EKS-CIS-00118

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CIS-00118

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FAK	426.0	6.2E-128	355	607	253

Status

Unreviewed

Ensembl Protein

ENSCSAVP00000008664

UniProt Accession

H2YTK3;

Protein Name

Protein Synonyms/Alias

Gene Name

Csa.5720

Gene Synonyms/Alias

Csa.5720;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCSAVG00000005150	ENSCSAVP00000008664	ENSCSAVT00000008774
ENSCSAVG00000005150	ENSCSAVP00000008663	ENSCSAVT00000008773
ENSCSAVG00000005150	ENSCSAVP00000008662	ENSCSAVT00000008772
ENSCSAVG00000005150	ENSCSAVP00000008668	ENSCSAVT00000008778
ENSCSAVG00000005150	ENSCSAVP00000008667	ENSCSAVT00000008777
ENSCSAVG00000005150	ENSCSAVP00000008666	ENSCSAVT00000008776
ENSCSAVG00000005150	ENSCSAVP00000008665	ENSCSAVT00000008775
ENSCSAVG00000005150	ENSCSAVP00000008669	ENSCSAVT00000008779
ENSCSAVG00000005150	ENSCSAVP00000008671	ENSCSAVT00000008781
ENSCSAVG00000005150	ENSCSAVP00000008670	ENSCSAVT00000008780

Organism

Ciona savignyi

Functional Description

Protein Length

878

Protein Sequence
(FASTA)

RIHPDGLHFE DCFGLRLRHI KSGDIFWLHF SQTMTEVKEK YEIIHPIEEC KYELRVRYIP 60

RSIQDMLDRD RSTFNYYHNQ VFSDYLEAVA EKVDHETAIK LGCLEIRRYF KDMPSTVFEK 120

KSNFELLERE VGLRKFLPKS VVDSMKTKDL RRIITREFKT VSHLTEEQCV FRFFEILKKI 180

TRFDQEIFRC ALGTGWSVAV ELVVGPEDGI SYWTDKGSTP TILAEFSQVL SIQTDSSTDP 240

SKKGVLLLKI HGANDPLTIT TTSLFVAENI ADLIDGYCRL VNNTDQSLIV RANKNSSKRF 300

SDPRPLPSIT LNDTNNRKSF PCVTDTDDYA EITEDLYNVP EHFDYEINRD NIHVVTTVGE 360

GQFGDVHKGI YSTREIPEMP VAIKTCKFQG QDGMGMADRL LEEAHTMRQF EHPHIVRLIG 420

VCTEEPVWIV MEFCKYGEMR SYLQTNKHSL DTTMLITYTY QLSQALCYLE QKKFVHRDVA 480

ARNILVAQPD CIKLGDFGLS RYMEDQNYYT ASKGKLPIKW MAPESINFRR FTTATDVWMF 540

AVCCWEILMM GVKPFQGVKN NDVIGKIEAG ERLAMPSNCR PAMYSLMSRC WSYDPGFRPL 600

FEEIQHELCF QLDTDMEKDI DEKAKTQPVT PRIPTPTREP RSHVPKRQPR LPGKPTRHPP 660

EIGAQDNDCR GSCHEKLRQL QLEESKLEEN LRLQQKQAEA DKLWLQQEEQ QLANLCYVTV 720

RNAMNAPPPP SMPPAKPPRN LSTKDPTPTM KLDREGDTVY RDTMLVVKAV LQANQEIMGA 780

KSEEIFVLVK NIGKALKELC TSLDQEITSL PADYHREIDM AQKTTNKDLA QVINQMKLVK 840

RFYSTTQVTD YKKCMMAATQ VLAMDAKNLL DVVDKARL 878

Nucleotide Sequence
(FASTA)

