EKS-DAR-00355
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00355
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec446.16.3E-134381631251
StatusUnreviewed
Ensembl ProteinENSDARP00000124430
UniProt AccessionE7F4S0;
Protein Name
Protein Synonyms/Alias
Gene Namebtk
Gene Synonyms/Alias btk;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000004433ENSDARP00000027383ENSDART00000009758
ENSDARG00000004433ENSDARP00000124430ENSDART00000148737
OrganismDanio rerio
Functional Description
Protein Length640
Protein Sequence
(FASTA)
MADRVLEEVF IKRSQQKKKT SPLNFKERLF VLTHDKISYY DYDAEKAKRK SLKGYVDIEK 60
IRCVEVVLPE DSAPPDRHYP FQIVYDEGPL YVFAKSDQIR KHWIHELKNV VRFNKDLMQK 120
YHPCFWEDGV WKCCLQEVKQ AMGCRVLETK NGGVFKRGSK NRDSRKPLPP TPEEEKPARP 180
LPPEPPMPPA FSIGMTVIAE YEYAPMTTND LELRKDEEYT LLEISDPNWF KAKDKYGKEG 240
YIPSNYIVQA LNGLEKYDWY CKNINRSQAE NLLKTENKDG GFLVRDSGKF TGKYTVSVFT 300
KAGGETSGSC RHYNILLTAD GQFYLAEKHN FTNIPELINY HQHNAAGLVS RLKYIVSNRA 360
QNAPCTAGLG YGSWEIDPRQ LTFIRELGNG QFGVVKYGKW QGRHDVAIKM VKEGSMSEDD 420
FIEEAKVMMK LCHGNLVQLY GVCTKQRPIY IVTEYLANGC LLNYLQEGLL NPTSIALLEM 480
CKDVSEGMKY LEANQFIHRD LAARNCLVDS NGTIKVTDFG LSRYVLDDEY TSSVGSKFPV 540
RWSPPEVLLY CKFSSKSDIW AFGVLMWEIY TQGRMPYDRW NNTEIVEKIS AGHRLYRPQM 600
ANENVFAIMN SCWHERPDER PTFQELVGVI KDLLFSMQEI 640
Nucleotide Sequence
(FASTA)
ATGGCAGACA GAGTTCTGGA GGAGGTTTTC ATAAAGCGGT CCCAGCAGAA GAAAAAGACC 60
TCGCCTTTAA ACTTTAAAGA ACGGCTGTTT GTACTCACAC ATGATAAGAT CTCCTACTAT 120
GACTATGATG CTGAAAAAGC GAAAAGGAAA AGCCTGAAAG GTTATGTGGA CATTGAAAAG 180
ATCAGATGTG TGGAGGTTGT TTTACCAGAA GACAGTGCAC CTCCTGACCG GCACTACCCA 240
TTTCAGATTG TCTATGATGA AGGCCCTCTT TATGTATTTG CGAAGTCAGA TCAAATCCGA 300
AAGCACTGGA TACATGAACT TAAAAATGTG GTGCGGTTCA ACAAGGACCT GATGCAGAAG 360
TACCACCCTT GTTTTTGGGA AGACGGCGTG TGGAAGTGTT GCCTTCAGGA GGTCAAGCAG 420
GCTATGGGAT GCAGGGTGCT GGAGACCAAA AATGGAGGGG TTTTCAAAAG AGGATCTAAG 480
AACCGCGATT CCAGGAAGCC TCTTCCACCA ACACCTGAGG AGGAAAAGCC AGCCCGGCCT 540
TTGCCCCCCG AGCCGCCCAT GCCTCCTGCC TTCAGCATAG GCATGACCGT TATAGCTGAA 600
TACGAATACG CACCAATGAC TACCAATGAC TTAGAGCTGA GAAAGGATGA GGAGTACACA 660
CTTTTGGAAA TCTCTGATCC CAATTGGTTT AAAGCTAAAG ATAAATACGG AAAGGAAGGC 720
TACATACCGA GTAACTACAT CGTTCAGGCT TTAAATGGAT TGGAGAAATA TGATTGGTAC 780
TGCAAGAACA TCAACCGCAG TCAGGCAGAA AATTTACTAA AAACAGAAAA CAAAGATGGC 840
GGTTTCTTGG TGAGAGACTC TGGCAAATTC ACTGGAAAAT ACACTGTTTC TGTGTTCACC 900
AAGGCTGGAG GGGAGACTTC TGGCAGCTGC AGACACTACA ACATACTGCT CACTGCAGAC 960
GGCCAGTTCT ATCTAGCGGA GAAGCACAAC TTTACCAATA TCCCAGAGCT TATTAATTAC 1020
CATCAGCACA ATGCTGCAGG TCTGGTGAGC AGACTAAAGT ACATTGTGTC TAATCGGGCT 1080
CAGAATGCTC CCTGCACTGC TGGTCTGGGT TATGGATCTT GGGAGATCGA TCCACGCCAG 1140
CTTACATTTA TCAGAGAACT TGGAAATGGA CAGTTCGGTG TGGTAAAGTA TGGGAAATGG 1200
CAAGGCCGTC ACGACGTGGC CATTAAAATG GTCAAAGAGG GCTCGATGTC TGAGGACGAC 1260
TTCATTGAAG AGGCCAAGGT CATGATGAAA CTCTGTCACG GAAACCTGGT ACAGCTCTAT 1320
GGTGTGTGCA CGAAACAAAG ACCCATCTAC ATAGTCACAG AATATCTCGC AAATGGATGT 1380
