EKS-CAP-00149

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00149

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	546.5	9.0E-165	468	747	280

Status

Unreviewed

Ensembl Protein

ENSCPOP00000016266

UniProt Accession

H0VZY2;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR3

Gene Synonyms/Alias

FGFR3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000025595	ENSCPOP00000016266	ENSCPOT00000019693

Organism

Cavia porcellus

Functional Description

Protein Length

805

Protein Sequence
(FASTA)

LPRPGCSCAQ HCVALAGGLG VGPPRCYLTV ALLPAEALGP ESGQQAQVVF GSGDTVELSC 60

HPPRGGPVGP TVWVKDGEGL VSSDRILVGP QRLQVLNASL EDAGAYSCKQ QLTQRVLCRF 120

GVRVTDTPSS GDDEDGEDVA EDIAGAPYWT RPERMDKKLL AVPAANTVRF RCPAAGNPTP 180

SISWLKNGKE FRGEHRIGGI KLRHQQWSLV MESVVPSDRG NYTCVVENKF GSIRQTYTLD 240

VLERSPHRPI LQAGLPANQT AVLGSDVEFH CKVYSDAQPH IQWLKHVEVN GSKVGPDGTP 300

YVTVLKTAGA NTTNKELEVL SLRNVTFEDA GEYTCLAGNS IGFSHHSAWL VVLPAEEELA 360

EADTAGSVYA GVLSYGVGFF LFILVVAAVT LCRLRSPPKK GLGSPTVHKV SRFPLKRQVS 420

LESNSSMNSN TPLVRIARLS SGEGPTLANV SELELPADPK WELSRSRLTL GKPLGEGCFG 480

QVVMAEAIGI DKDRAAKPVT VAVKMLKDDA TDKDLSDLVS EMEMMKMIGK HKNIINLLGA 540

CTVHVSAGPL YVLVEYAAKG NLREYLRARR PPGLDYSFDT CKLPEEQLTF KDLVSCAYQV 600

ARGMEYLASQ KCIHRDLAAR NVLVTEDNVM KIADFGLARD VHNLDYYKKT TNGRLPVKWM 660

APEALFDRVY THQSDVWSFG VLLWEIFTLG GSPYPGIPVE ELFKLLKEGH RMDKPANCTQ 720

DLYMIMRECW HAVPSQRPTF KQLVEDLDRI LTVTSTDEYL DLSVPFEQYS PGGQDTSSSS 780

SSGDDSVFTH DLLSPAPPGS GGPRT 805

Nucleotide Sequence
(FASTA)

