EKS-DAR-00599

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00599

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	363.3	1.5E-108	13	265	253

Status

Unreviewed

Ensembl Protein

ENSDARP00000043865

UniProt Accession

F1RB74;

Protein Name

Protein Synonyms/Alias

Serine/threonine-protein kinase PLK4;

Gene Name

plk4

Gene Synonyms/Alias

plk4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000004576	ENSDARP00000043865	ENSDART00000043866

Organism

Danio rerio

Functional Description

Protein Length

941

Protein Sequence
(FASTA)

MSVSIGDKIE DFKVLTLLGK GSFACVYRAK SVNTGLEVAI KMIDKKAMHK AGMVQRVINE 60

VEIQCRLKHP SVLELYNYFE DSNYVYLVLE MCHNGEMSRY LKERKNPFTE EEARHFMHQI 120

VKGMLYLHTH GIMHRDLTLT NLLLTTSMNI KIADFGLATQ LKLPSEKHFT MCGTPNYISP 180

EVATRSAHGL ESDVWSLGCM FYAFLTGRPP FDTDTVKRTL NKVVLGEYQM PMHISAEAQD 240

LIQQLLQKNP ALRPSLSAVL DHPFMTQSGP TASKDSGSSD GGSIDSGIAT ISTASNATNN 300

SSSSRLQRRT RQMIGQPLPS RMAPIPSHSH HSTSSSFKSG QDWQPNSQDD LSRMGVGRIP 360

VGADSGRPHS RYLRRAHSSD RSAVGYSHNP QEAELERCHS EEMLSGAGRL FPQTSGYRNA 420

PHGYSKHDRL PSPPVKQPAN PASSFSTSTH STRQQMPDSQ TQPWFSNDGV FKRPADMSGH 480

SSSGSFHSER GPIGTQTSCS DKPSGLHSQQ QQPILFQHNN PGPCREDAFV SGHMPEPQAY 540

SDAQFPCPPL SKGKANTEKK DKVCPKKSFP PLCAARLKPI RQKTKNAVVS ILGNGEVCME 600

LLKGQGAQER VKEVLRISCD GSMVTVYQPN EGKGFPVLDH PPSPPEDILI CSFDDLPEKY 660

WKKYQYATKF VQLVKSKTPK VTLYTKFAKC MLMENSPNPD LEVCFYDGAK THKTSEQVRV 720

VEKSGKSYTV KGDVGLSGLN PECRLYIELS EEGHRMCLSL EAAITAEEQR SSKNTPFFPI 780

TIGRRPVNPV PPAPAPSSSS SCRPAAAAEV AHVCLSPPQH PQITPSMISY AGSDLTTASV 840

AKGSSPVRKD ERTVNSGKVL KSIFVPNIGW ASQLTTGEVW VQFNDGSQLM VQVGVSCITF 900

TSPEGHITRY KENEKLPELV KEKLHCLSSI LGLLANPAAR C 941

Nucleotide Sequence
(FASTA)

