EKS-CIS-00134

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CIS-00134

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	329.2	1.7E-98	86	343	258

Status

Unreviewed

Ensembl Protein

ENSCSAVP00000000056

UniProt Accession

H2Y407;

Protein Name

Protein Synonyms/Alias

Gene Name

Csa.8999

Gene Synonyms/Alias

Csa.8999;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCSAVG00000000026	ENSCSAVP00000000055	ENSCSAVT00000000056
ENSCSAVG00000000026	ENSCSAVP00000000056	ENSCSAVT00000000057

Organism

Ciona savignyi

Functional Description

Protein Length

502

Protein Sequence
(FASTA)

WVAMFDYDAK ADDELTLQSG QHVEVISKDI GVSGDEGWWT GKIANKLGIF PSNYVQPKHN 60

VASHDGVIEQ KILITVPEID FSELALQEII GVGGFGKVYH GFWSDKEVAI KAAKVDPDED 120

ASITLENVRA EARLFSLLSH KNILQLEGVC LQQPNLCIVL EYAQGGALNR CLVGKKLPPH 180

VLVDWALQIA EGMHYLHNEA PVPLIHRDLK SSNVLIKEPI GDSDDILNKT MKISDFGLAR 240

EMYKTTKMSA AGTYAWMAPE VIKSSTYSKA SDVWSYGILL WELLTGEQPY RGIDGLAVAY 300

GVAVNKLTLP IPTTCPKEFK DLLQRCWSSN SQMRPSFKMI LTDLQTIAES NFTSVPDDSF 360

QCMQDDWRLE IQAMFDDLRA KEKELCSREE ALTRATLQHK LQEEYLKERE RELHERELVV 420

VERELNIYLQ KKGEDSSTQG KPHPAKRKGK FKRSKVAKHG GISEPTDFQH KLSVKASVVN 480

ENHTSALQSM IQHDAANPFI AP 502

Nucleotide Sequence
(FASTA)

