EKS-CAP-00278

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00278

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	287.2	9.1E-86	9	265	257

Status

Unreviewed

Ensembl Protein

ENSCPOP00000014681

UniProt Accession

H0VVF5;

Protein Name

Protein Synonyms/Alias

Gene Name

CHEK1

Gene Synonyms/Alias

CHEK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000026175	ENSCPOP00000014681	ENSCPOT00000021421

Organism

Cavia porcellus

Functional Description

Protein Length

475

Protein Sequence
(FASTA)

MAVPFVEDWD LVQTLGEGAY GEVQLAVNRI TEEAVAVKIV DMKRAVDCPE NIKKEICINK 60

MLNHENVVKF YGHRREGNIQ YLFLEYCSGG ELFDRIEPDI GMPEQDAQRF FHQLMAGVVY 120

LHGIGITHRD IKPENLLLDE RDNLKISDFG LATVFRHNNR ERLLNKMCGT LPYVAPELLK 180

RKEFHAEPVD VWSCGIVLTA MLAGELPWDQ PSDSCQEYVD WKEKKTYLNP WKKIDSAPLA 240

LLHKILVENP SIRITIPDIK KDRWYNKPLK KGNKKVQDED DCYKKRPGRF YLKIFLLSMT 300

PYVCSLSEEN VKYSSSQPEP RTGLSLWDTC PSYIDKLVQG ISFSQPACPD HMLLNSQLVG 360

TPGSSQNPWQ RLVKRMTRFF TKLDADKSYQ CLKETCEKLG YQWKKSCMNQ VTVSTTDRRN 420

NKLIFKVNLV EMNEKILVDF RLSKGDGLEF KRHFLKIKGK LSDVVSSQKV WLPAT 475

Nucleotide Sequence
(FASTA)

ATGGCCGTGC CCTTCGTGGA AGACTGGGAC TTGGTGCAGA CCCTGGGAGA AGGGGCCTAT 60

GGAGAAGTTC AACTTGCTGT GAATAGAATA ACTGAAGAGG CAGTTGCAGT GAAGATTGTA 120

GACATGAAGC GTGCCGTAGA TTGTCCAGAA AACATTAAGA AAGAGATCTG TATCAATAAA 180

ATGTTAAATC ATGAAAATGT AGTGAAATTC TATGGTCACA GGAGAGAAGG CAATATCCAG 240

TATCTATTTC TGGAGTACTG TAGTGGGGGA GAGCTTTTTG ATAGAATAGA GCCAGACATA 300

GGCATGCCTG AACAAGATGC TCAGAGGTTC TTCCATCAAC TCATGGCAGG GGTGGTTTAT 360

CTGCATGGTA TTGGAATAAC TCACAGGGAT ATTAAGCCAG AAAATCTCCT TTTGGATGAA 420

AGGGATAACC TCAAAATCTC TGACTTTGGC TTGGCCACAG TGTTTCGGCA TAATAATCGT 480

GAACGTTTAT TGAACAAGAT GTGTGGTACT TTACCTTATG TTGCTCCAGA ACTTCTAAAG 540

AGAAAGGAAT TTCATGCAGA ACCAGTTGAT GTTTGGTCCT GTGGAATAGT GCTTACTGCC 600

ATGTTGGCTG GAGAATTGCC ATGGGACCAG CCCAGTGACA GTTGTCAGGA ATATGTTGAT 660

TGGAAAGAAA AGAAGACGTA TCTCAACCCT TGGAAAAAAA TTGATTCTGC TCCACTAGCT 720

CTGCTACATA AAATCCTAGT TGAAAATCCA TCGATCAGGA TTACCATTCC AGACATCAAA 780

AAAGATAGAT GGTACAATAA ACCACTCAAG AAAGGTAATA AGAAAGTTCA GGATGAGGAT 840

GATTGTTATA AGAAAAGACC TGGTAGATTT TATTTAAAGA TATTTCTATT GAGCATGACG 900

CCCTATGTCT GTAGTCTTAG TGAAGAGAAT GTGAAGTACT CCAGTTCTCA GCCAGAACCA 960

CGGACGGGTC TTTCCTTATG GGATACCTGT CCCTCGTACA TCGATAAACT GGTACAAGGG 1020

ATCAGTTTTT CCCAACCCGC ATGCCCTGAT CATATGCTTC TGAATAGTCA GTTAGTTGGC 1080

ACCCCAGGAT CTTCACAGAA CCCCTGGCAG CGGTTGGTCA AAAGAATGAC ACGTTTCTTT 1140

ACCAAACTGG ATGCAGATAA ATCTTACCAG TGCCTGAAAG AGACTTGTGA GAAGTTGGGC 1200

TATCAATGGA AAAAGAGTTG TATGAATCAG GTTACTGTGT CAACAACTGA CAGGAGAAAC 1260

AATAAACTGA TTTTCAAAGT GAATTTGGTA GAAATGAATG AGAAGATATT GGTTGACTTC 1320

CGGCTTTCTA AGGGTGATGG ATTGGAGTTC AAGAGACACT TTCTGAAGAT TAAGGGGAAG 1380

CTGAGTGATG TTGTGAGCAG CCAGAAGGTT TGGCTTCCTG CCACATGA 1428

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         ++l++tlGeg++g+V+la+++ t+e+vavKi++ k++  +  e+ik+Ei i k+l+h+n+

Q: 9     WDLVQTLGEGAYGEVQLAVNRITEEAVAVKIVDMKRAV-DCPENIKKEICINKMLNHENV  67

         7899******************************7765.5579*****************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +k++   ++ +  yl+ley+sggeLfd+ie +  ++e++a+++f+ql+++v Ylh  gi+

Q: 68    VKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEQDAQRFFHQLMAGVVYLHGIGIT  127

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg...klletfcGsppYaaPellkgkkYegp  177

         HrD+KpeNllld+++n+ki+DFGla++f+++   +ll+++cG++pY+aPellk+k+++++

Q: 128   HRDIKPENLLLDERDNLKISDFGLATVFRHNnreRLLNKMCGTLPYVAPELLKRKEFHAE  187

         **************************9988877799************************

S: 178   kvDvWslGvvLyalvtgklPfdee..nlkellekilkgkleipkk.lskelesLlrklLv  234

         +vDvWs+G+vL a+++g+lP+d++  +++e++++ +k+++  p k +++    Ll+k+Lv

Q: 188   PVDVWSCGIVLTAMLAGELPWDQPsdSCQEYVDWKEKKTYLNPWKkIDSAPLALLHKILV  247

         ***********************97679999999999999888878**************

S: 235   vdpekRatieeilkhewl  252

         ++p+ R+ti +i+k++w+

Q: 248   ENPSIRITIPDIKKDRWY  265

         *****************5

Domain Sequence
(FASTA)

WDLVQTLGEG AYGEVQLAVN RITEEAVAVK IVDMKRAVDC PENIKKEICI NKMLNHENVV 60

KFYGHRREGN IQYLFLEYCS GGELFDRIEP DIGMPEQDAQ RFFHQLMAGV VYLHGIGITH 120

RDIKPENLLL DERDNLKISD FGLATVFRHN NRERLLNKMC GTLPYVAPEL LKRKEFHAEP 180

VDVWSCGIVL TAMLAGELPW DQPSDSCQEY VDWKEKKTYL NPWKKIDSAP LALLHKILVE 240

NPSIRITIPD IKKDRWY 257

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013