EKS-CIS-00139

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CIS-00139

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	294.6	7.7E-88	911	1175	265

Status

Unreviewed

Ensembl Protein

ENSCSAVP00000008373

UniProt Accession

H2YSR1;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCSAVG00000004980	ENSCSAVP00000008374	ENSCSAVT00000008482
ENSCSAVG00000004980	ENSCSAVP00000008373	ENSCSAVT00000008481
ENSCSAVG00000004980	ENSCSAVP00000008372	ENSCSAVT00000008480
ENSCSAVG00000004980	ENSCSAVP00000008371	ENSCSAVT00000008479

Organism

Ciona savignyi

Functional Description

Protein Length

1179

Protein Sequence
(FASTA)

SPNRRPPSPN TDGISPYSPE VTTKKVNVLK ARLYLLQQNG PNSFRIGGDS PEHKYLVIIG 60

PQSCNCGRGI FCIHVLFVML RVFQLEPTST LLWRKTLKNY EVESLFKSYH ERCNSRISPK 120

KKSRVQRLVS HLASGADKHA DTSSNSDDQC SSKGEEENCP ICLLQMVDGE SVTVCEVGCR 180

NKLHTHCVNI WAEECRRNGG PLKCPLCRVV WKPADTSHVA GMGPLMVDIP HEYTELADTW 240

TQAFGWEMVS CLFSSHPNVR ENALRRLSHD ITGALLTNIQ LTDPNDDHTS DDSDSSMRGA 300

TGGGSSSLSS NAYLASCCAI LAMVCGDPEY RVYITALRTL RAMMAYTQCR NSEDVQAFQR 360

LLAPVIETIL FKCADSNRRN VQLSVSTVME LCRGQSGELA VGKEMVSGES LGIGNVVYLL 420

SFLDFGGSPD TSSWQWMLGR LNALGELFRE FKSELSIRIY HSTDTSVGIP ISVMCGQILS 480

LMHEHNFPAQ SLQDGEEGLS PGLSISIYFL LFLLRTILSC LIMLKIKKND FLCFSHHQVS 540

LFRPIRCVSP GTNDQHTTDL GLSTSPLVNS DNTAELLNSS DTTVQTAIQN CDMTINYQYH 600

DSGFAVADLE SEKEVLSPID GVMTGSKSDP VTPLSSLENP SSKGGEQHPV RPSLLRLKSE 660

SSAFREPNTN SSKFASTRHT SDFGASFAPQ ASRDRSSSRD SSTSSTSCCE DFRRASERRL 720

SVRELADNIN RKNNRLAVTN QSKKSDTSPG FKKQALEKSP SAPTTKEDGL KSAPNKMQTT 780

DATLSHTRPL ALKAAIERRG TLSSSVEDLL AESDHSQAEK TPVTFKSEIG DVPLEHGNES 840

YEADLAMQCS CRMKIEEEED KLFAHTLAVS YIQDALPTVP HLSFTEDDVD IVRVQDETTD 900

IQKEYKENKQ WCKGAQIGLG AFSACYQARD MFTGTLMAVK QVNHVRCSAV EERQVLAVIT 960

EEISLMRRLS HPNIVRLHGI TKEGPLYNIF IEWCAGGSVS TLLSHYGAFN EGVIMNYTLQ 1020

LLRGLSYIHE QYLIHRDIKG ANLLIDSTGQ RLRISDFGAA ARLASKGTGA GEFQGQLLGT 1080

IAFMAPEVLR GEQYGRSCDV WGCGCVITEM ASGKPPWEAD MHSNHLALIF KIASSPTVPP 1140

IPDHLSPAMK DLCRRCLQAN PRDRPTAQQL LKHPVFIRW 1179

Nucleotide Sequence
(FASTA)