TGGGTGGCCA TGTTCGACTA TGATGCAAAG GCAGATGATG AGTTGACTCT TCAGTCTGGT 60

CAGCATGTGG AGGTAATATC CAAAGATATC GGGGTGTCTG GGGATGAAGG CTGGTGGACT 120

GGGAAAATTG CAAATAAACT TGGAATCTTT CCAAGCAATT ATGTGCAGCC GAAGCATAAT 180

GTGGCGTCAC ACGATGGGGT CATAGAGCAG AAAATATTGA TCACTGTTCC TGAGATCGAC 240

TTCTCTGAAC TCGCGCTTCA AGAAATCATT GGTGTTGGGG GGTTCGGGAA GGTTTATCAT 300

GGGTTCTGGT CGGATAAAGA GGTCGCTATA AAAGCTGCGA AAGTTGACCC TGATGAAGAT 360

GCCAGTATTA CACTTGAGAA CGTACGCGCT GAGGCCAGGC TATTCTCGCT TCTGTCCCAT 420

AAAAACATAC TTCAGTTGGA AGGAGTGTGT CTGCAACAGC CTAACTTATG TATTGTGTTG 480

GAATATGCTC AGGGTGGAGC ATTGAATCGA TGTCTGGTTG GCAAGAAACT TCCCCCCCAT 540

GTGTTAGTCG ACTGGGCGTT GCAAATAGCC GAGGGGATGC ATTACCTTCA TAACGAGGCA 600

CCCGTTCCAC TTATTCATAG AGATCTAAAG TCAAGCAATG TGCTGATAAA AGAACCAATC 660

GGTGACAGCG ATGATATTTT GAACAAAACG ATGAAAATCT CTGATTTCGG TCTCGCAAGA 720

GAAATGTACA AAACAACTAA AATGAGTGCG GCTGGTACTT ATGCGTGGAT GGCACCTGAA 780

GTTATTAAAT CATCGACATA TTCCAAAGCA AGCGATGTGT GGAGTTACGG CATCTTACTG 840

TGGGAGTTAT TAACTGGGGA GCAGCCATAC CGAGGCATTG ATGGACTTGC TGTAGCGTAT 900

GGTGTGGCCG TCAATAAACT CACCCTTCCC ATCCCAACCA CCTGTCCCAA GGAATTCAAA 960

GATCTTCTGC AACGTTGTTG GTCGTCGAAC TCCCAGATGC GGCCGTCCTT CAAGATGATC 1020

CTCACCGACC TACAAACGAT CGCTGAGTCC AACTTCACCT CTGTTCCCGA CGATTCCTTC 1080

CAATGCATGC AGGATGATTG GAGACTCGAG ATCCAAGCCA TGTTCGATGA CCTCAGGGCG 1140

AAGGAGAAGG AGTTGTGCAG CAGGGAGGAA GCATTGACGC GAGCCACGCT GCAACACAAA 1200

CTGCAGGAGG AATATCTGAA GGAGCGTGAG CGAGAACTTC ACGAGCGAGA GCTGGTCGTG 1260

GTTGAACGGG AACTCAACAT CTATCTGCAG AAGAAAGGTG AAGACTCCTC TACTCAGGGG 1320

AAACCCCATC CCGCTAAGCG GAAAGGGAAG TTTAAACGAA GCAAGGTTGC GAAACATGGT 1380

GGAATAAGCG AGCCAACCGA TTTCCAGCAC AAGTTATCGG TGAAAGCGTC GGTTGTGAAC 1440

GAAAACCACA CGAGTGCGCT ACAGAGCATG ATCCAGCACG ACGCAGCGAA CCCATTCATC 1500

GCCCCC 1506

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpniie  60

         l+e+ig g fgkvy + w +keva+K+++++  e  + +le+++ ea+l+s lsh+ni++

Q: 86    LQEIIGVGGFGKVYHGFWSDKEVAIKAAKVDPDEdaSITLENVRAEARLFSLLSHKNILQ  145

         689***************************9998667789********************

S: 61    llGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120

         l Gvcl++pnl++v+ey++gg+L+++l +   ++++++vlv+walqiA+Gm+YLh+eap+

Q: 146   LEGVCLQQPNLCIVLEYAQGGALNRCLVG---KKLPPHVLVDWALQIAEGMHYLHNEAPV  202

         *****************************...99**************************

S: 121   kiihrdLksknvLl........seekktlkicdFGtarelskstkmsaagtlawmaPEvl  172

         ++ihrdLks+nvL+        +  +kt+ki+dFG are+ k+tkmsaagt+awmaPEv+

Q: 203   PLIHRDLKSSNVLIkepigdsdDILNKTMKISDFGLAREMYKTTKMSAAGTYAWMAPEVI  262

         *******************9988899**********************************

S: 173   keekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkL  232

         k++++s++sDvwSyg++LWellt+e+Py++++ la+ay+va+++l+lpip++cp+++k+L

Q: 263   KSSTYSKASDVWSYGILLWELLTGEQPYRGIDGLAVAYGVAVNKLTLPIPTTCPKEFKDL  322

         ************************************************************

S: 233   mkecwnedpekRpsfseivks  253

         +++cw+++++ Rpsf++i++

Q: 323   LQRCWSSNSQMRPSFKMILTD  343

         *****************9875

Domain Sequence
(FASTA)

LQEIIGVGGF GKVYHGFWSD KEVAIKAAKV DPDEDASITL ENVRAEARLF SLLSHKNILQ 60

LEGVCLQQPN LCIVLEYAQG GALNRCLVGK KLPPHVLVDW ALQIAEGMHY LHNEAPVPLI 120

HRDLKSSNVL IKEPIGDSDD ILNKTMKISD FGLAREMYKT TKMSAAGTYA WMAPEVIKSS 180

TYSKASDVWS YGILLWELLT GEQPYRGIDG LAVAYGVAVN KLTLPIPTTC PKEFKDLLQR 240

CWSSNSQMRP SFKMILTD 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR015785	; MAPKKK9/10/11-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00219

; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013