EPS-CIS-00009

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CIS-00009

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP5	496.0	3.4E-149	177	482	306

Status

Unreviewed

Ensembl Protein

ENSCSAVP00000013266

UniProt Accession

H2Z6Q5;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

Csa.5196

Gene Synonyms/Alias

Csa.5196;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCSAVG00000007787	ENSCSAVP00000013267	ENSCSAVT00000013417
ENSCSAVG00000007787	ENSCSAVP00000013266	ENSCSAVT00000013416

Organism

Ciona savignyi

Functional Description

Protein Length

488

Protein Sequence
(FASTA)

MAECAVNGDS DVLIRAEKFK EEANQLFKDK KYEEAVELYT RAIEANPKSS VYHANRSFAH 60

LRLENYGFAL EDASTAIACD KKYIKAYYRR ASAYMSLGKF KPALRDLEAV VKVRPTDKDA 120

RMKYNACSKI VKQKAFEKAI ACDDNKKPVS ETINLENITV EDSYSGPHIP EDGIDPAFME 180

NLVQTFKKQG KLHRRYAYKI LLEVKQILAS LPSLVDIVVE KDNKLTVCGD VHGQYYDLCH 240

VFDINGLPSL DNPYLFNGDF VDRGSWSVEV ILVLLGYKVL YPHNFHLVRG NHETDYMNQM 300

YGFEGEVKAK YDGMMMQLFS EVFNWLPLSY CVNRKVLIMH GGLMEQDNVT LEDLRSIDRN 360

RQPPESGLMC DLLWSDPQMQ SGRGPSKRGV SCQFGPDITS KFLKHNELDY IIRSHECKNG 420

GYEEQHNGKC ITIFSAPNYC DQMGNKGAFI TLRSPDLKPK FTQFDAVSHP EVQPMAYANS 480

FMRMPGMF 488

Nucleotide Sequence
(FASTA)