ATGAGCGTCT CAATCGGTGA CAAGATTGAG GACTTCAAGG TTCTCACCTT GTTGGGTAAA 60

GGCTCCTTTG CGTGTGTCTA CAGAGCTAAA TCTGTAAACA CAGGATTGGA AGTGGCGATC 120

AAAATGATTG ACAAGAAAGC CATGCACAAA GCTGGAATGG TGCAGAGAGT CATTAATGAG 180

GTGGAGATTC AGTGCCGGTT AAAGCATCCA TCAGTTCTCG AGCTGTACAA TTACTTTGAG 240

GACAGTAATT ATGTGTACCT GGTTCTGGAG ATGTGTCACA ACGGGGAGAT GAGCCGCTAC 300

CTAAAGGAGA GGAAAAATCC TTTTACAGAG GAAGAGGCGA GGCATTTCAT GCACCAGATT 360

GTAAAGGGCA TGCTGTACCT CCACACTCAT GGGATTATGC ACAGGGACCT AACATTGACC 420

AACCTCCTGC TCACCACCAG CATGAACATT AAAATCGCAG ACTTTGGTTT AGCCACCCAA 480

CTCAAGCTTC CCAGTGAGAA GCACTTCACC ATGTGCGGCA CACCCAACTA CATTTCACCC 540

GAAGTGGCCA CGCGCAGCGC TCACGGCCTG GAGTCAGACG TCTGGTCACT GGGCTGCATG 600

TTTTACGCCT TTCTCACAGG ACGACCGCCC TTTGACACAG ACACTGTCAA ACGCACCCTC 660

AATAAGGTGG TGCTGGGAGA GTATCAGATG CCCATGCACA TATCAGCAGA GGCTCAGGAT 720

CTAATCCAGC AGCTGTTACA AAAGAACCCA GCCCTCAGAC CGAGTCTTTC TGCAGTGCTG 780

GACCACCCGT TTATGACTCA AAGTGGGCCC ACCGCAAGCA AAGACTCCGG CAGCAGCGAC 840

GGAGGCTCCA TCGACAGCGG AATCGCCACA ATATCCACAG CTTCAAATGC AACCAACAAC 900

AGCAGCAGCA GTCGGTTACA GAGGCGAACC AGGCAGATGA TTGGGCAGCC GTTGCCCAGT 960

CGTATGGCAC CAATCCCTAG CCACTCCCAT CATTCCACCA GCTCCAGTTT TAAGAGTGGG 1020

CAGGACTGGC AGCCAAATTC ACAAGATGAT TTATCCAGGA TGGGCGTTGG GAGAATTCCC 1080

GTGGGTGCTG ACAGCGGAAG GCCTCATTCT CGCTACCTGA GACGAGCTCA TTCGTCAGAT 1140

CGATCTGCTG TTGGGTACAG CCACAATCCA CAGGAGGCAG AGCTGGAGAG ATGTCACTCA 1200

GAAGAGATGC TTTCAGGGGC TGGACGGTTA TTTCCACAGA CCTCCGGCTA TAGAAACGCA 1260

CCACATGGAT ACTCGAAACA CGACAGGCTT CCCTCTCCAC CTGTAAAACA ACCTGCTAAT 1320

CCGGCATCAT CTTTCTCTAC GTCCACTCAT TCAACGAGAC AACAAATGCC GGATTCCCAA 1380

ACACAGCCCT GGTTCAGCAA TGATGGAGTG TTCAAGAGGC CGGCAGACAT GAGCGGTCAC 1440

AGCAGCAGTG GGAGTTTCCA CTCTGAACGA GGGCCAATCG GGACACAAAC CTCCTGCAGT 1500

GACAAACCCA GCGGCCTTCA CTCTCAGCAG CAGCAGCCCA TCCTCTTCCA GCACAACAAC 1560

CCCGGGCCCT GCAGGGAAGA TGCATTTGTA TCAGGACACA TGCCAGAACC TCAGGCCTAT 1620

TCTGACGCAC AGTTTCCATG TCCACCGCTC TCCAAAGGCA AAGCAAACAC AGAGAAGAAG 1680

GACAAAGTGT GCCCTAAGAA GAGCTTCCCT CCGCTCTGTG CTGCCAGACT CAAGCCTATT 1740

CGACAGAAGA CTAAAAATGC TGTTGTCAGC ATTTTGGGCA ATGGAGAGGT GTGTATGGAG 1800

CTGCTGAAAG GACAAGGAGC TCAGGAAAGA GTCAAAGAAG TACTTCGGAT ATCCTGTGAT 1860

GGATCTATGG TGACAGTGTA CCAGCCTAAT GAAGGAAAAG GGTTCCCTGT GCTGGATCAT 1920

CCACCCTCAC CACCTGAAGA CATCCTCATC TGCAGCTTTG ATGATTTACC AGAAAAATAC 1980

TGGAAGAAAT ACCAGTACGC CACAAAGTTT GTGCAGCTGG TCAAATCTAA GACTCCAAAA 2040

GTCACCTTAT ACACCAAATT TGCCAAGTGC ATGTTGATGG AGAACTCTCC TAATCCAGAC 2100

