EKS-CIS-00142

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CIS-00142

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	396.0	7.1E-119	147	410	264

Status

Unreviewed

Ensembl Protein

ENSCSAVP00000003859

UniProt Accession

H2YEW1;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCSAVG00000002279	ENSCSAVP00000003859	ENSCSAVT00000003917

Organism

Ciona savignyi

Functional Description

Protein Length

467

Protein Sequence
(FASTA)

TSLCMNLTLP ISMYFHAVPR EDAFERGPLL NVTIELGTNI FYAPGVVDVR KPHGSIDIAS 60

IIVPVLVGII VILIIIMFLV WRNRGKKDNQ PDSVAYTANQ SNNYHGNSTR NNERFPLISS 120

TSISDQLSPQ ILQEMSTVLI SRSKLVVDRD NIIGKGHFGT VYHGEYITTQ ISKLNGNPIN 180

RKVAIKTLSR IEDTKAVEKF LQEGLMMSDF DHENVLTLIG ISMDDDGSPM VVLPYMMHGD 240

LLQFIRKPTN NPTVKDLIGF GLQACKGMNY LASHRFVHRD LAARNCMLDE TYVVKVADFG 300

LARDIYEKEY YKPHERGGGM PIKWMALESL QQQTFTIKTD VWSFGILLWE LLTRGVTPYP 360

DVDAFDILHY ILDGRRLRQP QYCPDALYEL MLSCWHPSPD TRPDFKTLVR DMEKIYGEIY 420

GVHYPGKAGE MWLDVNYINV QDVHIYPSQV RTSESRSTGG SMVHEVF 467

Nucleotide Sequence
(FASTA)

ACATCCCTGT GTATGAATCT GACTCTTCCT ATCTCCATGT ACTTCCATGC AGTGCCAAGA 60

GAGGATGCTT TCGAGAGAGG CCCGCTACTT AACGTGACCA TCGAGCTTGG CACCAACATC 120

TTCTATGCAC CGGGGGTGGT GGATGTGAGA AAACCTCATG GTAGTATCGA CATCGCCAGC 180

ATTATTGTTC CTGTACTTGT GGGGATCATT GTTATCCTCA TAATAATAAT GTTCCTGGTA 240

TGGAGGAATC GAGGAAAGAA GGACAATCAA CCAGACAGTG TCGCATACAC CGCCAACCAA 300

TCCAACAACT ATCACGGGAA CAGCACCAGA AACAACGAAC GCTTCCCACT AATCAGTTCC 360

ACTTCAATAT CCGATCAACT TTCCCCTCAA ATCCTCCAAG AAATGAGTAC CGTCCTGATT 420

TCGAGGTCCA AGCTTGTTGT TGACAGGGAT AACATTATTG GCAAGGGTCA TTTCGGCACT 480

GTGTACCACG GAGAGTATAT AACGACACAA ATTAGTAAGC TCAATGGTAA CCCAATCAAT 540

AGAAAGGTGG CCATCAAGAC ACTCTCACGA ATCGAAGACA CAAAAGCCGT CGAAAAATTC 600

CTACAAGAAG GATTGATGAT GAGCGATTTT GATCACGAGA ATGTCCTCAC GCTGATCGGG 660

ATCAGCATGG ATGACGATGG ATCTCCGATG GTGGTCCTCC CTTACATGAT GCATGGGGAT 720

CTGCTGCAGT TCATCAGGAA ACCAACCAAC AACCCTACAG TGAAGGATCT GATCGGGTTC 780

GGTTTACAAG CTTGCAAAGG GATGAACTAC CTCGCCTCAC ATAGATTCGT GCACAGAGAT 840

CTTGCAGCTC GAAACTGTAT GCTGGATGAG ACTTACGTAG TAAAGGTTGC GGATTTTGGG 900

TTGGCTCGTG ATATCTACGA GAAGGAATAC TACAAACCAC ATGAACGAGG TGGAGGGATG 960

CCTATCAAGT GGATGGCCCT TGAGAGTCTT CAACAGCAGA CGTTTACCAT TAAAACCGAT 1020

GTCTGGTCTT TCGGTATCTT GTTATGGGAA CTACTAACGC GTGGAGTAAC TCCCTATCCT 1080

GATGTTGACG CATTTGATAT ACTCCACTAC ATACTGGACG GACGTCGGCT ACGACAGCCC 1140

CAATACTGCC CCGATGCGCT GTACGAGCTC ATGCTCAGCT GCTGGCATCC CTCCCCTGAT 1200

ACAAGACCTG ATTTCAAGAC CCTCGTGCGC GATATGGAGA AGATATACGG GGAAATTTAT 1260

GGGGTCCATT ACCCAGGTAA AGCGGGTGAA ATGTGGCTTG ATGTGAACTA CATCAATGTA 1320

CAAGATGTTC ACATCTACCC GTCACAAGTA CGGACGTCTG AAAGTAGAAG CACGGGTGGC 1380

AGTATGGTGC ATGAGGTGTT C 1401

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsask.......kikvavksleritdiekveeflreglv  53

         vd +++iGkGhfG+vy+ge++ ++         + kva+k+l+ri d++ ve+fl+egl+

Q: 147   VDRDNIIGKGHFGTVYHGEYITTQISklngnpiNRKVAIKTLSRIEDTKAVEKFLQEGLM  206

         67899**************98765431111122569************************

S: 54    mkeldhpnvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvak  113

         m+++dh nvl+l+Gi++dd+g+p+vvlpym +Gdl +fir++++n+tvkdl++f+lq  k

Q: 207   MSDFDHENVLTLIGISMDDDGSPMVVLPYMMHGDLLQFIRKPTNNPTVKDLIGFGLQACK  266

         ************************************************************

S: 114   gmeylaskkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwl  173

         gm+ylas++fvhrdlaarnc+lde+++vkvadfGlard+++ke+y   +er+  +p+kw+

Q: 267   GMNYLASHRFVHRDLAARNCMLDETYVVKVADFGLARDIYEKEYYKP-HERGGGMPIKWM  325

         ********************************************976.567779******

S: 174   aleslqtfkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycp  233

         aleslq++  ft+k+dvwsfG+llwelltrg tpy++v++fd+ +y+ +grrlr+p+ycp

Q: 326   ALESLQQQT-FTIKTDVWSFGILLWELLTRGVTPYPDVDAFDILHYILDGRRLRQPQYCP  384

         ******999.**************************************************

S: 234   dklydvmlkcwkakpaerpqfsdlvs  259

         d+ly++ml+cw+++p++rp+f  lv

Q: 385   DALYELMLSCWHPSPDTRPDFKTLVR  410

         *********************99986

Domain Sequence
(FASTA)

VDRDNIIGKG HFGTVYHGEY ITTQISKLNG NPINRKVAIK TLSRIEDTKA VEKFLQEGLM 60

MSDFDHENVL TLIGISMDDD GSPMVVLPYM MHGDLLQFIR KPTNNPTVKD LIGFGLQACK 120

GMNYLASHRF VHRDLAARNC MLDETYVVKV ADFGLARDIY EKEYYKPHER GGGMPIKWMA 180

LESLQQQTFT IKTDVWSFGI LLWELLTRGV TPYPDVDAFD ILHYILDGRR LRQPQYCPDA 240

LYELMLSCWH PSPDTRPDFK TLVR 264

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00219

; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013