EKS-CIS-00072

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CIS-00072

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	412.4	6.8E-124	118	377	260

Status

Unreviewed

Ensembl Protein

ENSCSAVP00000009056

UniProt Accession

H2YUP9;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCSAVG00000005351	ENSCSAVP00000009056	ENSCSAVT00000009170
ENSCSAVG00000005351	ENSCSAVP00000009060	ENSCSAVT00000009174
ENSCSAVG00000005351	ENSCSAVP00000009061	ENSCSAVT00000009175
ENSCSAVG00000005351	ENSCSAVP00000009062	ENSCSAVT00000009176
ENSCSAVG00000005351	ENSCSAVP00000009059	ENSCSAVT00000009173
ENSCSAVG00000005351	ENSCSAVP00000009057	ENSCSAVT00000009171
ENSCSAVG00000005351	ENSCSAVP00000009058	ENSCSAVT00000009172

Organism

Ciona savignyi

Functional Description

Protein Length

861

Protein Sequence
(FASTA)

LFPQTCMPCY EGCRNCTGIN REDCMHALST EQEVAIAIAV PLVVVTCIFI LILFFGCRHR 60

RKVLKRKQQR SIWKLGIDGH SPEEQNVDPR ARLMEPMTPS GVAPNQAQLR IVKEAELRIG 120

KILGSGAFGT VHKGYWIPDL APRERVKVPV AIKVLRDESS QVASNEILDE AFVMASCEHP 180

NLVRLLGISL SQRIMLITQL MPLGNLLEYV RDNKDNIGSQ HMLNWSLQIA KGMRYLSEEK 240

HLVHRDLAAR NVLVKSPNHV RITDFGLAKL LDVKEDVYRA EGGKMPIKWL ALESIQHRIF 300

TQKSDVWSFG ITMWELMTFG KKPYENVPAR EVHTLLERGE RLPQPYVCTI DIYMLLIKCW 360

TVDAEARPTF RELSEELSKM ARDPQRYVVI DNDGLLNDLP SPITLEFLRS LMHDEGDDFP 420

ITDAEEYLHP QPQEGRRVTT ADPNQFSLQP VPAMVPWKRQ HHQHPLSSTS SQQGLLGRGS 480

GRFMHGPAKT SDRRLDSVMT TMTNLSSVSG SLPNGASTPG LNSELDDGHE IVLGATGNSR 540

GIVMHYTPIS TASNNFQAFQ DSDAVFIPSN LDKHPPGPRS NQNGEDCAEP PRVTRAREDS 600

TTLRYSAEPV SLMRQQTKPN EYLDPSDFPP SPFALKPPVN IFDTLPPSAI ANPEYEPSFI 660

PSDSESGTAG VTQDTFEEIL EDDREYENIV SMVPNPMKVV PEQHGVAGQH LTALGLRHGS 720

HSDESTNSEK RDSGMQTDDE DVKKSDRATS VANPEYDFLG DDSSGGGLTQ FSGGFPENET 780

EYVNNSVVDP NSNPAKHPNG YADDEIFTGV SLADPKTRER ILCGKNSIGR TYSEPDSGVG 840

IEVAVDNILY HKLGPAWDTH E 861

Nucleotide Sequence
(FASTA)

