EKS-DAR-00839
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00839
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/DMPK441.03.0E-13284346263
StatusUnreviewed
Ensembl ProteinENSDARP00000008454
UniProt AccessionF1R417;
Protein Name
Protein Synonyms/Alias
Gene Namerock2b
Gene Synonyms/Alias rock2b;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000004877ENSDARP00000008454ENSDART00000002777
ENSDARG00000004877ENSDARP00000117860ENSDART00000147168
OrganismDanio rerio
Functional Description
Protein Length1387
Protein Sequence
(FASTA)
GHRAAAMSTG AGKRIESRVR KLETLIKNQK SPLNLESLLD SVTALALDLN HPALRKNKNI 60
DAFLSRYEKA VCNLKELQVK LDDFDRVKLI GRGAFGAVQL VRHKVSQQVY AMKQLSKFEM 120
VKRSDSAFFW EERDIMAFSQ SPWIVQLCCA FQDEKYLYLV MEFMPGGDLV TLTSNYDIPE 180
EWAQFYTAEV VLALDAIHSL GFIHRDIKPD NMLLDRNGHL KLADFGTCMK MDSTGMVRCD 240
TAVGTPDYIS PEVLMSQGGT GYYGRECDWW SVGVFIYELL VGDTPFYSES LVGTYGKIMD 300
HKNSLTFPDD IEMSKNAKDL ICAFLSSREV RLGRTGVDEI KCHPFFKNDQ WTFDTIRDTM 360
APVVPELSSD IDTSNFDDDI KDDPIGTETF PPPRAFAGNQ LPFVGFTYFR EDQLLTQQNK 420
CSEEDIIEDH GLNHTESNDL EKRLKKLEEK FKHEMQAKEE LENKCRIANQ RLEKLSKDLE 480
EEVNARQEAE DNLRSLEKEK VLLKHQRTQS VRKAGLETDR KRLLENEVSS LKEQLAELKK 540
KNQISHLSAE KNIHLERQLE EVSAKLQAEL EESERLKKAQ IEAFRQSQQL ELSLRELQER 600
LAQLENSRLV LEQDKLSLQT SLELEKRERN AGSETITDLQ DFCFGLEEDP QVGNKLLSSV 660
LISLSQLQED LTTLEKEKNK QEIDLSFKLK AVQQSLEQEE AEHKTTKARL ADNNKINQSI 720
EAKSETLKDM EHKLLEERSA KQQLENRLMQ LEKENSVLDC DYKQAKHELQ ELRSLKENLT 780
EQVEVLNVRV QQETQRKTLC QGDLKVQRQE INSLRSSEQQ LKQELNHLLE LKLTLEKQNQ 840
ELSKEREESE KQLKEMKDQL EAEQYFTKLY KTQIRELKEE SDEKVKLYKD AQQRIEDLQE 900
ERDSLASQLE VSLTKADSEQ LARITVEEQY SDLEKEKIMK ELEIKDMIAR HRQDLAEKDG 960
TINSKLEESN RTLTVDVANL ASEKEELNNK LKHIQQKLEK IKEEEKQMKS LTVSYEKQIQ 1020
VEKTLKIQAI NKLAEVMKKT DGRPHQINNT DIRRKEKEIR QLQLQLRTEK EKLNHSIIKY 1080
QREINDMQAM IAEESQVRLE MQMSLDSKDS DIERLRSQLT SLSIHSLDTT SISSIGNDLD 1140
SDEAYPAAES GLEGWLSMPA KNTKRFGWDK KYVVVSSKKI LFYDSEQDRE QSSPFMILDI 1200
DKLFHVRPVT QTDVYRADPR EIPRIFQILY ANEGESKKEE LPVESLSVTE RSLCIPHKGH 1260
EFVLTLYHFP SSCEVCPRPL WHVFRPPPAL ECRRCRVKCH KDHIDRKEEV LAPCRVNYDM 1320
STAKEMLLLA NSTEEQKKWV SRLLKRVPRK PSIAHSSSIA ISAAPSEATP TTLSPQPSPR 1380
LAQSSPR 1387
Nucleotide Sequence
(FASTA)
GGACACCGAG CTGCCGCAAT GTCGACCGGA GCGGGGAAGA GAATAGAGAG CCGGGTGAGA 60
AAACTAGAGA CGCTGATCAA GAACCAGAAA TCACCGTTGA ACTTGGAGAG TTTGCTGGAT 120