CGAATCCACC CCGATGGACT CCACTTTGAG GATTGCTTCG GGCTGCGACT GCGCCACATT 60

AAGAGTGGAG ACATATTCTG GCTCCACTTC AGCCAAACCA TGACCGAAGT GAAGGAGAAA 120

TATGAGATTA TTCACCCGAT CGAAGAGTGC AAATATGAGC TTCGGGTGCG GTATATCCCA 180

CGTAGCATCC AGGATATGCT GGACAGAGAC AGAAGCACCT TCAACTATTA CCACAACCAG 240

GTATTTTCCG ACTATTTGGA AGCAGTAGCG GAGAAAGTGG ACCACGAAAC AGCCATCAAA 300

CTTGGCTGTC TTGAAATCCG ACGATATTTC AAAGACATGC CGAGTACTGT CTTTGAAAAG 360

AAATCAAATT TTGAACTCTT GGAGCGTGAA GTTGGTCTTC GTAAATTCCT CCCGAAATCG 420

GTCGTTGACT CGATGAAGAC GAAGGATCTG AGGAGGATTA TCACCCGGGA GTTCAAGACC 480

GTCAGCCACC TCACCGAGGA GCAGTGCGTC TTCCGATTCT TCGAGATCCT CAAAAAGATC 540

ACCAGATTCG ACCAGGAGAT CTTTAGATGC GCACTTGGGA CTGGCTGGAG CGTCGCGGTG 600

GAGTTGGTCG TGGGTCCTGA GGACGGGATC AGTTATTGGA CGGATAAAGG ATCGACCCCA 660

ACTATATTAG CCGAATTTTC GCAGGTACTT TCAATACAAA CCGATTCCTC AACTGACCCA 720

AGCAAGAAGG GAGTACTCCT GCTGAAAATA CACGGCGCAA ATGACCCACT AACGATCACC 780

ACAACTTCAC TGTTCGTGGC AGAGAACATA GCTGACCTTA TAGACGGATA CTGTAGATTG 840

GTCAACAACA CGGACCAGAG TCTGATTGTT CGTGCGAATA AAAACAGCTC AAAACGTTTC 900

AGCGACCCGC GACCTCTCCC TTCAATTACG TTAAACGACA CGAATAACCG AAAATCGTTC 960

CCCTGCGTTA CAGATACCGA TGATTACGCT GAGATTACCG AAGACCTTTA CAACGTCCCT 1020

GAACACTTCG ATTACGAAAT CAACCGTGAC AATATTCATG TCGTCACAAC GGTTGGTGAA 1080

GGACAGTTCG GTGACGTGCA CAAGGGGATA TACAGCACCC GAGAGATCCC CGAAATGCCG 1140

GTTGCGATTA AAACCTGCAA ATTCCAAGGA CAGGACGGGA TGGGAATGGC TGATCGGTTG 1200

TTAGAAGAAG CTCACACGAT GCGACAGTTC GAGCATCCGC ACATTGTCCG CCTCATCGGG 1260

GTTTGCACTG AAGAACCGGT CTGGATTGTC ATGGAATTCT GCAAGTACGG CGAGATGAGG 1320

TCGTACTTAC AAACCAACAA GCACAGTCTT GATACCACCA TGCTGATAAC ATACACCTAC 1380

CAACTCAGCC AAGCTCTGTG TTATCTGGAA CAAAAGAAAT TCGTGCACAG AGACGTCGCA 1440

GCGCGGAATA TCCTGGTTGC GCAACCCGAC TGCATTAAAC TCGGCGACTT CGGTTTGTCG 1500

AGGTACATGG AGGATCAGAA CTACTACACG GCGTCCAAAG GCAAGCTCCC CATCAAATGG 1560

ATGGCACCGG AATCCATTAA TTTCAGGAGA TTTACGACCG CCACGGACGT ATGGATGTTT 1620

GCCGTGTGCT GTTGGGAGAT ACTCATGATG GGCGTCAAGC CGTTCCAGGG GGTCAAGAAT 1680

AATGACGTCA TCGGCAAAAT CGAGGCTGGA GAGAGACTAG CGATGCCGTC CAACTGCAGA 1740

CCAGCAATGT ACAGCCTCAT GTCAAGATGC TGGTCGTACG ATCCCGGGTT CAGACCTCTC 1800

TTCGAGGAAA TACAACACGA GTTATGCTTT CAGCTCGATA CGGACATGGA AAAGGATATC 1860

GACGAAAAGG CGAAGACGCA ACCGGTGACC CCGCGGATAC CCACCCCAAC CCGGGAGCCA 1920

AGGTCCCATG TACCCAAGCG GCAACCAAGG TTACCCGGGA AGCCGACCCG CCATCCCCCC 1980

GAAATCGGCG CCCAGGATAA TGACTGCCGA GGTTCGTGTC ACGAGAAATT GCGTCAACTC 2040

CAGCTCGAAG AATCGAAATT AGAGGAAAAC CTGAGGTTGC AACAGAAACA AGCGGAAGCC 2100

GACAAGTTGT GGCTCCAACA GGAAGAACAA CAACTGGCTA ATCTTTGTTA CGTCACAGTG 2160

AGAAACGCGA TGAACGCCCC ACCCCCACCT TCGATGCCCC CAGCCAAACC CCCGCGCAAC 2220

CTCTCCACGA AAGACCCCAC CCCCACCATG AAACTGGACA GGGAAGGCGA CACGGTATAC 2280