TCACCCAACC GAAGACCCCC ATCTCCAAAT ACAGATGGGA TTTCACCCTA CAGTCCTGAA 60

GTCACGACAA AAAAGGTAAA TGTTTTGAAA GCTCGACTCT ACCTCCTGCA GCAAAATGGT 120

CCGAATTCAT TTCGTATTGG TGGAGATTCA CCTGAGCACA AATATCTGGT TATTATTGGA 180

CCTCAGTCAT GCAACTGCGG TCGAGGTATC TTTTGTATTC ATGTCCTGTT TGTCATGTTA 240

CGGGTGTTTC AACTCGAACC CACCAGCACT TTATTGTGGA GGAAAACTTT AAAGAATTAT 300

GAGGTCGAGT CCTTGTTCAA GAGCTACCAT GAGCGGTGCA ATTCAAGGAT ATCACCCAAG 360

AAGAAATCCA GGGTGCAAAG GCTGGTGTCA CACTTAGCAA GTGGAGCAGA TAAGCATGCA 420

GATACATCAA GCAATAGCGA CGATCAGTGC TCTTCCAAAG GAGAAGAAGA GAATTGTCCG 480

ATATGTCTTC TACAGATGGT GGATGGAGAG TCGGTCACTG TGTGCGAAGT TGGCTGCAGG 540

AATAAACTGC ATACTCACTG TGTTAATATA TGGGCTGAAG AATGCAGAAG GAATGGGGGT 600

CCTTTGAAAT GCCCGTTATG TAGGGTGGTG TGGAAACCCG CTGACACCTC ACATGTGGCT 660

GGCATGGGTC CACTTATGGT GGATATACCT CATGAGTACA CTGAGCTTGC TGACACCTGG 720

ACCCAGGCCT TCGGCTGGGA AATGGTGTCT TGCTTGTTTT CGAGCCATCC TAATGTGAGA 780

GAAAATGCAT TACGACGATT GTCGCACGAT ATCACTGGTG CTTTACTTAC CAACATTCAG 840

TTGACTGACC CTAATGACGA TCATACCTCA GACGACTCTG ACAGTTCTAT GCGAGGAGCC 900

ACTGGTGGTG GCTCGTCCAG TCTCTCCAGC AACGCTTACC TGGCATCGTG CTGTGCCATA 960

CTCGCCATGG TTTGTGGGGA TCCGGAATAC AGGGTCTACA TCACTGCATT GCGAACATTG 1020

CGTGCTATGA TGGCGTACAC TCAGTGTAGA AACAGCGAAG ATGTTCAAGC TTTTCAAAGA 1080

TTGCTTGCTC CTGTTATCGA GACCATCCTG TTCAAATGTG CAGACTCTAA CAGACGGAAC 1140

GTCCAACTTT CTGTAAGCAC TGTTATGGAA CTATGTCGTG GACAATCTGG TGAACTTGCT 1200

GTGGGAAAGG AAATGGTTTC TGGAGAATCT CTGGGAATCG GGAATGTCGT TTATCTTCTT 1260

TCGTTCCTTG ATTTTGGAGG AAGTCCTGAT ACCTCATCGT GGCAGTGGAT GTTGGGAAGA 1320

CTCAACGCTC TCGGGGAGCT CTTCCGGGAA TTCAAGTCTG AGTTATCAAT CAGGATATAT 1380

CATTCTACTG ATACATCTGT GGGAATCCCA ATCTCTGTTA TGTGTGGCCA GATTCTCAGT 1440

CTCATGCATG AACACAACTT CCCAGCCCAG AGTTTGCAAG ATGGCGAGGA GGGTCTTTCT 1500

CCAGGTTTGT CCATTTCTAT ATATTTTCTG TTGTTTTTAT TAAGGACTAT TTTAAGTTGT 1560

CTTATTATGC TTAAAATTAA AAAAAATGAT TTTCTTTGTT TCTCTCATCA TCAGGTATCT 1620

CTATTTCGTC CTATAAGATG TGTCAGTCCA GGGACGAACG ACCAACACAC GACTGATCTT 1680

GGCCTTTCCA CATCGCCACT AGTAAATAGT GACAACACAG CGGAGCTTTT AAATTCAAGC 1740

GATACAACTG TCCAAACAGC AATACAGAAC TGTGACATGA CCATCAACTA TCAGTACCAT 1800

GACTCTGGCT TTGCTGTGGC GGATTTGGAA AGCGAAAAAG AAGTTTTGTC GCCAATTGAT 1860

GGGGTGATGA CAGGAAGTAA ATCCGATCCC GTAACCCCAC TTTCGTCGCT TGAAAACCCA 1920

AGTTCCAAGG GTGGAGAGCA ACACCCGGTT CGGCCTTCCT TGCTCAGGTT AAAGTCGGAA 1980

TCGTCTGCGT TTAGAGAACC GAACACGAAC TCCTCGAAAT TCGCGTCCAC CCGACATACG 2040

AGTGATTTCG GTGCCTCATT TGCTCCTCAA GCCTCTCGAG ATCGCAGCAG CAGTAGGGAT 2100

TCATCCACCT CCTCCACATC GTGCTGTGAG GACTTCAGGA GAGCATCCGA GCGCAGGTTA 2160

AGTGTGCGGG AGCTCGCCGA TAATATCAAC CGGAAGAACA ACCGACTTGC TGTGACAAAT 2220

CAATCAAAAA AATCCGACAC CTCGCCCGGT TTCAAAAAAC AAGCATTGGA AAAATCTCCC 2280

TCAGCACCTA CTACCAAAGA GGATGGGTTA AAATCGGCTC CTAACAAAAT GCAAACAACT 2340

GATGCCACTC TGTCACACAC CAGGCCATTA GCATTGAAAG CTGCCATAGA GAGGCGTGGT 2400

ACACTCAGTT CAAGTGTGGA AGATTTATTG GCGGAATCCG ATCATTCCCA AGCGGAAAAA 2460

