EKS-CIS-00205

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CIS-00205

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	435.7	6.2E-131	329	585	257

Status

Unreviewed

Ensembl Protein

ENSCSAVP00000007935

UniProt Accession

H2YRH4;

Protein Name

Protein Synonyms/Alias

Gene Name

Csa.2703

Gene Synonyms/Alias

Csa.2703;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCSAVG00000004735	ENSCSAVP00000007939	ENSCSAVT00000008045
ENSCSAVG00000004735	ENSCSAVP00000007938	ENSCSAVT00000008044
ENSCSAVG00000004735	ENSCSAVP00000007937	ENSCSAVT00000008043
ENSCSAVG00000004735	ENSCSAVP00000007936	ENSCSAVT00000008042
ENSCSAVG00000004735	ENSCSAVP00000007935	ENSCSAVT00000008041
ENSCSAVG00000004735	ENSCSAVP00000007934	ENSCSAVT00000008040
ENSCSAVG00000004735	ENSCSAVP00000007933	ENSCSAVT00000008039
ENSCSAVG00000004735	ENSCSAVP00000007932	ENSCSAVT00000008038
ENSCSAVG00000004735	ENSCSAVP00000007940	ENSCSAVT00000008046
ENSCSAVG00000004735	ENSCSAVP00000007941	ENSCSAVT00000008047

Organism

Ciona savignyi

Functional Description

Protein Length

661

Protein Sequence
(FASTA)

MQLYIGANAS HKFKLKERKR GRRNAVRRRI HRVSGHKFLA TYLRQPTFCS HCKDFIWGLV 60

GKQGYQCQSC TCVVHKRCHE LVLKKCPGCK TEIPNPSLGR INFNVPHKFR PHNYPFFTFC 120

DHCGSLLYGL YSQGLQCKAC KLNVHKRCAA NISNSCGINE KQLADMLKEI GKLGINSGSS 180

KKVVLFNNKV NYLFKPKSSL FRPALESKSD SFALRVIIHG RNNGQSIFNL SEYITPKFPC 240

CSIFNRNLAL MLLSIDSLAF NVSRVKCVGV LNHISIHNNQ NVFVYSWERS AKFEIEVKFN 300

MFVNGSATKQ RLTSSNSNPS KTSVKLTDFI FIKVLGKGSF GKVMLAELRA TKEIFAVKVL 360

KKDVISAEDD VDCTMTEKRV LALEHPFLTS LHSCFQNRER LFFIMEYVNG GDLMFQIQKS 420

RKFSEERSRF YAAEVILALQ FLHKHGIVYR DIKLDNILLD QDGHCKLADF GMCREGVKDG 480

NLATTFCGTP DYIAPEILQE LDYGVSVDWW ALGVLMYEML AGQPPFEADN EDDLFESIMN 540

DDVLYPVWLT KNAVNILEMF MTKKPARRLG CGSTGESAIL QHPFFATMDW VALENKQIEP 600

PFKPSVKNIY DTTNFDSDFT RMSPRFTPIP SQSLAAIHQT DFRGFSYVNP AYTGGLKSGS 660

S 661

Nucleotide Sequence
(FASTA)

ATGCAACTTT ACATAGGAGC CAACGCGAGC CACAAGTTTA AACTGAAAGA GCGTAAACGT 60

GGACGTCGAA ACGCCGTTCG AAGACGAATC CACCGTGTCA GTGGCCACAA GTTCCTTGCC 120

ACGTACCTAA GGCAGCCAAC CTTCTGCTCA CACTGCAAAG ATTTTATATG GGGTTTAGTG 180

GGGAAGCAAG GTTACCAGTG CCAATCATGC ACATGTGTTG TGCATAAGAG ATGCCATGAA 240

CTAGTTTTAA AGAAATGTCC TGGCTGCAAA ACAGAAATAC CCAACCCGTC GCTGGGTCGG 300

ATCAACTTCA ACGTGCCCCA CAAGTTCCGA CCCCACAATT ACCCGTTTTT CACCTTCTGC 360

GACCACTGTG GCTCTCTATT GTACGGCCTT TATTCTCAGG GTTTGCAATG CAAAGCATGC 420

AAGTTAAACG TTCACAAACG GTGCGCTGCA AATATTTCGA ACTCATGTGG TATCAACGAG 480

AAGCAATTGG CCGACATGCT GAAAGAGATT GGAAAGCTCG GTATTAACAG CGGCAGTTCA 540

AAGAAGGTTG TTTTATTTAA TAATAAAGTA AACTATCTTT TTAAACCCAA AAGTTCATTG 600

TTTAGACCAG CACTAGAATC GAAATCGGAT AGTTTTGCAT TACGGGTAAT TATTCATGGA 660

AGGAATAATG GCCAATCTAT TTTCAATTTG TCTGAGTATA TTACCCCAAA ATTTCCCTGC 720

TGTTCGATTT TTAACCGAAA TCTCGCTTTA ATGCTATTAA GTATCGATTC CTTGGCTTTT 780

AACGTCTCCC GAGTAAAATG CGTTGGTGTG TTGAACCACA TATCTATCCA CAACAACCAA 840

AACGTCTTTG TATATTCGTG GGAAAGAAGT GCCAAATTTG AAATAGAAGT TAAATTTAAC 900

ATGTTTGTCA ATGGTTCTGC CACAAAGCAG CGACTCACAT CCTCCAACAG CAACCCCAGC 960

AAAACATCAG TCAAACTCAC AGACTTCATT TTCATTAAGG TCCTTGGAAA AGGGAGCTTC 1020

GGAAAGGTAA TGCTAGCGGA ACTCCGCGCC ACGAAGGAAA TATTCGCGGT GAAAGTATTG 1080

AAGAAGGATG TGATAAGTGC AGAGGATGAC GTTGATTGCA CGATGACAGA GAAACGAGTT 1140

CTCGCGCTCG AGCATCCCTT TCTCACCTCC CTGCATTCCT GCTTCCAGAA CCGAGAGCGA 1200

TTGTTCTTCA TCATGGAGTA CGTCAACGGT GGAGACCTCA TGTTCCAGAT CCAGAAATCG 1260

AGGAAGTTCT CCGAGGAACG ATCCCGCTTC TACGCGGCGG AAGTCATCCT CGCACTGCAG 1320

TTCCTACACA AGCATGGAAT CGTGTATAGG GATATAAAGC TGGACAACAT ACTACTCGAC 1380

CAAGACGGCC ACTGCAAGCT GGCCGACTTC GGAATGTGCA GGGAGGGTGT GAAGGATGGG 1440

AACCTCGCCA CCACATTCTG TGGAACCCCA GATTATATTG CCCCTGAGAT TCTCCAAGAG 1500

CTCGACTACG GAGTGTCGGT GGATTGGTGG GCACTTGGAG TCCTCATGTA CGAGATGCTG 1560

GCCGGGCAAC CACCTTTCGA AGCTGATAAC GAGGATGATT TGTTTGAATC CATCATGAAC 1620

GATGATGTTT TGTATCCTGT GTGGTTGACC AAGAACGCAG TCAACATACT AGAAATGTTC 1680

ATGACGAAGA AGCCAGCTCG GAGGTTGGGA TGCGGGAGCA CGGGGGAGTC GGCCATCTTG 1740

CAACATCCAT TCTTTGCCAC CATGGATTGG GTGGCGCTGG AGAACAAACA GATAGAACCT 1800

CCGTTCAAAC CATCAGTGAA AAACATCTAT GACACGACAA ACTTTGACTC TGATTTCACG 1860

CGGATGTCTC CCCGATTCAC CCCAATCCCC TCCCAGTCCC TCGCCGCCAT CCATCAGACA 1920

GATTTCCGGG GGTTTTCCTA CGTCAACCCC GCTTACACCG GGGGCTTGAA GAGCGGTTCC 1980

TCC 1983

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f ++kvlGkGsfgkv+lael+ t+e++a+kvlkkdv+  +ddv++t++ekrvlal  ++p

Q: 329   FIFIKVLGKGSFGKVMLAELRATKEIFAVKVLKKDVISAEDDVDCTMTEKRVLAL--EHP  386

         88**************************************************987..79*

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl++l+scfq ++rlff++eyvnGGdlmf+iqk+rk++eer+rfyaae+ilal+flh++g

Q: 387   FLTSLHSCFQNRERLFFIMEYVNGGDLMFQIQKSRKFSEERSRFYAAEVILALQFLHKHG  446

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         i+yrd+kldn+lld++Gh+kladfG+c+e++ +g+ ++tfcGtPdyiaPeil+e +yg s

Q: 447   IVYRDIKLDNILLDQDGHCKLADFGMCREGVKDGNLATTFCGTPDYIAPEILQELDYGVS  506

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdwwalGvl+yemlagq+Pfe+++ed+lfesi++++vlyP++l+k+av+il+ ++tk+p+

Q: 507   VDWWALGVLMYEMLAGQPPFEADNEDDLFESIMNDDVLYPVWLTKNAVNILEMFMTKKPA  566

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         +rlG+ ++ge++i +h+ff

Q: 567   RRLGCGSTGESAILQHPFF  585

         ******************9

Domain Sequence
(FASTA)

FIFIKVLGKG SFGKVMLAEL RATKEIFAVK VLKKDVISAE DDVDCTMTEK RVLALEHPFL 60

TSLHSCFQNR ERLFFIMEYV NGGDLMFQIQ KSRKFSEERS RFYAAEVILA LQFLHKHGIV 120

YRDIKLDNIL LDQDGHCKLA DFGMCREGVK DGNLATTFCG TPDYIAPEIL QELDYGVSVD 180

WWALGVLMYE MLAGQPPFEA DNEDDLFESI MNDDVLYPVW LTKNAVNILE MFMTKKPARR 240

LGCGSTGESA ILQHPFF 257

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR018029	; C2_membr_targeting.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00168	; C2; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50004	; C2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013