EKS-CIS-00081

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CIS-00081

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	343.9	5.9E-103	14	271	258

Status

Unreviewed

Ensembl Protein

ENSCSAVP00000009142

UniProt Accession

H2YUY5;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCSAVG00000005385	ENSCSAVP00000009142	ENSCSAVT00000009256
ENSCSAVG00000005385	ENSCSAVP00000009141	ENSCSAVT00000009255
ENSCSAVG00000005385	ENSCSAVP00000009144	ENSCSAVT00000009258
ENSCSAVG00000005385	ENSCSAVP00000009143	ENSCSAVT00000009257
ENSCSAVG00000005385	ENSCSAVP00000009140	ENSCSAVT00000009254
ENSCSAVG00000005385	ENSCSAVP00000009139	ENSCSAVT00000009253
ENSCSAVG00000005385	ENSCSAVP00000009138	ENSCSAVT00000009252
ENSCSAVG00000005385	ENSCSAVP00000009146	ENSCSAVT00000009260
ENSCSAVG00000005385	ENSCSAVP00000009145	ENSCSAVT00000009259
ENSCSAVG00000005385	ENSCSAVP00000009147	ENSCSAVT00000009261

Organism

Ciona savignyi

Functional Description

Protein Length

792

Protein Sequence
(FASTA)

PSADISRKNP QDDFELLQRV GSGTYGDVYK AKHNVSKEFA AIKVIKLEPG DDFSIIQQEI 60

IMMKDCKHDN IVAYFGSYLR RDKLWIAMEY CGGGSMQDIY HVTGPLDEKL IAYVCRETLK 120

GLAYLHSKGK MHRDIKGANI LLTDDGSVKL ADFGVSAQIT QTIAKRKSFI GTPYWMAPEV 180

AAVERKGGYN QQCDVWAVGI TSIEFAELQP PMFDLHPMRA LFLMSKSSFQ PPKLKDKQKW 240

SAEFHLFVKQ ALTKNPKRRP SSEKMLQHPF VMQDGLVAKL GSDMLKRSRE PQIGEDDLMN 300

VIPKRRIQSS RPKEERQGKT KSEAICRFSL YFHMNPLPSM YICISQLFRS IQFIYPASGR 360

PPVRPMSRAL NGAAQETSLL GRPTVPISMA KPTLAEPEDD DVTPTGSPNK FHPLSESISS 420

ASQQKDLSTT PSLNVVNGLP PTPKVHMGAC FTKVFNGCPL KINCASSWVH PDSHDQYILF 480

GADEGIYTLN LHELHENTME QLFPRKCVWL YVISNVLMSI SGNRTPQLYS HNLVGLHENA 540

QRNQRIHLPE KMVPRRFAVS MKVPDTKNCQ QCSVVRNQYN GHKYLCAALQ QAVVLLQWYE 600

PMKKFLLIKQ LDYPLPHPLR VFELLVTPEA EFPLVCYGEG GPPSIHYHLN TIDLNSTSST 660

SWFADQAPGA TQLAVVNVTQ LEKDTLLICL ERDVKIISLT GKLKSSRKLA SELHFDFVTK 720

NIGNILAFHE HGMQGRSFRN NEVTQEICDR SRIFRLLSCY RVIVLESKPT DNPKELSNLY 780

ILAGHEDMSS VF 792

Nucleotide Sequence
(FASTA)