TCAGTAACTG CCCTTGCCCT TGATCTGAAC CATCCAGCAC TGAGAAAGAA CAAAAACATA 180
GATGCCTTCT TAAGCAGATA TGAAAAAGCC GTGTGCAACC TCAAGGAACT ACAGGTGAAG 240
CTGGATGATT TTGATCGAGT CAAGCTGATC GGTCGTGGAG CGTTTGGCGC AGTGCAGCTG 300
GTACGGCACA AAGTATCTCA ACAAGTTTAT GCCATGAAGC AGCTCAGCAA GTTTGAGATG 360
GTCAAGCGCT CTGACTCCGC CTTTTTCTGG GAGGAGCGTG ACATCATGGC TTTCTCCCAG 420
AGCCCTTGGA TAGTTCAGCT GTGCTGTGCA TTCCAAGATG AAAAGTACCT TTATTTGGTG 480
ATGGAGTTCA TGCCAGGTGG AGATCTGGTG ACTCTGACCA GCAACTATGA CATCCCAGAG 540
GAATGGGCTC AATTCTATAC GGCAGAAGTG GTGCTGGCAC TCGACGCCAT CCATTCTCTG 600
GGCTTCATCC ACAGAGACAT CAAACCAGAC AACATGCTGC TGGACCGCAA TGGACACCTC 660
AAACTCGCAG ACTTTGGCAC ATGCATGAAG ATGGACTCGA CTGGTATGGT ACGCTGTGAC 720
ACTGCTGTTG GGACACCTGA TTACATTTCT CCAGAGGTTT TAATGTCTCA AGGAGGGACT 780
GGTTATTACG GTCGCGAGTG TGACTGGTGG TCTGTTGGTG TTTTTATTTA TGAGCTTCTA 840
GTGGGCGACA CTCCATTTTA TTCCGAGTCT CTGGTGGGCA CATATGGAAA GATCATGGAT 900
CACAAGAACA GCTTAACTTT CCCAGATGAT ATTGAAATGT CAAAGAATGC CAAAGACCTC 960
ATCTGTGCCT TTCTGAGTAG CAGGGAGGTG AGGCTTGGCC GAACTGGAGT GGATGAAATA 1020
AAATGTCACC CCTTCTTTAA GAATGATCAG TGGACCTTCG ACACCATACG AGACACCATG 1080
GCTCCAGTGG TGCCAGAGCT GAGTAGCGAT ATTGACACCA GTAACTTTGA TGATGACATT 1140
AAGGATGATC CGATAGGAAC AGAGACGTTC CCTCCGCCCC GTGCCTTCGC AGGGAACCAG 1200
CTACCATTTG TGGGTTTCAC CTATTTCAGG GAGGACCAAT TGTTAACACA ACAAAATAAG 1260
TGTTCAGAGG AAGATATCAT TGAAGATCAT GGCTTAAACC ACACAGAGTC TAACGACCTG 1320
GAGAAGAGGC TGAAAAAGTT GGAGGAAAAA TTCAAACATG AGATGCAAGC AAAGGAAGAA 1380
CTGGAAAATA AATGCCGAAT AGCAAATCAG CGGCTGGAGA AATTGTCCAA AGATCTTGAA 1440
GAAGAAGTGA ATGCGAGACA GGAGGCGGAA GACAACCTGA GATCCCTGGA GAAAGAGAAA 1500
GTTTTACTGA AACACCAGCG TACACAGAGC GTAAGAAAAG CTGGTCTAGA GACCGACAGA 1560
AAACGGCTGC TGGAGAATGA AGTAAGCAGC CTGAAAGAGC AGCTTGCCGA ACTGAAGAAA 1620
AAGAACCAGA TCTCTCATCT GTCTGCTGAG AAGAACATTC ACCTGGAAAG ACAGCTGGAG 1680
GAGGTGAGTG CCAAGCTTCA GGCCGAGCTG GAGGAGTCGG AGAGGCTGAA GAAGGCCCAG 1740
ATCGAGGCCT TTAGACAGTC CCAGCAGCTG GAGCTTTCCC TCAGGGAGCT GCAGGAGCGT 1800
CTGGCCCAGC TGGAGAACAG CAGGCTGGTT CTGGAGCAGG ACAAACTCAG CCTGCAGACC 1860
TCGCTAGAGC TGGAGAAACG AGAGAGAAAC GCCGGCTCAG AGACCATCAC TGACCTGCAG 1920
GATTTTTGCT TTGGATTAGA GGAAGATCCT CAAGTTGGAA ATAAACTTCT GTCTTCTGTT 1980
TTGATCAGTC TGTCTCAATT ACAAGAGGAT CTTACAACCC TGGAAAAGGA GAAGAATAAG 2040
CAGGAGATCG ACCTCTCCTT CAAACTCAAA GCAGTTCAGC AGAGTCTGGA GCAGGAGGAG 2100
GCTGAACATA AAACCACTAA AGCCAGATTG GCCGACAACA ACAAAATCAA CCAATCCATA 2160
