EKS-CIS-00048

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CIS-00048

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	324.6	5.4E-97	234	529	296

Status

Unreviewed

Ensembl Protein

ENSCSAVP00000011874

UniProt Accession

H2Z2R2;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCSAVG00000006972	ENSCSAVP00000011874	ENSCSAVT00000012012

Organism

Ciona savignyi

Functional Description

Protein Length

576

Protein Sequence
(FASTA)

MKNAVILIFF VNVFVVVPSW AMQCRQCRTQ LDPDNCNSTT CTLDCPTVDC SCLGLCRTQV 60

FLNYTGKHRV QAYCLQQICP TRAKYQNLYS KRQIDGYCDV ENNVVNCECA YDDCNHVIKF 120

ESTTDSDVET TEEEDESWVV ILGAVSGVAF LCVCIGVLWY CVRRYQRIKD EDFESKLTSG 180

SRLSSDDASL IDVGWDESGK HSYSTYRYSS SIATQYSRGS RGNVLNHNEQ YLPIELQKII 240

GRGQFAEVWK ANLQQDSSAP QVVSVKVFRL HNYGAWRQEK DMLTESWMRH NNIIEFYASE 300

QHTVRGRLQY WLVTAYYQEG SLTEFLRKNV LDWDQFCDMC ISITKGMSYL HAERDESGRP 360

KIPIAHRDVK SCNILVKDGR RECVLADFGL SLKLDPELSK DELANAGQVG TSRYMAPELL 420

ERLVNLTDIE MFKRVDVYAM GLVMWEMANR CEASEGMASP YKPPFGDQIN DRPTKDQMLL 480

LVCKDRQLPD IPEKWRKHKG LSEFIDTVLN ESWEYDAEAR ITAHCVFERF KTIRHLGDVD 540

KQGSDVDKEG SDVEDKIREK AKNESNRISE VISTVV 576

Nucleotide Sequence
(FASTA)

ATGAAAAATG CAGTGATATT AATCTTTTTT GTGAATGTAT TTGTTGTTGT CCCATCCTGG 60

GCAATGCAAT GTCGCCAATG CAGGACACAG CTTGATCCAG ATAACTGCAA CTCCACCACA 120

TGTACACTAG ATTGCCCCAC GGTCGACTGC AGCTGCCTCG GTTTGTGTCG CACCCAAGTT 180

TTTCTCAATT ATACAGGGAA GCATAGAGTC CAGGCATATT GTTTGCAACA GATATGCCCA 240

ACGAGAGCAA AATACCAAAA CCTATATAGT AAGCGTCAGA TAGATGGGTA TTGTGACGTA 300

GAGAACAACG TGGTAAACTG TGAATGTGCG TATGACGACT GCAATCACGT GATCAAGTTC 360

GAATCAACCA CAGATTCTGA CGTTGAAACC ACGGAAGAGG AAGACGAATC GTGGGTGGTT 420

ATTCTCGGGG CGGTTTCCGG AGTTGCCTTC CTGTGCGTTT GCATCGGAGT GTTGTGGTAC 480

TGCGTCAGGC GTTACCAGCG CATTAAAGAT GAAGACTTTG AGAGCAAGTT GACATCCGGG 540

AGCAGATTAT CGTCGGATGA TGCGAGTCTC ATAGACGTGG GTTGGGACGA GAGTGGAAAG 600

CACAGTTATT CTACATACAG ATACTCATCA AGCATTGCGA CTCAGTACAG CCGCGGGTCA 660

CGTGGTAATG TGCTAAACCA CAACGAACAA TATCTGCCCA TCGAGCTTCA GAAAATAATC 720

GGTCGTGGCC AATTTGCTGA AGTTTGGAAG GCAAATCTGC AGCAGGACTC TTCTGCGCCG 780

CAAGTGGTTT CTGTAAAGGT GTTCCGTCTG CATAACTACG GTGCATGGAG ACAAGAAAAG 840

GACATGCTTA CAGAGAGTTG GATGAGGCAC AACAACATCA TCGAGTTTTA CGCTTCGGAA 900

CAGCACACTG TGCGTGGAAG ATTACAGTAC TGGCTCGTTA CCGCGTATTA TCAAGAGGGA 960

AGTCTCACTG AGTTTCTAAG GAAAAATGTT CTTGATTGGG ATCAATTTTG CGATATGTGC 1020

ATTTCCATCA CGAAAGGCAT GTCGTACTTG CACGCCGAGA GAGACGAGTC GGGCCGTCCA 1080

AAGATCCCGA TCGCCCATCG GGATGTTAAA AGCTGTAATA TTCTCGTGAA GGACGGAAGA 1140

AGGGAGTGCG TGTTGGCCGA TTTCGGGTTA TCCTTGAAAC TTGATCCGGA ATTAAGTAAA 1200

GATGAACTGG CTAACGCTGG TCAAGTCGGG ACATCTCGCT ACATGGCTCC CGAGTTGCTG 1260

GAGCGCCTTG TTAACCTTAC CGATATTGAG ATGTTTAAAC GAGTCGACGT GTACGCGATG 1320

GGACTTGTGA TGTGGGAGAT GGCGAACCGT TGTGAAGCGT CTGAAGGTAT GGCGTCGCCG 1380

TATAAGCCAC CATTCGGGGA CCAAATAAAC GACCGACCAA CGAAAGACCA GATGCTATTG 1440

CTGGTGTGCA AAGACCGCCA ACTCCCTGAT ATACCCGAGA AGTGGAGAAA GCACAAGGGT 1500

CTTTCGGAGT TCATAGACAC AGTACTGAAC GAGTCATGGG AATACGACGC CGAAGCGCGA 1560

ATCACCGCTC ACTGCGTCTT CGAGCGCTTT AAGACCATAC GTCATTTGGG TGACGTCGAC 1620

AAGCAGGGAA GTGACGTCGA CAAGGAAGGA AGTGACGTCG AGGACAAGAT TCGCGAGAAA 1680

GCAAAGAACG AATCGAACCG GATATCCGAG GTCATATCAA CAGTTGTTTG A 1731

Domain Profile

S: 1     lklleligkGrygeVwkaklrg.....eevAvKifstedeaswkrEkeiyqtvllrheni  55

         ++l+++ig+G+++eVwka+l++     + v vK+f  ++  +w++Ek++ ++  +rh+ni

Q: 234   IELQKIIGRGQFAEVWKANLQQdssapQVVSVKVFRLHNYGAWRQEKDMLTESWMRHNNI  293

         6899*****************98988899*******************************

S: 56    lqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHee  115

         ++f a+++++ + + +++lvt+y+++gsL+++L +++ld+++ + ++ s+++G+++LH+e

Q: 294   IEFYASEQHTVRGRLQYWLVTAYYQEGSLTEFLRKNVLDWDQFCDMCISITKGMSYLHAE  353

         ************************************************************

S: 116   ivgtkgkkKpaiaHRDlkskNilvkk.dltcciaDlGLalkleeekeeldlaansqvGtk  174

            ++g+ K  iaHRD+ks Nilvk+  + c++aD+GL+lkl+ e ++ +la+  qvGt

Q: 354   R-DESGRPKIPIAHRDVKSCNILVKDgRRECVLADFGLSLKLDPELSKDELANAGQVGTS  412

         5.66799******************83568******************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPE+le  +nl+d+e fkr+DvY++gLv+WE+a Rce++++++ +yk+pf ++++ +

Q: 413   RYMAPELLERLVNLTDIEMFKRVDVYAMGLVMWEMANRCEASEGMASPYKPPFGDQINDR  472

         ************************************************************

S: 235   PsleemkevvvekklrPkipeawkkkealkels.klleecWdadpeaRltalrvkkr  290

         P+ ++m  +v+++++ P ipe+w+k++ l+e+  ++l+e+W+ d+eaR ta++v +r

Q: 473   PTKDQMLLLVCKDRQLPDIPEKWRKHKGLSEFIdTVLNESWEYDAEARITAHCVFER  529

         ***************************99886515789***************9876

Domain Sequence
(FASTA)

IELQKIIGRG QFAEVWKANL QQDSSAPQVV SVKVFRLHNY GAWRQEKDML TESWMRHNNI 60

IEFYASEQHT VRGRLQYWLV TAYYQEGSLT EFLRKNVLDW DQFCDMCISI TKGMSYLHAE 120

RDESGRPKIP IAHRDVKSCN ILVKDGRREC VLADFGLSLK LDPELSKDEL ANAGQVGTSR 180

YMAPELLERL VNLTDIEMFK RVDVYAMGLV MWEMANRCEA SEGMASPYKP PFGDQINDRP 240

TKDQMLLLVC KDRQLPDIPE KWRKHKGLSE FIDTVLNESW EYDAEARITA HCVFER 296

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004872	; F:receptor activity
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013