TTATTTCCAC AGACTTGTAT GCCTTGTTAT GAAGGTTGCC GAAACTGCAC TGGCATCAAC 60

AGAGAAGATT GCATGCACGC TTTGAGTACG GAACAGGAAG TGGCTATCGC AATCGCTGTC 120

CCCCTAGTGG TGGTAACATG CATCTTTATA CTGATTCTCT TCTTTGGATG CCGACATCGT 180

AGGAAGGTAC TTAAACGGAA GCAGCAACGC AGTATATGGA AATTGGGTAT AGATGGGCAC 240

TCCCCGGAAG AGCAAAACGT CGACCCTCGA GCACGACTCA TGGAACCGAT GACACCTAGT 300

GGTGTCGCCC CCAACCAAGC TCAACTCAGA ATCGTAAAGG AAGCAGAATT AAGAATCGGC 360

AAAATTTTGG GTTCTGGTGC CTTTGGGACA GTCCATAAAG GATACTGGAT CCCGGACTTA 420

GCACCAAGAG AGAGAGTGAA GGTCCCAGTT GCGATCAAAG TCCTTCGAGA CGAGTCCTCC 480

CAAGTAGCAA GCAACGAAAT ACTCGACGAA GCGTTCGTGA TGGCATCATG TGAGCACCCG 540

AATCTCGTGA GACTTCTTGG GATCAGTCTA TCGCAGCGTA TCATGCTCAT CACGCAGCTC 600

ATGCCGCTAG GGAATCTTCT AGAATACGTA CGAGACAACA AAGACAACAT TGGTTCCCAG 660

CATATGCTGA ACTGGAGTCT CCAAATTGCA AAGGGTATGA GGTATCTATC AGAGGAGAAA 720

CATCTCGTCC ATCGGGACCT AGCAGCTCGT AACGTACTCG TTAAATCACC CAACCATGTC 780

CGCATTACTG ACTTCGGATT GGCTAAGCTC TTAGATGTTA AAGAAGACGT ATACAGAGCG 840

GAAGGTGGTA AGATGCCAAT CAAGTGGTTG GCGTTGGAAT CCATTCAACA CCGCATATTC 900

ACACAAAAGA GTGATGTTTG GAGTTTTGGT ATCACAATGT GGGAACTGAT GACATTTGGA 960

AAGAAACCGT ACGAAAATGT TCCAGCTCGC GAAGTGCATA CTCTGCTTGA AAGAGGTGAG 1020

AGACTTCCCC AGCCGTACGT TTGCACCATC GACATCTACA TGCTCCTTAT CAAGTGCTGG 1080

ACGGTGGACG CAGAGGCACG ACCCACGTTC CGAGAGCTTT CTGAGGAGCT ATCAAAGATG 1140

GCACGCGACC CACAGCGATA CGTCGTCATT GACAACGACG GGTTACTCAA CGACCTCCCC 1200

AGCCCCATCA CATTGGAGTT CCTTCGCTCG CTGATGCACG ACGAGGGAGA CGACTTCCCC 1260

ATCACAGATG CCGAGGAATA TCTACATCCT CAACCACAAG AAGGGCGACG AGTCACCACA 1320

GCTGACCCGA ACCAATTCTC CCTCCAACCC GTACCAGCCA TGGTTCCATG GAAGCGTCAA 1380

CACCACCAAC ACCCTCTCTC TTCCACTTCC TCACAACAGG GGCTTTTGGG ACGGGGTAGT 1440

GGCCGATTTA TGCATGGGCC GGCAAAGACG TCAGATCGGC GTTTGGATTC TGTCATGACA 1500

ACCATGACGA ACCTGTCGAG CGTAAGTGGG TCTCTCCCTA ACGGCGCCAG CACCCCGGGA 1560

CTCAACTCTG AGCTCGACGA TGGTCACGAG ATTGTGCTGG GGGCAACGGG GAATTCCCGG 1620

GGCATTGTGA TGCACTACAC CCCGATTTCT ACCGCGAGCA ACAACTTCCA GGCTTTCCAG 1680

GATTCCGACG CTGTTTTCAT CCCTTCCAAC CTAGATAAAC ACCCACCGGG ACCCAGGTCT 1740

AACCAGAATG GTGAGGATTG TGCGGAACCC CCACGGGTCA CCCGGGCGCG GGAGGACAGC 1800

ACGACACTCA GATATAGCGC AGAACCAGTT TCCCTCATGA GACAACAGAC CAAACCCAAT 1860

GAATACTTGG ACCCAAGTGA TTTCCCACCC TCCCCGTTTG CGTTGAAGCC CCCTGTTAAC 1920

ATCTTCGACA CTTTACCCCC GTCCGCCATC GCTAACCCTG AATACGAACC CAGTTTTATA 1980

CCTTCAGATT CAGAGTCTGG AACGGCCGGG GTCACCCAAG ATACTTTCGA GGAGATTTTA 2040