CTGCCCAGGC CTGGCTGCTC CTGTGCCCAG CACTGTGTGG CCCTGGCAGG GGGCTTGGGT 60

GTTGGTCCTC CTAGGTGCTA TCTCACTGTT GCCCTTTTGC CTGCAGAGGC CCTGGGGCCG 120

GAGTCTGGCC AGCAGGCGCA GGTGGTCTTT GGCAGTGGGG ACACTGTGGA GCTGAGCTGC 180

CACCCACCCA GAGGTGGCCC TGTGGGCCCC ACAGTCTGGG TCAAGGATGG AGAGGGGCTG 240

GTGTCCTCAG ACCGCATCCT GGTGGGTCCC CAGCGGCTGC AGGTGCTGAA TGCTTCCCTC 300

GAGGACGCCG GGGCCTACAG CTGCAAGCAG CAGCTGACGC AGCGTGTGCT GTGCCGCTTC 360

GGTGTGCGTG TGACAGATAC CCCCTCCTCA GGAGATGATG AAGACGGAGA AGACGTGGCT 420

GAAGACATAG CAGGGGCCCC GTACTGGACT CGGCCCGAGC GGATGGACAA GAAGCTGCTG 480

GCTGTACCAG CTGCCAACAC TGTGCGCTTC CGCTGCCCAG CTGCTGGTAA CCCCACACCC 540

TCCATCTCCT GGCTAAAGAA TGGGAAGGAA TTCCGTGGGG AGCATCGCAT TGGGGGCATC 600

AAACTGCGGC ACCAGCAGTG GAGCCTGGTC ATGGAGAGTG TGGTGCCCTC AGACCGAGGT 660

AACTACACAT GCGTAGTGGA GAACAAGTTC GGCAGCATCC GGCAGACATA CACGCTGGAC 720

GTGCTGGAGC GCTCTCCACA TCGGCCTATC CTGCAAGCAG GGCTGCCGGC CAACCAGACA 780

GCTGTGCTGG GGAGCGACGT GGAGTTCCAC TGTAAGGTGT ACAGCGATGC GCAGCCCCAT 840

ATCCAGTGGC TGAAGCATGT GGAGGTGAAT GGCAGCAAGG TGGGCCCTGA TGGCACACCC 900

TACGTCACCG TTCTCAAGAC GGCGGGCGCT AACACCACCA ACAAGGAGCT AGAGGTTCTG 960

TCCTTGCGCA ATGTCACCTT TGAGGATGCG GGGGAGTATA CCTGTCTGGC GGGCAATTCT 1020

ATCGGGTTTT CCCATCACTC TGCGTGGCTG GTGGTGCTGC CAGCAGAGGA GGAGCTGGCA 1080

GAGGCGGACA CGGCGGGCAG TGTGTATGCA GGCGTCCTCA GCTACGGGGT GGGCTTCTTC 1140

CTCTTCATCC TGGTGGTGGC GGCTGTGACC CTCTGCCGCT TGCGCAGCCC ACCCAAGAAG 1200

GGCCTGGGTT CCCCCACCGT GCACAAAGTC TCCCGTTTTC CGCTCAAGCG ACAGGTGTCC 1260

TTGGAGTCCA ACTCATCCAT GAACTCCAAC ACGCCTCTGG TCCGCATCGC CCGGCTGTCC 1320

TCGGGGGAGG GCCCCACACT GGCCAACGTG TCTGAGCTTG AGCTGCCTGC TGATCCCAAG 1380

TGGGAGCTGT CTCGGTCCCG GCTGACCCTG GGCAAGCCCC TTGGAGAGGG CTGCTTTGGC 1440

CAGGTGGTCA TGGCAGAGGC CATTGGTATC GACAAGGACC GTGCTGCCAA GCCGGTCACC 1500

GTGGCCGTGA AGATGCTGAA AGATGACGCC ACTGACAAGG ACCTTTCGGA CCTGGTGTCA 1560

GAGATGGAAA TGATGAAGAT GATCGGCAAA CACAAGAACA TCATCAACCT GCTGGGCGCC 1620

TGCACGGTGC ACGTGTCTGC AGGGCCCCTG TATGTGCTGG TGGAGTATGC TGCCAAGGGC 1680

AACCTGCGGG AGTACCTGCG GGCGCGGCGG CCCCCAGGCT TGGACTACTC CTTCGATACC 1740

TGCAAGCTGC CTGAGGAGCA GCTCACCTTC AAAGACCTGG TGTCCTGTGC CTACCAGGTG 1800

GCCCGGGGTA TGGAGTATCT GGCCTCTCAA AAGTGCATAC ACAGGGACCT GGCCGCCCGA 1860

AACGTGCTGG TGACTGAAGA CAATGTGATG AAGATCGCAG ACTTCGGCCT GGCTCGAGAT 1920

GTGCACAACC TCGACTACTA CAAGAAGACC ACCAATGGCC GGCTGCCAGT GAAGTGGATG 1980

GCACCCGAGG CCCTGTTTGA CCGAGTCTAC ACCCACCAGA GTGATGTTTG GTCCTTTGGA 2040

GTCCTGCTCT GGGAGATCTT CACACTGGGG GGCTCCCCAT ACCCTGGCAT CCCCGTGGAA 2100

GAGCTTTTCA AGCTGCTAAA GGAGGGGCAC CGTATGGACA AGCCGGCCAA CTGCACACAG 2160

GATCTGTACA TGATCATGCG TGAGTGCTGG CATGCTGTGC CCTCGCAAAG GCCCACCTTC 2220

AAGCAGCTGG TGGAGGACCT GGACCGCATC CTCACTGTGA CATCTACTGA CGAGTACCTG 2280

GACCTGTCCG TGCCGTTTGA GCAGTATTCA CCCGGTGGTC AGGACACGTC TAGCTCCAGC 2340

TCCTCTGGGG ACGACTCTGT GTTCACACAC GACCTGCTGT CCCCGGCCCC GCCTGGCAGC 2400

GGAGGCCCTC GGACGTGA 2418

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aeaig+dkd+++k vtvavkmlk+datdkdl+dlvseme++k+

Q: 468   LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKM  527

         79**********************************************************

S: 61    iGkhkniinllGact...qeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeq  117

         iGkhkniinllGact    +Gplyv+veyaakGnlre+lrarrp+g ++s d++k +eeq

Q: 528   IGKHKNIINLLGACTvhvSAGPLYVLVEYAAKGNLREYLRARRPPGLDYSFDTCKLPEEQ  587

         **************944457****************************************

S: 118   ltekdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyy  177

         lt+kdlvs+ayqvarGmeylas+kcihrdlaarnvlvtednv+kiadfGlardvh++dyy

Q: 588   LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYY  647

         ************************************************************

S: 178   kkttnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllk  237

         kkttnGrlpvkwmapealfdrvyt+qsdvwsfGvllwei+tlGgspypgi+veelfkllk

Q: 648   KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLK  707

         ************************************************************

S: 238   eGhrmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         eGhrm+kpa+ct++ly++mrecwha++s+rptfkqlvedl

Q: 708   EGHRMDKPANCTQDLYMIMRECWHAVPSQRPTFKQLVEDL  747

         **************************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA IGIDKDRAAK PVTVAVKMLK DDATDKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTVHVSA GPLYVLVEYA AKGNLREYLR ARRPPGLDYS FDTCKLPEEQ 120

LTFKDLVSCA YQVARGMEYL ASQKCIHRDL AARNVLVTED NVMKIADFGL ARDVHNLDYY 180

KKTTNGRLPV KWMAPEALFD RVYTHQSDVW SFGVLLWEIF TLGGSPYPGI PVEELFKLLK 240

EGHRMDKPAN CTQDLYMIMR ECWHAVPSQR PTFKQLVEDL 280

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR013151	; Immunoglobulin.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF00047	; ig; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00408	; IGc2; 2.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013