH 60

GQFYDLLNIF ELNGLPSETN PYIFNGDFVD RGSFSVEVIL TLFGFKLLYP DHFHLLRGNH 120

ETDNMNQIYG FEGEVKAKYT AQMYELFSEV FEWLPLAQCI NGKVLIMHGG LFSEDGVTLD 180

DIRKIERNRQ PPDSGPMCDL LWSDPQPQNG RSVSKRGVSC QFGPDITKAF LEENHLDYII 240

RSHEVKAEGY EVAHGGRCVT VFSAPNYCDQ MGNKASYIHL RGSDLRPQFH QFTAVPHPNV 300

KPMAYANTLL QL 312

Keyword

Complete proteome; Hydrolase; Iron; Metal-binding; Reference proteome; Repeat; TPR repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.
IPR011236	; Ser/Thr_PPase_5.
IPR001440	; TPR-1.
IPR013026	; TPR-contain_dom.
IPR011990	; TPR-like_helical.
IPR019734	; TPR_repeat.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.
PF00515	; TPR_1; 1.

SMARTs

SM00156	; PP2Ac; 1.
SM00028	; TPR; 3.

Prosites

PS00125	; SER_THR_PHOSPHATASE; 1.
PS50005	; TPR; 3.
PS50293	; TPR_REGION; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013