EKS-CAP-00267

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00267

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	359.2	9.9E-108	18	269	252

Status

Unreviewed

Ensembl Protein

ENSCPOP00000015580

UniProt Accession

H0VXZ9;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK1

Gene Synonyms/Alias

SIK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000026214	ENSCPOP00000015580	ENSCPOT00000022424

Organism

Cavia porcellus

Functional Description

Protein Length

768

Protein Sequence
(FASTA)

MVIMSELSQQ KTLRVGFYDV ERTLGKGNFA VVKLARHRVT KTQVAIKIID KTRLDPSNLE 60

KIYREVQLMK LLNHPHIIRL YQVMETKDML YIVTEFAKNG EMFDYLTANG HLSEKEARRK 120

FWQILSAVEY CHNHHIVHRD LKTENLLLDA NMDVKLADFG FGNFYKPGEP LSTWCGSPPY 180

AAPEVFEGKE YEGPQLDIWS LGVVLYVLVC GSLPFDGPNL PTLRQRVLEG RFRIPFFMSQ 240

DCEMLIRRML VVDPAKRITI AQIWQHRWMQ ADPTLLQQAD PALSMLGYTS NLGDYNEQAL 300

GIMQALGIDR KKTVESLQNS SYNHFAAIYY LLLERLKEHR GAQPLARPVP TRQPRPRSSD 360

LGGLEVPPEG LPIDPLRSSL LCPQPQVLVQ SVLQAEMDCD LHSSLQPLFF AGDTNGTGMF 420

PHRSISPSSL LDTAISEEAR QGPSLEEEPE VQELLRGSTG RRHTLAEVST HFSPLAPPCI 480

VVSSSASAGT SEGTSSDSCL TFSAGEGPAG FSGGLTTQGL LGTCSPVRMA SPFLGAQSAT 540

PVLQAQGGLG GAVLLPVSFQ EGRRASDTSL TQGLKAFRQQ LRKNARTKGF LGLNKIKGLA 600

RQVCQASSSR ASRGGLSSFH APTPSPSLQS GGSGGREGRS LLEDVLHQQR LLQLQHHPGS 660

PPSCPQAPQP PPAPAPYVLA PCDGLLVSGL PLLPAPLLHS GTSPVTSTAQ LLDTQLHISS 720

SPATLLPGAL APCFARLAPG CDPSGRLQGD CEMEDLTSGQ RGTFVLVQ 768

Nucleotide Sequence
(FASTA)

