EKS-CIS-00017

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CIS-00017

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Abl	450.3	1.9E-135	202	454	253

Status

Unreviewed

Ensembl Protein

ENSCSAVP00000002406

UniProt Accession

H2YAQ8;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCSAVG00000001408	ENSCSAVP00000002406	ENSCSAVT00000002445

Organism

Ciona savignyi

Functional Description

Protein Length

473

Protein Sequence
(FASTA)

MENRRGSDED FFVVLYPIES SERNQLSLRK GCQLRVLRYN GTEEWCEAKV LSTGEEGNNA 60

KCATVGSVGW VPSNYITPAT SLNMHTWYHG PVSRAAAEYL LSSGINGSFL VRDSESCQGQ 120

LSVSVRFNAS VYHYRINTDK AGLFYISPEH RFKTLPELVH HHSYAPDGLA AILHYPVAKS 180

AKPAVYSMSP DYDEWEIDRN EIHMKQRLGG GQYGDVYEAV WKRYNKTVAV KTFREDTTNT 240

DEFLKEAAVL KSIKHPNLVQ LLGVCTREPP FYIVTEFMSE GNLLEYLRRC SKDEIDGIVL 300

LHISVQVALA MEYLETRNYI HRDLAARNCL IEENNVVKVA DFGLSRLMAS GDDYTARAGA 360

KFPIKWTAPE SLAYNRFSTK SDVWSFGILL WEISTYGMSP YPGVDLSLVY EKLEKGYRMD 420

SPPCCPSNIY SLMLDCECCW SWDANERPTF AEIRGRLDGM FHDSNPEFAG NNR 473

Nucleotide Sequence
(FASTA)

ATGGAGAACC GCAGAGGCAG TGATGAGGAT TTTTTTGTTG TTCTTTATCC AATAGAATCA 60

TCAGAAAGAA ATCAACTTTC ACTTCGAAAA GGTTGTCAGC TTCGTGTTCT AAGATACAAC 120

GGCACAGAAG AATGGTGTGA GGCAAAGGTT TTGTCAACTG GAGAGGAAGG AAATAATGCC 180

AAGTGTGCAA CGGTGGGCTC AGTCGGCTGG GTTCCAAGCA ATTACATAAC ACCAGCCACA 240

TCATTAAACA TGCACACGTG GTATCATGGT CCAGTGTCAA GGGCCGCTGC TGAGTATCTG 300

CTTTCTAGCG GCATAAATGG CAGTTTTCTG GTTAGAGACA GTGAAAGTTG TCAAGGCCAA 360

CTGTCGGTTT CTGTTCGATT TAATGCGTCT GTTTATCATT ACCGTATAAA TACAGACAAG 420

GCTGGCTTGT TCTACATATC ACCGGAGCAC AGGTTTAAAA CCTTACCGGA ATTAGTTCAC 480

CACCATTCTT ATGCCCCTGA TGGACTAGCC GCTATTTTAC ATTACCCTGT TGCTAAAAGT 540

GCGAAACCTG CTGTGTACAG CATGTCCCCA GACTATGATG AGTGGGAGAT TGACCGAAAC 600

GAGATCCACA TGAAGCAAAG ATTGGGTGGT GGCCAATATG GGGATGTATA TGAAGCAGTT 660

TGGAAGCGGT ACAACAAGAC GGTTGCAGTT AAGACTTTCA GGGAAGACAC CACCAACACA 720

GACGAATTCC TTAAGGAGGC CGCTGTGCTG AAATCAATTA AACATCCCAA TCTAGTACAG 780

TTGCTAGGGG TGTGCACTCG TGAACCACCG TTTTACATCG TAACCGAATT CATGAGCGAA 840

GGGAATCTTC TGGAATACTT GCGTCGATGC AGCAAGGATG AAATAGATGG CATCGTGTTG 900

CTGCACATAT CAGTGCAAGT TGCATTGGCC ATGGAGTACC TGGAAACAAG GAACTATATT 960

CATCGCGACC TGGCGGCACG AAACTGTCTT ATAGAAGAGA ACAACGTCGT AAAAGTTGCC 1020

GACTTCGGTC TCTCTCGACT GATGGCATCT GGTGATGATT ATACCGCTCG CGCTGGAGCA 1080

AAGTTCCCCA TCAAATGGAC AGCTCCTGAA AGTTTAGCCT ACAATCGATT TTCAACGAAA 1140

TCTGACGTGT GGTCATTTGG AATTCTATTA TGGGAAATCT CAACATATGG GATGTCCCCT 1200

TACCCTGGCG TAGACTTGAG CTTGGTGTAT GAGAAGTTAG AAAAGGGCTA CCGAATGGAT 1260

TCCCCACCAT GTTGTCCAAG CAATATCTAC TCTCTTATGC TGGATTGTGA GTGCTGTTGG 1320

AGTTGGGATG CAAACGAACG ACCAACCTTC GCCGAGATAA GAGGAAGACT CGACGGAATG 1380

TTCCACGACT CTAATCCCGA GTTTGCTGGG AACAACAGG 1419

Domain Profile

S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60

         i mk++lgggqyg+vye+vwk+y+ tvavkt++edt + +eflkeaav+k +khpnlvql

Q: 202   IHMKQRLGGGQYGDVYEAVWKRYNKTVAVKTFREDTTNTDEFLKEAAVLKSIKHPNLVQL  261

         78**********************************************************

S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120

         lgvctreppfyi+tefms+gnll+ylr+++++e++ +vll+++ q++ ameyle++n+ih

Q: 262   LGVCTREPPFYIVTEFMSEGNLLEYLRRCSKDEIDGIVLLHISVQVALAMEYLETRNYIH  321

         ************************************************************

S: 121   rdlaarnclvgenklvkvadfglsrlmk.edtytahagakfpikwtapeslaynkfsiks  179

         rdlaarncl+ en++vkvadfglsrlm  +d yta agakfpikwtapeslayn+fs+ks

Q: 322   RDLAARNCLIEENNVVKVADFGLSRLMAsGDDYTARAGAKFPIKWTAPESLAYNRFSTKS  381

         ***************************638******************************

S: 180   dvwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmra...cwk  236

         dvw+fg+llwei+tygmspypg+dls vye+lekgyrm+ p  cp ++y+lm++   cw

Q: 382   DVWSFGILLWEISTYGMSPYPGVDLSLVYEKLEKGYRMDSPPCCPSNIYSLMLDcecCWS  441

         ****************************************************863337**

S: 237   wspsdrpsfaeih  249

         w++ +rp+faei

Q: 442   WDANERPTFAEIR  454

         ***********96

Domain Sequence
(FASTA)

IHMKQRLGGG QYGDVYEAVW KRYNKTVAVK TFREDTTNTD EFLKEAAVLK SIKHPNLVQL 60

LGVCTREPPF YIVTEFMSEG NLLEYLRRCS KDEIDGIVLL HISVQVALAM EYLETRNYIH 120

RDLAARNCLI EENNVVKVAD FGLSRLMASG DDYTARAGAK FPIKWTAPES LAYNRFSTKS 180

DVWSFGILLW EISTYGMSPY PGVDLSLVYE KLEKGYRMDS PPCCPSNIYS LMLDCECCWS 240

WDANERPTFA EIR 253

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013