EKS-CIS-00152

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CIS-00152

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	313.3	1.3E-93	445	715	271

Status

Unreviewed

Ensembl Protein

ENSCSAVP00000012329

UniProt Accession

H2Z418;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCSAVG00000007251	ENSCSAVP00000012329	ENSCSAVT00000012472
ENSCSAVG00000007251	ENSCSAVP00000012330	ENSCSAVT00000012473
ENSCSAVG00000007251	ENSCSAVP00000012328	ENSCSAVT00000012471

Organism

Ciona savignyi

Functional Description

Protein Length

723

Protein Sequence
(FASTA)

LKCVADGSMG ISITWHKNGI ALSALAHIIQ WETQKNGLTF ESTLQFQSLT RQDEGSYVCT 60

ATNQMGVMVS SNAATVIILG PPVITEGPQD ITTNLHNSSF RLPCTAHGPP DISNITWNYA 120

FPSNPYLLEL PSVDMVITDN VTQYDISCSA TNDLGTVTSN IATIYLRRVP TSPVISHVIP 180

GKNMAEIWWL VDFSDVQVCV VKVLEDGGVL VASNQVSAPT NAIIVRNLNP SEQYTALVKC 240

HNYIGFSKWS EPYSFTPVTS LVSPQNVSLT FSPNQTTVSW RKTLHIVKGN LTGYRLEVYD 300

VRNSNKKSYE FSSQTLSAIL TGLTTHMEYG VRVCGLSGSQ KGPFSRLLTF HVPEFISPNG 360

AFVVITIVIV ILILTIVAAF CYCFKRKSAK QRENMVSYDQ VSGGGTLKTL NDYYTPMSNN 420

GSMSVTAQLE DMVRDVLIEN NRVELDVVLG EGEFGFVYKA QLSAGDKDAY AGEVHGNVAV 480

KSIKMNGYAF SEVESFIKEG LRMKDLDHPN VMRLIGISFT EEDEDRHNLV TPLVLLPYMP 540

NGDLRSYLFT LRTSGLSKKM TVHKLLLFAL DVAKGMQYLA ERSFIHRDLA ARNCMLDGDY 600

NVVVSDFGLS RKVYSESYYR QTHISKMPVK WMAIESLVDN VFTTKSDVWA FGVTVWEILS 660

MSQTPYPGVA NHEVHQLLRN GTRLSKPPHC PAKIWYRAVF PCWTVQVHER PSFDDIVETL 720

EDI 723

Nucleotide Sequence
(FASTA)