CTGCTGAATT ACTTGCAGGA GGGTCTCTTA AACCCCACGA GTATTGCGCT TCTTGAGATG 1440
TGCAAAGATG TCAGCGAGGG CATGAAATAC TTAGAGGCCA ATCAGTTCAT CCATAGAGAC 1500
CTGGCTGCAA GGAACTGTTT AGTGGACTCA AATGGAACAA TTAAAGTGAC TGATTTTGGA 1560
TTGTCAAGAT ATGTTCTGGA TGATGAATAC ACCAGCTCTG TCGGATCAAA GTTTCCAGTG 1620
CGCTGGTCAC CTCCTGAAGT CCTCCTTTAC TGCAAGTTCA GCAGCAAGTC AGACATCTGG 1680
GCATTTGGCG TTTTGATGTG GGAGATTTAC ACTCAGGGCA GAATGCCGTA CGATCGGTGG 1740
AACAACACAG AGATTGTGGA GAAGATTTCT GCAGGACACC GGCTTTATCG TCCACAAATG 1800
GCCAATGAAA ATGTCTTTGC CATTATGAAC AGCTGTTGGC ATGAGAGACC CGATGAGAGG 1860
CCCACGTTCC AGGAACTTGT TGGGGTCATC AAGGATTTGC TTTTCAGTAT GCAAGAGATA 1920
TAA 1923
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+++elg+gqfgvvk+gkw++++dvaik++keg+mse+dfieeakvmmkl h +lvqly
Q: 381   LTFIRELGNGQFGVVKYGKWQGRHDVAIKMVKEGSMSEDDFIEEAKVMMKLCHGNLVQLY  440
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc+kq+piyivteyl+ngcllnyl+e   + ++  llemckdv+egm+yle ++fihrd
Q: 441   GVCTKQRPIYIVTEYLANGCLLNYLQEGLLNPTSIALLEMCKDVSEGMKYLEANQFIHRD  500
         **************************9999999999************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclvd++ ++kv+dfgl+ryvldd+y+ssvg+kfpv+wsppevl y k+ssksd+w
Q: 501   LAARNCLVDSNGTIKVTDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLLYCKFSSKSDIW  560
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         afgvlmwe++++g++py++ +n+e+vek+s g+rlyrp++a+++v+ +m+scw+e+p+er
Q: 561   AFGVLMWEIYTQGRMPYDRWNNTEIVEKISAGHRLYRPQMANENVFAIMNSCWHERPDER  620
         ************************************************************
S: 241   ptfkellsale  251
         ptf+el+  ++
Q: 621   PTFQELVGVIK  631
         ******98875
Domain Sequence
(FASTA)
LTFIRELGNG QFGVVKYGKW QGRHDVAIKM VKEGSMSEDD FIEEAKVMMK LCHGNLVQLY 60
GVCTKQRPIY IVTEYLANGC LLNYLQEGLL NPTSIALLEM CKDVSEGMKY LEANQFIHRD 120
LAARNCLVDS NGTIKVTDFG LSRYVLDDEY TSSVGSKFPV RWSPPEVLLY CKFSSKSDIW 180
AFGVLMWEIY TQGRMPYDRW NNTEIVEKIS AGHRLYRPQM ANENVFAIMN SCWHERPDER 240
PTFQELVGVI K 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00098
EKS-ANC-00100
EKS-BOT-00108
EKS-CAJ-00109
EKS-CAF-00109
EKS-CAP-00103
EKS-CIS-00119
EKS-DRM-00050
EKS-EQC-00104
EKS-FEC-00102
EKS-GAM-00052
EKS-GAG-00088
EKS-GAA-00127
EKS-HOS-00110
EKS-ICT-00102
EKS-LAC-00112
EKS-LOA-00102
EKS-MAM-00103
EKS-MEG-00083
EKS-MOD-00109
EKS-MUM-00109
EKS-MUP-00110
EKS-MYL-00121
EKS-NOL-00100
EKS-ORN-00132
EKS-ORA-00087
EKS-ORC-00099
EKS-ORL-00124
EKS-OTG-00109
EKS-PAT-00098
EKS-PES-00092
EKS-PEM-00054
EKS-POA-00100
EKS-PTV-00097
EKS-RAN-00109
EKS-SAH-00100
EKS-SOA-00057
EKS-SUS-00094
EKS-TAR-00136
EKS-TEN-00126
EKS-XET-00090
EKS-XIM-00130
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0009952; P:anterior/posterior pattern specification
GO:0035556; P:intracellular signal transduction
GO:0030178; P:negative regulation of Wnt receptor signaling pathway
GO:0060828; P:regulation of canonical Wnt receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013