EKS-DAR-00545

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00545

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	428.3	2.1E-128	45	306	262

Status

Unreviewed

Ensembl Protein

ENSDARP00000020470

UniProt Accession

Q7T2F2;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase-activated protein kinase 2a;

Gene Name

mapkapk2a

Gene Synonyms/Alias

mapkapk2a;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000002552	ENSDARP00000020470	ENSDART00000027532

Organism

Danio rerio

Functional Description

Protein Length

382

Protein Sequence
(FASTA)

MLTNANSPPK FPNQQQQQQQ QNPPQFMLGK GSLQIKKNAI TDDYKITNQV LGLGINGRVL 60

EIFYKRSGEK LALKMLHDCP KARREVELHW RASSCTHIVK IVDVYENLYQ NRKCLLIVME 120

CMDGGELFSR IQDRGDQAFT EREASDIMKS IGEAIQYLHA INIAHRDVKP ENLLYTSKRP 180

NALLKLTDFG FAKETTTHNS LATPCYTPYY VAPEVLGPEK YDKSCDMWSL GVIMYILLCG 240

YPPFYSNHGL AISPGMKKRI RMGQYEFPNP EWSEVSEEAK QLIRTLLKTE PTQRMTITEF 300

MNHPWINQSM EVPQTPLHTS RVLKEEKDTW EDVKEEMTSA LATMRVDYEQ IKIKRIEDST 360

NPLLIKRRKK TTVAPENETP AC 382

Nucleotide Sequence
(FASTA)

ATGTTGACTA ACGCCAACAG TCCGCCGAAG TTTCCAAACC AACAGCAGCA ACAACAACAG 60

CAAAATCCAC CTCAGTTCAT GCTGGGAAAA GGATCGCTTC AGATCAAGAA AAATGCCATT 120

ACCGACGACT ACAAGATCAC TAACCAGGTG CTGGGACTGG GCATCAATGG CAGAGTGCTA 180

GAGATCTTTT ACAAGAGGAG TGGAGAGAAG CTCGCTTTAA AGATGCTTCA TGACTGCCCA 240

AAAGCTAGAC GAGAGGTGGA ACTGCACTGG CGGGCCTCGT CCTGTACCCA TATCGTCAAA 300

ATTGTTGACG TCTATGAAAA TCTCTACCAA AACAGGAAGT GCCTTCTTAT TGTAATGGAG 360

TGTATGGACG GAGGTGAGCT CTTCAGTCGG ATCCAGGATA GAGGGGACCA GGCATTCACT 420

GAGAGAGAGG CTTCTGATAT TATGAAGAGC ATAGGAGAGG CCATTCAGTA TTTACATGCG 480

ATAAACATCG CACACAGAGA CGTTAAGCCA GAGAACCTTT TATATACCTC TAAAAGGCCA 540

AACGCCCTTC TCAAACTGAC AGACTTCGGA TTTGCAAAGG AGACCACCAC ACACAACTCT 600

CTGGCCACCC CCTGCTATAC TCCTTATTAT GTTGCCCCAG AGGTGCTTGG TCCAGAAAAG 660

TATGACAAGT CCTGTGACAT GTGGTCTTTG GGTGTCATCA TGTATATTCT ACTCTGCGGT 720

TACCCTCCTT TCTATTCGAA TCATGGATTG GCAATATCTC CTGGTATGAA GAAACGAATC 780

CGAATGGGAC AGTATGAGTT TCCAAATCCT GAGTGGTCGG AAGTGTCAGA GGAAGCCAAG 840

CAGCTTATCA GAACATTACT GAAAACGGAG CCAACACAGA GGATGACCAT AACAGAGTTT 900

ATGAACCACC CTTGGATCAA TCAATCAATG GAGGTTCCAC AGACACCCCT ACACACCAGC 960

CGTGTTTTGA AAGAAGAGAA AGACACATGG GAAGATGTCA AGGAGGAAAT GACTAGTGCC 1020

TTGGCAACAA TGAGAGTCGA CTATGAGCAA ATCAAAATCA AGAGGATTGA AGACTCGACC 1080

AATCCGCTGC TGATAAAGAG GAGAAAGAAA ACCACCGTAG CTCCTGAAAA CGAGACTCCT 1140

GCTTGTTAA 1149

Domain Profile

S: 1     klteevlGeGisgkvlecvkkktgekyalkilkdrkkvrrevelhvqasghknivelidv  60

         k+t++vlG Gi+g+vle++ k++gek alk+l+d++k+rrevelh++as++++iv+++dv

Q: 45    KITNQVLGLGINGRVLEIFYKRSGEKLALKMLHDCPKARREVELHWRASSCTHIVKIVDV  104

         5899********************************************************

S: 61    fensfedekrlllvlekleGGellsriqer..kaftekeasevvkdiasalkflhsknia  118

         +en ++++k+ll+v+e+++GGel+sriq+r  +afte+eas+++k+i++a+++lh  nia

Q: 105   YENLYQNRKCLLIVMECMDGGELFSRIQDRgdQAFTEREASDIMKSIGEAIQYLHAINIA  164

         *******************************9****************************

S: 119   hrDlkpenlLyeskeknapvklcDfglaketeeeeelktpcltaeyvaPevleaekeeal  178

         hrD+kpenlLy+sk+ na +kl+Dfg+aket+++++l+tpc+t++yvaPevl++ek

Q: 165   HRDVKPENLLYTSKRPNALLKLTDFGFAKETTTHNSLATPCYTPYYVAPEVLGPEK----  220

         ********************************************************....

S: 179   lydksCDlWslGvilyillcGypPfyskkgraiskklkeriqegkyefPeeeWsevseea  238

          ydksCD+WslGvi+yillcGypPfys++g ais+++k+ri++g+yefP++eWsevseea

Q: 221   -YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKKRIRMGQYEFPNPEWSEVSEEA  279

         .***********************************************************

S: 239   kdlirklLkrdpkerltieevlnhpwv  265

         k+lir+lLk++p++r+ti+e++nhpw+

Q: 280   KQLIRTLLKTEPTQRMTITEFMNHPWI  306

         **************************8

Domain Sequence
(FASTA)

KITNQVLGLG INGRVLEIFY KRSGEKLALK MLHDCPKARR EVELHWRASS CTHIVKIVDV 60

YENLYQNRKC LLIVMECMDG GELFSRIQDR GDQAFTEREA SDIMKSIGEA IQYLHAINIA 120

HRDVKPENLL YTSKRPNALL KLTDFGFAKE TTTHNSLATP CYTPYYVAPE VLGPEKYDKS 180

CDMWSLGVIM YILLCGYPPF YSNHGLAISP GMKKRIRMGQ YEFPNPEWSE VSEEAKQLIR 240

TLLKTEPTQR MTITEFMNHP WI 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0016301	; F:kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0055113	; P:epiboly involved in gastrulation with mouth forming second

KEGG

dre:327321

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013