EKS-CIS-00186

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CIS-00186

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	249.8	3.3E-74	4	205	202

Status

Unreviewed

Ensembl Protein

ENSCSAVP00000003181

UniProt Accession

H2YCY2;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCSAVG00000001892	ENSCSAVP00000003181	ENSCSAVT00000003230
ENSCSAVG00000001892	ENSCSAVP00000003180	ENSCSAVT00000003229

Organism

Ciona savignyi

Functional Description

Protein Length

992

Protein Sequence
(FASTA)

MENYQVLELI GEGSFGKVYK GRKKYTGSTV ALKFIPKAGK SEKDLRNLHR EIDIMSDLRH 60

PNIIQLLDNF ETEQEVVVVT EYAEGELFQI LEDDGKLSED QVQQIAGQLV SALYYLHSHR 120

ILHRDMKPQN ILIGKGGVVK LCDFGFARAM SMNTLVLTSI KGTPLYMSPE LVEEKPYDHN 180

ADLWSLGCIL YELFVGKPPI ITQQATSKGG GSKILRKARQ KMAEKEKKSK ETHKTEDTKA 240

KKEQSKSKLP QIKLKKSTKS DTAAKLKQTE KIPNMKQLSL QDRDLEDSED DWQEIIDATD 300

PNNMQLTAPM TLLSDAEFRR KIVEEIQIAK DKALAGKMSG ASTFRSIVKV ATNLLATKCD 360

SDLLWKFCSE LQIPFQFLEM LDHIWKSDAQ KKRSWSYKIS TDIVGLLTTF VASDFNVRNI 420

SGTQQINTQR EFGDTAVKII HTLSKIIPSK LQNNHSLQDQ VLLCIIFTCE SVDHGQNATV 480

AAKVYKELSQ SGILEVISDH SFNRTWARDL QNDRFTEIQA LYISALAAVT HIPVIGLPIR 540

RYKHLCTNTV AKLINASVIP SLPAVLSNPN TCANCLKVIY SCAQINRDVC KLLSTDAVFK 600

VLMNILKGGV QVTNLEAQVI DLVLNTLTTL VMYTPAPAKF LLEGEADLAA NMLTQSVEPT 660

HILSAAGLVF ELSNLGAVFE IGLGEFFNSI SNAVSNLTEQ LVTDGDHQSV NGLLQCGGWT 720

ALWYRLGHAV NVDIKDERDT ETLPSTRLLT ARSNDPYDPM LMSQDAILSF LSLATSVFAW 780

DPSKSFPLFT ISNGIVLMSL VALLSDEFIH SPNIQETTEP DEMPELLEEL VIQTLQCLCF 840

PFAIELSDQL LQQIVTCFSE LDVLPIVLHR CVQNVSHKSL EVPMRLLSKL TTHHGQSLDR 900

FVQICTQNTT KSRNILNYLK QAVISPGTSM EAKSELLGLL NFAVRSKPDK NSMFASEIFF 960

NLGKSPIPAS LCFQSMDTNL QTQACHLLGN LL 992

Nucleotide Sequence
(FASTA)