CTGGAGGTGT GCTTTTATGA TGGTGCAAAA ACCCATAAGA CAAGTGAACA GGTGCGCGTG 2160

GTGGAGAAAA GTGGGAAGTC GTATACAGTG AAGGGTGACG TTGGTCTGAG TGGGCTCAAT 2220

CCTGAATGCA GACTCTATAT AGAGCTTTCT GAGGAGGGAC ATCGAATGTG TCTGTCTTTG 2280

GAAGCTGCAA TCACTGCTGA GGAGCAGCGC AGCTCTAAAA ACACTCCATT CTTTCCCATC 2340

ACCATCGGCA GGAGGCCTGT GAACCCGGTG CCTCCGGCTC CCGCTCCTTC ATCTTCATCT 2400

TCCTGCCGTC CAGCGGCTGC AGCAGAGGTG GCTCACGTGT GTCTCAGTCC TCCGCAGCAT 2460

CCTCAAATCA CTCCATCAAT GATTTCCTAT GCGGGGTCAG ACTTGACCAC AGCCAGTGTG 2520

GCTAAAGGCA GCTCTCCGGT CCGCAAAGAT GAACGCACCG TTAACTCTGG AAAAGTGCTC 2580

AAGTCCATTT TTGTGCCCAA CATTGGATGG GCCTCTCAGC TAACCACTGG CGAGGTCTGG 2640

GTTCAGTTTA ATGACGGGTC GCAGCTGATG GTTCAAGTTG GCGTCTCTTG CATCACTTTT 2700

ACCTCCCCCG AAGGACACAT CACAAGGTAT AAAGAGAACG AGAAGTTACC AGAGCTGGTG 2760

AAAGAGAAAC TCCACTGTCT GTCCAGCATC TTGGGTCTTC TGGCCAATCC CGCCGCCCGA 2820

TGCTGA 2826

Domain Profile

S: 2     ergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkni  61

         ++  llGkG+fa +y++k+++t+ ++a+k+++k++++k+ + ++v +e+ei ++lkh+++

Q: 13    KVLTLLGKGSFACVYRAKSVNTGLEVAIKMIDKKAMHKAGMVQRVINEVEIQCRLKHPSV  72

         67789*******************************************************

S: 62    vklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekri  120

         ++ly++fed+++vylvle+c+++++ ++lk+r +++te+e+r++++qiv+g++ylh++ i

Q: 73    LELYNYFEDSNYVYLVLEMCHNGEMSRYLKERkNPFTEEEARHFMHQIVKGMLYLHTHGI  132

         ******************************99679*************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         +hrdl+l+nl+l+ ++++ki+dfGlat+l+ ++e++ t+cGtPnyi+Pev+++++h+le+

Q: 133   MHRDLTLTNLLLTTSMNIKIADFGLATQLKLPSEKHFTMCGTPNYISPEVATRSAHGLES  192

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+WslGc++y++l+G+PPf+t+++k t++k++  ey++P ++s+ea++li++ll+k+P+

Q: 193   DVWSLGCMFYAFLTGRPPFDTDTVKRTLNKVVLGEYQMPMHISAEAQDLIQQLLQKNPAL  252

         ************************************************************

S: 241   rpsleevlkdefl  253

         rpsl++vl+++f+

Q: 253   RPSLSAVLDHPFM  265

         ***********98

Domain Sequence
(FASTA)

KVLTLLGKGS FACVYRAKSV NTGLEVAIKM IDKKAMHKAG MVQRVINEVE IQCRLKHPSV 60

LELYNYFEDS NYVYLVLEMC HNGEMSRYLK ERKNPFTEEE ARHFMHQIVK GMLYLHTHGI 120

MHRDLTLTNL LLTTSMNIKI ADFGLATQLK LPSEKHFTMC GTPNYISPEV ATRSAHGLES 180

DVWSLGCMFY AFLTGRPPFD TDTVKRTLNK VVLGEYQMPM HISAEAQDLI QQLLQKNPAL 240

RPSLSAVLDH PFM 253

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

dre:368390

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013