EKS-CIS-00095

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CIS-00095

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	365.4	2.8E-109	603	910	308

Status

Unreviewed

Ensembl Protein

ENSCSAVP00000018674

UniProt Accession

H2ZM58;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCSAVG00000010972	ENSCSAVP00000018674	ENSCSAVT00000018878

Organism

Ciona savignyi

Functional Description

Protein Length

946

Protein Sequence
(FASTA)

AGAVAVRGVE ATPEIQLTLL ESTGALQDAA ACYERIIQRS PGLLPYQEGY IKCLIDLGQL 60

STAANYIDGT LASNPQWEEA LKASRIEACW RLGQWESLDD HVTSVSMTTR DPMTTWSAGI 120

GRLLLAIRAK EWNNVTSLLD GLYENQTAPL SAASMGNGSY QRGYAYILRL HMLADMERVT 180

ELVKQEEITS QVVEDITSMW HLRLQAVQPS FRAREPILSL SRAMLPLVAP SECNKNLGKL 240

WLQSSKLARK SAYGWSASLP SNTHLPQYCI EHAKLLWHKG ESHRALQTLQ RGVSEYFSSS 300

DSLDCEQRRT RAKVMLLVAK LMEESSSFDS NMVLRQYKEV VSYMNDWEDS HFYCAKYYDK 360

LMTTLLGDNR SVGKSHHLYY IMHHYGQALC YGTTHIYEPL TKLLTVWLDY GTNAAKLEKQ 420

GKPQSQEDIQ RLLDVMSNLR NKLPAHIFYV AFSQLTSRIC HPHEPTYSEL KEILVKVIQN 480

FPQRALWAMM AISKSSYEQR ATRCQEIFKR VTYKDPSLLK MVSDTTKLTN QLLQLCNKPV 540

SNVQPLSINT HFKSLKKLVE EPSFSEIMLP LQKFLTATLP QRKNTVFGSQ AKHNPFPLST 600

VHIVGFNDQV EILSSLQRPK KVSIRASDGT SHTFLCKPKD DLRKDARLTE FAAIVNKCLD 660

RDAESGRRHL RIRTYAVVPL NEECGLIEWV NNTVVFRHIV LPIYKARKLH TTGMQLKSWQ 720

CLVSDPLQKK LDIFRNKLLP RHPPVFHEWF LSTFPDPSTW YNARLAYARS LAVMSMVGYI 780

LGLGDRHGEN ILFDSKSGEA MHVDFNCLFN KGQTLEVPEI VPFRLTHNLV NAMGPTKYEG 840

FFRRACEVTM NVLREQREPL MSVLKTFIHD PLVEWSRRGR SSSSSSADTN EKALSHVNDI 900

DKRLRGIIAK NKGLPLSIEG HVHYLIQEAT SEENLCQMYI GWAPFM 946

Nucleotide Sequence
(FASTA)

