EKS-CAP-00434

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00434

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	569.9	2.2E-171	582	910	329

Status

Unreviewed

Ensembl Protein

ENSCPOP00000014753

UniProt Accession

H0VVM7;

Protein Name

Protein Synonyms/Alias

Gene Name

CSF1R

Gene Synonyms/Alias

CSF1R;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000024309	ENSCPOP00000014753	ENSCPOT00000027110

Organism

Cavia porcellus

Functional Description

Protein Length

958

Protein Sequence
(FASTA)

MGPGALLVLL VATVWHGHGV PVIEPSGPEL IVQPGTKVIL RCTGNGSVEW DGPIFPHWNL 60

DPDAPSSNLV TNNATFQNTG TYRCTESGDP QGGSAIIHLY VKDPRRPWNL LAQEVTVFEG 120

QDALLPCLLT DPELKASVSL MRVRGRPVLR QTNYSFSPWY GFTIHKAQVL ESQDYQCSAS 180

VGGRKLTTLG IRLIVKKALV LSGPPTLTLQ PTELTRIRGE AALIVCSASD VDVDFNVFLT 240

RGDTKLKISQ YFDFHDDRYQ KVLTLSLKEA GFQDAGNYSC TAQNAQFTNS TSMIFRVVES 300

AYLNLTSEQD LLQQVTVGEN IKLEVKVEAY PRLQGYNWTY LGPFSDHKHK LNFNITKGTY 360

RYTSSLILTR VKPSEAGRYS FLARNEGGWS ALTFNLTLRY IPEVSVTWKL INGSYTLLCV 420

ASGYPQPNVT WLKCNGHTDR CDKAQVLRVW EDSNPEVLSQ KPFHKVIVRS QLTIETLEPN 480

VTYECRASNS MGNSSGSTGP VTRVHGRQLE EPFFTPVMVA CISITESPAV LLATIRLPLL 540

LQKPKYQVRW KIIESYEGNN YTFIDPTQLP YNEKWEFPRN NLQFGKTLGA GAFGKVVEAT 600

AFGLGKEDAV LKVAVKMLKS TAHADEKEAL MSELKIMSHL GQHENIVNLL GACTYGGPVL 660

VITEYCCYGD LLNFLRKKAE DMLGPSLNPG QDPEGDTGYK NIHLEKKYVH RDSGFSSQGL 720

DTYVEMRPVS TSSNDSSSEQ GLDKEEKRPL ELWDLLHFSS QVAQGMAFLA SKNCIHRDVA 780

ARNVLLTNGH VAKIGDFGLA RDIMNDSNYI VKGNARLPVK WMAPESIFDC VYTVQSDVWS 840

YGILLWEIFS LGLNPYPGIL VNSKFYKLVK DGYQMAQPAF APKNIYSIMQ ACWDLEPTRR 900

PTFQQICFLL QEQAQADRRE QDYVNLQPEE ESSSEQLACC EPGDIAQPLL QPNNYQFC 958

Nucleotide Sequence
(FASTA)

