EKS-CIS-00207

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CIS-00207

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	425.7	7.3E-128	339	593	255

Status

Unreviewed

Ensembl Protein

ENSCSAVP00000006782

UniProt Accession

H2YN78;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCSAVG00000004057	ENSCSAVP00000006782	ENSCSAVT00000006869
ENSCSAVG00000004057	ENSCSAVP00000006780	ENSCSAVT00000006867
ENSCSAVG00000004057	ENSCSAVP00000006781	ENSCSAVT00000006868

Organism

Ciona savignyi

Functional Description

Protein Length

666

Protein Sequence
(FASTA)

MPPFVRVKIV RFELTGQHHG SVSDYFVAIN VKECVVQNGI RGTLMQKKKT IYPEWDGCFD 60

SHLKDGRVIQ MVLMQKPDKL VSECNIGLQI LADKCRNQSI GGSGTDVWLD LKPEGRLMVQ 120

VKLFVEQEDI NQQAQDELPT RTIQGRRGAI KKAKVHMVKG HELTARFFHQ PTFCSVCKDF 180

MWGLNKQGYQ CKECGIAMHK KCVACILSKC SRSTERSDTT MYLKERFKIN MPHRFKVFSY 240

KRFTFCDHCG SMLYGLIRQG VRCEECGTNA HHKCYKKMAH TCGVNQALLA AALEKLDKLP 300

SVQVIFVFLP KIHIKRSLGN HCGKIKGGPS KLNQYGEDFK FLKVLGKGSF GKVLLAELKG 360

RNKFYAVKAL KKDVVVEDDD IECTMVERRV LELSCQHPYL THLFCTYQTK EHLFFVMEYL 420

NGGDLMFHIQ ASGRFTEQRA KFYAAEITLG LEYLHSKGII YRDLKLDNVL LDSDGHTKIA 480

DFGMCRENMS DTNKASTFCG TPDYIAPEIL QGRKYSFGVD WWSSGVLLYE MMLGQSPFHG 540

EEEEDLFNSI QKKEPIYPRW MPRQAVDCVK QLIQKDPAQR LGVCSDVKKH PFFSSIDFDL 600

LLSRKINPPF KPKVRSPSDY SNFDKEFLSA TTRLTKADKD VIASLDQALF DGFSFVNPQS 660

KKWLNT 666

Nucleotide Sequence
(FASTA)

