EKS-CAP-00146

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00146

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Csk	435.4	4.7E-131	194	437	244

Status

Unreviewed

Ensembl Protein

ENSCPOP00000017861

UniProt Accession

H0W4G0;

Protein Name

Protein Synonyms/Alias

Gene Name

MATK

Gene Synonyms/Alias

MATK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000025357	ENSCPOP00000017861	ENSCPOT00000023216

Organism

Cavia porcellus

Functional Description

Protein Length

465

Protein Sequence
(FASTA)

HPQRRWAPGT QCITKCEHSR PKPGELAFRK GDVVTILEAC ENKSWYRAKH HGSGQEGLLA 60

AGALREREAL SADPKLSLMP WFHGKISGQE AVQQLQPPED GLFLVRESAR HPGDYVLCVS 120

FGHDVIHYRV LHRDGHLTID EAVCFCNLMD MVEHYSKDKG PICTKLVKPK RKQGTKSAEE 180

ELAKAGWLLD LQHLTLGGPI GEGEFGAVLQ GEYLGQKVAV KNIKCDVTAQ AFLDETAVMT 240

KLQHRNLVRL LGVILHQGLY IVMENVTKGN LVNFLRTRGR ALVPATQLLQ FSLHVAEGME 300

YLESKKLVHR DLAARNILVS EDLVAKVSDF GLAKAERKGL DASRLPVKWT APEALKHGKF 360

SSKSDVWSFG VLLWEVFSYG RAPYPKMSLK EVSEAVEQGY RMEPPEGCPG PVLALMGSCW 420

EAEPARRPPF RKVAEKLARE VRSRPPRPPG GQGLWVSGPL RPAPP 465

Nucleotide Sequence
(FASTA)

CACCCCCAGA GGCGCTGGGC CCCCGGCACC CAGTGCATCA CCAAGTGCGA GCACTCGCGC 60

CCCAAGCCCG GGGAGCTGGC CTTCCGCAAG GGCGACGTGG TCACCATCCT GGAGGCCTGC 120

GAGAACAAGA GCTGGTACCG TGCCAAGCAC CACGGGAGTG GCCAGGAGGG GCTGCTGGCG 180

GCGGGCGCGC TGCGGGAGCG CGAGGCCCTC TCCGCGGACC CCAAGCTCAG CCTCATGCCG 240

TGGTTCCACG GGAAGATCTC GGGCCAGGAG GCCGTGCAGC AGCTGCAGCC GCCCGAGGAC 300

GGGCTGTTCC TGGTGCGCGA ATCTGCGCGA CACCCGGGCG ACTACGTGCT CTGCGTCAGC 360

TTCGGCCACG ACGTCATCCA CTACCGCGTG CTGCATCGCG ACGGCCACCT GACCATCGAC 420

GAGGCCGTGT GCTTCTGCAA CCTCATGGAC ATGGTGGAGC ACTACAGCAA GGATAAGGGA 480

CCCATCTGCA CCAAGCTGGT GAAGCCCAAG AGGAAGCAGG GGACCAAGTC GGCGGAAGAG 540

GAGCTGGCCA AGGCTGGCTG GCTCCTGGAC CTGCAGCACC TGACACTGGG CGGCCCCATC 600

GGAGAGGGGG AGTTTGGAGC CGTCCTGCAG GGCGAGTACC TGGGGCAGAA GGTGGCCGTG 660

AAGAACATCA AGTGCGACGT GACGGCCCAG GCCTTCCTGG ACGAGACGGC GGTGATGACG 720

AAGCTGCAGC ACCGGAACCT GGTGCGGCTG CTGGGCGTCA TCCTGCACCA GGGCCTGTAC 780

ATCGTCATGG AGAACGTGAC CAAGGGCAAC CTGGTGAACT TCCTGCGCAC GCGGGGCCGC 840

GCCCTGGTCC CCGCCACTCA GCTGCTGCAG TTTTCGCTGC ACGTGGCTGA GGGGATGGAG 900

TATCTGGAGA GCAAGAAGCT GGTCCACCGC GACCTGGCCG CTCGCAACAT CCTGGTGTCC 960

GAGGACCTGG TGGCCAAGGT CAGCGACTTC GGCCTGGCCA AAGCCGAGCG CAAGGGCCTG 1020

GACGCGAGCC GGCTGCCGGT CAAGTGGACG GCGCCCGAGG CGCTCAAGCA CGGGAAGTTC 1080

TCCAGCAAGT CAGACGTCTG GAGTTTCGGG GTGCTCCTGT GGGAAGTCTT CTCCTACGGA 1140

AGGGCCCCGT ACCCCAAGAT GTCGCTGAAG GAGGTGTCGG AGGCGGTGGA GCAGGGCTAC 1200

CGCATGGAGC CCCCCGAGGG CTGCCCGGGC CCGGTGCTGG CGCTCATGGG CAGCTGCTGG 1260

GAGGCGGAGC CCGCGCGCCG GCCGCCCTTC CGCAAGGTGG CGGAGAAGCT GGCGCGGGAG 1320

GTGCGCAGCC GGCCACCTCG GCCCCCCGGC GGGCAGGGAC TGTGGGTCTC GGGTCCCCTC 1380

CGGCCCGCAC CCCCG 1395

Domain Profile

S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60

         l+lg  ig+gefg+vl+gey g+kvavk+ik+d+taqaflde++vmtkl+h+nlv+llgv

Q: 194   LTLGGPIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKLQHRNLVRLLGV  253

         578899******************************************************

S: 61    ileekglylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrdl  120

         il++ gly+v+e v+kg+lv++lr+rgral+  +qll+f+l+vaegmeyleskklvhrdl

Q: 254   ILHQ-GLYIVMENVTKGNLVNFLRTRGRALVPATQLLQFSLHVAEGMEYLESKKLVHRDL  312

         ***9.*******************************************************

S: 121   aarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgil  180

         aarn+lvsedlvakvsdfglak+e+k+ld+++lpvkwtapealk++kfs+ksdvwsfg+l

Q: 313   AARNILVSEDLVAKVSDFGLAKAERKGLDASRLPVKWTAPEALKHGKFSSKSDVWSFGVL  372

         ************************************************************

S: 181   lweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfak  240

         lwe+fs+gr+pyp+++lk+v++ave+gy+me+pegcp+ v  lm ++we+e+a+rp+f+k

Q: 373   LWEVFSYGRAPYPKMSLKEVSEAVEQGYRMEPPEGCPGPVLALMGSCWEAEPARRPPFRK  432

         ************************************************************

S: 241   lkekl  245

         ++ekl

Q: 433   VAEKL  437

         **997

Domain Sequence
(FASTA)

LTLGGPIGEG EFGAVLQGEY LGQKVAVKNI KCDVTAQAFL DETAVMTKLQ HRNLVRLLGV 60

ILHQGLYIVM ENVTKGNLVN FLRTRGRALV PATQLLQFSL HVAEGMEYLE SKKLVHRDLA 120

ARNILVSEDL VAKVSDFGLA KAERKGLDAS RLPVKWTAPE ALKHGKFSSK SDVWSFGVLL 180

WEVFSYGRAP YPKMSLKEVS EAVEQGYRME PPEGCPGPVL ALMGSCWEAE PARRPPFRKV 240

AEKL 244

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013