CTCAAATGTG TTGCTGATGG ATCAATGGGG ATTTCAATTA CGTGGCACAA AAATGGCATT 60

GCCCTATCAG CCCTTGCACA TATTATTCAG TGGGAGACTC AAAAGAATGG GCTGACATTT 120

GAAAGTACGT TGCAGTTTCA AAGCCTGACT AGGCAAGATG AAGGAAGTTA TGTATGTACT 180

GCAACTAATC AGATGGGTGT AATGGTGTCT TCTAATGCAG CTACAGTGAT CATCCTCGGG 240

CCTCCAGTCA TTACTGAAGG GCCACAGGAT ATTACAACTA ATTTGCATAA CTCATCGTTC 300

CGACTTCCTT GTACTGCGCA TGGTCCGCCA GATATTTCAA ACATCACATG GAACTACGCA 360

TTTCCATCCA ACCCCTACCT TCTAGAACTA CCTAGTGTTG ATATGGTGAT CACTGACAAT 420

GTCACACAGT ACGATATTTC TTGCTCGGCA ACGAATGATT TAGGGACCGT GACATCAAAC 480

ATAGCAACTA TTTATCTAAG AAGAGTGCCG ACTTCCCCAG TAATAAGCCA CGTGATACCT 540

GGAAAAAATA TGGCGGAAAT CTGGTGGTTG GTTGATTTTT CCGATGTGCA GGTCTGTGTG 600

GTGAAAGTAT TGGAAGATGG AGGTGTTTTG GTTGCATCGA ACCAAGTCTC TGCACCAACT 660

AATGCAATTA TAGTTCGAAA TTTAAATCCT TCAGAGCAGT ACACCGCGCT AGTCAAATGC 720

CATAACTACA TAGGTTTTTC CAAATGGAGT GAACCATACA GCTTCACGCC AGTTACGAGT 780

CTGGTTTCAC CACAGAACGT GTCGTTGACT TTTAGCCCAA ATCAAACCAC TGTAAGTTGG 840

CGAAAAACTC TTCACATTGT AAAGGGAAAC CTTACAGGCT ACCGGCTAGA GGTGTACGAT 900

GTTCGCAACT CAAATAAAAA ATCCTATGAG TTCTCTAGTC AAACATTATC AGCAATTTTA 960

ACGGGTCTAA CGACGCACAT GGAATATGGT GTCAGAGTTT GCGGGTTATC GGGATCACAG 1020

AAAGGACCTT TCTCCCGCCT GTTAACATTT CACGTCCCAG AATTTATCTC CCCTAATGGT 1080

GCTTTTGTTG TAATAACCAT TGTTATTGTT ATCTTAATAT TAACAATTGT TGCGGCCTTT 1140

TGTTATTGTT TCAAAAGGAA ATCGGCCAAA CAAAGGGAAA ACATGGTATC GTATGACCAG 1200

GTATCTGGGG GCGGAACTCT AAAAACTCTG AATGATTATT ACACCCCAAT GTCGAACAAC 1260

GGGTCAATGT CCGTTACAGC TCAGTTGGAG GATATGGTCC GGGATGTGCT AATTGAGAAT 1320

AATCGAGTCG AACTTGACGT GGTTTTGGGA GAAGGAGAGT TTGGTTTTGT GTATAAAGCC 1380

CAGCTCAGTG CAGGGGATAA AGACGCATAT GCTGGCGAGG TTCATGGAAA CGTGGCGGTG 1440

AAGTCGATTA AAATGAACGG ATATGCATTT AGCGAGGTGG AGAGTTTTAT TAAAGAAGGC 1500

CTGCGGATGA AAGATCTTGA CCACCCTAAT GTGATGCGTC TTATCGGGAT CTCATTCACT 1560

GAAGAAGATG AAGATCGACA TAATCTTGTT ACTCCGCTGG TGTTGCTGCC TTACATGCCT 1620

AACGGTGATC TGCGCAGTTA CCTCTTCACG CTGCGAACTT CAGGCTTGTC AAAGAAGATG 1680

ACGGTCCATA AACTGCTTCT TTTTGCTCTG GATGTTGCCA AAGGGATGCA ATATTTGGCG 1740

GAAAGGAGTT TTATTCATCG GGATTTGGCC GCTCGAAACT GCATGCTGGA TGGCGATTAT 1800

AACGTGGTAG TGTCGGACTT TGGTTTATCG CGTAAAGTTT ACTCAGAGAG TTATTACCGA 1860

CAGACCCACA TTTCAAAAAT GCCGGTAAAG TGGATGGCAA TCGAGAGTTT AGTGGACAAC 1920

GTTTTCACCA CCAAGTCCGA CGTTTGGGCG TTCGGCGTGA CGGTTTGGGA AATACTTTCA 1980

ATGAGTCAAA CACCGTACCC TGGGGTCGCG AACCACGAGG TTCACCAGCT GCTGCGAAAT 2040

GGAACTCGGT TAAGCAAACC ACCTCACTGC CCTGCCAAGA TTTGGTACCG AGCAGTGTTT 2100

CCATGCTGGA CGGTGCAAGT TCACGAGAGG CCTAGTTTTG ACGATATTGT GGAAACACTG 2160

GAGGATATC 2169

Domain Profile

S: 3     lgkvlgegefgsvmegqlkqedgsil......kvavktlkldiiarseieeflseaacmk  56

         l  vlgegefg v ++ql   d          +vavk +k++  a se+e f++e   mk

Q: 445   LDVVLGEGEFGFVYKAQLSAGDKDAYagevhgNVAVKSIKMNGYAFSEVESFIKEGLRMK  504

         6779**************987753321222237***************************

S: 57    efdhpnvirlvgvsless..ekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqt  114

         ++dhpnv+rl+g+s+  +  ++ +l +p+v+lp+m  gdl ++l+  r +   +++ +

Q: 505   DLDHPNVMRLIGISFTEEdeDRHNLVTPLVLLPYMPNGDLRSYLFTLRTSGLSKKMTVHK  564

         ***************87611567899**********************************

S: 115   lvkfmvdiasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgri  174

         l+ f +d+a+gm+yl++r fihrdlaarncml+ d  v+v+dfgls+k+ys  yyrq  i

Q: 565   LLLFALDVAKGMQYLAERSFIHRDLAARNCMLDGDYNVVVSDFGLSRKVYSESYYRQTHI  624

         ************************************************************

S: 175   aklpvkwiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrl  234

         +k+pvkw+aiesl d+v+t+ksdvwafgvt+wei +  qtpy+gv n+e+++ l++g rl

Q: 625   SKMPVKWMAIESLVDNVFTTKSDVWAFGVTVWEILSMSQTPYPGVANHEVHQLLRNGTRL  684

         ************************************************************

S: 235   kqpedcldel.ydlmyrcweadpkdrpsfsv  264

          +p++c  ++ y  ++ cw+++ ++rpsf +

Q: 685   SKPPHCPAKIwYRAVFPCWTVQVHERPSFDD  715

         ******98875899***************76

Domain Sequence
(FASTA)

LDVVLGEGEF GFVYKAQLSA GDKDAYAGEV HGNVAVKSIK MNGYAFSEVE SFIKEGLRMK 60

DLDHPNVMRL IGISFTEEDE DRHNLVTPLV LLPYMPNGDL RSYLFTLRTS GLSKKMTVHK 120

LLLFALDVAK GMQYLAERSF IHRDLAARNC MLDGDYNVVV SDFGLSRKVY SESYYRQTHI 180

SKMPVKWMAI ESLVDNVFTT KSDVWAFGVT VWEILSMSQT PYPGVANHEV HQLLRNGTRL 240

SKPPHCPAKI WYRAVFPCWT VQVHERPSFD D 271

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 1.
PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013