ATGCCGCCAT TTGTTCGTGT AAAAATCGTT CGTTTTGAAT TAACTGGCCA ACATCACGGA 60

AGCGTTTCTG ATTATTTTGT GGCTATCAAC GTGAAAGAGT GTGTTGTGCA AAATGGTATA 120

CGTGGGACAC TTATGCAAAA GAAAAAAACC ATCTACCCTG AGTGGGATGG CTGCTTTGAT 180

TCTCACTTAA AAGATGGTAG AGTAATTCAG ATGGTCCTCA TGCAGAAACC CGACAAGCTG 240

GTTAGTGAGT GCAACATTGG TCTCCAGATA TTGGCGGATA AATGCAGGAA CCAAAGCATT 300

GGTGGCTCTG GTACAGATGT TTGGCTTGAC CTGAAGCCAG AAGGAAGACT GATGGTGCAA 360

GTGAAGCTGT TTGTAGAACA GGAAGATATC AACCAACAAG CACAGGATGA ACTGCCAACC 420

CGAACCATTC AGGGACGGAG AGGGGCAATA AAAAAGGCTA AAGTTCATAT GGTCAAAGGT 480

CATGAACTCA CTGCACGATT TTTCCACCAA CCTACTTTTT GCTCTGTGTG CAAAGATTTT 540

ATGTGGGGAC TCAATAAACA AGGATACCAA TGCAAAGAAT GCGGTATTGC TATGCATAAG 600

AAATGTGTTG CCTGTATTCT CAGCAAGTGT AGTCGGTCCA CTGAACGCTC TGACACAACA 660

ATGTACCTGA AGGAACGTTT CAAAATCAAC ATGCCACATA GGTTTAAAGT TTTTAGTTAC 720

AAAAGATTCA CGTTTTGTGA CCATTGTGGG TCAATGCTGT ATGGACTTAT CAGGCAAGGT 780

GTACGATGCG AAGAATGTGG CACAAATGCT CACCACAAAT GTTACAAGAA GATGGCTCAC 840

ACATGCGGTG TCAACCAGGC TTTGCTGGCA GCTGCGCTGG AAAAGTTGGA CAAACTACCG 900

TCTGTACAGG TAATCTTTGT ATTCTTGCCC AAGATTCATA TAAAACGAAG TCTGGGGAAC 960

CACTGCGGCA AGATCAAAGG AGGCCCCAGC AAACTAAACC AATACGGCGA AGATTTCAAA 1020

TTTCTTAAAG TTTTAGGAAA AGGAAGCTTT GGAAAGGTTC TCCTAGCTGA GCTGAAGGGG 1080

CGAAATAAAT TCTATGCAGT AAAAGCATTA AAGAAAGACG TTGTTGTTGA AGATGATGAC 1140

ATAGAATGCA CAATGGTGGA ACGACGCGTG TTGGAATTGT CCTGTCAACA TCCCTACCTT 1200

ACCCATCTTT TCTGTACATA CCAGACAAAG GAGCATTTAT TCTTTGTGAT GGAATATTTG 1260

AATGGAGGTG ATCTGATGTT CCACATACAA GCCAGCGGGA GGTTCACTGA GCAACGAGCC 1320

AAGTTCTATG CTGCGGAAAT TACACTTGGC CTGGAGTATC TTCATAGTAA AGGGATCATA 1380

TACCGCGATT TGAAGTTGGA CAACGTATTA TTGGATTCAG ATGGCCATAC TAAGATAGCT 1440

GACTTTGGAA TGTGTCGGGA AAATATGAGT GACACCAACA AAGCTTCAAC ATTTTGTGGA 1500

ACTCCCGACT ATATTGCCCC CGAGATCCTT CAAGGGAGGA AGTATAGTTT TGGAGTGGAT 1560

TGGTGGTCAA GTGGGGTTTT GTTGTATGAG ATGATGCTGG GGCAATCCCC ATTCCATGGT 1620

GAAGAAGAGG AAGACTTGTT TAACTCCATC CAGAAGAAGG AGCCAATCTA TCCACGCTGG 1680

ATGCCTCGAC AGGCCGTGGA TTGCGTTAAA CAGCTAATTC AAAAAGACCC AGCGCAACGA 1740

CTTGGAGTTT GCAGTGACGT AAAAAAGCAT CCTTTCTTCA GTTCCATTGA TTTTGATTTG 1800

TTATTGTCGA GAAAGATTAA CCCCCCTTTT AAACCGAAAG TGCGCTCTCC AAGCGACTAC 1860

AGCAACTTTG ACAAGGAATT CCTCTCTGCC ACCACTCGCC TTACTAAGGC AGACAAAGAT 1920

GTCATCGCAT CACTTGATCA AGCTTTGTTC GACGGGTTTA GTTTTGTGAA TCCACAAAGT 1980

AAAAAGTGGT TGAACACT 1998

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f++lkvlGkGsfgkvllaelk+++++ya+k lkkdvv++ddd+e+t+ve+rvl+l+ ++p

Q: 339   FKFLKVLGKGSFGKVLLAELKGRNKFYAVKALKKDVVVEDDDIECTMVERRVLELSCQHP  398

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         +l++lf+++qt+++lffv+ey+nGGdlmfhiq ++++ e+ra+fyaaei+l+l++lh+kg

Q: 399   YLTHLFCTYQTKEHLFFVMEYLNGGDLMFHIQASGRFTEQRAKFYAAEITLGLEYLHSKG  458

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnvlld++Gh k+adfG+c+e++ + +++stfcGtPdyiaPeil++++y++

Q: 459   IIYRDLKLDNVLLDSDGHTKIADFGMCRENMSDTNKASTFCGTPDYIAPEILQGRKYSFG  518

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdww+ Gvllyem++gqsPf+ge+e++lf+si++ke++yP+++ ++av+++k+l++kdp+

Q: 519   VDWWSSGVLLYEMMLGQSPFHGEEEEDLFNSIQKKEPIYPRWMPRQAVDCVKQLIQKDPA  578

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         +rlGv     +d+k+h+ff

Q: 579   QRLGV----CSDVKKHPFF  593

         ****9....4689999998

Domain Sequence
(FASTA)

FKFLKVLGKG SFGKVLLAEL KGRNKFYAVK ALKKDVVVED DDIECTMVER RVLELSCQHP 60

YLTHLFCTYQ TKEHLFFVME YLNGGDLMFH IQASGRFTEQ RAKFYAAEIT LGLEYLHSKG 120

IIYRDLKLDN VLLDSDGHTK IADFGMCREN MSDTNKASTF CGTPDYIAPE ILQGRKYSFG 180

VDWWSSGVLL YEMMLGQSPF HGEEEEDLFN SIQKKEPIYP RWMPRQAVDC VKQLIQKDPA 240

QRLGVCSDVK KHPFF 255

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013