ATGGAGAATT ATCAAGTTTT GGAATTAATC GGGGAAGGGT CTTTTGGGAA AGTTTATAAA 60

GGGCGCAAGA AATACACTGG CTCCACTGTT GCCCTTAAAT TCATTCCCAA AGCCGGAAAA 120

TCTGAAAAGG ATTTACGGAA TTTGCATCGC GAAATTGATA TAATGTCGGA TCTTCGACAT 180

CCAAACATTA TTCAACTTCT TGATAACTTT GAAACTGAGC AAGAAGTTGT TGTGGTTACG 240

GAATATGCAG AAGGAGAGTT GTTTCAAATC TTGGAGGACG ATGGAAAGCT GTCGGAAGAT 300

CAGGTCCAGC AGATAGCAGG TCAACTCGTT TCTGCTCTGT ATTACTTGCA CTCGCACAGA 360

ATCCTGCATC GTGACATGAA ACCACAGAAC ATATTGATTG GGAAAGGAGG GGTGGTGAAG 420

TTGTGCGACT TTGGCTTTGC AAGGGCAATG AGCATGAACA CTCTTGTTTT GACCTCGATT 480

AAAGGCACCC CCCTGTACAT GTCTCCAGAA CTGGTGGAGG AAAAACCATA TGACCACAAT 540

GCTGATTTGT GGTCTTTGGG GTGCATTTTA TACGAGTTGT TTGTGGGCAA ACCACCTATC 600

ATCACGCAAC AGGCAACCTC AAAAGGTGGC GGATCAAAGA TTTTGCGGAA AGCGCGGCAA 660

AAGATGGCTG AAAAAGAGAA AAAATCAAAA GAAACCCACA AAACTGAAGA TACCAAAGCT 720

AAAAAAGAAC AGAGTAAAAG CAAATTGCCT CAGATTAAAC TAAAGAAATC AACCAAATCC 780

GACACTGCTG CAAAATTAAA ACAAACTGAG AAAATACCAA ATATGAAACA GCTGAGTTTG 840

CAGGATCGTG ATCTTGAGGA TTCTGAAGAT GATTGGCAGG AGATAATTGA TGCAACGGAT 900

CCCAACAACA TGCAGCTTAC TGCTCCTATG ACACTCTTAT CCGATGCCGA ATTTCGTAGA 960

AAAATTGTGG AAGAAATTCA AATCGCGAAA GATAAAGCGC TCGCTGGAAA GATGAGCGGT 1020

GCATCAACAT TCAGATCAAT TGTTAAAGTG GCCACAAATT TATTGGCGAC AAAATGCGAC 1080

TCTGATCTGC TTTGGAAGTT CTGCAGCGAG CTGCAGATTC CATTTCAGTT CCTTGAGATG 1140

TTGGATCACA TTTGGAAGTC AGACGCTCAG AAAAAACGCT CGTGGTCGTA CAAAATATCA 1200

ACGGACATTG TCGGACTTTT AACCACATTC GTCGCTAGTG ATTTTAATGT GAGAAACATC 1260

AGTGGCACTC AACAGATCAA TACTCAACGA GAATTCGGTG ATACCGCGGT CAAAATCATC 1320

CACACGCTGT CGAAAATCAT ACCCTCGAAA CTGCAAAACA ACCATAGCTT ACAAGACCAG 1380

GTGTTACTGT GCATCATATT CACCTGCGAA AGTGTCGACC ATGGACAGAA CGCGACTGTA 1440

GCTGCGAAAG TATACAAAGA ATTATCACAA AGCGGGATAC TAGAAGTGAT ATCCGACCAC 1500

AGCTTTAACA GAACATGGGC ACGTGACCTC CAAAACGATA GATTCACTGA AATCCAAGCG 1560

CTGTATATTT CAGCGCTCGC AGCAGTGACA CACATCCCGG TGATAGGGTT GCCGATACGA 1620

AGATATAAAC ACCTGTGCAC TAACACTGTT GCAAAGTTGA TAAATGCCTC CGTTATCCCA 1680

AGTCTACCAG CGGTGTTATC CAACCCAAAC ACTTGTGCAA ACTGCTTGAA AGTGATTTAT 1740

TCGTGCGCGC AAATTAACCG CGATGTTTGC AAACTGTTAA GTACAGATGC AGTGTTCAAA 1800

GTGCTGATGA ATATACTAAA AGGTGGTGTG CAAGTAACTA ATCTAGAGGC TCAAGTGATT 1860

GACCTTGTGC TAAATACACT GACAACTTTG GTGATGTATA CACCTGCACC TGCGAAATTT 1920

CTGCTTGAGG GTGAAGCTGA TTTAGCCGCT AATATGCTGA CACAGTCAGT CGAACCGACA 1980

CATATATTAA GCGCAGCTGG GTTGGTGTTT GAACTTAGCA ATCTTGGTGC TGTGTTCGAG 2040

ATTGGACTTG GAGAGTTCTT CAACTCTATA AGCAACGCTG TTTCAAACCT GACGGAGCAG 2100