ATGGTGATCA TGTCGGAGTT GAGCCAGCAG AAAACCCTCC GCGTGGGCTT CTACGACGTG 60

GAGCGCACCC TGGGCAAAGG CAATTTCGCG GTGGTGAAGC TGGCCCGGCA TCGAGTCACC 120

AAAACGCAGG TTGCAATAAA AATAATTGAT AAAACACGAT TAGATCCAAG CAACTTGGAG 180

AAAATCTACC GTGAGGTCCA GCTGATGAAG CTGTTGAACC ACCCCCACAT CATCAGGCTG 240

TACCAGGTTA TGGAAACCAA GGACATGCTT TACATTGTGA CTGAGTTCGC AAAGAATGGA 300

GAGATGTTTG ATTACCTGAC CGCCAATGGG CACCTGAGTG AGAAGGAAGC GAGGAGGAAG 360

TTCTGGCAGA TCTTGTCAGC CGTGGAGTAC TGCCACAACC ACCACATAGT GCACCGGGAC 420

CTCAAGACGG AGAACCTGCT GCTGGACGCC AACATGGATG TCAAGCTGGC AGATTTTGGA 480

TTCGGGAATT TCTACAAGCC CGGAGAGCCT CTGTCTACGT GGTGTGGAAG CCCCCCGTAT 540

GCAGCCCCTG AAGTCTTTGA GGGCAAGGAG TATGAAGGCC CCCAGCTGGA CATCTGGAGC 600

CTGGGCGTCG TCCTCTACGT CCTCGTCTGT GGTTCTCTCC CTTTCGACGG ACCCAATCTG 660

CCAACACTGA GGCAGCGGGT GCTGGAGGGC CGCTTCAGGA TCCCCTTCTT TATGTCTCAA 720

GACTGCGAGA TGCTCATTCG CCGTATGCTG GTGGTGGACC CTGCCAAACG CATCACCATT 780

GCCCAGATCT GGCAGCACCG CTGGATGCAG GCCGACCCCA CCCTCCTGCA GCAGGCTGAC 840

CCTGCCCTCT CCATGCTCGG TTACACCTCC AACCTGGGCG ATTACAATGA GCAGGCGCTG 900

GGCATCATGC AGGCGCTTGG CATCGACCGG AAGAAGACCG TGGAGTCGCT GCAGAACAGC 960

AGCTATAACC ACTTTGCTGC CATTTACTAC CTCCTGCTCG AGCGCCTCAA GGAACACCGA 1020

GGCGCCCAAC CACTGGCCCG CCCCGTACCC ACTCGGCAGC CCCGGCCCAG GAGCTCGGAC 1080

CTCGGTGGTC TGGAGGTGCC TCCTGAAGGC CTCCCCATCG ACCCTTTACG GTCCTCCCTG 1140

CTATGCCCGC AGCCCCAGGT CTTGGTGCAG TCCGTCCTGC AGGCTGAGAT GGACTGTGAC 1200

CTTCACAGCT CATTGCAGCC CCTGTTCTTC GCGGGAGACA CCAATGGCAC CGGCATGTTC 1260

CCGCACCGCT CCATCTCCCC CAGCAGCCTG CTGGACACAG CCATCAGCGA GGAGGCCAGG 1320

CAGGGGCCCA GCCTGGAGGA GGAACCCGAG GTCCAGGAGC TCCTGCGGGG CAGCACAGGC 1380

CGCAGGCACA CACTGGCCGA GGTCTCCACG CACTTCTCTC CCCTCGCCCC ACCCTGTATC 1440

GTCGTGTCCT CCTCTGCCTC GGCAGGGACC TCGGAAGGAA CCAGCTCCGA CAGCTGTCTG 1500

ACCTTCTCTG CAGGTGAAGG CCCTGCTGGG TTCAGCGGCG GCCTGACCAC CCAGGGGCTG 1560

CTGGGCACCT GCTCTCCAGT CAGAATGGCC TCGCCTTTCC TGGGGGCACA ATCGGCCACC 1620

CCTGTGCTGC AGGCTCAGGG GGGTCTGGGT GGAGCTGTCC TGCTGCCCGT CAGCTTCCAG 1680

GAGGGACGGA GAGCATCGGA CACGTCACTG ACGCAAGGGC TGAAGGCCTT CCGGCAGCAG 1740

CTGAGAAAAA ATGCGAGGAC CAAAGGGTTC CTGGGACTGA ACAAGATCAA GGGGCTGGCG 1800

CGCCAGGTGT GCCAGGCCTC CTCTAGCCGA GCATCCAGGG GTGGCCTGAG CTCCTTCCAC 1860

GCCCCTACAC CAAGCCCCAG CCTGCAGAGT GGCGGCTCTG GTGGTCGCGA AGGCAGAAGC 1920

CTGCTGGAGG ATGTGCTGCA CCAGCAGAGG CTGCTCCAGT TACAGCACCA CCCAGGCAGC 1980

CCTCCCAGCT GCCCTCAGGC CCCGCAGCCA CCTCCCGCCC CAGCCCCATA TGTGCTGGCT 2040

CCCTGTGACG GCCTCCTGGT GTCGGGGCTC CCACTGCTGC CAGCGCCCCT CCTGCACAGC 2100

GGGACATCCC CCGTGACATC AACTGCACAG CTCCTGGACA CCCAGCTGCA CATCAGCTCC 2160

AGCCCCGCCA CCCTCCTCCC TGGGGCCCTG GCTCCCTGCT TTGCCAGGCT GGCCCCGGGC 2220

TGCGACCCCT CTGGGCGGCT GCAAGGGGAC TGCGAGATGG AGGATCTGAC ATCTGGCCAG 2280

CGGGGCACGT TCGTTCTGGT GCAGTGA 2307

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++ +tlG+g+f+ Vkla+h+ tk++va+Kii+k++l+ ++leki+rE++++k l+hp+i

Q: 18    YDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDPSNLEKIYREVQLMKLLNHPHI  77

         899*********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         i+l++v+etk++ly+v+e+a++ge+fdy++++g+l+ekear+ f q++sav+Y+h+++iv

Q: 78    IRLYQVMETKDMLYIVTEFAKNGEMFDYLTANGHLSEKEARRKFWQILSAVEYCHNHHIV  137

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++++k+aDFG++n++k+g+ l+t+cGsppYaaPe+++gk+Yegp++D

Q: 138   HRDLKTENLLLDANMDVKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLD  197

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +WslGvvLy+lv+g+lPfd++nl +l++++l+g+++ip+ +s+++e L+r++Lvvdp+kR

Q: 198   IWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCEMLIRRMLVVDPAKR  257

         ************************************************************

S: 241   atieeilkhewl  252

         +ti +i +h+w+

Q: 258   ITIAQIWQHRWM  269

         ***********8

Domain Sequence
(FASTA)

YDVERTLGKG NFAVVKLARH RVTKTQVAIK IIDKTRLDPS NLEKIYREVQ LMKLLNHPHI 60

IRLYQVMETK DMLYIVTEFA KNGEMFDYLT ANGHLSEKEA RRKFWQILSA VEYCHNHHIV 120

HRDLKTENLL LDANMDVKLA DFGFGNFYKP GEPLSTWCGS PPYAAPEVFE GKEYEGPQLD 180

IWSLGVVLYV LVCGSLPFDG PNLPTLRQRV LEGRFRIPFF MSQDCEMLIR RMLVVDPAKR 240

ITIAQIWQHR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013