CGGGATACTA TGCTGGTGGT GAAAGCTGTA CTGCAGGCAA ACCAGGAGAT AATGGGCGCC 2340

AAGTCGGAAG AGATATTCGT GCTTGTGAAG AACATCGGCA AAGCATTAAA GGAACTGTGC 2400

ACCAGCCTTG ATCAGGAGAT AACCAGTCTG CCGGCAGATT ACCACCGGGA AATCGACATG 2460

GCTCAGAAGA CGACGAACAA AGATTTAGCT CAAGTCATCA ACCAGATGAA ACTCGTCAAA 2520

CGATTCTACA GTACAACACA AGTCACCGAT TATAAAAAAT GTATGATGGC GGCAACTCAA 2580

GTCTTAGCGA TGGACGCCAA GAACTTACTC GACGTCGTCG ACAAAGCAAG ACTG 2634

Domain Profile

S: 4     sriigegqfgdvyegvylspknekiavaiktckkdtsd..ekkekflsealimkkldhph  61

           ++gegqfgdv++g+y +++ + + vaiktck + +d     +++l+ea +m++++hph

Q: 355   VTTVGEGQFGDVHKGIYSTREIPEMPVAIKTCKFQGQDgmGMADRLLEEAHTMRQFEHPH  414

         5789*****************************87766125789****************

S: 62    ivkligiieeepvwiimelaklgelraylkvnkeslklatlvlyayqlstalayleskkf  121

         iv+lig+++eepvwi+me++k+ge+r+yl++nk+sl+++ l+ y+yqls+al+yle kkf

Q: 415   IVRLIGVCTEEPVWIVMEFCKYGEMRSYLQTNKHSLDTTMLITYTYQLSQALCYLEQKKF  474

         ************************************************************

S: 122   vhrdiaarnvlvsspecvklgdfglsryvededyykasktklpikwmspesinfrrftta  181

         vhrd+aarn+lv+ p+c+klgdfglsry+ed++yy ask+klpikwm+pesinfrrftta

Q: 475   VHRDVAARNILVAQPDCIKLGDFGLSRYMEDQNYYTASKGKLPIKWMAPESINFRRFTTA  534

         ************************************************************

S: 182   sdvwmfgvclweilmlgvkpfqgvknkdvigklekgerlplpencppvlyslmtkcwayd  241

         +dvwmf+vc weilm+gvkpfqgvkn+dvigk+e gerl +p nc p++yslm++cw+yd

Q: 535   TDVWMFAVCCWEILMMGVKPFQGVKNNDVIGKIEAGERLAMPSNCRPAMYSLMSRCWSYD  594

         ************************************************************

S: 242   pskrprftelkas  254

         p  rp f+e++ +

Q: 595   PGFRPLFEEIQHE  607

         *********9876

Domain Sequence
(FASTA)

VTTVGEGQFG DVHKGIYSTR EIPEMPVAIK TCKFQGQDGM GMADRLLEEA HTMRQFEHPH 60

IVRLIGVCTE EPVWIVMEFC KYGEMRSYLQ TNKHSLDTTM LITYTYQLSQ ALCYLEQKKF 120

VHRDVAARNI LVAQPDCIKL GDFGLSRYME DQNYYTASKG KLPIKWMAPE SINFRRFTTA 180

TDVWMFAVCC WEILMMGVKP FQGVKNNDVI GKIEAGERLA MPSNCRPAMY SLMSRCWSYD 240

PGFRPLFEEI QHE 253

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0005925	; C:focal adhesion
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0004871	; F:signal transducer activity
GO:0007172	; P:signal complex assembly
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR014352	; FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR005189	; Focal_adhesion_kin_target_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00373	; FERM_M; 1.
PF03623	; Focal_AT; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00295	; B41; 1.
SM00219	; TyrKc; 1.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013