ATGGCTGAAT GTGCAGTGAA CGGAGACTCC GATGTTTTAA TCAGAGCGGA GAAGTTCAAA 60

GAAGAGGCAA ACCAGCTCTT TAAAGACAAG AAGTATGAAG AGGCTGTGGA ACTTTACACA 120

CGTGCGATTG AAGCAAATCC CAAGTCCAGC GTGTATCACG CCAATAGGAG CTTTGCTCAT 180

CTTCGGCTGG AGAATTATGG ATTCGCATTA GAAGATGCAT CTACTGCAAT TGCCTGTGAT 240

AAGAAATACA TCAAGGCTTA CTACAGGAGA GCATCAGCAT ACATGTCCCT GGGGAAGTTT 300

AAGCCAGCTC TCAGGGATTT GGAAGCGGTC GTAAAAGTCC GCCCCACAGA CAAGGACGCA 360

AGGATGAAGT ACAACGCTTG TAGCAAAATC GTGAAACAAA AAGCTTTCGA GAAAGCCATC 420

GCCTGCGACG ATAACAAGAA ACCTGTGTCA GAAACCATCA ACTTGGAAAA TATCACGGTA 480

GAAGACAGTT ATAGCGGCCC CCACATACCT GAAGATGGAA TTGATCCTGC GTTTATGGAG 540

AACTTGGTTC AAACTTTCAA GAAGCAGGGC AAACTTCACC GGCGATACGC CTACAAAATA 600

TTACTCGAGG TCAAGCAGAT ATTGGCTTCT CTCCCATCTT TGGTCGATAT AGTCGTCGAA 660

AAGGATAACA AGCTGACAGT GTGTGGTGAT GTGCACGGTC AGTATTACGA TCTCTGCCAC 720

GTTTTCGACA TCAATGGTCT ACCTTCTCTT GATAATCCTT ACTTGTTCAA CGGTGATTTC 780

GTGGACAGAG GCTCGTGGTC GGTGGAAGTA ATTCTGGTGC TGCTAGGGTA CAAAGTCTTG 840

TACCCACACA ACTTCCATTT AGTTCGTGGT AACCATGAAA CTGACTACAT GAACCAGATG 900

TATGGTTTCG AAGGAGAAGT GAAAGCGAAA TACGATGGAA TGATGATGCA ACTCTTCAGC 960

GAAGTCTTCA ACTGGCTCCC CCTGTCTTAC TGTGTGAATA GGAAAGTTCT GATAATGCAC 1020

GGGGGCCTAA TGGAACAGGA CAATGTAACG CTTGAGGACC TTCGCTCAAT CGACCGAAAC 1080

CGACAGCCTC CTGAGAGTGG TCTCATGTGC GACCTCTTGT GGTCAGATCC ACAGATGCAG 1140

TCCGGTCGAG GCCCAAGTAA ACGAGGGGTA AGCTGTCAAT TTGGCCCCGA CATTACGTCC 1200

AAGTTCCTCA AGCACAACGA ACTCGATTAT ATAATAAGGA GCCATGAATG CAAGAATGGG 1260

GGATATGAGG AGCAACACAA CGGGAAATGC ATAACAATCT TCTCGGCCCC CAATTATTGT 1320

GACCAGATGG GTAATAAGGG GGCTTTTATC ACCCTACGGA GCCCTGATTT GAAACCGAAG 1380

TTTACACAGT TTGATGCAGT AAGTCATCCA GAAGTTCAGC CGATGGCTTA CGCCAATTCC 1440

TTCATGAGAA TGCCTGGAAT GTTT 1464

Domain Profile

S: 6     efikklvndlklkkkllrkkavailvsvadvlfklevelennskedvkitvcGdthGqfy  65

          f+++lv+ +k+++kl+r+ a++il++v+++l+ l  +++  +++d+k+tvcGd+hGq+y

Q: 177   AFMENLVQTFKKQGKLHRRYAYKILLEVKQILASLPSLVDIVVEKDNKLTVCGDVHGQYY  236

         69**********************************************************

S: 66    dllnifelnGlpseknpylfnGdfvdrGsfsveviltlfglkllyPdhffllrGnhesdn  125

         dl  +f++nGlps +npylfnGdfvdrGs+svevil+l g+k+lyP++f+l rGnhe+d

Q: 237   DLCHVFDINGLPSLDNPYLFNGDFVDRGSWSVEVILVLLGYKVLYPHNFHLVRGNHETDY  296

         ************************************************************

S: 126   mnkiyGfegevkakytaklyelfaevfewlPlaqlingkvlvmhGGlfsedgvtlddirk  185

         mn++yGfegevkaky   +++lf+evf+wlPl+ ++n kvl+mhGGl+ +d+vtl+d+r

Q: 297   MNQMYGFEGEVKAKYDGMMMQLFSEVFNWLPLSYCVNRKVLIMHGGLMEQDNVTLEDLRS  356

         ************************************************************

S: 186   iernaqPPeeGalcellWsdPqeanGrgvskrGvglqfGpdvtkrfleenkldyiirshe  245

         i+rn+qPPe+G++c+llWsdPq ++Grg+skrGv++qfGpd+t +fl++n+ldyiirshe

Q: 357   IDRNRQPPESGLMCDLLWSDPQMQSGRGPSKRGVSCQFGPDITSKFLKHNELDYIIRSHE  416

         ************************************************************

S: 246   vkaegveveqkgklvtvfsapnycdsqgnlasvihvrnddlrliietfeavehpdvkpma  305

          k +g+e +++gk++t+fsapnycd++gn++++i +r+ dl++++ +f+av+hp+v+pma

Q: 417   CKNGGYEEQHNGKCITIFSAPNYCDQMGNKGAFITLRSPDLKPKFTQFDAVSHPEVQPMA  476

         ************************************************************

S: 306   ysngll  311

         y+n+ +

Q: 477   YANSFM  482

         ***976

Domain Sequence
(FASTA)

AFMENLVQTF KKQGKLHRRY AYKILLEVKQ ILASLPSLVD IVVEKDNKLT VCGDVHGQYY 60

DLCHVFDING LPSLDNPYLF NGDFVDRGSW SVEVILVLLG YKVLYPHNFH LVRGNHETDY 120

MNQMYGFEGE VKAKYDGMMM QLFSEVFNWL PLSYCVNRKV LIMHGGLMEQ DNVTLEDLRS 180

IDRNRQPPES GLMCDLLWSD PQMQSGRGPS KRGVSCQFGP DITSKFLKHN ELDYIIRSHE 240

CKNGGYEEQH NGKCITIFSA PNYCDQMGNK GAFITLRSPD LKPKFTQFDA VSHPEVQPMA 300

YANSFM 306

Keyword

Complete proteome; Hydrolase; Iron; Metal-binding; Reference proteome; Repeat; TPR repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.
IPR011236	; Ser/Thr_PPase_5.
IPR001440	; TPR-1.
IPR013026	; TPR-contain_dom.
IPR011990	; TPR-like_helical.
IPR019734	; TPR_repeat.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.
PF00515	; TPR_1; 1.

SMARTs

SM00156	; PP2Ac; 1.
SM00028	; TPR; 3.

Prosites

PS00125	; SER_THR_PHOSPHATASE; 1.
PS50005	; TPR; 2.
PS50293	; TPR_REGION; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013