GCAGGTGCCG TGGCGGTGCG TGGTGTTGAA GCCACGCCAG AGATACAACT TACACTGCTG 60

GAGAGCACAG GAGCATTGCA GGACGCAGCA GCCTGCTACG AACGGATCAT CCAAAGATCC 120

CCAGGATTGC TCCCGTACCA AGAAGGATAT ATCAAGTGTT TGATCGACTT GGGACAACTA 180

TCCACTGCCG CCAACTATAT CGATGGAACA TTGGCTTCCA ACCCACAATG GGAGGAAGCC 240

TTGAAAGCTT CTAGAATCGA AGCTTGCTGG AGACTCGGCC AATGGGAGAG CTTGGATGAT 300

CATGTGACCT CAGTTTCCAT GACGACTCGT GACCCCATGA CCACATGGAG TGCTGGAATC 360

GGTCGATTGC TGCTGGCTAT CCGTGCTAAA GAGTGGAATA ATGTCACCAG TCTACTCGAT 420

GGGTTATATG AGAATCAAAC GGCCCCACTA TCGGCTGCGA GCATGGGGAA TGGGTCCTAC 480

CAGCGTGGAT ACGCTTACAT ACTACGGCTC CACATGCTCG CTGACATGGA AAGGGTCACT 540

GAACTGGTGA AGCAGGAAGA AATAACCAGC CAAGTTGTAG AGGATATCAC TTCCATGTGG 600

CATCTGCGCT TGCAAGCAGT TCAACCATCG TTCCGCGCTA GAGAGCCTAT ACTGTCGCTC 660

AGTCGAGCTA TGCTGCCTCT AGTCGCTCCG TCAGAATGCA ATAAAAACCT TGGAAAGCTT 720

TGGCTTCAAA GCTCAAAACT CGCTCGCAAA TCTGCGTATG GTTGGTCTGC TAGTCTGCCC 780

AGCAATACCC ATCTACCTCA ATATTGCATT GAACACGCCA AACTCCTGTG GCACAAGGGT 840

GAAAGCCACA GAGCGTTGCA GACGTTACAA CGTGGGGTAA GCGAATATTT CTCCAGCTCC 900

GATTCCCTCG ACTGCGAGCA AAGGAGAACG AGGGCAAAGG TCATGCTCCT AGTGGCGAAA 960

CTGATGGAAG AATCGTCAAG TTTCGACAGC AACATGGTTC TCCGTCAGTA CAAGGAGGTT 1020

GTGAGTTACA TGAATGACTG GGAAGACTCC CACTTCTATT GCGCCAAATA TTACGACAAA 1080

CTGATGACAA CTCTCCTCGG GGATAATAGA AGTGTCGGCA AATCTCACCA CTTGTACTAC 1140

ATTATGCATC ACTACGGACA AGCGTTATGC TACGGCACAA CCCATATCTA TGAACCACTC 1200

ACCAAACTAC TCACTGTGTG GCTCGATTAT GGGACAAACG CCGCTAAGTT GGAAAAACAG 1260

GGGAAGCCCC AGAGTCAGGA AGACATCCAA AGATTGCTCG ACGTGATGTC CAACCTCCGG 1320

AACAAACTAC CAGCTCATAT TTTCTACGTC GCGTTCTCTC AACTCACATC ACGGATATGT 1380

CATCCTCATG AGCCAACTTA CTCAGAACTG AAGGAAATCC TTGTGAAAGT GATCCAGAAC 1440

TTTCCGCAGC GTGCTCTTTG GGCGATGATG GCGATATCTA AGTCTTCCTA CGAACAGCGA 1500

GCCACTAGAT GTCAGGAGAT TTTCAAACGA GTCACTTACA AAGACCCGAG TTTGTTGAAG 1560

ATGGTCTCGG ATACCACAAA ACTCACCAAC CAACTTCTCC AACTCTGCAA CAAACCTGTC 1620

AGCAACGTTC AACCACTGAG CATCAACACA CATTTCAAGT CGCTTAAAAA GCTGGTAGAG 1680

GAGCCAAGCT TCAGCGAGAT AATGCTACCG CTCCAAAAGT TCCTGACAGC CACCTTGCCA 1740

CAGAGGAAAA ACACAGTGTT TGGCTCACAG GCCAAGCACA ACCCATTTCC ACTCTCCACA 1800

GTTCATATTG TTGGCTTCAA TGACCAGGTT GAAATTTTAT CATCGCTCCA ACGGCCGAAG 1860

AAAGTGTCAA TCCGAGCGAG TGACGGCACC TCGCACACGT TCCTTTGTAA ACCGAAGGAC 1920

GATCTGCGCA AAGACGCCCG GTTGACCGAG TTCGCCGCCA TCGTCAACAA ATGTTTGGAC 1980

AGAGACGCCG AGTCTGGTAG AAGACACCTG CGCATCCGGA CATATGCGGT GGTTCCCCTA 2040

AACGAGGAAT GTGGGTTAAT AGAATGGGTA AACAACACGG TGGTGTTCCG TCATATCGTG 2100

CTGCCCATCT ACAAAGCCAG GAAGCTACAT ACGACAGGAA TGCAGCTCAA GTCGTGGCAA 2160

TGCCTGGTGT CAGATCCTCT ACAGAAGAAG CTGGACATCT TCCGCAACAA ATTACTTCCC 2220

CGTCACCCTC CCGTGTTCCA CGAGTGGTTC CTCTCCACCT TCCCCGACCC GAGTACCTGG 2280

TACAACGCTC GTCTCGCATA CGCAAGGTCT CTTGCTGTCA TGTCTATGGT GGGGTACATT 2340

