EKS-CIS-00119

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CIS-00119

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	390.8	2.3E-117	361	610	250

Status

Unreviewed

Ensembl Protein

ENSCSAVP00000017508

UniProt Accession

H2ZIT9;

Protein Name

Protein Synonyms/Alias

Gene Name

Csa.1818

Gene Synonyms/Alias

Csa.1818;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCSAVG00000010310	ENSCSAVP00000017511	ENSCSAVT00000017702
ENSCSAVG00000010310	ENSCSAVP00000017512	ENSCSAVT00000017703
ENSCSAVG00000010310	ENSCSAVP00000017510	ENSCSAVT00000017701
ENSCSAVG00000010310	ENSCSAVP00000017507	ENSCSAVT00000017698
ENSCSAVG00000010310	ENSCSAVP00000017506	ENSCSAVT00000017697
ENSCSAVG00000010310	ENSCSAVP00000017509	ENSCSAVT00000017700
ENSCSAVG00000010310	ENSCSAVP00000017508	ENSCSAVT00000017699
ENSCSAVG00000010310	ENSCSAVP00000017503	ENSCSAVT00000017694
ENSCSAVG00000010310	ENSCSAVP00000017505	ENSCSAVT00000017696
ENSCSAVG00000010310	ENSCSAVP00000017504	ENSCSAVT00000017695

Organism

Ciona savignyi

Functional Description

Protein Length

618

Protein Sequence
(FASTA)

MDESEIKVGA MTKRSQQKRS YGPVNFKERV FVLTQSKLSY YEGTIYKRGK VKGSFPVSTI 60

TFVGPINDRA LNRKSSFQVR LTSIIHNDCY LYCCTRSQDE RNEWINAIKQ VCQSQNNFLK 120

DHYHPDIYNN GMWQCCNHSE KNARGCQTSG DAQPHAPGPL PKDTVRHDQE TTVVALYDFT 180

PQESGDVALT MGETYTVTDT SRPYWWKVRN KRGEEGYIPA NFVKYQTGDG LETMSWFQKD 240

MTRQRAEYLL KQDGKEGNFI VRDSSQPSVI YTLSVVTKGG QIKGPVVVKH YHIKKNSCDE 300

FYLSEKHSMP NIIDLINYHK HNAGGLVTRL RQAPLSLEGN PQPSTHMFSN SKWEIDFNEL 360

DFHSELGSGQ FGVVKLATIR GKQYVAVKIM KEGTMEEDQF IEEAEVMTKL THPNLVGLYG 420

VVVQQRPICI VTEFMEEGCL LDYIRKHTHL QSHPDHLLDM SYQICSAMKY LESQNMIHRD 480

LAARNCLVGR NMVVKVADFG LTRYVLDDEY TSSLGSKFPI KWAAPEVLNY TKFSSKSDVW 540

AFGILVWELF TGGKMPYRAL SNTEVVERVA HGHRLERPQS CPHDVYRLML KTWDMEPEKR 600

PSFNNLCYEV EDIIDVVN 618

Nucleotide Sequence
(FASTA)