CCATCAGCCG ATATCTCGCG TAAAAATCCT CAAGATGATT TTGAACTGTT ACAGCGAGTT 60

GGAAGTGGAA CTTATGGGGA TGTATACAAG GCAAAACACA ATGTTTCCAA GGAGTTCGCA 120

GCTATTAAAG TGATAAAGCT GGAACCAGGT GACGACTTCT CAATTATACA GCAAGAAATA 180

ATAATGATGA AAGACTGCAA ACATGATAAC ATTGTTGCAT ACTTTGGCAG CTACTTAAGG 240

CGGGACAAAT TATGGATAGC TATGGAGTAC TGTGGTGGAG GATCCATGCA AGATATATAT 300

CATGTAACTG GTCCTCTAGA TGAAAAACTG ATTGCATACG TGTGTCGGGA GACACTTAAG 360

GGTTTGGCAT ACCTTCACAG TAAAGGGAAA ATGCACAGAG ACATCAAGGG AGCGAACATT 420

TTACTCACGG ATGACGGCTC TGTGAAACTA GCTGACTTTG GAGTTTCAGC CCAAATAACA 480

CAAACTATCG CCAAACGTAA ATCTTTCATT GGGACTCCTT ACTGGATGGC ACCCGAAGTT 540

GCTGCAGTGG AAAGGAAAGG GGGTTACAAC CAGCAGTGTG ATGTGTGGGC AGTTGGCATT 600

ACCTCAATTG AATTTGCTGA GCTGCAACCC CCAATGTTTG ACCTGCATCC AATGAGAGCT 660

CTTTTTCTCA TGTCCAAGTC GAGCTTTCAA CCACCCAAGC TGAAGGACAA GCAAAAATGG 720

TCAGCTGAGT TTCATTTATT TGTTAAACAA GCTCTCACTA AAAACCCTAA AAGGCGACCT 780

TCGTCAGAAA AAATGCTTCA GCACCCATTT GTTATGCAAG ATGGCTTGGT AGCAAAACTT 840

GGTTCAGATA TGCTGAAAAG ATCAAGGGAA CCGCAAATTG GGGAAGATGA TTTGATGAAT 900

GTCATCCCAA AACGAAGGAT TCAATCGTCC AGACCTAAAG AGGAAAGACA AGGAAAAACG 960

AAATCTGAAG CCATTTGTAG GTTCAGCTTG TATTTTCATA TGAACCCTCT ACCAAGTATG 1020

TACATTTGCA TTTCACAGTT ATTTCGTTCA ATTCAATTTA TCTACCCAGC ATCTGGTCGG 1080

CCCCCTGTCA GACCGATGTC CCGAGCATTA AACGGTGCGG CACAAGAAAC AAGTCTATTG 1140

GGTCGCCCGA CAGTCCCAAT TTCAATGGCG AAACCCACCT TAGCTGAGCC CGAAGATGAC 1200

GATGTAACTC CAACAGGAAG TCCGAATAAA TTTCATCCGT TATCTGAATC CATATCGTCT 1260

GCATCGCAGC AGAAGGATCT ATCTACCACA CCAAGTCTTA ATGTTGTCAA TGGCCTTCCC 1320

CCCACCCCAA AAGTGCATAT GGGCGCTTGC TTTACCAAAG TGTTTAACGG ATGCCCTTTG 1380

AAAATCAACT GCGCATCAAG TTGGGTGCAT CCTGACTCGC ACGACCAGTA TATTCTGTTT 1440

GGCGCAGATG AGGGGATATA CACACTCAAT TTGCATGAGT TGCATGAGAA CACTATGGAG 1500

CAACTCTTTC CTAGGAAGTG TGTATGGCTG TATGTGATCA GCAACGTCCT TATGTCGATT 1560

TCAGGCAATC GGACGCCACA ACTTTATTCC CACAACCTGG TTGGACTGCA TGAAAATGCT 1620

CAGCGAAATC AAAGAATTCA TCTGCCAGAA AAAATGGTCC CTAGGAGGTT TGCGGTGTCG 1680

ATGAAGGTTC CCGACACGAA GAACTGCCAG CAATGCTCCG TGGTTCGCAA CCAATACAAC 1740

GGACATAAAT ACCTATGCGC CGCTCTACAG CAGGCAGTTG TGCTCCTGCA GTGGTATGAA 1800

CCAATGAAAA AATTCCTGCT GATAAAGCAA CTGGACTACC CCCTGCCTCA CCCACTTAGA 1860

GTGTTCGAAC TGCTGGTGAC GCCAGAGGCT GAATTCCCAC TGGTGTGTTA CGGTGAAGGC 1920

GGCCCACCAT CGATTCACTA CCATCTGAAC ACGATTGATT TAAACAGCAC ATCATCGACT 1980

TCGTGGTTTG CTGATCAAGC CCCTGGTGCC ACACAACTCG CTGTGGTAAA CGTAACTCAA 2040

CTTGAAAAAG ACACTCTGCT TATATGTCTA GAGCGTGATG TCAAGATAAT CAGCTTGACA 2100

GGAAAACTGA AGTCGAGCAG GAAATTGGCA TCCGAACTTC ACTTTGATTT TGTCACTAAA 2160

AATATAGGCA ACATCCTGGC ATTCCACGAA CACGGGATGC AAGGCAGAAG CTTCCGGAAT 2220

AATGAGGTCA CACAGGAGAT TTGTGATCGC AGCAGGATCT TCCGCTTACT TAGTTGTTAC 2280

CGAGTCATAG TGCTTGAGAG CAAGCCTACA GACAATCCAA AGGAACTGTC AAACCTATAC 2340

ATTCTGGCTG GCCACGAGGA TATGTCTTCT GTGTTCTAA 2379

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +ell+++g+G++g+vy+a+++ ++e++aik+i+le  ++ + +q+ei ++k++kh niv+

Q: 14    FELLQRVGSGTYGDVYKAKHNVSKEFAAIKVIKLEPGDDFSIIQQEIIMMKDCKHDNIVA  73

         899*********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y++s+l++++lw+ mey+ gGs++d+++  ++ +l+E+ iay++re+lk+L+ylHsk+++

Q: 74    YFGSYLRRDKLWIAMEYCGGGSMQDIYH--VTGPLDEKLIAYVCRETLKGLAYLHSKGKM  131

         ****************************..******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179

         Hrdik++niLlt++g+VkL+dfgv+aq+++t +krk+++gtpywmAPEv a+e + gY++

Q: 132   HRDIKGANILLTDDGSVKLADFGVSAQITQTIAKRKSFIGTPYWMAPEVAAVErKGGYNQ  191

         ****************************************************98889***

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237

         ++D+w++GIt+ie ae +pP++dl+p++al++++k++  ppklk+k+k+s ef+ fv+++

Q: 192   QCDVWAVGITSIEFAELQPPMFDLHPMRALFLMSKSSfqPPKLKDKQKWSAEFHLFVKQA  251

         ***********************************9998*********************

S: 238   lqknpekRpsasellkhkFl  257

         l+knp++Rps++++l+h+F+

Q: 252   LTKNPKRRPSSEKMLQHPFV  271

         *******************7

Domain Sequence
(FASTA)

FELLQRVGSG TYGDVYKAKH NVSKEFAAIK VIKLEPGDDF SIIQQEIIMM KDCKHDNIVA 60

YFGSYLRRDK LWIAMEYCGG GSMQDIYHVT GPLDEKLIAY VCRETLKGLA YLHSKGKMHR 120

DIKGANILLT DDGSVKLADF GVSAQITQTI AKRKSFIGTP YWMAPEVAAV ERKGGYNQQC 180

DVWAVGITSI EFAELQPPMF DLHPMRALFL MSKSSFQPPK LKDKQKWSAE FHLFVKQALT 240

KNPKRRPSSE KMLQHPFV 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013