CTAGGATTAG GCGATCGTCA CGGTGAAAAT ATCCTTTTTG ACTCGAAGAG TGGAGAAGCT 2400

ATGCATGTCG ACTTCAACTG TTTGTTTAAT AAAGGACAAA CATTGGAGGT CCCAGAAATA 2460

GTCCCATTTC GCCTCACCCA CAATCTTGTC AACGCCATGG GTCCCACAAA GTATGAAGGA 2520

TTCTTTCGCC GTGCTTGTGA GGTCACAATG AATGTGTTGC GGGAACAAAG GGAACCGCTT 2580

ATGAGTGTAT TGAAGACCTT CATCCACGAT CCTCTGGTCG AGTGGAGTCG ACGTGGACGA 2640

AGCTCTTCCT CATCATCTGC TGACACCAAT GAGAAAGCGT TGTCACACGT CAATGATATC 2700

GATAAACGTC TGAGGGGAAT TATTGCAAAG AACAAAGGAC TTCCGTTGTC AATAGAAGGA 2760

CATGTTCATT ACCTTATTCA GGAGGCCACC AGCGAAGAAA ACTTGTGCCA GATGTATATT 2820

GGGTGGGCGC CTTTCATGTG A 2841

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         i gf+++veil+s+q+pkk+++r sdg ++ +L+k+k+Dlr+d+r+ ++  +vN++L +d

Q: 603   IVGFNDQVEILSSLQRPKKVSIRASDGTSHTFLCKPKDDLRKDARLTEFAAIVNKCLDRD  662

         679*********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

         +e+ rr+L irty+Vvpl++++gliewv+ntv  ++++  +++ ++             +

Q: 663   AESGRRHLRIRTYAVVPLNEECGLIEWVNNTVVFRHIVLPIYKARKLHTT--------GM  714

         **************************************988888777664........44

S: 121   stvqarkpklkhlklslevfkevlenlvpkdllkklllekfpspeewfelrkaytrslAv  180

         + +  +   ++ l+++l++f++ l +++p+ ++++++l++fp+p  w++ r ay+rslAv

Q: 715   QLKSWQCLVSDPLQKKLDIFRNKLLPRHPP-VFHEWFLSTFPDPSTWYNARLAYARSLAV  773

         444444556778889999***********8.*****************************

S: 181   islvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivna  240

         +s+vgyiLgLgdrh en+l+d+++ge +h+df++ f+k++t l+vpe+vPFRLT+n+vna

Q: 774   MSMVGYILGLGDRHGENILFDSKSGEAMHVDFNCLFNKGQT-LEVPEIVPFRLTHNLVNA  832

         *****************************************.******************

S: 241   lgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkkkkktsketeeelaek  300

         +g+t+ eG fr++ce +++vlre++e l+++L++f++dplv+w+   ++s+  + + +ek

Q: 833   MGPTKYEGFFRRACEVTMNVLREQREPLMSVLKTFIHDPLVEWSRRGRSSSSSSADTNEK  892

         ********************************************988999999999****

S: 301   akaealkikkllskveka  318

         a  +  +i k+l+++

Q: 893   ALSHVNDIDKRLRGIIAK  910

         ************999754

Domain Sequence
(FASTA)

IVGFNDQVEI LSSLQRPKKV SIRASDGTSH TFLCKPKDDL RKDARLTEFA AIVNKCLDRD 60

AESGRRHLRI RTYAVVPLNE ECGLIEWVNN TVVFRHIVLP IYKARKLHTT GMQLKSWQCL 120

VSDPLQKKLD IFRNKLLPRH PPVFHEWFLS TFPDPSTWYN ARLAYARSLA VMSMVGYILG 180

LGDRHGENIL FDSKSGEAMH VDFNCLFNKG QTLEVPEIVP FRLTHNLVNA MGPTKYEGFF 240

RRACEVTMNV LREQREPLMS VLKTFIHDPL VEWSRRGRSS SSSSADTNEK ALSHVNDIDK 300

RLRGIIAK 308

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0016301	; F:kinase activity
GO:0016773	; F:phosphotransferase activity, alcohol group as acceptor

KEGG

InterPros

IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR011990	; TPR-like_helical.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013