GAAGACGATC GAGAGTATGA AAATATTGTT TCTATGGTCC CGAACCCGAT GAAGGTGGTG 2100

CCCGAGCAGC ACGGGGTGGC CGGGCAGCAC CTGACAGCCC TGGGGCTCCG GCACGGGTCT 2160

CACAGCGACG AGAGCACAAA CTCGGAAAAA CGGGATTCCG GGATGCAGAC TGATGACGAA 2220

GATGTGAAGA AAAGTGATCG CGCTACATCC GTCGCGAACC CTGAATACGA TTTCCTCGGG 2280

GACGACAGCT CCGGGGGCGG TTTGACCCAA TTTTCGGGGG GATTCCCCGA AAACGAGACG 2340

GAGTACGTGA ACAACAGCGT CGTCGACCCG AACTCGAACC CCGCGAAACA CCCTAACGGG 2400

TATGCGGACG ACGAGATTTT CACCGGGGTC AGTCTGGCGG ACCCGAAGAC GCGGGAACGG 2460

ATTCTTTGCG GGAAGAATTC AATCGGGAGG ACGTATTCGG AGCCAGACAG TGGGGTTGGG 2520

ATCGAGGTGG CAGTCGACAA TATTTTGTAT CACAAACTCG GACCTGCTTG GGACACCCAC 2580

GAGTAG 2586

Domain Profile

S: 2     kklkvlGsGafGtvykGiwipe...genvkipvaikvleektgkkankelldealvlasl  58

         +  k+lGsGafGtv+kG wip+    e+vk+pvaikvl++++++ a++e+ldea+v+as

Q: 118   RIGKILGSGAFGTVHKGYWIPDlapRERVKVPVAIKVLRDESSQVASNEILDEAFVMASC  177

         6789*****************987679*********************************

S: 59    dhanlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyl.  117

         +h+nlvrllg+ ls+ ++l+tql+plG+ll+yvr++kd++Gsq++lnw++qiakGm+yl

Q: 178   EHPNLVRLLGISLSQRIMLITQLMPLGNLLEYVRDNKDNIGSQHMLNWSLQIAKGMRYLs  237

         **********************************************************96

S: 118   eekrlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilk  177

         eek+lvhrdlaarnvlvkspnhv+itdfGlakll+ +e+ ++aeggk+pikwlalesi++

Q: 238   EEKHLVHRDLAARNVLVKSPNHVRITDFGLAKLLDVKEDVYRAEGGKMPIKWLALESIQH  297

         7899********************************************************

S: 178   rkythqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlv  237

         r++t++sdvws+G+t+wel+tfG+kpy+++pa+e++ lle+Gerl+qp +ctid+ym l+

Q: 298   RIFTQKSDVWSFGITMWELMTFGKKPYENVPAREVHTLLERGERLPQPYVCTIDIYMLLI  357

         ************************************************************

S: 238   kcwmidaesrpkfkelaeef  257

         kcw +dae+rp+f+el ee+

Q: 358   KCWTVDAEARPTFRELSEEL  377

         ****************9986

Domain Sequence
(FASTA)

RIGKILGSGA FGTVHKGYWI PDLAPRERVK VPVAIKVLRD ESSQVASNEI LDEAFVMASC 60

EHPNLVRLLG ISLSQRIMLI TQLMPLGNLL EYVRDNKDNI GSQHMLNWSL QIAKGMRYLS 120

EEKHLVHRDL AARNVLVKSP NHVRITDFGL AKLLDVKEDV YRAEGGKMPI KWLALESIQH 180

RIFTQKSDVW SFGITMWELM TFGKKPYENV PAREVHTLLE RGERLPQPYV CTIDIYMLLI 240

KCWTVDAEAR PTFRELSEEL 260

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 4.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013