GAGGCAAAGT CTGAGACCCT GAAAGACATG GAACATAAGC TGTTGGAAGA ACGATCTGCG 2220
AAGCAACAAC TGGAAAACAG ACTGATGCAG CTGGAGAAGG AAAACTCTGT ATTAGACTGT 2280
GATTACAAAC AAGCCAAACA TGAGCTTCAG GAGCTCCGCT CGCTCAAAGA AAATCTCACA 2340
GAGCAGGTGG AGGTGCTGAA TGTGCGGGTG CAGCAGGAGA CACAGAGGAA AACTCTCTGT 2400
CAAGGTGATC TCAAAGTTCA GAGGCAGGAG ATCAACAGCC TGCGGTCATC AGAACAACAG 2460
CTCAAACAAG AACTCAACCA TCTGCTGGAG CTCAAACTCA CACTGGAGAA ACAAAACCAG 2520
GAGCTGTCCA AGGAACGAGA AGAATCTGAA AAACAGCTGA AGGAGATGAA GGACCAGCTG 2580
GAGGCTGAGC AGTACTTCAC GAAACTGTAC AAGACTCAGA TTCGAGAGCT GAAAGAGGAA 2640
AGCGATGAAA AGGTTAAACT CTACAAAGAT GCTCAGCAGA GAATAGAGGA CCTGCAGGAA 2700
GAGAGGGACT CGTTAGCGTC TCAGTTGGAG GTGAGCCTGA CGAAGGCTGA CTCTGAACAG 2760
TTGGCTCGCA TCACCGTTGA AGAGCAATAC TCGGACCTGG AGAAAGAGAA GATCATGAAG 2820
GAACTGGAGA TAAAGGACAT GATCGCCAGA CACCGGCAGG ATCTTGCAGA AAAGGACGGT 2880
ACCATCAACT CGAAGCTGGA GGAGTCAAAC CGTACGCTGA CTGTGGATGT TGCCAACCTG 2940
GCCAGTGAGA AAGAGGAGCT CAACAATAAA CTGAAGCACA TACAGCAAAA GCTGGAGAAG 3000
ATCAAAGAAG AAGAGAAACA GATGAAATCT CTCACAGTGT CGTATGAGAA GCAGATACAG 3060
GTGGAGAAAA CACTCAAGAT TCAGGCTATA AACAAGCTGG CGGAGGTCAT GAAGAAGACG 3120
GACGGCAGGC CACACCAAAT CAACAACACA GACATCCGCA GGAAGGAGAA GGAGATCAGA 3180
CAACTCCAGC TGCAGCTCCG CACGGAGAAA GAAAAGCTTA ACCACTCCAT CATCAAATAC 3240
CAGAGAGAAA TCAACGACAT GCAGGCTATG ATAGCAGAGG AGTCTCAGGT GCGTCTGGAG 3300
ATGCAGATGT CTCTGGACAG TAAAGACAGT GATATTGAGC GTCTGCGCAG TCAACTCACG 3360
TCTCTGAGCA TTCACTCTCT GGACACCACC AGCATCAGCA GCATCGGCAA TGACCTGGAT 3420
TCTGACGAGG CATATCCAGC CGCAGAGTCC GGTCTTGAAG GATGGCTCTC AATGCCTGCC 3480
AAAAACACCA AACGGTTTGG ATGGGATAAG AAGTATGTGG TTGTGAGCAG CAAGAAAATC 3540
CTGTTTTATG ACTCTGAACA AGACCGAGAG CAGTCCAGTC CATTCATGAT CCTGGACATT 3600
GACAAACTCT TCCACGTGAG ACCCGTCACT CAGACAGATG TTTACCGCGC AGATCCCAGA 3660
GAAATCCCTC GCATCTTCCA GATACTATAT GCGAATGAAG GAGAGAGCAA GAAAGAGGAG 3720
CTGCCCGTGG AGTCGTTATC TGTGACTGAG AGGTCACTGT GTATCCCACA CAAGGGTCAC 3780
GAGTTTGTTC TGACGCTTTA TCACTTCCCC TCGAGCTGCG AGGTCTGTCC ACGACCCTTA 3840
TGGCACGTCT TCAGACCTCC GCCGGCTCTC GAGTGCAGAC GCTGTAGAGT CAAGTGCCAT 3900
AAAGACCACA TCGATCGCAA AGAAGAGGTC CTCGCTCCAT GTAGAGTGAA TTACGACATG 3960
TCCACAGCGA AAGAGATGCT GCTGCTGGCA AACTCCACAG AGGAGCAGAA GAAGTGGGTC 4020
AGTCGGCTGC TCAAGAGGGT TCCGCGTAAA CCTTCCATCG CCCACTCTTC CAGCATAGCC 4080
ATATCCGCTG CGCCCTCAGA GGCAACACCC ACTACCCTTT CCCCTCAGCC GTCGCCTCGC 4140