TTGGTCACCG ACGGAGATCA TCAATCCGTG AACGGACTTC TGCAGTGTGG TGGGTGGACA 2160

GCGCTCTGGT ATCGACTCGG ACACGCAGTT AACGTGGACA TCAAGGACGA GCGCGACACA 2220

GAGACGCTCC CATCAACTCG ACTGCTTACA GCCAGGAGCA ATGATCCTTA CGACCCAATG 2280

CTAATGTCAC AGGATGCAAT TTTATCCTTC TTATCACTCG CAACATCTGT ATTTGCATGG 2340

GATCCTTCGA AATCATTCCC ATTGTTTACC ATCAGCAACG GAATCGTGCT GATGAGTCTT 2400

GTCGCTCTGC TATCCGACGA ATTCATTCAC AGTCCCAACA TCCAAGAGAC AACCGAACCT 2460

GACGAGATGC CAGAGCTGCT AGAAGAGCTG GTGATCCAAA CTCTTCAATG CCTTTGCTTT 2520

CCTTTTGCAA TTGAGTTATC GGATCAGCTC TTGCAGCAAA TCGTGACTTG TTTTTCTGAG 2580

CTTGATGTGC TGCCCATTGT GCTTCACAGA TGCGTTCAAA ATGTGTCTCA TAAGTCTCTT 2640

GAAGTACCGA TGAGGTTATT AAGCAAACTG ACCACTCACC ATGGCCAAAG TTTAGACCGA 2700

TTTGTCCAGA TTTGCACACA AAACACAACA AAGTCGAGGA ATATATTAAA TTACCTAAAA 2760

CAAGCTGTAA TAAGTCCTGG GACAAGTATG GAAGCAAAAA GTGAACTGCT TGGTTTGTTA 2820

AACTTTGCCG TTCGATCCAA ACCTGACAAA AACAGCATGT TTGCTTCTGA AATTTTCTTC 2880

AACTTGGGGA AATCTCCAAT TCCTGCGTCC TTGTGTTTCC AATCCATGGA CACCAACTTG 2940

CAAACTCAGG CGTGTCACCT TCTAGGCAAC TTGTTG 2976

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkkl.kkslenlekeikilkelkhen  59

         y++ e iG+Gsf+ vykgr +k t ++vA+k++ k+++ +k l+nl++ei+i+ +l+h+n

Q: 4     YQVLELIGEGSFGKVYKGR-KKYTGSTVALKFIPKAGKsEKDLRNLHREIDIMSDLRHPN  62

         7899***************.9***************999*********************

S: 60    ivalldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskki  119

         i++lld +et++ev++v+ey++ g+L ++l+++++Lsed+v++++ ql+sal++Lhs++i

Q: 63    IIQLLDNFETEQEVVVVTEYAE-GELFQILEDDGKLSEDQVQQIAGQLVSALYYLHSHRI  121

         **********************.*************************************

S: 120   vhrDlkPqniLlsyadakkelkkvtlkladFglarvlkeesma.atlkGsplYmaPEvvk  178

         +hrD+kPqniL+         k + +kl+dFg+ar+++ +++  +++kG+plYm+PE+v+

Q: 122   LHRDMKPQNILIG--------KGGVVKLCDFGFARAMSMNTLVlTSIKGTPLYMSPELVE  173

         *************........899*****************999****************

S: 179   eqqydakaDlWSiGtilyellvGkpPfaaesi  210

         e+ yd++aDlWS+G+ilyel+vGkpP  +++

Q: 174   EKPYDHNADLWSLGCILYELFVGKPPIITQQA  205

         **************************977654

Domain Sequence
(FASTA)

YQVLELIGEG SFGKVYKGRK KYTGSTVALK FIPKAGKSEK DLRNLHREID IMSDLRHPNI 60

IQLLDNFETE QEVVVVTEYA EGELFQILED DGKLSEDQVQ QIAGQLVSAL YYLHSHRILH 120

RDMKPQNILI GKGGVVKLCD FGFARAMSMN TLVLTSIKGT PLYMSPELVE EKPYDHNADL 180

WSLGCILYEL FVGKPPIITQ QA 202

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013