EKS-DAR-00431
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00431
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR555.73.0E-167157432276
StatusUnreviewed
Ensembl ProteinENSDARP00000124213
UniProt AccessionF1QPA0;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene Namefgfr3
Gene Synonyms/Alias fgfr3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000004782ENSDARP00000011898ENSDART00000013534
ENSDARG00000004782ENSDARP00000111401ENSDART00000125883
ENSDARG00000004782ENSDARP00000124213ENSDART00000149661
OrganismDanio rerio
Functional Description
Protein Length497
Protein Sequence
(FASTA)
TAGINTTDKE LEILYLTNVS FEDAGQYTCL AGNSIGYNHH SAWLTVLPAV EMEREDDYAD 60
ILIYVTSCVL FILTMVIIIL CRMWINTQKT LPAPPVQKLS KFPLKRQVSL ESNSSMNSNT 120
PLVRIARLSS SDGPMLPNVS ELELPSDPKW EFTRTKLTLG KPLGEGCFGQ VVMAEAIGID 180
KEKPNKPLTV AVKMLKDDGT DKDLSDLVSE MEMMKMIGKH KNIINLLGAC TQDGPLYVLV 240
EYASKGNLRE YLRARRPPGM DYSFDTCKIP NETLTFKDLV SCAYQVARGM EYLASKKCIH 300
RDLAARNVLV TEDNVMKIAD FGLARDVHNI DYYKKTTNGR LPVKWMAPEA LFDRVYTHQS 360
DVWSYGVLLW EIFTLGGSPY PGIPVEELFK LLKEGHRMDK PANCTHELYM IMRECWHAVP 420
SQRPTFRQLV EDHDRVLSMT STDEYLDLSV PFEQYSPTCP DSNSTCSSGD DSVFAHDPLP 480
EEPCLPKHHH SNGVIRT 497
Nucleotide Sequence
(FASTA)
ACTGCTGGGA TAAATACTAC GGATAAAGAG CTGGAGATTC TCTACCTGAC CAATGTGTCT 60
TTCGAGGATG CGGGGCAATA CACTTGTCTG GCAGGGAACT CGATTGGCTA TAACCATCAC 120
TCTGCTTGGC TTACAGTCTT ACCAGCGGTG GAGATGGAGA GAGAGGATGA TTATGCAGAC 180
ATCCTCATCT ATGTGACAAG CTGCGTGCTC TTCATTCTCA CCATGGTCAT CATTATTCTC 240
TGCCGAATGT GGATAAACAC GCAGAAGACT CTCCCGGCAC CACCTGTTCA AAAACTGTCC 300
AAATTCCCCC TCAAGAGACA GGTGTCCTTG GAATCCAACT CTTCCATGAA TTCAAACACC 360
CCGCTGGTCA GGATCGCCCG CCTGTCATCC AGCGATGGGC CGATGTTGCC TAACGTGTCT 420
GAACTTGAAC TGCCCTCTGA CCCCAAGTGG GAGTTTACTC GAACAAAGTT AACGTTGGGG 480
AAACCGTTGG GAGAGGGCTG CTTTGGGCAG GTGGTGATGG CTGAAGCCAT TGGGATTGAC 540
AAAGAAAAAC CCAACAAACC TCTAACTGTT GCTGTCAAGA TGCTCAAAGA TGACGGCACA 600
GATAAAGACC TGTCAGACCT TGTGTCTGAA ATGGAGATGA TGAAGATGAT TGGGAAACAT 660
AAGAACATCA TTAACTTGCT GGGAGCATGT ACTCAAGACG GTCCTCTGTA CGTGCTGGTA 720
GAATACGCCT CTAAAGGGAA TCTTAGGGAA TACTTACGAG CCAGAAGGCC ACCTGGGATG 780
GACTACTCAT TCGACACCTG TAAGATCCCA AACGAAACGC TAACATTTAA AGACCTGGTG 840
TCCTGCGCCT ATCAGGTCGC CAGGGGTATG GAGTACCTGG CCTCAAAGAA GTGTATCCAT 900
AGGGACCTCG CAGCCCGGAA TGTTCTGGTT ACCGAGGACA ACGTGATGAA GATTGCAGAC 960
TTCGGCCTTG CCAGAGATGT GCACAACATT GACTACTACA AGAAGACCAC CAACGGTCGT 1020
CTGCCCGTCA AATGGATGGC ACCAGAAGCA CTGTTCGATC GCGTCTACAC GCACCAGAGC 1080
GATGTGTGGT CTTATGGTGT GTTGTTGTGG GAGATTTTCA CTCTTGGTGG ATCCCCGTAT 1140
CCAGGTATCC CAGTGGAGGA GCTCTTTAAA CTGCTGAAGG AAGGCCATCG GATGGACAAA 1200
CCGGCCAACT GCACTCATGA ACTGTACATG ATCATGCGAG AATGTTGGCA TGCTGTTCCT 1260
TCACAAAGAC CCACGTTCAG ACAGCTGGTG GAGGACCACG ACAGGGTTCT TTCCATGACC 1320
TCCACTGACG AGTACCTGGA CCTCTCTGTA CCGTTCGAGC AGTATTCACC GACCTGTCCG 1380
GACTCCAACA GCACCTGTTC CTCTGGCGAT GACTCTGTGT TTGCCCACGA CCCCTTACCT 1440
GAGGAGCCAT GCCTCCCTAA ACACCACCAC AGCAACGGGG TCATACGAAC ATAA 1494
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aeaig+dk+k++k  tvavkmlk+d tdkdl+dlvseme++k+
Q: 157   LTLGKPLGEGCFGQVVMAEAIGIDKEKPNKPLTVAVKMLKDDGTDKDLSDLVSEMEMMKM  216
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyv+veya+kGnlre+lrarrp+g+++s d++k+++e+lt+
Q: 217   IGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKIPNETLTF  276
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlardvh+idyykkt
Q: 277   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNIDYYKKT  336
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvws+Gvllwei+tlGgspypgi+veelfkllkeGh
Q: 337   TNGRLPVKWMAPEALFDRVYTHQSDVWSYGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH  396
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlved  276
         rm+kpa+ct+ely++mrecwha++s+rptf+qlved
Q: 397   RMDKPANCTHELYMIMRECWHAVPSQRPTFRQLVED  432
         **********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA IGIDKEKPNK PLTVAVKMLK DDGTDKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVLVEYASKG NLREYLRARR PPGMDYSFDT CKIPNETLTF 120
KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD VHNIDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSYG VLLWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPANCTH ELYMIMRECW HAVPSQRPTF RQLVED 276
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ciona savignyi"; ?>Gasterosteus aculeatus"; ?>
EKS-CIS-00182
EKS-GAA-00177
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008284; P:positive regulation of cell proliferation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013