ATGGGCCCAG GGGCTCTGCT GGTCCTGCTG GTGGCCACAG TTTGGCATGG TCACGGGGTT 60

CCAGTAATAG AACCCAGCGG CCCTGAGCTG ATTGTGCAGC CAGGTACAAA GGTGATCCTC 120

CGATGCACGG GCAATGGCAG TGTGGAATGG GATGGCCCCA TCTTCCCTCA CTGGAACCTG 180

GACCCCGATG CCCCCAGCAG CAACCTGGTC ACCAATAACG CCACTTTCCA AAACACGGGG 240

ACCTATCGCT GCACCGAGTC TGGAGACCCC CAGGGGGGCA GCGCCATCAT CCACCTCTAT 300

GTCAAAGACC CTCGCAGGCC CTGGAACCTG CTGGCACAGG AAGTGACAGT GTTTGAGGGT 360

CAGGACGCCC TGTTGCCCTG TCTGCTAACT GACCCTGAGC TGAAGGCGAG TGTCTCCTTG 420

ATGCGTGTGC GTGGCCGGCC TGTCTTGCGC CAAACCAACT ACTCCTTCTC GCCCTGGTAC 480

GGTTTCACCA TCCATAAGGC CCAGGTCCTC GAGAGCCAGG ACTACCAGTG CAGCGCTTCA 540

GTGGGCGGCC GGAAGTTGAC AACCCTTGGC ATCCGACTCA TCGTGAAGAA AGCCTTAGTC 600

CTTTCAGGGC CCCCGACTCT GACACTGCAG CCTACAGAGC TGACGCGGAT TCGAGGGGAG 660

GCTGCCCTGA TTGTGTGCTC AGCCAGTGAC GTGGACGTGG ACTTCAACGT CTTCTTAACT 720

CGCGGAGACA CCAAGCTCAA AATTTCTCAA TACTTTGATT TCCATGATGA CCGTTACCAG 780

AAAGTCCTGA CTCTTAGCCT GAAGGAAGCA GGCTTCCAAG ATGCTGGCAA TTATTCCTGC 840

ACAGCCCAAA ATGCCCAGTT CACCAACTCT ACCTCCATGA TCTTCAGGGT AGTCGAGAGT 900

GCTTACTTGA ACTTGACCTC TGAGCAGGAC CTCCTCCAGC AGGTGACTGT GGGTGAGAAC 960

ATCAAACTCG AAGTCAAGGT GGAGGCCTAC CCCAGACTGC AAGGTTATAA CTGGACCTAC 1020

CTGGGACCCT TCTCCGACCA CAAGCACAAG CTTAATTTTA ACATCACCAA GGGCACATAC 1080

AGGTACACCT CCAGCCTCAT CCTGACCCGT GTCAAGCCCT CCGAGGCTGG CCGCTATTCC 1140

TTCCTGGCCC GGAATGAGGG GGGCTGGAGT GCTCTGACCT TCAACCTCAC CCTGCGATAC 1200

ATCCCAGAGG TCAGTGTCAC ATGGAAGCTC ATCAATGGTT CCTATACCCT ACTCTGTGTT 1260

GCCTCTGGGT ACCCGCAGCC CAATGTGACC TGGCTGAAGT GCAACGGCCA CACTGACAGA 1320

TGTGATAAGG CCCAGGTGCT ACGTGTCTGG GAGGACTCGA ACCCTGAGGT CCTGAGCCAG 1380

AAACCCTTCC ACAAAGTGAT TGTTCGGAGC CAGTTGACCA TTGAGACCCT GGAGCCCAAC 1440

GTGACCTATG AGTGCAGGGC CTCCAACAGC ATGGGGAACA GCTCCGGGTC CACTGGGCCT 1500

GTCACTAGAG TCCACGGCAG GCAGCTTGAG GAGCCCTTCT TCACACCGGT AATGGTCGCC 1560

TGCATCTCCA TCACCGAATC CCCTGCTGTT CTGCTAGCTA CCATTCGGCT CCCTCTCCTT 1620

CTGCAGAAGC CCAAGTACCA AGTGCGCTGG AAGATCATTG AGAGCTACGA AGGCAACAAC 1680

TACACCTTCA TCGACCCCAC CCAGCTGCCC TACAATGAGA AGTGGGAGTT CCCCCGAAAC 1740

AACCTTCAGT TTGGTAAGAC CCTTGGAGCT GGTGCCTTTG GGAAGGTGGT AGAGGCCACG 1800

GCCTTTGGTC TGGGCAAAGA AGATGCTGTC CTGAAAGTGG CCGTCAAGAT GCTGAAGTCC 1860

ACAGCTCATG CGGATGAGAA GGAGGCCCTC ATGTCGGAAC TGAAGATCAT GAGTCACCTG 1920

GGGCAGCATG AGAACATAGT CAACCTTCTG GGAGCCTGCA CCTACGGAGG CCCTGTCCTG 1980

GTCATCACTG AGTACTGCTG CTATGGCGAT CTGCTAAACT TTCTGAGAAA GAAGGCTGAG 2040

GACATGCTGG GACCCAGCCT GAATCCAGGC CAGGACCCTG AAGGCGATAC TGGCTACAAG 2100

AACATCCACC TGGAAAAGAA ATATGTCCAC AGGGACAGTG GCTTCTCTAG CCAGGGTCTG 2160

GACACCTATG TGGAAATGAG GCCAGTCTCT ACTTCCTCAA ATGACTCTTC CTCTGAACAA 2220

GGCCTGGACA AGGAGGAGAA ACGGCCACTA GAGCTCTGGG ACCTCCTGCA CTTCTCCAGT 2280

CAAGTGGCCC AGGGCATGGC CTTTCTGGCT TCCAAGAATT GTATCCACCG GGACGTGGCT 2340

