EPS-CIS-00005

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CIS-00005

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	234.7	1.5E-69	24	292	269

Status

Unreviewed

Ensembl Protein

ENSCSAVP00000013711

UniProt Accession

H2Z7Z9;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCSAVG00000008039	ENSCSAVP00000013711	ENSCSAVT00000013869

Organism

Ciona savignyi

Functional Description

Protein Length

384

Protein Sequence
(FASTA)

MGAFLDKPKI EKQIEEGKGN ALEYAVSSMQ GWRVDMEDSH TAKLSLPGLP SWSFFAVFDG 60

HAGSKVAEHS SEHLLDSILS HANFKKIIES SEKGKIEDEK LVKKAIVDSF LLFDHKMRNI 120

SDAKTGFDRS GSTCVCVLIT PHRFYFINCG DSRGLLCRQG TVEFATLDHK PCNPLERERI 180

QNAGGNVLIQ RVNGSLAVSR ALGDYEYKNV EDKSQTEQLV SPEPDITCIE RSFKEDEFII 240

LACDGIFDVS NNEELTSYVL SRLAITDNLV TVCNDVVDMS LNKGSRDNMT LVLLALPSIP 300

KPDEKAKEEE AKLDEQLRVL MKDVRNTRGE NMDFSYILQT LITDESKIQG LPPGGGIYSK 360

RAFLEKVYKE LYPDENPTSP GSMN 384

Nucleotide Sequence
(FASTA)

ATGGGGGCAT TTTTAGATAA ACCGAAGATA GAGAAGCAAA TTGAAGAGGG GAAAGGGAAT 60

GCACTGGAAT ATGCAGTGAG CAGTATGCAA GGTTGGAGGG TAGACATGGA AGACAGCCAC 120

ACTGCTAAAC TGTCATTGCC AGGGCTCCCA TCATGGTCAT TTTTTGCCGT TTTCGATGGA 180

CATGCTGGCT CTAAAGTTGC AGAGCATTCA TCTGAACACC TGCTGGACAG CATTCTCTCT 240

CATGCCAACT TTAAAAAGAT TATTGAGTCC AGTGAAAAGG GCAAAATAGA AGATGAGAAG 300

TTGGTAAAAA AGGCGATTGT TGATTCATTT CTCCTTTTTG ACCACAAGAT GCGAAACATC 360

TCTGACGCGA AAACGGGATT CGACAGGAGT GGATCAACTT GCGTTTGTGT GCTTATCACG 420

CCCCATCGCT TTTATTTTAT AAACTGTGGT GACTCTAGGG GTCTGCTGTG TCGACAGGGA 480

ACAGTTGAAT TTGCAACACT AGACCATAAA CCGTGTAATC CACTTGAAAG AGAGCGAATC 540

CAAAACGCCG GTGGAAACGT TCTTATCCAG CGTGTGAATG GCTCCCTGGC TGTGTCACGT 600

GCTCTCGGCG ACTATGAGTA CAAAAATGTG GAGGACAAAT CTCAAACAGA ACAATTGGTC 660

TCTCCGGAAC CAGACATAAC ATGCATTGAA CGTTCATTCA AAGAAGATGA ATTTATTATA 720

TTAGCATGTG ACGGAATTTT CGATGTCTCC AACAATGAGG AATTAACGAG CTATGTATTA 780

TCTCGGTTAG CAATCACCGA TAACCTTGTG ACAGTGTGCA ACGATGTCGT TGATATGAGT 840

TTAAATAAAG GAAGCCGTGA CAACATGACC CTCGTTCTAC TTGCTCTTCC ATCAATTCCA 900

AAACCAGATG AAAAAGCTAA AGAAGAAGAA GCTAAGCTTG ATGAACAACT GAGAGTTCTA 960

ATGAAAGATG TGAGAAACAC AAGAGGTGAA AACATGGACT TTTCATACAT TTTACAAACT 1020

TTAATTACGG ATGAAAGTAA GATACAAGGC CTTCCTCCTG GTGGTGGCAT CTACTCCAAG 1080

CGTGCTTTTC TGGAGAAAGT GTATAAAGAG CTTTACCCAG ATGAAAACCC AACGAGTCCA 1140

GGATCTATGA AT 1152

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheila  62

         + v+s++g+r +med++t++ ++   p+    ++ff+v+DGh+gs+va+  se+l + +

Q: 24    YAVSSMQGWRVDMEDSHTAKLSLPGLPS----WSFFAVFDGHAGSKVAEHSSEHLLDSIL  79

         7899*************98666655554....9************************999

S: 63    eele..........sseseerkvkkalakaFlstdeelkvleeksldidksGstavvali  112

            +           + ++e+ vkka+ ++Fl +d ++++++++++  d+sGst+v++li

Q: 80    SHANfkkiiessekGKIEDEKLVKKAIVDSFLLFDHKMRNISDAKTGFDRSGSTCVCVLI  139

         998899998888776667888899************************************

S: 113   kdsklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvL  172

         ++  +y++n+GdSr +Lcr+g++   + dHkp ++ E+eRi++agg+v  +   Rv+G+L

Q: 140   TPHRFYFINCGDSRGLLCRQGTVEFATLDHKPCNPLERERIQNAGGNVLIQ---RVNGSL  196

         **************************************************9...******

S: 173   avsRalGdlylk.........pyvtpePevtshrlt.sedefliLasDGlwdvvsneeav  222

         avsRalGd+++k         ++v+peP++t ++++ +edef+iLa+DG++dv +nee+

Q: 197   AVSRALGDYEYKnvedksqteQLVSPEPDITCIERSfKEDEFIILACDGIFDVSNNEELT  256

         ***********************************638888*******************

S: 223   slvrdvlekkeaeqeaakkLvklalargskdnvsai  258

         s+v ++l  ++++ ++++ +v+++l++gs+dn++ +

Q: 257   SYVLSRLAITDNLVTVCNDVVDMSLNKGSRDNMTLV  292

         *********************************766

Domain Sequence
(FASTA)

YAVSSMQGWR VDMEDSHTAK LSLPGLPSWS FFAVFDGHAG SKVAEHSSEH LLDSILSHAN 60

FKKIIESSEK GKIEDEKLVK KAIVDSFLLF DHKMRNISDA KTGFDRSGST CVCVLITPHR 120

FYFINCGDSR GLLCRQGTVE FATLDHKPCN PLERERIQNA GGNVLIQRVN GSLAVSRALG 180

DYEYKNVEDK SQTEQLVSPE PDITCIERSF KEDEFIILAC DGIFDVSNNE ELTSYVLSRL 240

AITDNLVTVC NDVVDMSLNK GSRDNMTLV 269

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013