EKS-CIS-00097

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CIS-00097

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	316.5	2.1E-94	2	266	265

Status

Unreviewed

Ensembl Protein

ENSCSAVP00000006863

UniProt Accession

H2YNF5;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCSAVG00000004092	ENSCSAVP00000006862	ENSCSAVT00000006949
ENSCSAVG00000004092	ENSCSAVP00000006863	ENSCSAVT00000006950

Organism

Ciona savignyi

Functional Description

Protein Length

354

Protein Sequence
(FASTA)

LPKVVVAVGS DGLDRKHLVK GRDDLRQDAV MQQVFQLVNV LLAKDPNTKS LSIQTYKVVP 60

LSQKSGLVQW CDGTIPIGVY LVGNPGEMGA HHRHRPHDMS AMACRKALGS VGGKGLEVKF 120

GKYKEICAKF KPVFRHFFTE KFVVPRDWFA KRQSYTKSVA VSSIVGYVLG LGDRHVQNIL 180

INCNTAEIVH IDLGVAFEQG RCLPTPETVP FRLTRDIVDG MGLCGVEGVF RRCCEKTMVV 240

MRSSYDAITT IVEVLLYDPL HDWTLSPSKA RTLQVLIEFL LLFKSLKQAS VLTASDAQNT 300

NKLAERVLLR LQEKLLGTEE GSVLSVRGQV NMLIQQASDP VRLCQLFAGW QPYL 354

Nucleotide Sequence
(FASTA)

CTTCCCAAAG TTGTTGTGGC GGTTGGTTCT GATGGTTTGG ATCGGAAGCA CTTGGTTAAG 60

GGTCGCGACG ATTTGAGACA AGATGCTGTT ATGCAACAGG TTTTCCAATT GGTAAACGTA 120

CTTCTGGCAA AGGACCCGAA CACCAAAAGT CTCAGTATTC AAACGTACAA AGTAGTTCCA 180

TTGTCACAGA AAAGTGGTCT CGTTCAGTGG TGTGATGGGA CCATTCCTAT TGGGGTATAC 240

TTAGTTGGTA ACCCTGGTGA AATGGGGGCT CACCACAGGC ACAGACCCCA CGACATGTCA 300

GCCATGGCTT GCAGGAAGGC ACTGGGCAGC GTGGGTGGGA AGGGTTTAGA GGTCAAGTTT 360

GGGAAGTACA AGGAAATTTG CGCCAAGTTT AAACCCGTGT TCCGACACTT TTTCACCGAG 420

AAGTTTGTCG TCCCCCGAGA TTGGTTTGCG AAAAGGCAAT CTTATACAAA AAGTGTTGCC 480

GTTTCTTCCA TTGTTGGCTA TGTGCTGGGG TTGGGAGATA GACATGTCCA GAATATCTTG 540

ATAAACTGCA ACACTGCTGA AATAGTGCAC ATAGATCTTG GGGTTGCGTT TGAGCAGGGA 600

AGGTGCTTAC CCACTCCTGA AACTGTCCCC TTTCGTCTCA CCCGTGATAT CGTGGATGGG 660

ATGGGGTTAT GTGGGGTTGA GGGGGTTTTT CGGAGGTGTT GTGAGAAAAC AATGGTGGTT 720

ATGAGGTCAT CTTATGACGC AATAACCACC ATTGTCGAGG TTCTGCTCTA TGATCCACTA 780

CATGACTGGA CACTCTCTCC CAGTAAAGCC AGAACTCTTC AGGTATTGAT TGAGTTCTTA 840

CTCTTATTTA AATCCCTTAA GCAGGCTTCT GTTTTGACTG CTTCCGACGC GCAAAATACG 900

AACAAACTAG CAGAGCGAGT GCTGCTAAGA CTTCAGGAGA AACTACTGGG AACGGAAGAA 960

GGCTCTGTGC TAAGTGTGCG CGGGCAAGTT AACATGCTAA TACAACAAGC GTCCGACCCA 1020

GTGCGATTAT GCCAACTTTT TGCTGGTTGG CAACCTTACC TGTAA 1065

Domain Profile

S: 17    pkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdketsrrkLkirtykVv  76

         pk ++  Gsdg  +  Lvkg++Dlrqd++++q+f+lvN lLakd++t  + L+i+tykVv

Q: 2     PKVVVAVGSDGLDRKHLVKGRDDLRQDAVMQQVFQLVNVLLAKDPNT--KSLSIQTYKVV  59

         7788889*************************************976..79*********

S: 77    plstrsgliewventvsLkellkklvekkavlldqpisyrykdlstvqarkpklkhlkls  136

         pls++sgl++w+++t++++ +l     ++++ +    + r++d+s++ +rk   ++  +

Q: 60    PLSQKSGLVQWCDGTIPIGVYLVGNPGEMGAHH----RHRPHDMSAMACRKALGSVGGKG  115

         **********************99999999988....59***********8766665555

S: 137   ....levfkevlenlvpkdllkklllekfpspeewfelrkaytrslAvislvgyiLgLgd  192

             +  +ke++ +++p  ++++++ ekf  p +wf++r++yt+s+Av+s+vgy+LgLgd

Q: 116   levkFGKYKEICAKFKP--VFRHFFTEKFVVPRDWFAKRQSYTKSVAVSSIVGYVLGLGD  173

         33445569*********..9****************************************

S: 193   rhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivnalgvtgveGvfra  252

         rh++n+li+ +t+e+vhid+gvafe++++ l++pe+vPFRLTr+iv+++g +gveGvfr+

Q: 174   RHVQNILINCNTAEIVHIDLGVAFEQGRC-LPTPETVPFRLTRDIVDGMGLCGVEGVFRR  232

         *****************************.******************************

S: 253   sceavlrvlreskeklltiLevflydplvdwkkk  286

         +ce+++ v+r+s + ++ti+ev+lydpl dw+ +

Q: 233   CCEKTMVVMRSSYDAITTIVEVLLYDPLHDWTLS  266

         ********************************82

Domain Sequence
(FASTA)

PKVVVAVGSD GLDRKHLVKG RDDLRQDAVM QQVFQLVNVL LAKDPNTKSL SIQTYKVVPL 60

SQKSGLVQWC DGTIPIGVYL VGNPGEMGAH HRHRPHDMSA MACRKALGSV GGKGLEVKFG 120

KYKEICAKFK PVFRHFFTEK FVVPRDWFAK RQSYTKSVAV SSIVGYVLGL GDRHVQNILI 180

NCNTAEIVHI DLGVAFEQGR CLPTPETVPF RLTRDIVDGM GLCGVEGVFR RCCEKTMVVM 240

RSSYDAITTI VEVLLYDPLH DWTLS 265

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000077	; P:DNA damage checkpoint
GO:0006281	; P:DNA repair
GO:0016572	; P:histone phosphorylation
GO:0090399	; P:replicative senescence
GO:0010212	; P:response to ionizing radiation
GO:0000723	; P:telomere maintenance

KEGG

InterPros

IPR015519	; ATM/Tel1.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.

Pfam

PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013