GCTCGAAATG TGCTGCTCAC CAATGGGCAT GTGGCCAAGA TTGGGGACTT TGGGCTGGCT 2400

AGGGACATCA TGAATGACTC CAACTACATC GTCAAGGGCA ATGCCCGCCT GCCTGTGAAG 2460

TGGATGGCAC CAGAGAGCAT CTTCGACTGC GTCTACACAG TTCAGAGCGA TGTCTGGTCC 2520

TACGGCATCC TTCTCTGGGA GATTTTTTCA TTGGGACTGA ACCCCTACCC TGGCATCCTG 2580

GTGAACAGCA AGTTCTATAA GCTGGTGAAA GATGGATACC AAATGGCCCA GCCTGCCTTT 2640

GCCCCGAAGA ACATATACAG CATCATGCAA GCCTGCTGGG ACCTGGAGCC CACTCGCAGA 2700

CCCACTTTCC AACAGATCTG CTTCCTTCTC CAGGAGCAGG CTCAAGCAGA CAGGAGAGAG 2760

CAGGACTATG TTAATCTGCA GCCGGAGGAA GAAAGCTCCA GTGAGCAGCT GGCCTGCTGT 2820

GAGCCAGGGG ACATTGCCCA GCCCCTGCTG CAGCCCAACA ACTACCAGTT CTGCTGA 2877

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         l++Gk+lG+GafGkvveata+Gl+k+davlkvavkmlksta+++ekealmselki+shlG

Q: 582   LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG  641

         79**********************************************************

S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120

         +henivnllGact gGp++viteyccyGdlln+lr+k+e +l  sl+  +++e ++ +k+

Q: 642   QHENIVNLLGACTYGGPVLVITEYCCYGDLLNFLRKKAEDMLGPSLNPGQDPEGDTGYKN  701

         ************************************************************

S: 121   l.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179

         + l++k+++++s +ss++ ++yv++++    vs+s++d+ +++             l++e

Q: 702   IhLEKKYVHRDSGFSSQGLDTYVEMRP----VSTSSNDSSSEQG------------LDKE  745

         *999***********************....8888887766655............7889

S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239

         ++++lel+dll+fs+qva+Gm+flasknc+hrd+aarnvllt+G+v+ki+dfGlardim+

Q: 746   EKRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMN  805

         99**********************************************************

S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299

         dsny+vkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pypg+lv+skf

Q: 806   DSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKF  865

         ************************************************************

S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344

         ykl+k+Gy+maqpa+a+++iy+imq+cw+ ep++rp+f+q++ ll

Q: 866   YKLVKDGYQMAQPAFAPKNIYSIMQACWDLEPTRRPTFQQICFLL  910

         ******************************************986

Domain Sequence
(FASTA)

LQFGKTLGAG AFGKVVEATA FGLGKEDAVL KVAVKMLKST AHADEKEALM SELKIMSHLG 60

QHENIVNLLG ACTYGGPVLV ITEYCCYGDL LNFLRKKAED MLGPSLNPGQ DPEGDTGYKN 120

IHLEKKYVHR DSGFSSQGLD TYVEMRPVST SSNDSSSEQG LDKEEKRPLE LWDLLHFSSQ 180

VAQGMAFLAS KNCIHRDVAA RNVLLTNGHV AKIGDFGLAR DIMNDSNYIV KGNARLPVKW 240

MAPESIFDCV YTVQSDVWSY GILLWEIFSL GLNPYPGILV NSKFYKLVKD GYQMAQPAFA 300

PKNIYSIMQA CWDLEPTRRP TFQQICFLL 329

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 4.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

Created Date

20-Feb-2013