ATGGACGAAT CTGAGATCAA AGTTGGTGCG ATGACAAAAC GGTCTCAGCA GAAGAGAAGT 60

TATGGACCGG TTAACTTTAA AGAGAGGGTA TTTGTTCTTA CTCAAAGCAA ACTGTCCTAC 120

TATGAAGGTA CTATATATAA ACGGGGTAAA GTAAAAGGAA GTTTTCCAGT ATCAACCATC 180

ACCTTTGTTG GTCCAATCAA TGATAGAGCT TTAAACAGAA AAAGTTCATT TCAGGTAAGA 240

TTAACATCAA TAATTCACAA TGATTGCTAC CTGTACTGCT GCACAAGGAG CCAAGACGAA 300

AGAAATGAAT GGATTAATGC AATCAAACAA GTTTGTCAAT CACAGAATAA CTTTTTGAAA 360

GACCATTACC ACCCCGATAT ATATAATAAT GGAATGTGGC AGTGTTGTAA CCATTCCGAG 420

AAAAATGCCA GAGGGTGTCA GACATCTGGC GATGCCCAAC CCCATGCCCC CGGACCACTA 480

CCTAAAGATA CAGTGAGACA TGACCAAGAA ACCACTGTGG TCGCGCTTTA CGATTTTACG 540

CCTCAGGAAA GTGGAGATGT TGCACTAACC ATGGGAGAGA CATATACAGT AACAGATACA 600

AGTCGTCCAT ATTGGTGGAA AGTGCGCAAC AAGCGTGGAG AAGAGGGTTA TATTCCGGCT 660

AACTTTGTCA AGTACCAAAC AGGAGATGGT CTTGAAACTA TGAGTTGGTT CCAGAAAGAC 720

ATGACTCGCC AGCGTGCAGA ATATTTGCTG AAACAAGATG GGAAAGAAGG GAATTTTATT 780

GTGAGGGATT CTTCCCAGCC ATCAGTTATT TACACACTGT CTGTTGTCAC TAAAGGGGGG 840

CAAATCAAAG GACCAGTGGT AGTGAAGCAT TATCACATCA AGAAGAACAG CTGCGATGAG 900

TTCTATCTGT CGGAAAAGCA TTCCATGCCC AATATCATAG ACCTCATCAA CTATCACAAG 960

CACAATGCTG GAGGTTTGGT GACCCGCTTA CGACAAGCCC CGTTATCATT GGAGGGAAAT 1020

CCCCAACCAT CCACACATAT GTTCAGCAAC TCCAAATGGG AAATAGATTT CAATGAATTA 1080

GATTTCCACA GTGAACTTGG AAGTGGTCAA TTTGGAGTGG TGAAGCTTGC GACTATACGT 1140

GGGAAGCAGT ATGTTGCCGT GAAGATTATG AAAGAGGGAA CAATGGAAGA GGATCAGTTC 1200

ATTGAGGAAG CTGAAGTTAT GACGAAGCTC ACTCATCCCA ACCTGGTTGG TTTGTATGGG 1260

GTGGTTGTCC AACAACGACC CATTTGTATC GTCACTGAGT TTATGGAGGA AGGGTGTTTG 1320

TTGGATTACA TCAGGAAGCA CACGCATTTG CAGAGTCACC CTGATCATCT GCTTGATATG 1380

TCATACCAGA TCTGCTCTGC CATGAAATAT CTGGAGTCGC AGAACATGAT CCACCGAGAC 1440

CTTGCAGCTC GAAATTGTTT AGTTGGTCGG AACATGGTAG TGAAGGTGGC AGACTTTGGT 1500

CTCACCAGGT ATGTGTTGGA TGACGAATAC ACTAGCTCGC TTGGTAGTAA ATTCCCGATC 1560

AAATGGGCTG CCCCAGAGGT GTTGAACTAC ACAAAATTCA GCTCAAAATC TGATGTGTGG 1620

GCATTTGGAA TACTCGTGTG GGAGTTGTTT ACTGGTGGCA AGATGCCGTA TCGAGCACTG 1680

AGCAACACTG AGGTTGTGGA ACGTGTGGCT CATGGACACC GATTGGAGCG TCCACAAAGC 1740

TGTCCCCATG ATGTGTACCG CCTTATGTTG AAAACATGGG ACATGGAGCC GGAGAAAAGA 1800

CCTTCTTTTA ACAACCTCTG CTACGAGGTG GAAGATATCA TCGATGTAGT GAAC 1854

Domain Profile

S: 2     tllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqlyg  61

          +  elgsgqfgvvkl   r+k+ va+k++keg+m e++fieea+vm+kl+hp+lv lyg

Q: 361   DFHSELGSGQFGVVKLATIRGKQYVAVKIMKEGTMEEDQFIEEAEVMTKLTHPNLVGLYG  420

         5788********************************************************

S: 62    vclkqkpiyivteylengcllnylrekkkkl.ekelllemckdvcegmeylerksfihrd  120

         v ++q+pi+ivte++e+gcll+y+r++ +   + ++ll+m +++c +m+yle++++ihrd

Q: 421   VVVQQRPICIVTEFMEEGCLLDYIRKHTHLQsHPDHLLDMSYQICSAMKYLESQNMIHRD  480

         **************************9886515678************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv++++vvkv+dfgl+ryvldd+y+ss g+kfp+kw++pevl+y+k+ssksdvw

Q: 481   LAARNCLVGRNMVVKVADFGLTRYVLDDEYTSSLGSKFPIKWAAPEVLNYTKFSSKSDVW  540

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         afg+l+we+f+ gk+py   sn+evve+v++g+rl+rp+++++ vy++m + w+ +pe+r

Q: 541   AFGILVWELFTGGKMPYRALSNTEVVERVAHGHRLERPQSCPHDVYRLMLKTWDMEPEKR  600

         ************************************************************

S: 241   ptfkellsal  250

         p+f++l  ++

Q: 601   PSFNNLCYEV  610

         *****98776

Domain Sequence
(FASTA)

DFHSELGSGQ FGVVKLATIR GKQYVAVKIM KEGTMEEDQF IEEAEVMTKL THPNLVGLYG 60

VVVQQRPICI VTEFMEEGCL LDYIRKHTHL QSHPDHLLDM SYQICSAMKY LESQNMIHRD 120

LAARNCLVGR NMVVKVADFG LTRYVLDDEY TSSLGSKFPI KWAAPEVLNY TKFSSKSDVW 180

AFGILVWELF TGGKMPYRAL SNTEVVERVA HGHRLERPQS CPHDVYRLML KTWDMEPEKR 240

PSFNNLCYEV 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013