CTCGCTCAGT CTTCACCCAG A 4161
Domain Profile
S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60
         f+ +k+iGrGafg v++vr+k +++vyamk l+k+e++kr++saff+eerd++++++s+w
Q: 84    FDRVKLIGRGAFGAVQLVRHKVSQQVYAMKQLSKFEMVKRSDSAFFWEERDIMAFSQSPW  143
         6789********************************************************
S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120
         ivql +afqdekylylvme+++GGdl+tl s+y+  +pee+a+fy+ae+vlald++h+lg
Q: 144   IVQLCCAFQDEKYLYLVMEFMPGGDLVTLTSNYD--IPEEWAQFYTAEVVLALDAIHSLG  201
         **********************************..************************
S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180
         ++hrdikpdn+lld++Gh+kladfG+c+k++++g+v++++avGtpdyispevl +++ g+
Q: 202   FIHRDIKPDNMLLDRNGHLKLADFGTCMKMDSTGMVRCDTAVGTPDYISPEVLMSQG-GT  260
         *******************************************************99.9*
S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240
         g+yg+ecdwws+Gv++yellvg+tpfy+eslv ty+ki++hk+sl+fp+d ++s++akdl
Q: 261   GYYGRECDWWSVGVFIYELLVGDTPFYSESLVGTYGKIMDHKNSLTFPDDIEMSKNAKDL  320
         ************************************************************
S: 241   ikklltsreerlgregiedlkkhpff  266
         i+++l+sre rlgr g++++k+hpff
Q: 321   ICAFLSSREVRLGRTGVDEIKCHPFF  346
         *************************9
Domain Sequence
(FASTA)
FDRVKLIGRG AFGAVQLVRH KVSQQVYAMK QLSKFEMVKR SDSAFFWEER DIMAFSQSPW 60
IVQLCCAFQD EKYLYLVMEF MPGGDLVTLT SNYDIPEEWA QFYTAEVVLA LDAIHSLGFI 120
HRDIKPDNML LDRNGHLKLA DFGTCMKMDS TGMVRCDTAV GTPDYISPEV LMSQGGTGYY 180
GRECDWWSVG VFIYELLVGD TPFYSESLVG TYGKIMDHKN SLTFPDDIEM SKNAKDLICA 240
FLSSREVRLG RTGVDEIKCH PFF 263
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0005543; F:phospholipid binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000910; P:cytokinesis
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011072; HR1_rho-bd.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR017892; Pkinase_C.
IPR001849; Pleckstrin_homology.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR020684; Rho-assoc_coiled-coil_kin.
IPR015008; Rho-bd.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF02185; HR1; 1.
PF00169; PH; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
PF08912; Rho_Binding; 1.
SMARTs
SM00109; C1; 1.
SM00233; PH; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
Created Date20-Feb-2013