EKS-CIS-00219

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CIS-00219

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	433.0	4.5E-130	32	316	285

Status

Unreviewed

Ensembl Protein

ENSCSAVP00000005272

UniProt Accession

H2YIX3;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCSAVG00000003142	ENSCSAVP00000005272	ENSCSAVT00000005343

Organism

Ciona savignyi

Functional Description

Protein Length

366

Protein Sequence
(FASTA)

KHKMAGPLNN MADREFNHYE LNKTDWEVPS KYEDLVPIGC GAYGSVCSTL NSQLKMRMAV 60

KKLARPFQSV THAKRTYREL RLLKHMHHEN VIGLLDVFTP ASSIENFTDM YLVTHLMGAD 120

LNQIIKSQKL TDDHVQFLIY QILRGLKYIH SAGIIHRDLK PSNIAVNEDC ELKILDFGLA 180

RLTDDQMTGY VATRWYRAPE IMLNWMHYNQ TVDIWSVGCI MAELLTGQTL FPGSDHIDQL 240

KSIMTLCGTP RDDLLEKIIS QSARNFIKNL PIIPKKEFIN VFVGANPKAV DLLERMLVLD 300

TDCRLTASEA LQHPYLEKFH DPEDEPTAPL YDKTYEDAEI SIDEWKQLAY DEIVNFKFSP 360

DLITDY 366

Nucleotide Sequence
(FASTA)

AAGCATAAAA TGGCTGGCCC TTTAAACAAC ATGGCTGATA GGGAATTTAA TCATTACGAG 60

TTAAACAAGA CTGATTGGGA GGTGCCATCT AAATATGAAG ATTTGGTTCC CATCGGTTGC 120

GGGGCTTATG GTTCGGTGTG TTCGACTCTT AACTCCCAAC TAAAAATGCG AATGGCGGTG 180

AAGAAATTGG CACGGCCGTT CCAGTCGGTC ACCCATGCGA AGCGCACGTA CAGAGAACTG 240

AGATTGCTCA AGCACATGCA CCATGAAAAC GTGATTGGAT TGCTCGACGT CTTCACCCCT 300

GCTTCCTCGA TTGAAAACTT TACCGACATG TACCTAGTCA CTCATCTTAT GGGTGCGGAT 360

TTGAACCAGA TCATTAAATC GCAGAAACTC ACTGACGACC ACGTGCAGTT TTTGATTTAC 420

CAGATCCTAA GAGGCCTAAA GTACATTCAC TCTGCCGGCA TTATTCACAG AGATTTAAAG 480

CCAAGTAATA TCGCTGTCAA CGAAGATTGC GAGTTAAAAA TCCTCGATTT CGGCCTTGCG 540

CGCTTAACAG ATGATCAAAT GACCGGTTAC GTGGCGACCA GATGGTACAG AGCACCGGAG 600

ATCATGCTAA ACTGGATGCA TTATAACCAG ACTGTTGATA TCTGGTCTGT GGGTTGTATC 660

ATGGCGGAAC TTCTAACAGG ACAGACTCTT TTCCCAGGCT CCGACCACAT TGATCAGTTA 720

AAATCCATCA TGACCTTATG CGGAACGCCG AGAGATGACT TGCTTGAGAA AATCATCTCA 780

CAGTCAGCGC GGAACTTCAT TAAAAACCTC CCCATCATTC CAAAGAAGGA ATTCATCAAC 840

GTATTTGTTG GCGCGAATCC GAAAGCAGTC GATTTACTAG AGCGCATGCT CGTGCTCGAC 900

ACTGACTGCC GGTTAACAGC AAGCGAGGCG TTGCAACATC CATATTTGGA GAAATTCCAC 960

GACCCAGAAG ATGAACCTAC AGCCCCTCTG TACGACAAGA CGTACGAAGA CGCCGAGATT 1020

TCGATAGACG AGTGGAAGCA ACTGGCTTAC GACGAAATAG TCAACTTTAA ATTTTCACCG 1080

GACCTTATAA CAGATTAC 1098

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         ye+l p+g Gayg v+s+ +++ + r+a+kkl+rpfq+ t+akrt+REl+llk+++heN+

Q: 32    YEDLVPIGCGAYGSVCSTLNSQLKMRMAVKKLARPFQSVTHAKRTYRELRLLKHMHHENV  91

         78899*******************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i lldvftp++++e+++d+Ylvt+lm++dL+++iksqkl+d+h+++l+yqilrglky+Hs

Q: 92    IGLLDVFTPASSIENFTDMYLVTHLMGADLNQIIKSQKLTDDHVQFLIYQILRGLKYIHS  151

         ************************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++vnedcelkildFGlar +d++    +t+yvatrwYraPei+l++++

Q: 152   AGIIHRDLKPSNIAVNEDCELKILDFGLARLTDDQ----MTGYVATRWYRAPEIMLNWMH  207

         **********************************9....*********************

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI+aElltg++lfpg+d+idql+ i++++gtp+++ l+ki s++arn+i

Q: 208   YNQTVDIWSVGCIMAELLTGQTLFPGSDHIDQLKSIMTLCGTPRDDLLEKIISQSARNFI  267

         ************************************************************

S: 241   kslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         k+lp ++kk+f ++f  a+++a+dLle++Lvld+d R++++eaL+hpYl

Q: 268   KNLPIIPKKEFINVFVGANPKAVDLLERMLVLDTDCRLTASEALQHPYL  316

         ************************************************7

Domain Sequence
(FASTA)

YEDLVPIGCG AYGSVCSTLN SQLKMRMAVK KLARPFQSVT HAKRTYRELR LLKHMHHENV 60

IGLLDVFTPA SSIENFTDMY LVTHLMGADL NQIIKSQKLT DDHVQFLIYQ ILRGLKYIHS 120

AGIIHRDLKP SNIAVNEDCE LKILDFGLAR LTDDQMTGYV ATRWYRAPEI MLNWMHYNQT 180

VDIWSVGCIM AELLTGQTLF PGSDHIDQLK SIMTLCGTPR DDLLEKIISQ SARNFIKNLP 240

IIPKKEFINV FVGANPKAVD LLERMLVLDT DCRLTASEAL QHPYL 285

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013