EKS-CIS-00182

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CIS-00182

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	375.6	1.1E-112	106	384	279

Status

Unreviewed

Ensembl Protein

ENSCSAVP00000012877

UniProt Accession

H2Z5L3;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCSAVG00000007558	ENSCSAVP00000012877	ENSCSAVT00000013026
ENSCSAVG00000007558	ENSCSAVP00000012876	ENSCSAVT00000013025
ENSCSAVG00000007558	ENSCSAVP00000012875	ENSCSAVT00000013024

Organism

Ciona savignyi

Functional Description

Protein Length

394

Protein Sequence
(FASTA)

ASGINQTGLN RLTLYNVTKS DAGIYMCRVS NYIGSTNQSA YLTDPPRLVP IENPDNIPRM 60

TKMEQPVMLY GNEQAWRRMC LPHADHIEIN IQPDLQWELK REDILLHERI DEGFFGQVFR 120

ADLIRCNGGR KEKIDAAVKM LKNTRTEKDM LDLLTEMDQM KRIGKHKNIV NLGVCTQNSI 180

LWLVTEYAQK GNLRDYLRRN RPSEMQYQFT NPDPNAPPPP RDEPLTYHAL MSAAHQVARG 240

MEYLSQKKCI HRDLAARNVL VTDEFVMKIA DFGLARDVRC NDYYRKQTRG HLPYKWMAVE 300

AMADNIFTPA TDVWSFGVLL WEIFSLGGSP YPGVKTHDLV RFLRSGDRLE QPQFASSELY 360

RLMRDCWEES PNRRPKFRQL VEDLDRMLAS ASNV 394

Nucleotide Sequence
(FASTA)

GCATCTGGTA TAAACCAGAC CGGACTAAAC AGACTTACAC TTTACAATGT GACAAAATCT 60

GACGCTGGGA TATACATGTG TCGGGTTTCC AACTATATTG GGTCGACCAA CCAATCAGCG 120

TATCTGACAG ACCCACCAAG GTTGGTCCCG ATCGAGAACC CGGACAACAT CCCGCGCATG 180

ACGAAGATGG AGCAACCAGT GATGCTGTAC GGGAACGAGC AGGCATGGAG GAGAATGTGT 240

CTTCCCCACG CCGATCATAT CGAGATCAAC ATCCAGCCGG ACCTTCAATG GGAGCTGAAG 300

AGAGAAGACA TCCTACTGCA TGAAAGAATC GACGAAGGGT TTTTCGGACA AGTCTTCCGG 360

GCAGATTTGA TCCGCTGTAA CGGGGGAAGA AAGGAGAAAA TTGACGCTGC TGTAAAAATG 420

CTTAAAAACA CACGCACGGA AAAAGACATG TTGGATCTCT TAACGGAAAT GGACCAGATG 480

AAAAGAATTG GGAAACACAA AAACATCGTC AACTTGGGAG TGTGCACCCA GAATTCAATC 540

CTTTGGCTTG TCACTGAGTA TGCACAAAAG GGGAATCTCA GGGATTACTT GCGACGCAAT 600

CGTCCAAGCG AGATGCAATA CCAGTTCACC AACCCGGATC CGAACGCACC TCCACCACCT 660

CGAGACGAAC CCCTCACCTA CCATGCACTT ATGTCCGCAG CCCACCAAGT CGCTAGAGGC 720

ATGGAGTACT TATCGCAGAA AAAGTGCATC CATCGGGATT TAGCCGCCAG AAACGTGTTG 780

GTGACTGACG AGTTTGTAAT GAAGATCGCT GACTTCGGGC TTGCACGTGA TGTGCGATGC 840

AACGACTATT ACAGAAAGCA AACACGGGGC CATCTTCCTT ACAAATGGAT GGCTGTCGAA 900

GCAATGGCTG ATAACATATT CACCCCAGCC ACTGATGTAT GGTCTTTCGG TGTCCTCTTG 960

TGGGAAATCT TCTCCCTTGG GGGTTCCCCA TACCCGGGAG TAAAGACCCA CGATCTGGTT 1020

CGGTTCCTGC GCTCCGGGGA CCGCTTGGAG CAGCCTCAGT TCGCCTCCTC GGAGTTGTAT 1080

CGCTTGATGA GGGATTGCTG GGAGGAGTCG CCGAATCGGC GTCCGAAGTT CCGACAGCTC 1140

GTGGAGGATT TGGATCGGAT GTTGGCGAGT GCATCCAACG TG 1182

Domain Profile

S: 3     lgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkliG  62

         l + + eG fGqv++a+ i  +  + k+++  avkmlk+  t+kd+ dl++em+ +k iG

Q: 106   LHERIDEGFFGQVFRADLIRCNGGR-KEKIDAAVKMLKNTRTEKDMLDLLTEMDQMKRIG  164

         667889************9888766.567899****************************

S: 63    khkniinllGactqeGplyviveyaakGnlreflrarrpkgeeask......dkskasee  116

         khkni+nl G+ctq+  l+++ eya+kGnlr++lr++rp++++++        ++   +e

Q: 165   KHKNIVNL-GVCTQNSILWLVTEYAQKGNLRDYLRRNRPSEMQYQFtnpdpnAPPPPRDE  223

         ******95.***********************************9988765444455688

S: 117   qltekdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidy  176

          lt + l+s a+qvarGmeyl+ kkcihrdlaarnvlvt++ v+kiadfGlardv+++dy

Q: 224   PLTYHALMSAAHQVARGMEYLSQKKCIHRDLAARNVLVTDEFVMKIADFGLARDVRCNDY  283

         ************************************************************

S: 177   ykkttnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkll  236

         y+k+t G lp kwma ea+ d+++t  +dvwsfGvllwei++lGgspypg+  ++l ++l

Q: 284   YRKQTRGHLPYKWMAVEAMADNIFTPATDVWSFGVLLWEIFSLGGSPYPGVKTHDLVRFL  343

         ************************************************************

S: 237   keGhrmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         ++G r+e+p+  ++ely lmr+cw+++++ rp f+qlvedl

Q: 344   RSGDRLEQPQFASSELYRLMRDCWEESPNRRPKFRQLVEDL  384

         ***************************************97

Domain Sequence
(FASTA)

LHERIDEGFF GQVFRADLIR CNGGRKEKID AAVKMLKNTR TEKDMLDLLT EMDQMKRIGK 60

HKNIVNLGVC TQNSILWLVT EYAQKGNLRD YLRRNRPSEM QYQFTNPDPN APPPPRDEPL 120

TYHALMSAAH QVARGMEYLS QKKCIHRDLA ARNVLVTDEF VMKIADFGLA RDVRCNDYYR 180

KQTRGHLPYK WMAVEAMADN IFTPATDVWS FGVLLWEIFS LGGSPYPGVK THDLVRFLRS 240

GDRLEQPQFA SSELYRLMRD CWEESPNRRP KFRQLVEDL 279

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 2.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 2.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013