ACACCGGTCA CTTTCAAATC AGAAATAGGT GACGTTCCTC TGGAGCATGG GAACGAGAGC 2520

TACGAAGCGG ATCTCGCGAT GCAGTGCTCC TGCAGGATGA AGATAGAGGA GGAGGAAGAC 2580

AAGCTCTTCG CGCACACCCT CGCAGTCAGC TACATCCAGG ATGCGCTGCC CACCGTTCCT 2640

CATCTCAGCT TCACGGAAGA CGATGTCGAC ATTGTTCGTG TGCAAGACGA GACCACTGAC 2700

ATACAGAAGG AGTACAAAGA GAACAAGCAG TGGTGCAAAG GAGCTCAAAT TGGTCTCGGG 2760

GCCTTCTCTG CATGCTACCA AGCTCGTGAT ATGTTCACAG GGACCTTGAT GGCCGTGAAA 2820

CAGGTCAACC ATGTGCGGTG CTCAGCAGTG GAAGAGAGAC AAGTGCTGGC GGTCATAACC 2880

GAGGAAATAT CTCTGATGCG CAGATTATCC CACCCTAATA TTGTTCGGTT GCACGGTATC 2940

ACCAAGGAGG GACCACTCTA CAACATCTTT ATTGAGTGGT GTGCAGGAGG TTCTGTGTCC 3000

ACACTTCTCT CACACTACGG GGCATTCAAC GAAGGAGTTA TCATGAACTA CACACTTCAG 3060

CTGCTGCGTG GGTTGTCCTA CATACACGAG CAGTACCTCA TCCACAGGGA CATAAAAGGT 3120

GCAAATTTGC TTATTGATTC CACGGGTCAG CGGTTACGGA TTAGCGATTT CGGTGCTGCT 3180

GCTAGACTGG CGTCAAAGGG CACCGGGGCA GGAGAATTCC AGGGTCAACT ACTGGGTACC 3240

ATAGCTTTCA TGGCCCCAGA GGTGTTACGA GGAGAGCAGT ACGGACGTAG TTGTGATGTG 3300

TGGGGCTGTG GTTGCGTCAT CACTGAGATG GCATCAGGGA AACCCCCTTG GGAGGCCGAT 3360

ATGCATTCAA ACCACCTCGC TCTCATTTTC AAGATCGCCT CCTCACCAAC AGTCCCTCCC 3420

ATACCCGACC ACTTATCACC TGCCATGAAA GATCTTTGCA GGCGATGCTT ACAGGCCAAT 3480

CCTCGTGACA GGCCAACTGC TCAGCAGCTT CTAAAGCACC CAGTTTTTAT TCGTTGG 3537

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+++y+a+d+ tg+l+avK+v+  + +  e++ ++  ++eEi+l+++l+

Q: 911   WCKGAQIGLGAFSACYQARDMFTGTLMAVKQVNHVRCSAVEERqVLAVITEEISLMRRLS  970

         7899****************************9876655544438899************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+niv+ +G+++e   ++if+E+++gGs+s+ll++yg+++e vi +yt q+l+gl+y+He

Q: 971   HPNIVRLHGITKEGPLYNIFIEWCAGGSVSTLLSHYGAFNEGVIMNYTLQLLRGLSYIHE  1030

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         + ++HRDiKgaN+l+ds  + +++sDFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1031  QYLIHRDIKGANLLIDStGQRLRISDFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1090

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+W  gcv+ em++gk+P++   ++++la++fk++++ t P+ip++ls++

Q: 1091  GE--QYGRSCDVWGCGCVITEMASGKPPWEadMHSNHLALIFKIASSPTVPPIPDHLSPA  1148

         98..8************************864467899**********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

         +kd+ ++cl+ +p++rp+a++LLkh++

Q: 1149  MKDLCRRCLQANPRDRPTAQQLLKHPV  1175

         *************************86

Domain Sequence
(FASTA)

WCKGAQIGLG AFSACYQARD MFTGTLMAVK QVNHVRCSAV EERQVLAVIT EEISLMRRLS 60

HPNIVRLHGI TKEGPLYNIF IEWCAGGSVS TLLSHYGAFN EGVIMNYTLQ LLRGLSYIHE 120

QYLIHRDIKG ANLLIDSTGQ RLRISDFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GEQYGRSCDV WGCGCVITEM ASGKPPWEAD MHSNHLALIF KIASSPTVPP IPDHLSPAMK 240

DLCRRCLQAN PRDRPTAQQL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011989	; ARM-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069	; Pkinase; 1.
PF04434	; SWIM; 1.
PF13639	; zf-RING_2; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 2.

Prints

Created Date

20-Feb-2013