| Tag | Content |
|---|
| EKPD ID | EKS-DAR-00084 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CMGC/CDK | 347.4 | 1.2E-103 | 4 | 288 | 285 |
|
| Status | Reviewed |
| Ensembl Protein | ENSDARP00000113146 |
| UniProt Accession | A8WIP6; Q5PRE2; |
| Protein Name | Cyclin-dependent kinase 20 |
| Protein Synonyms/Alias | Cell cycle-related kinase; Cell division protein kinase 20; |
| Gene Name | cdk20 |
| Gene Synonyms/Alias | cdk20; ccrk; si:dkeyp-77f7.1, zgc:101530; |
| Ensembl Information | |
| Organism | Danio rerio |
| Functional Description | Involved in cell growth. Activates cdk2, a kinaseinvolved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with bromi, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing gli2 to be properly activated in response to SHH signaling. |
| Protein Length | 344 |
Protein Sequence
(FASTA) | | MDQYSILGRI GEGAHGIVFK AKHIETGETV ALKKVALRRL EDGIPNQALR EIKALQEIED 60 | | NQYVVKLKDV FPHGTGFVLV FEYMLSDLSE VIRNSQRPLT ASQVKSYMMM LLKGVAFCHE 120 | | NSIMHRDLKP ANLLISSTGH LKIADFGLAR LFSNEGDRLY SHQVATRWYR APELLYGARK 180 | | YDEGVDLWAV GCIFGELLNN SPLFPGENDI EQLCCVLRVL GTPNQKVWPE ITELPDYNKI 240 | | TFKENPPIPL EEIVPDTSPQ AVDLLKKFLV YPSKQRISAR QALLHPYFFT DPLPAHHSEL 300 | | PIPQRGGKHS RQRMQPPHEF TVDRPLHESV VDPSLIQKHA MSCS 344 |
|
Nucleotide Sequence
(FASTA) | | ATGGACCAGT ATAGTATTCT TGGCCGGATT GGGGAAGGAG CTCACGGGAT TGTTTTCAAA 60 | | GCCAAACACA TTGAGACAGG AGAGACAGTG GCTTTGAAAA AAGTGGCCCT GCGAAGACTT 120 | | GAAGATGGCA TCCCGAACCA GGCGTTAAGA GAAATTAAAG CCCTGCAAGA GATTGAGGAC 180 | | AACCAATATG TTGTGAAGCT GAAGGACGTC TTCCCTCACG GCACAGGCTT TGTGCTGGTG 240 | | TTCGAGTACA TGTTATCAGA TCTGTCAGAA GTCATAAGGA ATTCCCAGCG TCCTCTCACC 300 | | GCATCCCAGG TCAAAAGTTA TATGATGATG CTGCTGAAAG GAGTGGCTTT CTGCCACGAG 360 | | AACTCCATCA TGCATAGGGA TCTGAAGCCT GCAAACCTTC TGATCAGCTC GACTGGTCAT 420 | | CTGAAAATCG CTGACTTTGG TCTGGCAAGG CTTTTTTCCA ATGAAGGAGA TCGTCTTTAC 480 | | AGTCACCAAG TGGCCACCAG ATGGTACAGA GCACCAGAAC TTTTATACGG TGCCCGAAAA 540 | | TATGACGAAG GAGTTGATCT CTGGGCTGTG GGCTGCATTT TCGGAGAGCT TTTGAATAAC 600 | | TCTCCACTTT TCCCTGGGGA GAATGACATT GAACAGTTGT GTTGTGTGCT CAGAGTGCTG 660 | | GGAACTCCCA ACCAGAAAGT CTGGCCGGAG ATAACCGAAC TACCAGACTA CAACAAGATC 720 | | ACATTTAAAG AAAACCCACC CATTCCTTTG GAGGAGATCG TACCTGACAC GTCACCACAA 780 | | GCTGTAGACC TGCTGAAGAA GTTTCTGGTC TATCCATCCA AACAGAGGAT CAGTGCTAGA 840 | | CAGGCTTTGC TCCATCCATA TTTCTTCACG GATCCGCTCC CGGCTCATCA TTCAGAGCTG 900 | | CCCATTCCTC AGCGTGGAGG AAAACACTCC AGACAGCGCA TGCAGCCGCC GCACGAGTTC 960 | | ACCGTCGATC GGCCTTTACA CGAGAGCGTG GTGGACCCGA GTCTCATCCA GAAGCATGCC 1020 | | ATGAGCTGTT CATGA 1035 |
|
| Domain Profile | S: 1 yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkel.khkn 59 | y+ l +igeG++g v+kak+ etge+vAlKk++l + ++g+p +alrEi+ l+e+ ++++ | Q: 4 YSILGRIGEGAHGIVFKAKHIETGETVALKKVALRRLEDGIPNQALREIKALQEIeDNQY 63 | 778899*************************************************77899 |
| S: 60 ivkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsn 119 | +vkL++v+ + + ++Lvfe++ +dL+++++++++ l+ ++vks++++ll+g+a++H+n | Q: 64 VVKLKDVFP-HGTGFVLVFEYMLSDLSEVIRNSQR-PLTASQVKSYMMMLLKGVAFCHEN 121 | *********.99********************999.************************ |
| S: 120 kilHRDlKpqNlLiskegklklaDfGlarafssplkt.ytkevvTlwYraPelLlgakeY 178 | +i+HRDlKp+NlLis++g+lk+aDfGlar fs++ ++ y+++v T+wYraPelL+ga++Y | Q: 122 SIMHRDLKPANLLISSTGHLKIADFGLARLFSNEGDRlYSHQVATRWYRAPELLYGARKY 181 | *******************************8888755********************** |
| S: 179 stavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ks 237 | ++ vD+W+vgci+ ell+++plf+g+++i+ql ++++lgtp++kvwpe+++lp+y+ + | Q: 182 DEGVDLWAVGCIFGELLNNSPLFPGENDIEQLCCVLRVLGTPNQKVWPEITELPDYNkIT 241 | *********************************************************789 |
| S: 238 fpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf 284 | f+++++ l+e v++++ +a+dll+k+l + k+Risa++al h+yf | Q: 242 FKENPPIPLEEIVPDTSPQAVDLLKKFLVYPSKQRISARQALLHPYF 288 | 9999999***************************************9 |
|
Domain Sequence
(FASTA) | | YSILGRIGEG AHGIVFKAKH IETGETVALK KVALRRLEDG IPNQALREIK ALQEIEDNQY 60 | | VVKLKDVFPH GTGFVLVFEY MLSDLSEVIR NSQRPLTASQ VKSYMMMLLK GVAFCHENSI 120 | | MHRDLKPANL LISSTGHLKI ADFGLARLFS NEGDRLYSHQ VATRWYRAPE LLYGARKYDE 180 | | GVDLWAVGCI FGELLNNSPL FPGENDIEQL CCVLRVLGTP NQKVWPEITE LPDYNKITFK 240 | | ENPPIPLEEI VPDTSPQAVD LLKKFLVYPS KQRISARQAL LHPYF 285 |
|
| Keyword | ATP-binding; Cell cycle; Cell division; Cell projection; Cilium; Complete proteome; Cytoplasm; Developmental protein; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |