EKS-CAP-00315

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAP-00315

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	446.6	3.4E-134	235	522	288

Status

Unreviewed

Ensembl Protein

ENSCPOP00000018932

UniProt Accession

H0W7H8;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1A

Gene Synonyms/Alias

BMPR1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCPOG00000026650	ENSCPOP00000018932	ENSCPOT00000022070

Organism

Cavia porcellus

Functional Description

Protein Length

533

Protein Sequence
(FASTA)

MTQLCVYIRL LGAYLFVVCH VQGQNLDSML HGAGVRSDSD PKKTVESGVT VAPEDTLPFL 60

KCYCSGHCPD DAINNTCITN GHCFAIIEED DQGETTLASG CMKYEGSDFQ CKDSPKAQPR 120

RTIECCRTNL CNQYLQPTLP PVVIGPFFDG SARWLAVLIS MAICIIAMII FSSCFCYKHY 180

CKSISNRRRY NRDLEQDEAF IPVGESLKDL IDQSQSSGSG SGLPLLVQRT IAKQIQMVRQ 240

VGKGRYGEVW MGKWRGEKVA VKVFFTTEEA SWFRETEIYQ TVLMRHENIL GFIAADIKGT 300

GSWTQLYLIT DYHENGSLYD FLKCATLDTR ALLKLAYSAA CGLCHLHTEI YGTQGKPAIA 360

HRDLKSKNIL IKKNGSCCIA DLGLAVKFNS DTNEVDVPLN TRVGTKRYMA PEVLDESLNK 420

NHFQPYIMAD IYSFGLIVWE MARRCVTGGI VEEYQLPYYN MVPSDPSYED MREVVCVKRL 480

RPLVSNRWNS DECLRAVLKL MSECWAHNPA SRLTALRVKK TLAKMVESQD VKI 533

Nucleotide Sequence
(FASTA)

ATGACTCAGC TCTGCGTTTA CATCAGGTTA CTGGGAGCCT ATCTGTTCGT CGTCTGCCAT 60

GTCCAAGGGC AGAATCTAGA CAGCATGCTC CACGGTGCCG GGGTGAGGTC AGACTCCGAC 120

CCCAAGAAGA CGGTGGAGAG CGGAGTGACC GTAGCGCCGG AGGACACCTT GCCGTTTCTA 180

AAGTGCTACT GCTCAGGACA CTGCCCGGAT GATGCCATCA ACAACACGTG CATAACGAAT 240

GGACATTGCT TCGCCATCAT AGAAGAAGAT GACCAAGGAG AAACCACTCT AGCTTCAGGG 300

TGTATGAAAT ACGAAGGGTC TGACTTCCAG TGCAAGGATT CTCCAAAAGC CCAGCCTCGC 360

CGGACCATAG AATGTTGTCG GACCAATCTG TGTAACCAGT ATTTGCAGCC GACACTTCCT 420

CCTGTCGTCA TAGGTCCATT TTTTGATGGC AGCGCTCGGT GGTTGGCCGT GCTCATCTCC 480

ATGGCCATCT GCATAATCGC TATGATCATC TTCTCCAGCT GCTTCTGTTA CAAACACTAC 540

TGCAAGAGCA TCTCAAACAG ACGCCGCTAC AATCGCGACT TGGAACAGGA CGAGGCGTTT 600

ATTCCGGTGG GAGAGTCTCT GAAAGACCTC ATTGACCAGT CGCAGAGCTC CGGCAGTGGG 660

TCCGGACTGC CCTTGCTGGT CCAGCGAACT ATTGCCAAAC AGATTCAGAT GGTGAGACAG 720

GTCGGGAAAG GCCGCTATGG AGAAGTGTGG ATGGGGAAGT GGCGCGGAGA GAAGGTGGCT 780

GTCAAAGTGT TTTTCACCAC GGAGGAGGCC AGCTGGTTCC GAGAGACGGA GATCTACCAG 840

ACGGTGCTGA TGCGCCACGA GAACATCCTC GGGTTCATAG CCGCAGACAT TAAAGGCACG 900

GGGTCCTGGA CGCAGCTCTA CCTGATCACT GATTACCATG AGAACGGGTC TCTCTACGAC 960

TTCCTGAAGT GTGCCACCCT GGACACCAGA GCCCTGCTCA AGCTGGCCTA CTCGGCTGCC 1020

TGCGGCCTGT GCCACCTGCA CACAGAGATT TACGGCACCC AGGGGAAGCC TGCGATTGCG 1080

CATCGCGACC TCAAGAGCAA GAACATCCTC ATCAAGAAGA ATGGGAGCTG CTGCATTGCT 1140

GACCTGGGCC TCGCGGTCAA GTTCAACAGT GACACCAATG AGGTGGATGT GCCCTTGAAT 1200

ACCAGGGTGG GCACCAAGCG CTACATGGCC CCGGAGGTGC TGGACGAAAG CCTGAACAAG 1260

AACCACTTCC AGCCCTACAT CATGGCCGAC ATCTACAGCT TCGGCCTGAT CGTCTGGGAG 1320

ATGGCCCGCC GCTGTGTCAC AGGAGGCATT GTGGAGGAGT ACCAGCTGCC GTACTACAAC 1380

ATGGTCCCCA GCGACCCGTC CTACGAGGAC ATGCGGGAGG TCGTGTGTGT CAAGCGCCTG 1440

CGGCCACTGG TGTCCAACCG CTGGAACAGT GACGAATGCC TGCGCGCCGT GCTGAAGCTC 1500

ATGTCCGAGT GCTGGGCCCA CAACCCGGCC TCCAGGCTCA CCGCGCTGAG GGTCAAGAAG 1560

ACGCTGGCCA AGATGGTGGA GTCCCAGGAC GTGAAGATCT GA 1602

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         +++++++gkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 235   IQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  294

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+d+Lk  tld++ ll+la+s+a+Gl+hLH+ei gt+

Q: 295   ADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQ  354

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNil+kk+++cciaDlGLa+k++++++e+d+  n++vGtkRYmaPE

Q: 355   G--KPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPE  412

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+ + +aD+Ys+gL++WE+a+Rc + +++veey+lp++++v+sdPs+e+m

Q: 413   VLDESLNKNHFQPYIMADIYSFGLIVWEMARRCVT-GGIVEEYQLPYYNMVPSDPSYEDM  471

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +evv++k+lrP ++++w+++e+l+++ kl++ecW+++p++Rltalrvkk+l

Q: 472   REVVCVKRLRPLVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRVKKTL  522

         *************************************************97

Domain Sequence
(FASTA)

IQMVRQVGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDFLKC ATLDTRALLK LAYSAACGLC HLHTEIYGTQ 120

GKPAIAHRDL KSKNILIKKN GSCCIADLGL AVKFNSDTNE VDVPLNTRVG TKRYMAPEVL 180

DESLNKNHFQ PYIMADIYSF GLIVWEMARR CVTGGIVEEY QLPYYNMVPS DPSYEDMREV 240

VCVKRLRPLV SNRWNSDECL RAVLKLMSEC WAHNPASRLT ALRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013